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PaquetLab

@paquetlab.bsky.social

390 followers 120 following 45 posts

3D iPSC models and CRISPR to investigate mechanisms of neurodegenerative and neurovascular disorders | Professor of Neurobiology at LMU Munich | https://isd-research.de/paquetlab

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PaquetLab @paquetlab.bsky.social · Mar 12

Open #Postdoc position @isd-research.bsky.social @lmumuenchen.bsky.social to develop an #iPSC-derived #BBB model. Fully funded and embedded in our international Foundation Leducq Network of Excellence www.brenda-leducq.de Experience in vascular biology or related field required. Please RP and apply

The research group of Prof. Dr. Dominik Paquet (https://www.isd-research.de/paquetlab) is looking for a Postdoc. Our research involves the development of human brain tissue models to study the molecular mechanisms of Alzheimer's disease, Frontotemporal dementia, stroke and other related brain diseases and to develop therapeutic approaches. We use state-of-the-art molecular and cell biological methods, such as induced pluripotent stem cells (iPSCs), advanced molecular biology techniques, CRISPR/Cas9 genome editing, brain tissue engineering, scRNAseq, proteomics etc. We offer a highly international, versatile, extremely well equipped and productive work environment.

We have received funding by an international research organization for a very interdisciplinary and collaborative project to develop a human iPSC model of the blood brain barrier and apply it to study neurovascular diseases, with a focus on Small vessel disease (SVD). The project will focus on CRISPR genome engineering of SVD-relevant mutations, differentiation of iPSCs into neurovascular cells, microfluidic 3D vascular tissue engineering, and identifying disease-relevant alterations by microscopy and omics techniques. It will be embedded in the highly collaborative and stimulating environment of the PaquetLab, ISD, SyNergy Cluster of Excellence, and our international collaboration network.

We are looking for a highly motivated individual with the following skills:

-extensive international scientific working experience in vascular
biology or a closely related research field (required)
-experience in molecular biology, biochemistry and/or omics
techniques; cell culture experience is a plus
-excellent English skills in speaking, writing about and
presenting scientific data
-interest in working in collaborative network of
friendly scientists around the world

A start date soon in 2025 is desired.

Join us!
dominik.paquet@med.uni-muenchen.de
www.isd-research.de/paquetlab
www.brenda-leducq.de

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PaquetLab @paquetlab.bsky.social · 1d

Big congrats to Mila @milaborri.bsky.social from the lab for obtaining a EU-funded #MCSA postdoc fellowship!! We look forward to working with you on developing #iPSC based vascularized human brain tissue models to study major #brain diseases, such as #Alzheimer's and #stroke!

PaquetLab @paquetlab.bsky.social · 7d

Great conference! Very happy to join again.

Stefan Hauser @stefanhauser.bsky.social · 8d

Join us for 𝗦𝘁𝗲𝗺 𝗖𝗲𝗹𝗹𝘀 𝗶𝗻 𝗡𝗲𝘂𝗿𝗼𝘀𝗰𝗶𝗲𝗻𝗰𝗲, 𝟮𝟱𝘁𝗵-𝟮𝟳𝘁𝗵 𝗼𝗳 𝗙𝗲𝗯𝗿𝘂𝗮𝗿𝘆, 𝟮𝟬𝟮𝟲 in Tübingen, Germany.

Register here until 30th of November:
👉 stemcelltuebingen.com
Speaker slots and stipends available

Please repost and spread the news!

@dzne.science
@hih-tuebingen.bsky.social
@tueneurocampus.bsky.social

PaquetLab @paquetlab.bsky.social · 9d

Very happy to be at the Barcelona #B4event blood-brain-barrier meeting and present our work this afternoon on a novel fully #iPSC based model of the #BBB that allows investigating neurovascular diseases! premc.org/blood-brain-...

Reposted by PaquetLab

Jay 🦋 @jay.bsky.team · 23d

What makes Bluesky different: it’s open source, so anyone can contribute to building the experience they want. And even if you build a whole new app, the protocol means you can migrate with your data, identity, and relationships intact.

str👻d @str4d.xyz · 25d

The eternally-great thing about open source: if something doesn't exist, and the devs don't have time to work on it themselves, you can just implement it for them!

If they decide not to take it as-is, you've still helped explore the design space.

And if they don't accept it, but you need it, fork!

str👻d @str4d.xyz · 25d

Figured out enough of the rsky-relay internals to implement this myself (reporting the data that it currently records):

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PaquetLab @paquetlab.bsky.social · Aug 7

Great #BBB Model to study malaria! Congrats Maria and Team!

