Guillaume Thibault
@gthibault.bsky.social
Associate Professor www.thibaultlab.com at Nanyang Technological University Singapore 🇸🇬. Endoplasmic Reticulum Stress and Unfolded Protein Response in health and diseases • Co-PI Mechanobiology Institute • MBoC Assoc Editor • University of Toronto alumni
The evidence is in the movement (or lack thereof). 👇
Left: Uninfected cells closing the wound.
Middle: Infected cells paralyzed by the bacteria.
Right ΔEET): Mutant bacteria that cannot produce the ROS. Note how the wound closes just like the healthy control!
Left: Uninfected cells closing the wound.
Middle: Infected cells paralyzed by the bacteria.
Right ΔEET): Mutant bacteria that cannot produce the ROS. Note how the wound closes just like the healthy control!
January 17, 2026 at 1:26 AM
The evidence is in the movement (or lack thereof). 👇
Left: Uninfected cells closing the wound.
Middle: Infected cells paralyzed by the bacteria.
Right ΔEET): Mutant bacteria that cannot produce the ROS. Note how the wound closes just like the healthy control!
Left: Uninfected cells closing the wound.
Middle: Infected cells paralyzed by the bacteria.
Right ΔEET): Mutant bacteria that cannot produce the ROS. Note how the wound closes just like the healthy control!
Most bacteria generate ROS inside their cell but E. faecalis generates ROS outside its cell.
Our study shows this process generates hydrogen peroxide at the wound interface. This oxidative stress triggers the unfolded protein response (UPR) in the host skin cells, stopping them from migrating.
Our study shows this process generates hydrogen peroxide at the wound interface. This oxidative stress triggers the unfolded protein response (UPR) in the host skin cells, stopping them from migrating.
January 17, 2026 at 1:26 AM
Most bacteria generate ROS inside their cell but E. faecalis generates ROS outside its cell.
Our study shows this process generates hydrogen peroxide at the wound interface. This oxidative stress triggers the unfolded protein response (UPR) in the host skin cells, stopping them from migrating.
Our study shows this process generates hydrogen peroxide at the wound interface. This oxidative stress triggers the unfolded protein response (UPR) in the host skin cells, stopping them from migrating.
Where are my tempeh and tapai? 😍
September 8, 2025 at 12:59 PM
Where are my tempeh and tapai? 😍
Your research future starts at NTU Singapore! We're recruiting for fully-funded PhDs & prestigious Postdoc fellowships. Join our info sessions across the US this Sept to learn more about launching your career at a world-class university. #PhD #PostdocJobs
Register 👇
forms.office.com/r/HYfKgmcAa0
Register 👇
forms.office.com/r/HYfKgmcAa0
September 2, 2025 at 11:46 AM
Your research future starts at NTU Singapore! We're recruiting for fully-funded PhDs & prestigious Postdoc fellowships. Join our info sessions across the US this Sept to learn more about launching your career at a world-class university. #PhD #PostdocJobs
Register 👇
forms.office.com/r/HYfKgmcAa0
Register 👇
forms.office.com/r/HYfKgmcAa0
🚨 JOB ALERT!
Ready to lead your own lab? NTU Singapore's Nanyang Assistant Professorship offers a 100% paid salary & a S$2.75M start-up. We're visiting the US this Sept to recruit top talent. Meet us in NYC, Boston & more! #FacultyJobs #TenureTrack
Register 👇 www.cognitoforms.com/Ntu18/NTUSin...
Ready to lead your own lab? NTU Singapore's Nanyang Assistant Professorship offers a 100% paid salary & a S$2.75M start-up. We're visiting the US this Sept to recruit top talent. Meet us in NYC, Boston & more! #FacultyJobs #TenureTrack
Register 👇 www.cognitoforms.com/Ntu18/NTUSin...
September 2, 2025 at 11:45 AM
🚨 JOB ALERT!
Ready to lead your own lab? NTU Singapore's Nanyang Assistant Professorship offers a 100% paid salary & a S$2.75M start-up. We're visiting the US this Sept to recruit top talent. Meet us in NYC, Boston & more! #FacultyJobs #TenureTrack
Register 👇 www.cognitoforms.com/Ntu18/NTUSin...
Ready to lead your own lab? NTU Singapore's Nanyang Assistant Professorship offers a 100% paid salary & a S$2.75M start-up. We're visiting the US this Sept to recruit top talent. Meet us in NYC, Boston & more! #FacultyJobs #TenureTrack
Register 👇 www.cognitoforms.com/Ntu18/NTUSin...
