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Haass Lab @haasslab.bsky.social · Aug 25

Check out our latest publication! 👇

Molecular Neurodegeneration @molneurodegen.bsky.social · Aug 20

'Early intervention anti-Aβ #immunotherapy attenuates #microglial activation without inducing exhaustion at residual plaques'

Lis de Weerd @lisdeweerd.bsky.social Selina Hummel, Stephan A. Müller...Christian Haass @haasslab.bsky.social #AlzheimersDisease #amyloid

bit.ly/3V8PDMa

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John Lukens @lukensjohnr.bsky.social · Jul 10

Microglia replacement halts the progression of microgliopathy in mice and humans @science.org www.science.org/doi/10.1126/...

Microglia replacement halts the progression of microgliopathy in mice and humans

Colony-stimulating factor 1 receptor (CSF1R) is primarily expressed in microglia. Its monoallelic mutation causes CSF1R-associated microgliopathy (CAMP), a major form of adult-onset leukoencephalopath...

www.science.org

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Reposted by Haass Lab

LMU Open Science Center @lmu-osc.bsky.social · Jul 11

Hackathon: Data Under Threat/Data Rescuing in #München

The LMU OSC runs a hackathon to support the #SciOp #SafeguardingResearch initiative: Rescuing research data that is deleted by the Trump administration.
📅 07/08/25 from 16 – 19 (only in-person)
👉 Details and signup: github.com/lmu-osc/safe...

GitHub - lmu-osc/safeguar.de-hackathon

Contribute to lmu-osc/safeguar.de-hackathon development by creating an account on GitHub.

github.com

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DZNE research center @dzne.science · Jun 16

Congratulations to Christian Haass (@haasslab.bsky.social)! He receives an honorary doctorate from the University of Eastern Finland for 30+ years of groundbreaking Alzheimer’s research on beta-amyloid proteins and new therapeutic approaches. 📸: UFE/Raija Törrönen & UFE/Niko Jouhkimainen

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Stand Up for Science! @standupforscience.bsky.social · Jun 1

HAPPY PRIDE 🏳️‍🌈

Under Trump, research using terms like “Trans,” “LGBTQ,” & “Gender identity” is being defunded. These terms reflect real people who deserve science that includes them.

Stand with us to protect LGBTQ+ science from political erasure.
grant-watch.us/nih-data.html
@rcmedphys.bsky.social

A word cloud made from flagged terms in terminated NIH grant proposals. The most prominent words in large font include “trans,” “diverse,” “diversity,” “minority,” “sex,” “expression,” “mental health,” “gender,” and “women.” Other visible terms include “LGBTQ,” “racial,” “underrepresented,” “disability,” “barriers,” “black,” “equity,” “health equity,” “vaccine,” “bias,” and “intersectionality.” The word cloud highlights terms related to identity, inclusion, and marginalized communities.

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Sarah Marzi @sj-marzi.bsky.social · May 27

How does APOE change your risk of developing Alzheimer's disease? At least partially by changing the function of immune cells in your brain 🧠🧬

New paper out in @natcomms.nature.com today: www.nature.com/articles/s41...

@ukdri.ac.uk @kingsioppn.bsky.social @imperialbrains.bsky.social

https://nature.com/articles/s4146…

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Deutsche Forschungsgemeinschaft @dfg.de · May 22

The #ClustersOfExcellence have been selected: today, the Excellence Commission approved 70 projects for funding. 45 clusters will continue and 25 will be newly established. Funding starts on 1 Jan 2026 for 7 years, with €539 million per year. The full list: www.dfg.de/resource/blo... 1/3

Map of Germany with the Clusters of Excellence

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LMU München @lmumuenchen.bsky.social · May 22

🎉 Major achievement for #LMU in the Excellence Strategy: All seven proposed Clusters of Excellence have successfully passed the review process and will be funded for seven years as of 2026. An outstanding result! 🎉 #ExcellenceCluster #LMUMunich #research Read more here: www.lmu.de/en/newsroom/...

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SyNergy - Munich Cluster for Systems Neurology @synergy-munich.bsky.social · Mar 6

💭 Our PhD & Postdoc reps initiated visits to our Technology Hubs for our researchers and kicked off with a visit to our Single-Cell and Spatial Transcriptome Hubs last week.

👋 Thanks Arek Kendirli, Janos Groh, Clara de la Rosa del Val, and Simon Frerich for hosting the first event of the series!

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The Freeman Lab @spencerfreeman.bsky.social · Feb 27

We've been studying mechanisms of resilience that protect lysosomes from damage and wrote a review on the topic. We consider lysosomal stress and damage on a spectrum. Please help me share as this is my first post 😀 and I don't have many followers! 🙏 Open Access: www.embopress.org/doi/full/10....