Maria Bernabeu @mariabernabeu.bsky.social · Aug 7

We are happy to show one ourt first exciting papers. We have developed a blood-brain barrier model to study the disruptive effects caused by the malaria parasite, Plasmodium falciparum.

First, congratulations to the fearless @liviapiatti.bsky.social and @alinabatzi.bsky.social

rdcu.be/ezBl7

Plasmodium falciparum egress disrupts endothelial junctions and activates JAK-STAT signaling in a microvascular 3D blood-brain barrier model

Nature Communications - Here the authors show that Plasmodium falciparum egress products disrupt endothelial barrier and activate JAK-STAT and interferon type response in a 3D blood-brain barrier...

rdcu.be

Reposted by PaquetLab

Selina Wray @selinawray.bsky.social · Jul 29

Primary paper: www.cell.com/cell-reports...

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Reposted by PaquetLab

LMU München @lmumuenchen.bsky.social · Jul 16

🎓🇩🇪 Over 500 LMU students will get the Germany Scholarship in 2025 – a record! 💡 It provides €300/month, funded half by the government, half by private sponsors. Supporting talent and social engagement, no matter their background. #LMU #Scholarship #Education 👉 Read more: www.lmu.de/en/newsroom/....

The LMU Germany Scholarship holders for 2025

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Reposted by PaquetLab

Stefan Hauser @stefanhauser.bsky.social · Jul 1

'Stem Cells in Neuroscience' is returning to Tübingen, Germany.

SAVE THE DATE: February 25-27, 2026.
More info: stemcelltuebingen.com

Please share
#stemcelltuebingen2026

@dzne.science
@hih-tuebingen.bsky.social
@unituebingen.bsky.social
@tueneurocampus.bsky.social

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Reposted by PaquetLab

Deutsche Forschungsgemeinschaft @dfg.de · May 22

The #ClustersOfExcellence have been selected: today, the Excellence Commission approved 70 projects for funding. 45 clusters will continue and 25 will be newly established. Funding starts on 1 Jan 2026 for 7 years, with €539 million per year. The full list: www.dfg.de/resource/blo... 1/3

Map of Germany with the Clusters of Excellence

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Reposted by PaquetLab

LMU München @lmumuenchen.bsky.social · May 22

🎉 Major achievement for #LMU in the Excellence Strategy: All seven proposed Clusters of Excellence have successfully passed the review process and will be funded for seven years as of 2026. An outstanding result! 🎉 #ExcellenceCluster #LMUMunich #research Read more here: www.lmu.de/en/newsroom/...

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PaquetLab @paquetlab.bsky.social · May 22

…and our research cluster @synergy-munich.bsky.social is one of the funded ones! Big congratulations to all involved!

Deutsche Forschungsgemeinschaft @dfg.de · May 22

Die #Exzellenzcluster stehen fest: Heute hat die Exzellenzkommission 70 Projekte zur Förderung ausgewählt. 45 Cluster werden fortgesetzt, 25 neu eingerichtet. Die Förderung beginnt ab 1. Jan. 2026 für 7 Jahre, die Fördersumme beträgt insg. 539 Mio. €/Jahr. Die Liste: www.dfg.de/resource/blo... 1/3

Deutschlandkarte der Verteilung der Exzellenzcluster auf Bundesländer und Universitäten.

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PaquetLab @paquetlab.bsky.social · May 7

Important engagement by our Master student Stella:

LMU München @lmumuenchen.bsky.social · May 7

🔬🌱 Master’s student Stella Chroni promotes #sustainability in science at LMU’s Martinsried Campus. Through the #GreenOffice, she supports research labs in reducing resource consumption & helps implementing more sustainable practices. More about Stella an her work for the Green Office at #LMU here:

The Sustainability of Science

Molecular Biology student Stella Chroni supports the Green Office on Martinsried Campus, promoting sustainable lab practices and raising awareness among scientists and peers.

www.lmu.de

Reposted by PaquetLab

Ursula von der Leyen @vonderleyen.ec.europa.eu · May 5

Europe’s choice is clear.

To put science at the heart of its economy.

To become the home of scientific freedom and collaboration.

And to welcome talent from all over the world.

I’m glad to present the first elements of our Choose Europe Initiative.

