Shannon Macauley
@macauleylab.bsky.social
Associate Prof, PhD, wife, mom. Alzheimer’s disease | metabolism | sleep| glia | I ❤️ lactate | macauleylab.com
**views are mine, not my employer**
**views are mine, not my employer**
Pinned
Shannon Macauley
@macauleylab.bsky.social
· Nov 13
The Energetic Collapse of the Alzheimer's Brain: Metabolic Inflexibility Across Cells and Networks
Metabolic inflexibility in Alzheimer's disease. Schematic illustrating the biphasic trajectory of metabolic activity relative to canonical Alzheimer's disease (AD) biomarkers. In the presymptomatic p...
onlinelibrary.wiley.com
Our new review is out today!
𝗧𝗵𝗲 𝗘𝗻𝗲𝗿𝗴𝗲𝘁𝗶𝗰 𝗖𝗼𝗹𝗹𝗮𝗽𝘀𝗲 𝗼𝗳 𝘁𝗵𝗲 𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿’𝘀 𝗕𝗿𝗮𝗶𝗻: 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝗰 𝗜𝗻𝗳𝗹𝗲𝘅𝗶𝗯𝗶𝗹𝗶𝘁𝘆 𝗔𝗰𝗿𝗼𝘀𝘀 𝗖𝗲𝗹𝗹𝘀 𝗮𝗻𝗱 𝗡𝗲𝘁𝘄𝗼𝗿𝗸𝘀
We argue that Alzheimer’s disease is not just a problem of brain hypometabolism, but a disorder of metabolic inflexibility.
onlinelibrary.wiley.com/doi/10.1111/...
𝗧𝗵𝗲 𝗘𝗻𝗲𝗿𝗴𝗲𝘁𝗶𝗰 𝗖𝗼𝗹𝗹𝗮𝗽𝘀𝗲 𝗼𝗳 𝘁𝗵𝗲 𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿’𝘀 𝗕𝗿𝗮𝗶𝗻: 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝗰 𝗜𝗻𝗳𝗹𝗲𝘅𝗶𝗯𝗶𝗹𝗶𝘁𝘆 𝗔𝗰𝗿𝗼𝘀𝘀 𝗖𝗲𝗹𝗹𝘀 𝗮𝗻𝗱 𝗡𝗲𝘁𝘄𝗼𝗿𝗸𝘀
We argue that Alzheimer’s disease is not just a problem of brain hypometabolism, but a disorder of metabolic inflexibility.
onlinelibrary.wiley.com/doi/10.1111/...
New work from our lab! Link: rdcu.be/e0sfU
𝗧𝗮𝘂 𝗛𝗶𝗷𝗮𝗰𝗸𝘀 𝗕𝗿𝗮𝗶𝗻 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝘀𝗺, 𝗗𝗿𝗶𝘃𝗶𝗻𝗴 𝗦𝗹𝗲𝗲𝗽 𝗟𝗼𝘀𝘀 𝗶𝗻 𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿’𝘀 𝗗𝗶𝘀𝗲𝗮𝘀𝗲
A quick thread on our findings!
𝗧𝗮𝘂 𝗛𝗶𝗷𝗮𝗰𝗸𝘀 𝗕𝗿𝗮𝗶𝗻 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝘀𝗺, 𝗗𝗿𝗶𝘃𝗶𝗻𝗴 𝗦𝗹𝗲𝗲𝗽 𝗟𝗼𝘀𝘀 𝗶𝗻 𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿’𝘀 𝗗𝗶𝘀𝗲𝗮𝘀𝗲
A quick thread on our findings!
Tau pathology reprograms glucose metabolism to support cortical hyperexcitability, excitatory/inhibitory imbalance, and sleep loss
npj Dementia - Tau pathology reprograms glucose metabolism to support cortical hyperexcitability, excitatory/inhibitory imbalance, and sleep loss
rdcu.be
January 23, 2026 at 6:13 PM
New work from our lab! Link: rdcu.be/e0sfU
𝗧𝗮𝘂 𝗛𝗶𝗷𝗮𝗰𝗸𝘀 𝗕𝗿𝗮𝗶𝗻 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝘀𝗺, 𝗗𝗿𝗶𝘃𝗶𝗻𝗴 𝗦𝗹𝗲𝗲𝗽 𝗟𝗼𝘀𝘀 𝗶𝗻 𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿’𝘀 𝗗𝗶𝘀𝗲𝗮𝘀𝗲
A quick thread on our findings!
𝗧𝗮𝘂 𝗛𝗶𝗷𝗮𝗰𝗸𝘀 𝗕𝗿𝗮𝗶𝗻 𝗠𝗲𝘁𝗮𝗯𝗼𝗹𝗶𝘀𝗺, 𝗗𝗿𝗶𝘃𝗶𝗻𝗴 𝗦𝗹𝗲𝗲𝗽 𝗟𝗼𝘀𝘀 𝗶𝗻 𝗔𝗹𝘇𝗵𝗲𝗶𝗺𝗲𝗿’𝘀 𝗗𝗶𝘀𝗲𝗮𝘀𝗲
A quick thread on our findings!
