Guillaume Thibault
@gthibault.bsky.social
Associate Professor www.thibaultlab.com at Nanyang Technological University Singapore 🇸🇬. Endoplasmic Reticulum Stress and Unfolded Protein Response in health and diseases • Co-PI Mechanobiology Institute • MBoC Assoc Editor • University of Toronto alumni
Excited to see our work covered by The Straits Times ! A great summary by Judith Tan 👇
www.straitstimes.com/singapore/he...
www.straitstimes.com/singapore/he...
S’pore study finds new way to disarm antibiotic-resistant bacteria, hasten healing of chronic wounds
Singapore scientists have found a new way to disarm antibiotic-resistant bacteria and speed up chronic wound healing using catalase. Read more at straitstimes.com. Read more at straitstimes.com.
www.straitstimes.com
January 17, 2026 at 3:47 AM
Excited to see our work covered by The Straits Times ! A great summary by Judith Tan 👇
www.straitstimes.com/singapore/he...
www.straitstimes.com/singapore/he...
Proud of this international effort led by NTU Singapore, @scelse.bsky.social and the University of Geneva.
Huge props to first author @aarontan.bsky.social and my co-lead @kimingeneva.bsky.social and other authors including @cenkcelik.bsky.social.
#ScienceAdvances #Microbiology #NTUsg
Huge props to first author @aarontan.bsky.social and my co-lead @kimingeneva.bsky.social and other authors including @cenkcelik.bsky.social.
#ScienceAdvances #Microbiology #NTUsg
January 17, 2026 at 1:26 AM
Proud of this international effort led by NTU Singapore, @scelse.bsky.social and the University of Geneva.
Huge props to first author @aarontan.bsky.social and my co-lead @kimingeneva.bsky.social and other authors including @cenkcelik.bsky.social.
#ScienceAdvances #Microbiology #NTUsg
Huge props to first author @aarontan.bsky.social and my co-lead @kimingeneva.bsky.social and other authors including @cenkcelik.bsky.social.
#ScienceAdvances #Microbiology #NTUsg
Crucially, we found that we can reverse this paralysis.
By adding antioxidants (like catalase) to the wound, we neutralized the ROS and restarted the healing process. This could be a new blueprint for treating chronic diabetic ulcers when combined with topical antimicrobials.
By adding antioxidants (like catalase) to the wound, we neutralized the ROS and restarted the healing process. This could be a new blueprint for treating chronic diabetic ulcers when combined with topical antimicrobials.
January 17, 2026 at 1:26 AM
Crucially, we found that we can reverse this paralysis.
By adding antioxidants (like catalase) to the wound, we neutralized the ROS and restarted the healing process. This could be a new blueprint for treating chronic diabetic ulcers when combined with topical antimicrobials.
By adding antioxidants (like catalase) to the wound, we neutralized the ROS and restarted the healing process. This could be a new blueprint for treating chronic diabetic ulcers when combined with topical antimicrobials.
The evidence is in the movement (or lack thereof). 👇
Left: Uninfected cells closing the wound.
Middle: Infected cells paralyzed by the bacteria.
Right ΔEET): Mutant bacteria that cannot produce the ROS. Note how the wound closes just like the healthy control!
Left: Uninfected cells closing the wound.
Middle: Infected cells paralyzed by the bacteria.
Right ΔEET): Mutant bacteria that cannot produce the ROS. Note how the wound closes just like the healthy control!
January 17, 2026 at 1:26 AM
The evidence is in the movement (or lack thereof). 👇
Left: Uninfected cells closing the wound.
Middle: Infected cells paralyzed by the bacteria.
Right ΔEET): Mutant bacteria that cannot produce the ROS. Note how the wound closes just like the healthy control!
Left: Uninfected cells closing the wound.
Middle: Infected cells paralyzed by the bacteria.
Right ΔEET): Mutant bacteria that cannot produce the ROS. Note how the wound closes just like the healthy control!
Most bacteria generate ROS inside their cell but E. faecalis generates ROS outside its cell.
Our study shows this process generates hydrogen peroxide at the wound interface. This oxidative stress triggers the unfolded protein response (UPR) in the host skin cells, stopping them from migrating.
Our study shows this process generates hydrogen peroxide at the wound interface. This oxidative stress triggers the unfolded protein response (UPR) in the host skin cells, stopping them from migrating.
January 17, 2026 at 1:26 AM
Most bacteria generate ROS inside their cell but E. faecalis generates ROS outside its cell.
Our study shows this process generates hydrogen peroxide at the wound interface. This oxidative stress triggers the unfolded protein response (UPR) in the host skin cells, stopping them from migrating.
Our study shows this process generates hydrogen peroxide at the wound interface. This oxidative stress triggers the unfolded protein response (UPR) in the host skin cells, stopping them from migrating.
Our application portal is open until 31 January 2026.
Learn more and apply here: www.ntu.edu.sg/science/admi...
#NTU #NTUScience #PhD #GradSchool #Scholarships #STEM #Singapore
Learn more and apply here: www.ntu.edu.sg/science/admi...
#NTU #NTUScience #PhD #GradSchool #Scholarships #STEM #Singapore
Graduate
www.ntu.edu.sg
November 5, 2025 at 3:00 AM
Our application portal is open until 31 January 2026.
Learn more and apply here: www.ntu.edu.sg/science/admi...
#NTU #NTUScience #PhD #GradSchool #Scholarships #STEM #Singapore
Learn more and apply here: www.ntu.edu.sg/science/admi...
#NTU #NTUScience #PhD #GradSchool #Scholarships #STEM #Singapore
Definitely well deserved. Congrats!
September 10, 2025 at 12:44 PM
Definitely well deserved. Congrats!
Congrats 😍. Am I going to e you at ASCB in Philly?
September 10, 2025 at 12:32 PM
Congrats 😍. Am I going to e you at ASCB in Philly?
Where are my tempeh and tapai? 😍
September 8, 2025 at 12:59 PM
Where are my tempeh and tapai? 😍
Reposted by Guillaume Thibault
And salary? Due to low taxes & subsidized housing, our offer provides a quality of life comparable to a US$215k - $300k salary in major US academic hubs like NYC or the Bay Area. A great deal for your science and your life.
September 2, 2025 at 11:45 AM
And salary? Due to low taxes & subsidized housing, our offer provides a quality of life comparable to a US$215k - $300k salary in major US academic hubs like NYC or the Bay Area. A great deal for your science and your life.
Reposted by Guillaume Thibault
What does our start-up package mean in US terms? It's equivalent to $3.8M package at a top US university. Why? We fully cover PI salary costs and 5 PhD scholarships, so your research grant is for research.
September 2, 2025 at 11:45 AM
What does our start-up package mean in US terms? It's equivalent to $3.8M package at a top US university. Why? We fully cover PI salary costs and 5 PhD scholarships, so your research grant is for research.