The SWEET project is a multicenter, randomized, controlled trial that shows that long-term consumption of sweeteners and sweetness enhancers improves body weight control and elicits beneficial gut microbiota changes in adults with overweight or obesity.

Emerging evidence that circulating levels of key metabolic intermediates are sensed by a range of G-Protein Coupled receptors (GPCRs) is providing critical new insights into the control of systemic me...

<em>Alzheimer's & Dementia: Translational Research & Clinical Interventions</em> journal bridges drug discovery research and clinical studies for dementia & Alzheimer's.

Cleveland Clinic seeks Chair of Neurosciences to lead 20 labs and 190 researchers, driving global innovation in brain health, neurological disease, & discovery

Nature Reviews Neurology, Published online: 04 September 2025; doi:10.1038/s41582-025-01132-4The neuronal ceroid lipofuscinoses, or Batten disease, are a group of fatal inherited neurodegenerative lysosomal storage disorders. Despite having defined genetic causes, the underlying disease mechanisms remain poorly understood and treatments are limited. Cooper and colleagues highlight recent advances in understanding the cell biology and disease pathogenesis, which could inform future therapeutic development.

Nature Communications - Metformin is under clinical trial for brain neuroprotection but how it may work is poorly understood. Here, the authors show that metformin helps myelin formation by human...

How reduced blood flow plays a role in progressive white matter loss during aging and associated cognitive decline is unclear. Here the authors show that selective constriction and rarefaction of capi...

As a group, our scientific community has a responsibility to unpack the ‘what’ and ‘why’ behind our work for the public, not least because much of our research is publicly funded. Here, I argue that a...

Rapid Eye Movement (REM) sleep degrades with age, and more severely in Alzheimer's disease (AD). REM sleep comprises about twenty percent of adult sleep, alternates between phasic and tonic periods, a...

Nature Reviews Endocrinology, Published online: 22 August 2025; doi:10.1038/s41574-025-01162-4This Review summarizes our current understanding of how the skeleton regulates whole-body energy metabolism; rather than viewing bone as the core regulator of systemic energy metabolism, the authors suggest that bone contributes to the regulation of the complex processes underlying whole-body energy metabolism.