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Ali Maximilian Erturk @erturklab.bsky.social · Feb 26

Excited to share our latest work with Denali Therapeutics as Deep Piction. Using our proprietary clearing & imaging, we’ve mapped the full targeting profile of brain-penetrating transport vehicles (ATVs) in both whole mouse bodies and monkey brains. nature.com/articles/s41...

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dammemarkus.bsky.social @dammemarkus.bsky.social · Dec 26

Our new paper on the proteolytic processing of TMEM106B is out in @cp-cellreports.bsky.social! TMEM106B undergoesphysiological shedding and additional C-terminal trimming. The new luminal-domain antibody is commercially available!
www.sciencedirect.com/science/arti...

Physiological shedding and C-terminal proteolytic processing of TMEM106B

Genetic variants in TMEM106B, coding for a transmembrane protein of unknown function, have been identified as critical genetic modulators in various n…

www.sciencedirect.com

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Johannes Levin @johanneslevin.bsky.social · Feb 21

We did it and now it is published: A highly Lewy-fold selective and quantitative Synuclein Aggregate Amplification Assay (SAA). Huge thanks to the amazing teams at MODAG GmbH, LMU Munich, and Bologna University!
rdcu.be/eaISM

A quantitative Lewy-fold-specific alpha-synuclein seed amplification assay as a progression marker for Parkinson’s disease

rdcu.be

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SyNergy - Munich Cluster for Systems Neurology @synergy-munich.bsky.social · Feb 18

👋 Meet our PhD and Postdoc Representatives

💭 The voice of our PhD students and Postdocs. A point of contact for feedback, questions, criticism, and improvements. And they organize extracurricular activities! Meet @angelikadannert.bsky.social, Clara, Lis and Nathalie.

🔗 Read more: lnkd.in/dKtzshqr

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Shannon Macauley @macauleylab.bsky.social · Feb 14

This is really interesting. Known for a long time lysosomal enzymes are secreted- it’s the principle of cross correction for lysosomal
Storage diseases. However the idea lysosomes are released or degrading plaques extracellularly is 🤯. Do they differ from EVs/EPs?

www.cell.com/cell-reports...

Microglia degrade Alzheimer’s amyloid-beta deposits extracellularly via digestive exophagy

Jacquet et al. shows that microglia use digestive exophagy to engage large Aβ deposits that cannot be phagocytosed, forming acidic extracellular compartments on the aggregates into which lysosomal enz...

www.cell.com

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PaquetLab @paquetlab.bsky.social · Feb 6

Big congrats to the winners, including Marvin Reich, PhD student co-supervised by our lab in a nice collab with @haasslab.bsky.social

DZNE research center @dzne.science · Feb 5

Congrats to these two first authors from DZNE Munich on receiving the "Best Paper Award" from the DZNE foundation! @shreeyakedia.bsky.social was honored for her paper published in “Nature Neuroscience”. Marvin Reich, received the award for his paper published in “Science Translational Medicine”.

The illustrations shows a neuron and the inscription "Best Paper Award".

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Dr Róisín McManus @roisinmcmanus.bsky.social · Feb 3

I am thrilled to share our latest article that has been published in @cp-immunity.bsky.social. We describe a new role for NLRP3 outside of its #inflammasome complex, where it can regulate microglial #metabolism & key metabolites that affect the epigenetic landscape(1)
www.cell.com/immunity/ful...

NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression

How NLRP3 impacts Alzheimer’s disease (AD) is unclear. McManus et al. find that NLRP3 is located at mitochondria where it regulates microglial metabolism. Depletion or chronic pharmacological inhibiti...

www.cell.com

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bioRxiv Neuroscience @biorxiv-neursci.bsky.social · Jan 31

Multimodal synapse analysis reveals restricted integration of transplanted neurons remodeled by TREM2 https://www.biorxiv.org/content/10.1101/2025.01.31.635250v1

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bioRxiv Neuroscience @biorxiv-neursci.bsky.social · Jan 27

Alpha-Synuclein co-pathology in Alzheimer's Disease drives tau accumulation https://www.biorxiv.org/content/10.1101/2025.01.24.634706v1

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PaquetLab @paquetlab.bsky.social · Jan 12

Very happy to announce that the PaquetLab is now on Bluesky. We are excited to connect with everyone interested in our research and present updates on our work and lab activities! Our lab engineers 3-dimensional models of #human-brain-tissue and the #BBB and applies them to investigate ...

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