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Mikala Egeblad

@megeblad.bsky.social

2.2K followers 350 following 69 posts

Bloomberg Distinguished Professor of Tumor Microenvironment. Johns Hopkins University School of Medicine.

Mikala Egeblad is a Bloomburg Distinguished Professor at Johns Hopkins School of Medicine. She is known for her research into cancer, and how it spreads in humans.

Source: Wikipedia

Biology 45%

Medicine 41%

Posts Media Videos Starter Packs

Reposted by Mikala Egeblad

Aguirre-Ghiso Lab @jaguirreghisolab.bsky.social · Jul 30

www.medpagetoday.com/hematologyon...

COVID Infection May Ignite Dormant Cancer in Survivors, Study Says

These patients should consider vaccination against respiratory viruses, according to researcher

www.medpagetoday.com

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Reposted by Mikala Egeblad

Aguirre-Ghiso Lab @jaguirreghisolab.bsky.social · Jul 30

Delighted to see this story out and collaborate with amazing teams led by @jdegregori.bsky.social Mercedes Rincon & @roelvermeulen.bsky.social. Proud to see science propelled by our lab @cdi-einstein.bsky.social expanded to better understand cancer dormancy. Congrats! www.nature.com/articles/s41...

Respiratory viral infections awaken metastatic breast cancer cells in lungs - Nature

Mouse models show that respiratory infections from viruses such as influenza and SARS-CoV-2 can trigger metastasis of dormant breast cancer cells in the lungs, a finding supported by epidemiological d...

www.nature.com

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Reposted by Mikala Egeblad

Max Kozlov @maxkozlov.bsky.social · Jul 30

Hidden in the lungs of some breast cancer survivors are tumor cells that can remain dormant for decades — until they one day trigger a relapse.

Now, experiments show for the first time these rogue cells can be roused from their slumber by common respiratory illnesses such as COVID-19 or the flu.

‘Sleeping’ cancer cells in the lungs can be roused by COVID and flu

Inflammation from the respiratory infections seems to be the culprit, study in mice finds.

www.nature.com

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Reposted by Mikala Egeblad

Duke Institute for Brain Sciences @dukebrain.bsky.social · Jul 25

For early career researchers in our community - this is invaluable. Info here:
public.csr.nih.gov/ForReviewers...

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Reposted by Mikala Egeblad

Hannah Meyer @hannahvmeyer.bsky.social · Jul 25

Check out how we tackled one of the fundamental challenges in immunology, out today @cp-cellsystems.bsky.social: www.cell.com/cell-systems.... Our major innovations are BATCAVE and BATMAN, two new players to get us closer to solving TCR-pMHC predictions!

T cell receptor cross-reactivity prediction improved by a comprehensive mutational scan database

Banerjee et al. present a comprehensive T cell receptor cross-reactivity database and a hierarchical Bayesian framework to predict T cell receptor targets. Together, they reveal structural and biochem...

www.cell.com

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Reposted by Mikala Egeblad

Aguirre-Ghiso Lab @jaguirreghisolab.bsky.social · Jul 23

@megeblad.bsky.social once more revealing significant cancer biology - Congrats!
www.nature.com/articles/s41...

Neutrophils drive vascular occlusion, tumour necrosis and metastasis - Nature

Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.

www.nature.com

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Mikala Egeblad @megeblad.bsky.social · Jul 17

As a new postdoc in my lab (@cshlnews.bsky.social → @jhu.edu) @adrover.bsky.social (now @crick.ac.uk) saw NETs in tumors—I shrugged. But he looked closer in 3D: NETs block tumor vessels, driving necrosis, hypoxia, EMT & metastasis.
🔗 www.nature.com/articles/s41...
@jhu-bdps.bsky.social @nature.com

Neutrophils drive vascular occlusion, tumour necrosis and metastasis - Nature

Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.

www.nature.com

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Reposted by Mikala Egeblad

Max Perutz Labs Vienna @maxperutzlabs.ac.at · Jul 23

📢 Open Call! The Max Perutz Labs invite applications for a Tenure-Track Professorship in Mechanistic Cell and Developmental Biology. More details ➡️ tinyurl.com/3fbkp89c

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Reposted by Mikala Egeblad

Elizabeth McKenna @elizsmckenna.bsky.social · Jul 22

It's my first #newPI roll call on BlueSky! Calling all new #cancer PIs who just started or who are about to start their labs! Please say hi and what you work on so I can follow you if I don't already! 😃

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Reposted by Mikala Egeblad

Elizabeth McKenna @elizsmckenna.bsky.social · Jul 18

Great news! The AACR journals are now on BlueSky! Be sure to follow @aacrjournals.bsky.social!! #FollowFriday

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Reposted by Jennifer A. Richeson, David M. Amodio, Elena Litchman , and 1 more Jennifer A. Richeson, David M. Amodio, Elena Litchman, Mikala Egeblad

Aaron J. Waltke @goodaaron.bsky.social · Jul 18

I can confirm the PBS Passport is a very good deal for $5/month or $2.50/month if you do yearly.