📣 Your research future starts at NTU Singapore! We're recruiting for fully-funded PhDs & prestigious Postdoc fellowships. Join our info sessions across the US this Sept to learn more about launching your career at a world-class university. #PhD #PostdocJobs
Register HERE: lnkd.in/gFsquxHe
Register HERE: lnkd.in/gFsquxHe
August 27, 2025 at 3:25 AM
📣 Your research future starts at NTU Singapore! We're recruiting for fully-funded PhDs & prestigious Postdoc fellowships. Join our info sessions across the US this Sept to learn more about launching your career at a world-class university. #PhD #PostdocJobs
Register HERE: lnkd.in/gFsquxHe
Register HERE: lnkd.in/gFsquxHe
📣 Ready to lead your own lab? NTU Singapore's Nanyang Assistant Professorship offers a 100% paid salary & a S$2.75M start-up package. We're visiting the US this Sept to recruit top talent. Meet us in NYC, Boston & more! #FacultyJobs #TenureTrack
Register HERE: lnkd.in/gSy5qpA7
Register HERE: lnkd.in/gSy5qpA7
August 27, 2025 at 3:24 AM
📣 Ready to lead your own lab? NTU Singapore's Nanyang Assistant Professorship offers a 100% paid salary & a S$2.75M start-up package. We're visiting the US this Sept to recruit top talent. Meet us in NYC, Boston & more! #FacultyJobs #TenureTrack
Register HERE: lnkd.in/gSy5qpA7
Register HERE: lnkd.in/gSy5qpA7
📢 Our new preprint is out! We show how the common gut bacterium 𝘌. 𝘧𝘢𝘦𝘤𝘢𝘭𝘪𝘴 stops wound healing. It uses a metabolic pathway, extracellular electron transport (EET), to stress host cells, halting their migration. Watch WT bacteria (orange) stop the cells while the mutant (blue) doesn't!
August 11, 2025 at 12:38 AM
📢 Our new preprint is out! We show how the common gut bacterium 𝘌. 𝘧𝘢𝘦𝘤𝘢𝘭𝘪𝘴 stops wound healing. It uses a metabolic pathway, extracellular electron transport (EET), to stress host cells, halting their migration. Watch WT bacteria (orange) stop the cells while the mutant (blue) doesn't!
Visiting Cambridge/Oxford/London w/ @sim0nredfern.bsky.social to connect w/ potential applicants for Nanyang Assistant Professorship (NAP) @ NTU SG. NAP offers tenure-track position w/ up to S$2.75M start-up. Join us and register at one of our recruitment events 👇
www.ntu.edu.sg/science/rese...
www.ntu.edu.sg/science/rese...
April 21, 2025 at 10:06 AM
Visiting Cambridge/Oxford/London w/ @sim0nredfern.bsky.social to connect w/ potential applicants for Nanyang Assistant Professorship (NAP) @ NTU SG. NAP offers tenure-track position w/ up to S$2.75M start-up. Join us and register at one of our recruitment events 👇
www.ntu.edu.sg/science/rese...
www.ntu.edu.sg/science/rese...
Great to hear I’m not the only one linking the perfect egg recipe to the old-school way of running PCR! 😂 I imagined a machine for it, and ChatGPT generated this—though, I must say, it looked much better in my head!
ChatGPT claims it got 6 egg compartments in the picture as I requested... failed!
ChatGPT claims it got 6 egg compartments in the picture as I requested... failed!
February 8, 2025 at 11:35 AM
Great to hear I’m not the only one linking the perfect egg recipe to the old-school way of running PCR! 😂 I imagined a machine for it, and ChatGPT generated this—though, I must say, it looked much better in my head!
ChatGPT claims it got 6 egg compartments in the picture as I requested... failed!
ChatGPT claims it got 6 egg compartments in the picture as I requested... failed!
🌟 BSc/MSc students graduating in 2025-26: Join NTU’s Global Connect Fellowship this July-August in Singapore!
S$5,000 stipend & housing
Mentorship from top researchers
Pre-PhD research & professional masterclasses
Explore NTU’s world-class campus
Apply 1-28 Feb 25 👇
www.ntu.edu.sg/about-us/glo...
S$5,000 stipend & housing
Mentorship from top researchers
Pre-PhD research & professional masterclasses
Explore NTU’s world-class campus
Apply 1-28 Feb 25 👇
www.ntu.edu.sg/about-us/glo...
January 17, 2025 at 5:33 AM
🌟 BSc/MSc students graduating in 2025-26: Join NTU’s Global Connect Fellowship this July-August in Singapore!
S$5,000 stipend & housing
Mentorship from top researchers
Pre-PhD research & professional masterclasses
Explore NTU’s world-class campus
Apply 1-28 Feb 25 👇
www.ntu.edu.sg/about-us/glo...
S$5,000 stipend & housing
Mentorship from top researchers
Pre-PhD research & professional masterclasses
Explore NTU’s world-class campus
Apply 1-28 Feb 25 👇
www.ntu.edu.sg/about-us/glo...
Awesome @ascbiology.bsky.social #CellBio2024 turnout! 😍 Not too late to join us for "MBoC Highlights: The Future of Cell Biology" in Room 32B.
