Gomes Lab
@gomeslab.bsky.social
2.3K followers
300 following
18 posts
We are focused on understanding how aging and other factors that shape host physiology regulate cancer progression, evolution and treatment responses
https://lab.moffitt.org/gomes/
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Gomes Lab
@gomeslab.bsky.social
· Jul 11
Cancer progression through the lens of age-induced metabolic reprogramming - Nature Reviews Cancer
In this Perspective, Lazure and Gomes argue that metabolic changes that occur as a result of ageing may shape tumour initiation and progression and the development of metastatic disease.
www.nature.com
Gomes Lab
@gomeslab.bsky.social
· Jul 11
Cancer progression through the lens of age-induced metabolic reprogramming - Nature Reviews Cancer
In this Perspective, Lazure and Gomes argue that metabolic changes that occur as a result of ageing may shape tumour initiation and progression and the development of metastatic disease.
www.nature.com
Reposted by Gomes Lab
Gomes Lab
@gomeslab.bsky.social
· Feb 3
Aging directs the differential evolution of KRAS-driven lung adenocarcinoma
Lung adenocarcinoma (LUAD), the most common histological subtype of lung cancer( [1][1], [2][2] ), is a disease of the elderly, with an average age of diagnosis of about 70 years of age( [3][3] ). Old...
www.biorxiv.org
Reposted by Gomes Lab
Reposted by Gomes Lab
Gomes Lab
@gomeslab.bsky.social
· Nov 27
Gomes Lab
@gomeslab.bsky.social
· Nov 25
Stan Drapela
@standrapela.bsky.social
· Nov 25
Čeští vědci získali v USA prestižní granty. Dozvěděli se to v úkrytu před hurikánem | Forbes
Čeští vědci Stanislav Drápela a Tomáš Zelenka z institutu Moffitt Cancer Center v americké Tampě získali nezávisle na sobě prestižní granty na výzkum proti rakovině.
forbes.cz
Gomes Lab
@gomeslab.bsky.social
· Nov 25
Reposted by Gomes Lab
Brendan Manning
@bdmanning.bsky.social
· Nov 21
Assistant Professor, Department of Molecular Metabolism
The Department of Molecular Metabolism (MET) at the Harvard T.H. Chan School of Public Health invites applications for the level of assistant professor. The shared interest of MET faculty is to explor...
academicpositions.harvard.edu
Reposted by Gomes Lab
Barbara Marte
@barbmarte.bsky.social
· Nov 20
Normal breast tissues harbour rare populations of aneuploid epithelial cells - Nature
Using single-cell DNA sequencing we show that most healthy women harbour rare populations of aneuploid epithelial cells with copy number alteration events in their breast tissue that expand and accumu...
www.nature.com
Reposted by Gomes Lab
Reposted by Gomes Lab
Camila dos Santos
@caoresco.bsky.social
· Nov 20
Epigenetic scars of Brca1 loss point toward breast cancer cell of origin - Nature Genetics
The two-hit hypothesis suggests that a second mutation is necessary for cancer development in cells with a defective tumor-suppressor gene, such as BRCA1. However, a study now shows that the loss of j...
www.nature.com
Gomes Lab
@gomeslab.bsky.social
· Nov 19
Reposted by Gomes Lab
Gomes Lab
@gomeslab.bsky.social
· Nov 18
Adipose tissue retains an epigenetic memory of obesity after weight loss - Nature
Stable epigenetic changes indicate the existence of an obesogenic memory in mouse adipocytes that primes cells for pathological responses in an obesogenic environment and potentially contributes to th...
www.nature.com
Reposted by Gomes Lab
Christian Frezza
@frezzalab.bsky.social
· Nov 18
Gomes Lab
@gomeslab.bsky.social
· Nov 17
Gomes Lab
@gomeslab.bsky.social
· Nov 17
Gomes Lab
@gomeslab.bsky.social
· Nov 16
Gomes Lab
@gomeslab.bsky.social
· Nov 16
Gomes Lab
@gomeslab.bsky.social
· Nov 16
Methylmalonic acid is exhausting! The story of an age-related metabolite that suppresses anti-tumor immunity
Methylmalonic acid (MMA) is a metabolite known to promote tumor progression within tumor cells but its impact on anti-tumor immune cells has not been studied. Here, we reveal a previously unknown immu...
communities.springernature.com