Reposted by Shannon Macauley
Plasma extracellular vesicles from APOE3 Christchurch carriers display a protective phenotype in early stages of autosomal dominant Alzheimer's disease alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Plasma extracellular vesicles from APOE3 Christchurch carriers display a protective phenotype in early stages of autosomal dominant Alzheimer's disease
INTRODUCTION
The PSEN1E280A mutation causes autosomal dominant Alzheimer's disease (ADAD) with predictable onset, enabling presymptomatic studies. Extracellular vesicles (EVs) are emerging biomarker.....
alz-journals.onlinelibrary.wiley.com
January 22, 2026 at 10:04 AM
Plasma extracellular vesicles from APOE3 Christchurch carriers display a protective phenotype in early stages of autosomal dominant Alzheimer's disease alz-journals.onlinelibrary.wiley.com/doi/10.1002/...
Reposted by Shannon Macauley
Chronic low-grade metabolic #inflammation drives insulin resistance and metabolic dysfunction in #obesity. Yun Sok Lee highlights the lesser known beneficial effects of this inflammation and how they can transition into detrimental outcomes. 🧪
Immunometabolism in obesity: Understanding the beneficial and detrimental roles of inflammation
Chronic low-grade metabolic inflammation (known as metaflammation) drives insulin resistance and metabolic dysfunction in obesity. This Essay discusses the immunometabolic mechanisms underlying…
plos.io
January 22, 2026 at 1:50 PM
Chronic low-grade metabolic #inflammation drives insulin resistance and metabolic dysfunction in #obesity. Yun Sok Lee highlights the lesser known beneficial effects of this inflammation and how they can transition into detrimental outcomes. 🧪
Reposted by Shannon Macauley
Cerebral amyloid angiopathy and Alzheimer's and related pathologies across APOE genotypes academic.oup.com/brain/advanc...
Cerebral amyloid angiopathy and Alzheimer's and related pathologies across APOE genotypes
Cerebral amyloid angiopathy is associated with age, APOE genotype, and Alzheimer’s disease pathology (AD). Mehta et al. now show that its severity is assoc
academic.oup.com
January 22, 2026 at 2:11 PM
Cerebral amyloid angiopathy and Alzheimer's and related pathologies across APOE genotypes academic.oup.com/brain/advanc...
Reposted by Shannon Macauley
The Shingles vaccine has outperformed all expectations. Why?
erictopol.substack.com/p/spotlight-...
erictopol.substack.com/p/spotlight-...
January 22, 2026 at 3:11 PM
The Shingles vaccine has outperformed all expectations. Why?
erictopol.substack.com/p/spotlight-...
erictopol.substack.com/p/spotlight-...
Reposted by Shannon Macauley
Peripheral cancer attenuates amyloid pathology in Alzheimer’s disease via cystatin-c activation of TREM2: @cellpress.bsky.social www.cell.com/cell/fulltex...
January 22, 2026 at 3:46 PM
Peripheral cancer attenuates amyloid pathology in Alzheimer’s disease via cystatin-c activation of TREM2: @cellpress.bsky.social www.cell.com/cell/fulltex...
Go Sanders Brown and the Macauley Lab! So bummed to miss it!
We had such a great evening cheering on the UK Women's Basketball team during the We Back Pat game! Cats win 94-89!
@ukresearch.bsky.social @ukhealthcare.uky.edu @macauleylab.bsky.social @pinarcoskun.bsky.social
@ukresearch.bsky.social @ukhealthcare.uky.edu @macauleylab.bsky.social @pinarcoskun.bsky.social
January 17, 2026 at 2:26 PM
Go Sanders Brown and the Macauley Lab! So bummed to miss it!
Reposted by Shannon Macauley
Great study on @molneurodegen.bsky.social showcasing the differences of Aβ generated from glutamatergic and GABAergic neurons with distinct implications for plaque compaction, reactive gliosis, and axonal dystrophy!
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Client Challenge
link.springer.com
January 11, 2026 at 3:47 PM
Great study on @molneurodegen.bsky.social showcasing the differences of Aβ generated from glutamatergic and GABAergic neurons with distinct implications for plaque compaction, reactive gliosis, and axonal dystrophy!
link.springer.com/article/10.1...
link.springer.com/article/10.1...