Amazing ideas about the future of #cellbiology
Amazing ideas about the future of #cellbiology
December 14, 2024 at 10:16 PM
Awesome @ascbiology.bsky.social #CellBio2024 turnout! 😍 Not too late to join us for "MBoC Highlights: The Future of Cell Biology" in Room 32B.
Amazing ideas about the future of #cellbiology
Amazing ideas about the future of #cellbiology
On my way to #CellBio2024! Can’t wait to catch up with some of you. If you see me, come say hi—promise I don’t bite (much)!
December 13, 2024 at 3:24 AM
On my way to #CellBio2024! Can’t wait to catch up with some of you. If you see me, come say hi—promise I don’t bite (much)!
We have a lineup of outstanding speakers 😍 for this year’s conference 👇. Please share the poster with your network to spread the word 📢!
December 11, 2024 at 12:23 AM
We have a lineup of outstanding speakers 😍 for this year’s conference 👇. Please share the poster with your network to spread the word 📢!
🚨 Our latest study, "Yeast Knowledge Graphs Database for Exploring Saccharomyces cerevisiae and Schizosaccharomyces pombe," has just been deposited in @biorxivpreprint.bsky.social ! We’re thrilled to share our work with the world! #KnowledgeGraphs
www.biorxiv.org/content/10.1101/2024.12.04.626523v1
www.biorxiv.org/content/10.1101/2024.12.04.626523v1
December 10, 2024 at 4:24 AM
🚨 Our latest study, "Yeast Knowledge Graphs Database for Exploring Saccharomyces cerevisiae and Schizosaccharomyces pombe," has just been deposited in @biorxivpreprint.bsky.social ! We’re thrilled to share our work with the world! #KnowledgeGraphs
www.biorxiv.org/content/10.1101/2024.12.04.626523v1
www.biorxiv.org/content/10.1101/2024.12.04.626523v1
Nice 10 km race with Chris Yip @cyclocrossguy.bsky.social and company at the #SCSM2024 🇸🇬. This was a good warm-up for tomorrow's full marathon 🏃♂️
November 30, 2024 at 9:28 AM
Nice 10 km race with Chris Yip @cyclocrossguy.bsky.social and company at the #SCSM2024 🇸🇬. This was a good warm-up for tomorrow's full marathon 🏃♂️
The cover of Nature Genetics for July 2024 has a familiar look to the cover of Molecular Cell that I designed back in 2012. Okay, Nature Genetics looks more professional than mine, but still, where is my copyright? 🤣
November 25, 2024 at 4:05 AM
The cover of Nature Genetics for July 2024 has a familiar look to the cover of Molecular Cell that I designed back in 2012. Okay, Nature Genetics looks more professional than mine, but still, where is my copyright? 🤣
Bluesky now has over 10 million users, and I was #2,054,832!
September 17, 2024 at 5:00 AM
Bluesky now has over 10 million users, and I was #2,054,832!
We will be at the #QSFair in #bangalore tomorrow 17 Dec.
I look forward talking about our master and PhD programmes at the NTU College of Science
I look forward talking about our master and PhD programmes at the NTU College of Science
December 16, 2023 at 4:29 AM
We will be at the #QSFair in #bangalore tomorrow 17 Dec.
I look forward talking about our master and PhD programmes at the NTU College of Science
I look forward talking about our master and PhD programmes at the NTU College of Science
On my way to Boston to attend #cellbio2023. Looking forward to the science, connecting with friends.
I will also talk about research and funding opportunities in Singapore. Come join us ononda Dec 4. See info below 👇
I will also talk about research and funding opportunities in Singapore. Come join us ononda Dec 4. See info below 👇
December 1, 2023 at 12:05 PM
On my way to Boston to attend #cellbio2023. Looking forward to the science, connecting with friends.
I will also talk about research and funding opportunities in Singapore. Come join us ononda Dec 4. See info below 👇
I will also talk about research and funding opportunities in Singapore. Come join us ononda Dec 4. See info below 👇
Enjoying the #EMBO #Proteostasis conference in Ericeira, Portugal. Very good talks and nice view 🤩
November 19, 2023 at 9:51 AM
Enjoying the #EMBO #Proteostasis conference in Ericeira, Portugal. Very good talks and nice view 🤩
2/🧵 #WoundInfections are a major concern, causing delays in healing and significant health issues. We wanted to understand the role of E. faecalis in these infections. 🤔 To do this, we used #scRNA-seq to analyze over 23,000 cells in infected and uninfected wounds. 🧬🔬
November 19, 2023 at 8:46 AM
2/🧵 #WoundInfections are a major concern, causing delays in healing and significant health issues. We wanted to understand the role of E. faecalis in these infections. 🤔 To do this, we used #scRNA-seq to analyze over 23,000 cells in infected and uninfected wounds. 🧬🔬