Thousands of hours of top notch content. NOVA is great. The new Ken Burns doc on Leonardo da Vinci is excellent.

You can sign up at the link below!

www.pbs.org/passport/lea...

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Mikala Egeblad @megeblad.bsky.social · Jul 18

I hear you 😉 We found a type of clot-causing neutrophils in cancer. By blocking tumor vessels, they drive tumor necrosis, which in turn cause metastasis. Key message: Necrosis can be an active process and necrosis can cause metastasis. Free link to article here: www.nature.com/articles/s41...

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Reposted by Mikala Egeblad

Trends in Cancer @cp-trendscancer.bsky.social · Jul 18

Platelets: tailoring metastasis treatment

The dreadful liaison between platelets and tumor cells was discovered half a century ago. Since then, a plethora of studies have characterized the contribution of platelets to primary tumor development, survival of circulating tumor cells in the bloodstream, and metastatic seeding and outgrowth. Yet, although these provided a deep understanding of how platelets shape cancer progression, the field suffers from a lack of additional knowledge required to design efficient therapeutic strategies. Here, we aim to summarize recent discoveries that identify new ways in which platelets shape metastasis beyond their initial intravascular role. We further discuss platelet-borne molecular targets that could represent new avenues for therapeutically targeting platelets’ contribution to metastasis.

dlvr.it

Reposted by Mikala Egeblad

Claire McCarthy @clairem402.bsky.social · Jul 18

Check out some #CoolScienceImages (with music by Victor Leksell) from a @nature.com paper. In the study, @adrover.bsky.social, @megeblad.bsky.social, et al. found that neutrophil extracellular traps (NETs) drive tumor necrosis and metastasis: www.nature.com/articles/s41...
#FluorescenceFriday 🧪

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Reposted by Mikala Egeblad

Alejandro Brenes @ajbrenes.com · Jul 17

Exciting new work at @nature.com showing that Neutrophil Extracellular Traps in the vasculature can actively promote necrosis in cancer and that targeting NETs is can reduce necrosis and metastasis. Great work from @adrover.bsky.social @megeblad.bsky.social

Neutrophils drive vascular occlusion, tumour necrosis and metastasis - Nature

Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.

www.nature.com

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Reposted by Mikala Egeblad

Jose M. Adrover @adrover.bsky.social · Jul 17

I’m happy to share our latest work on tumour necrosis! During my time in the @megeblad.bsky.social lab, we found that tumour necrosis is not a passive phenomenon secondary to tumour growth, but an active phenomenon driven by neutrophils and NETs! Thread below: (1/13)
www.nature.com/articles/s41...

Neutrophils drive vascular occlusion, tumour necrosis and metastasis - Nature

Neutrophils actively induce tumour necrosis, driving vascular occlusion, pleomorphic necrosis and metastasis.

www.nature.com

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Reposted by Mikala Egeblad

EACR - European Association for Cancer Research @helloeacr.bsky.social · Jul 15

[email protected] Postdoctoral Fellowships are awarded for a period of three years and support excellent postdoctoral researchers in laboratories throughout Europe. Is that you?

Apply by 20 August: eacr.org/eacr-fellows...

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Reposted by Mikala Egeblad

Ivan Zanoni @lozanzi.bsky.social · Jun 15

#WeekendRead! #BeyondNETosis! @caroleparentlab.bsky.social @sbarya.bsky.social &co show @natcellbio.nature.com that neutrophils can secrete nuclear-derived exosomes containing LTB4 & DNA which direct migration but at also favor inflammation resolution via neutrophil retrotransmigration!

Neutrophils secrete exosome-associated DNA to resolve sterile acute inflammation - Nature Cell Biology

Arya et al. report that migrating neutrophils resolve acute inflammation by releasing exosomes associated with nuclear DNA. This process is distinct from the release of neutrophil extracellular traps,...

go.nature.com

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Reposted by Mikala Egeblad

Claus Jorgensen @clausjorgensen.bsky.social · Jun 7

We are looking for a postdoctoral fellow to come work with us: www.cruk.manchester.ac.uk/career/mi-25... Please reach out

MI/25/33 - Postdoctoral Scientist Systems Oncology Group | Cancer Research UK Manchester Institute

Add brief description here

www.cruk.manchester.ac.uk

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Reposted by Erin Baker, Andrew R. Morral, Enzo Rossi , and 4 more Erin Baker, Andrew R. Morral, Enzo Rossi, Nancy T. Ammerman, Michelle Dion, Mikala Egeblad, Dominique C. Bergmann

Carl T. Bergstrom @carlbergstrom.com · Jun 6

Very smart, high ROI initiative from the Spencer Foundation.

Providing bridge funding for canceled NSF grants:

1) directs funds to projects already screened by a top-noch review process.
2) avoids imposing proposal prep costs on researchers.
3) ameliorates the disruption from GOP sabotage.