Reposted by Shannon Macauley
This ‘fundamental’ study uncovers how directing pyruvate into mitochondria can shrink cells by shifting their metabolism away from building amino acids and proteins.
buff.ly/hFHjKy9
buff.ly/hFHjKy9
December 27, 2025 at 11:01 AM
This ‘fundamental’ study uncovers how directing pyruvate into mitochondria can shrink cells by shifting their metabolism away from building amino acids and proteins.
buff.ly/hFHjKy9
buff.ly/hFHjKy9
Reposted by Shannon Macauley
Rethinking diabetes diagnosis: a meta-analysis shows that 1 h plasma glucose is superior to FPG, 2 h plasma glucose, #HbA1c or FPG plus HbA1c for detecting #Type2Diabetes earlier, potentially improving prevention and care #DiabetesResearch link.springer.com/article/10.1... 🔓
Superiority of 1 h plasma glucose vs fasting plasma glucose, 2 h plasma glucose and HbA1c for the diagnosis of type 2 diabetes - Diabetologia
Aims/hypothesis The IDF has proposed 1 h plasma glucose (1 h PG) as a diagnostic test for type 2 diabetes. This study evaluated the utility of 1 h PG in diagnosing type 2 diabetes, compared with fasti...
link.springer.com
December 23, 2025 at 9:04 AM
Rethinking diabetes diagnosis: a meta-analysis shows that 1 h plasma glucose is superior to FPG, 2 h plasma glucose, #HbA1c or FPG plus HbA1c for detecting #Type2Diabetes earlier, potentially improving prevention and care #DiabetesResearch link.springer.com/article/10.1... 🔓
Reposted by Shannon Macauley
Lactate dehydrogenase A (#LDHA)-driven metabolic and epigenetic reprogramming in beta cell dedifferentiation during diabetes development, identifying LDHA inhibition as a promising therapeutic target. #DiabetesResearch #Pancreatic-β-cell #Dedifferentiaton link.springer.com/article/10.1...
LDHA induces beta cell dedifferentiation in diabetes through metabolic and epigenetic reprogramming - Diabetologia
Aims/hypothesis Pancreatic beta cell dedifferentiation underlies the reversible reduction in beta cell mass and function in diabetes. Exploratory research into interventional targets and adjuvant ther...
link.springer.com
December 22, 2025 at 10:58 AM
Lactate dehydrogenase A (#LDHA)-driven metabolic and epigenetic reprogramming in beta cell dedifferentiation during diabetes development, identifying LDHA inhibition as a promising therapeutic target. #DiabetesResearch #Pancreatic-β-cell #Dedifferentiaton link.springer.com/article/10.1...
December 14, 2025 at 3:33 PM
This is so important in the context of Alzheimer’s. Many studies suggest MetS or diabetes is not associated with AD risk, however they fail to consider T2D is treated. This reinforces the idea that managing metabolic dysfunction has widespread improvement for many age related diseases.
Normalization of glucose in people with prediabetes, i.e. achieving remission, is linked to halving of major cardiovascular adverse events over ensuing decades
www.thelancet.com/journals/lan...
www.thelancet.com/journals/lan...
Prediabetes remission and cardiovascular morbidity and mortality: post-hoc analyses from the Diabetes Prevention Program Outcome study and the DaQing Diabetes Prevention Outcome study
Reaching prediatbetes remission is linked to a decades-long benefit, halving the risk
of cardiovascular death or hospitalisation for heart failure in diverse populations.
Targeting remission might rep...
www.thelancet.com
December 13, 2025 at 12:52 AM
This is so important in the context of Alzheimer’s. Many studies suggest MetS or diabetes is not associated with AD risk, however they fail to consider T2D is treated. This reinforces the idea that managing metabolic dysfunction has widespread improvement for many age related diseases.
Paper accepted!!!!!!! Yahooooo!!!
a woman is jumping in the air while a man holds her hands up .
ALT: a woman is jumping in the air while a man holds her hands up .
media.tenor.com
December 12, 2025 at 10:09 PM
Paper accepted!!!!!!! Yahooooo!!!
December 12, 2025 at 10:08 PM
December 11, 2025 at 9:44 PM
#ArtAdventCalendar, Day 10
Watercolor, alcohol inks, acrylics. Inspired by Ramon y Cajal and Greg Dunn’s work.
Watercolor, alcohol inks, acrylics. Inspired by Ramon y Cajal and Greg Dunn’s work.
December 10, 2025 at 7:46 PM
#ArtAdventCalendar, Day 10
Watercolor, alcohol inks, acrylics. Inspired by Ramon y Cajal and Greg Dunn’s work.
Watercolor, alcohol inks, acrylics. Inspired by Ramon y Cajal and Greg Dunn’s work.
December 8, 2025 at 9:23 PM
I forgot about this!
#ArtAdventCalendar Day 7
Watercolor, mouse, EVs.
Painted it for my student after we discovered a method to isolate EVs from the interstitial fluid of the mouse’s brain (Pait et al, 2023).
#ArtAdventCalendar Day 7
Watercolor, mouse, EVs.