→ europa.eu/!TTbWbJ

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Reposted by PaquetLab

Angelika Dannert @angelikadannert.bsky.social · Apr 24

Excited to be at #Tau2025 in London! I really enjoy the great and inspiring discussions with all the fellow Tau enthusiasts! 🔬👩‍🔬

PaquetLab @paquetlab.bsky.social · Apr 24

Great to be at #Tau2025 in London, where @angelikadannert.bsky.social from the lab presents our human #iPSC model of Tauopathies in a packed poster session

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PaquetLab @paquetlab.bsky.social · Apr 24

Great to be at #Tau2025 in London, where @angelikadannert.bsky.social from the lab presents our human #iPSC model of Tauopathies in a packed poster session

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PaquetLab @paquetlab.bsky.social · Apr 24

Great starter pack for Tau aficionados! Thanks Melissa

Melissa E. Murray @drneurochic.bsky.social · Apr 24

Love seeing the beautiful butterfly at #Tau2025 where 1000+ scientists and clinicians are gathering to share ideas to accelerate biomedical discoveries.

Here is a starter pack to quickly follow TAUrrific researchers. Let me know if I need to add anybody

go.bsky.app/KHno2VG
@millermb.bsky.social

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PaquetLab @paquetlab.bsky.social · Apr 19

https://sciencebusiness.net/r-d-funding/european-research-council/erc-double-allowance-researchers-moving-eu

Reposted by PaquetLab

VIB-KU Leuven Center for Brain & Disease Research @cbdresearch.bsky.social · Apr 18

🚀 New study reveals how four different anti-amyloid drugs interact with amyloid beta protein. They found that lecanemab performed best in binding to small oligomeric forms of the amyloid protein, suggesting a working model for treating people in the earlier stages of Alzheimer’s (1/4)

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Reposted by PaquetLab

ghazeskandari.bsky.social @ghazeskandari.bsky.social · Apr 14

Congratulations to
Dr. Jean Paul Chadarevian and the entire @blurtonjoneslab.bsky.social team for this beautiful piece of work: Harnessing human iPSC-microglia for CNS-wide delivery of disease modifying proteins." 👍👍👍
www.sciencedirect.com/science/arti...

Harnessing human iPSC-microglia for CNS-wide delivery of disease-modifying proteins

Widespread delivery of therapeutic proteins to the brain remains challenging. To determine whether human induced pluripotent stem cell (iPSC)-microgli…

www.sciencedirect.com

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Reposted by PaquetLab

Takeshi Uenaka @tuenaka.bsky.social · Apr 15

Losing sleep over #iPSC transgene silencing after differentiation?
Same here — too many times😭

So we built a PiggyBac construct that resists silencing.
Expression stays ON, even after differentiation.

Our #preprint is out👇
🔗 www.biorxiv.org/content/10.1...

Supported by @cziscience.bsky.social

Prevention of Transgene Silencing During Human Pluripotent Stem Cell Differentiation

While high and stable transgene expression can be achieved in undifferentiated pluripotent stem cells, conventional transgene expression systems are often silenced upon differentiation. Silencing occu...

www.biorxiv.org

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Reposted by PaquetLab

Eric Topol @erictopol.bsky.social · Apr 16

It has taken decades to get to this point, but stem cells for Parkinson's disease showing promise in 2 clinical trials
nature.com/articles/d41...
nature.com/articles/s41...
nature.com/articles/s41...

Clinical trials test the safety of stem-cell therapy for Parkinson’s disease

Transplanting dopamine-releasing neurons into the brain is a promising regenerative therapy for Parkinson’s disease. Two clinical trials show that it is safe, but more evidence is needed to prove its ...

nature.com

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PaquetLab @paquetlab.bsky.social · Apr 9

Very nice event! Thanks for organizing..

Reposted by PaquetLab

International Society for Molecular Neurodegeneration @ismnd.bsky.social · Apr 9

We are excited to announce Prof Malin Parmar, Ph.D. as our next webinar speaker!

Title: Developing a Stem Cell Based Therapy for #Parkinsons Disease

April 16 2025
9-10am (ET) 3-4pm (CET)
Host: Henrietta Nielsen, Ph.D.
Register: bit.ly/4jmX0d3

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PaquetLab @paquetlab.bsky.social · Apr 9

Welcome @ismnd.bsky.social to #Bluesky!

Reposted by PaquetLab

Marco A. Maximo Prado @maximoprado.bsky.social · Mar 31

The telling is not only that scientists are avoiding trips to the 🇺🇸 It is the fact that most interviewed for this piece asked to remain anonymous with (very real) fear of retaliation. by @klangin.bsky.social www.science.org/content/arti...

International scientists rethink U.S. conference attendance

Opposition to Trump administration and fears of customs run-ins are shifting travel plans

www.science.org

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