Rapid Response Bridge Funding Program

In the face of recent abrupt shifts in federal funding for education research, including large-scale terminations of National Science Foundation (NSF) research grant awards, we have developed a rap...

www.spencer.org

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Reposted by Mikala Egeblad

Michael Love @mikelove.bsky.social · May 29

Up until June 2 (Monday) you can apply for scholarship to attend GBCC2025 at Cold Spring Harbor Laboratory. This is the Bioconductor / Galaxy joint conference at the end of June. You should submit a poster abstract to apply for scholarship. Scholarship details below.

Scholarship Tiers:
• Tier 1 (registration + travel support up to $700) is limited and highly competitive.
Only select this if you cannot attend without travel funding. A brief justification is required.
• Tier 2 (registration only) is for applicants who can cover their own travel. You must confirm that travel funding is secured.
• Tier 3 will cover the VIRTUAL conference registration only.
What Registration Includes (Tiers 1 & 2)
• Full access to sessions, workshops, and networking events
• Daily meals (breakfast, lunch, dinner)
• Welcome reception and banquet
• On-campus housing
• Free on-site parking

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Reposted by Mikala Egeblad

Society for Immunotherapy of Cancer @sitcancer.bsky.social · May 29

Only a few days left before The CheckPoints: Rockin’ for a Cure! Join us on Sunday, June 1 at Buddy Guy’s Legends in Chicago. A suggested donation of $30 at the door will support the #SITCForwardFund. Learn more: www.sitcancer.org/about/the-ch...

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Reposted by Mikala Egeblad

Society for Developmental Biology @socdevbio.bsky.social · May 29

Michael Piacentino @mikepiacentino.bsky.social will be a speaker at #ICDB2025 and we couldn't be happier! Michael's work focuses on epidermal to mesenchimal transition in the highly migratory neural crest cells 🐤🧪

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Reposted by Adrienne Boire, Mikala Egeblad

danapeer.bsky.social @danapeer.bsky.social · May 14

I am pleased to share our recent publication, fruit of a wonderful collaboration with truly amazing colleagues @adrienneboire.bsky.social and @meningojan.bsky.social, whose work was a tour de force demonstrating that immunology in the brain is a different beast -> www.nature.com/articles/s41...

Interferon-γ orchestrates leptomeningeal anti-tumour response - Nature

Independent of antigen presentation, migratory CCR7+ dendritic cells orchestrate the influx, proliferation and cytotoxic action of natural killer cells to control cancer cell growth in the leptomening...

www.nature.com

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Reposted by Mikala Egeblad

Samara Reck-Peterson @samreckpeterson.bsky.social · May 13

As the incoming Chair of Biochemistry and Biophysics at Weill Cornell Medicine, I am looking for a Director of Research. Exciting opportunity for a PhD scientist to shape the future of this new Department! Apply here: jobs.weill.cornell.edu/NY/job/New-Y...

Director of Research, Biochemistry & Biophysics

jobs.weill.cornell.edu

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Reposted by Mikala Egeblad

Johanna Joyce @johannajoyce.bsky.social · Apr 30

Thanks to all at #AACR25 for an inspiring and impactful annual meeting!

Filled with cutting-edge science 🧪- and the direct impact of those discoveries for patients with #cancer

Special thanks to co-chairs @mvhlab.bsky.social @lilliansiu.bsky.social

#CancerResearchSavesLives

@theaacr.bsky.social

Opening session of #AACR25 annual meeting - with all attendees raising signs in support of cancer research funding #CancerResearchSavesLives

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Mikala Egeblad @megeblad.bsky.social · Apr 29

Spring 2009 I opened my lab and accepted two @cshlnews.bsky.social rotation students now reunited at #AACR25: University of Hawaii Cancer Center clinician-scientist Elizabeth Nakasone, and Mount Sinai assistant professor and @theaacr.bsky.social NextGen Star @elvinwag.bsky.social - Made my day!

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Reposted by Mikala Egeblad

Johanna Joyce @johannajoyce.bsky.social · Apr 29

We all know how much the microenvironment matters!

So grateful that the #TME field has so many fantastic - and supportive - women leaders 🙌

#AACR2025 🧪⚕️
#womeninscience
#payitforward

@theaacr.bsky.social

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Reposted by Mikala Egeblad

Jose M. Adrover @adrover.bsky.social · Apr 29

I had a wonderful time in the Tumor Microenvironment Working Group session! #AACR25 Thanks everyone for the warm welcome and lively discussion!

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Reposted by Mikala Egeblad

STAT @statnews.com · Apr 28

A clinical trial run by the National Cancer Institute seems to confirm that a single dose of the vaccine used to prevent infection with the human papilloma virus is just as effective as two

www.statnews.com/2025/04/28/h...

U.S. government researchers present 'phenomenal' new data on HPV vaccines

A new study seems to confirm that a single dose of the vaccine used to prevent HPV infection is just as effective as two — and, therefore, also helps to prevent cancer.

www.statnews.com

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