Painted it for my student after we discovered a method to isolate EVs from the interstitial fluid of the mouse’s brain (Pait et al, 2023).
December 7, 2025 at 4:57 PM
I forgot about this!
#ArtAdventCalendar Day 7
Watercolor, mouse, EVs.
Painted it for my student after we discovered a method to isolate EVs from the interstitial fluid of the mouse’s brain (Pait et al, 2023).
#ArtAdventCalendar Day 7
Watercolor, mouse, EVs.
Painted it for my student after we discovered a method to isolate EVs from the interstitial fluid of the mouse’s brain (Pait et al, 2023).
Reposted by Shannon Macauley
There's a software engineer in Hong Kong who makes incredibly detailed scientific diagrams for wikipedia, like this clickable metro-style map of metabolic pathways!!!
December 4, 2025 at 1:18 AM
There's a software engineer in Hong Kong who makes incredibly detailed scientific diagrams for wikipedia, like this clickable metro-style map of metabolic pathways!!!
So very pretty! Iba1, Cmec7a, Amylo-glo. Courtesy of @clairashley.bsky.social
December 5, 2025 at 4:54 AM
So very pretty! Iba1, Cmec7a, Amylo-glo. Courtesy of @clairashley.bsky.social
Reposted by Shannon Macauley
Kudos to Sanders-Brown researchers 𝐖𝐞𝐢𝐤𝐚𝐧𝐠 𝐂𝐚𝐢, 𝐏𝐡𝐃, 𝐉𝐨𝐬𝐡 𝐌𝐨𝐫𝐠𝐚𝐧𝐭𝐢, 𝐏𝐡𝐃, 𝐚𝐧𝐝 𝐃𝐚𝐧𝐢𝐞𝐥 𝐋𝐞𝐞, 𝐏𝐡𝐃., who shared about their COBRE Pilot grant projects during the second annual 𝐂𝐍𝐒-𝐌𝐞𝐭𝐚𝐛𝐨𝐥𝐢𝐬𝐦 𝐒𝐲𝐦𝐩𝐨𝐬𝐢𝐮𝐦!
@ukresearch.bsky.social @neurosciencerpa.bsky.social @macauleylab.bsky.social
@ukresearch.bsky.social @neurosciencerpa.bsky.social @macauleylab.bsky.social
December 3, 2025 at 10:05 PM
Kudos to Sanders-Brown researchers 𝐖𝐞𝐢𝐤𝐚𝐧𝐠 𝐂𝐚𝐢, 𝐏𝐡𝐃, 𝐉𝐨𝐬𝐡 𝐌𝐨𝐫𝐠𝐚𝐧𝐭𝐢, 𝐏𝐡𝐃, 𝐚𝐧𝐝 𝐃𝐚𝐧𝐢𝐞𝐥 𝐋𝐞𝐞, 𝐏𝐡𝐃., who shared about their COBRE Pilot grant projects during the second annual 𝐂𝐍𝐒-𝐌𝐞𝐭𝐚𝐛𝐨𝐥𝐢𝐬𝐦 𝐒𝐲𝐦𝐩𝐨𝐬𝐢𝐮𝐦!
@ukresearch.bsky.social @neurosciencerpa.bsky.social @macauleylab.bsky.social
@ukresearch.bsky.social @neurosciencerpa.bsky.social @macauleylab.bsky.social
We're very excited for our upcoming CNS Metabolism Symposium at University of Kentucky! We have a great line up of speakers, including our ATP Showcase and a keynote from Dr. Tim Ryan!
Register now!
uky.az1.qualtrics.com/jfe/form/SV_...
Register now!
uky.az1.qualtrics.com/jfe/form/SV_...
November 24, 2025 at 6:00 PM
We're very excited for our upcoming CNS Metabolism Symposium at University of Kentucky! We have a great line up of speakers, including our ATP Showcase and a keynote from Dr. Tim Ryan!
Register now!
uky.az1.qualtrics.com/jfe/form/SV_...
Register now!
uky.az1.qualtrics.com/jfe/form/SV_...
At SFN? Check out Dr. Karina Meyer-Acosta’s talk on APOE, neurodevelopment, and network formation using organoids. We were lucky to have Kaisha join the lab earlier this fall from Dr. Jenny Hsieh’s lab for her postdoc!
November 18, 2025 at 6:30 PM
At SFN? Check out Dr. Karina Meyer-Acosta’s talk on APOE, neurodevelopment, and network formation using organoids. We were lucky to have Kaisha join the lab earlier this fall from Dr. Jenny Hsieh’s lab for her postdoc!
At #SFN2025? Stop by @ncons95.bsky.social and Sierra’s posters to learn about research from the lab!
November 17, 2025 at 5:03 PM
At #SFN2025? Stop by @ncons95.bsky.social and Sierra’s posters to learn about research from the lab!