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Stephen O'Rahilly @stephenorahilly.bsky.social · 2d

Several a day!! What do you use now?

Stephen O'Rahilly @stephenorahilly.bsky.social · 6d

the research illustrates how the control of adipocyte lipolysis by circulating ketone bodies is important for normal metabolic homeostasis. Thanks to the many contributors in the two Cambridges!

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Stephen O'Rahilly @stephenorahilly.bsky.social · 6d

www.medrxiv.org/content/10.1... Working with our great collaborators at Pfizer we have uncovered a common genetic contributor to metabolic ill health/

Genetic impairment of ketone body signalling is a prevalent contributor to human metabolic dysfunction

Emerging evidence that circulating levels of key metabolic intermediates are sensed by a range of G-Protein Coupled receptors (GPCRs) is providing critical new insights into the control of systemic me...

www.medrxiv.org

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Stephen O'Rahilly @stephenorahilly.bsky.social · 12d

nature.com/articles/s44161-025-00712-3

Interesting. But studies of GDF15 on cells used GDF15 made in mammalian cells which is always contaminated by TGFB family members (see PMID: 29161287) some of which are active at fmolar concs. Yeast or bacterially derived is fine. Qkine is good source

Cardiac adaptation to endurance exercise training requires suppression of GDF15 via PGC-1α - Nature Cardiovascular Research

Khetarpal et al. show that the metabolic regulator PGC-1α is essential in heart muscle cells for exercise-driven cardiac growth, and that suppression of the stress-induced myokine GDF15 is required to enable cardiomyocyte adaptations to training.

nature.com

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Stephen O'Rahilly @stephenorahilly.bsky.social · Sep 4

Fantastic news. Processes designed to measure Research excellence should focus on whether research done at our universities is reproducible, represents a significant advance in understanding, and/or is actually or potentially useful. The rest is just prattle.

Patrick Vallance hits pause on Research Excellence Framework

Science minister announces review of controversial changes to research environment assessment

www.timeshighereducation.com

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Reposted by Stephen O'Rahilly

Daniel Drucker @danieljdrucker.bsky.social · Aug 14

The @easdnews.bsky.social Novo Nordisk Foundation Prize #Diabetes

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Reposted by Stephen O'Rahilly

Daniel Drucker @danieljdrucker.bsky.social · Aug 14

Expanding metabolic roles for the GIPR in oligodendrocytes #weightloss www.cell.com/cell-metabol...

Glucose-dependent insulinotropic polypeptide receptor signaling in oligodendrocytes increases the weight-loss action of GLP-1R agonism

Hansford et al. show that GIPR, a target of new weight-loss drugs, is found in brain cells called oligodendrocytes. GIPR helps these drugs access the brain and boosts weight loss. Without GIPR in thes...

www.cell.com

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Stephen O'Rahilly @stephenorahilly.bsky.social · Aug 9

So very sad. Davo was a truly great endocrine scientist.

Wiebke Arlt @wiebkearlt.bsky.social · Aug 7

Deeply saddened to hear about the passing of an all-time-great of endocrine research, David Mangelsdorf - I just saw him at #ENDO2025, a real shock! Read his obituary here www.utsouthwestern.edu/about-us/ass... @endocrinesociety.bsky.social @esendocrinology.bsky.social @socendocrinology.bsky.social

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Stephen O'Rahilly @stephenorahilly.bsky.social · Jul 3

sciencedirect.com/science/arti... Great to see further evidence emerging supporting the pressing need for trials of preconceptional GDF15 desensitisation with metformin for prevention of severe nausea and vomiting of pregnancy in women with a previous history. Congrats to @drfejzo.bsky.social

Pre-pregnancy metformin use associated with lower risk of severe nausea and vomiting of pregnancy and hyperemesis gravidarum

Severe nausea and vomiting of pregnancy and hyperemesis gravidarum are associated with adverse maternal, fetal, and child outcomes. The recurrence ris…

sciencedirect.com

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Stephen O'Rahilly @stephenorahilly.bsky.social · Jun 29

www.nytimes.com/2025/06/26/o... Amazing to see this article appear in the NYT. I hope many of my fellow endocrinologists are reading it @endocrinesociety.bsky.social

Opinion | How the Gay Rights Movement Radicalized, and Lost Its Way

www.nytimes.com

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Stephen O'Rahilly @stephenorahilly.bsky.social · Jun 15

OMG. This looks terrifying.

Eric Topol @erictopol.bsky.social · Jun 13

In today's WSJ by their editorial board
www.wsj.com/opinion/rfk-...

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Stephen O'Rahilly @stephenorahilly.bsky.social · May 24

Mice lacking this amino acid lost 30% body weight www.nature.com/articles/d41... Am I missing something? Mice engineered to have a specific and severe defect in amino acid metabolism get sick and lose weight. Might the rush to find new weight loss targets be impairing our critical faculties ?

Mice lacking this amino acid lost 30% of their body weight

But eliminating cysteine, which is found in high-protein foods, from human diets would be challenging.

www.nature.com

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Stephen O'Rahilly @stephenorahilly.bsky.social · May 22

I did start my talk by showing the photo and saying (with a wry smile, of course) how delighted I was to be in Uppsala….

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Stephen O'Rahilly @stephenorahilly.bsky.social · May 22

Had a great time at Lund university attending their Spring Meeting. Amused to see this poster outside the lecture theatre. Those old English universities: it’s hard to tell them apart 😊

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Reposted by Stephen O'Rahilly

NIHR Cambridge Biomedical Research Centre @cambridgebrc.bsky.social · Apr 29

📢 Job Vacancy! Institute of Metabolic Science
@ims-mrl.bsky.social are looking for a Research Nurse to join their team. Applications open until 30th May!

>>> For more info: bit.ly/4iIkrNo

@cuhnhs.bsky.social @mrcepid.bsky.social @stephenorahilly.bsky.social @cambridgeuni.bsky.social

Graphic of medicines on a blue background

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Stephen O'Rahilly @stephenorahilly.bsky.social · Apr 17

Indeed. And so ironic that while the new administration says it is very keen to understand the effects of food on health, their actions are resulting in the closure of one the US’s most effective labs in that area @kevinh-phd.bsky.social

Daniel Drucker @danieljdrucker.bsky.social · Apr 16

The world of science needs more colleagues like Dr. Kevin Hall. Honesty, integrity and high quality science, answering critical questions with broad implications for improving human health

Kevin Hall @kevinh-phd.bsky.social · Apr 16

After 21 years at my dream job, I’m very sad to announce my early retirement from the National Institutes of Health. My life’s work has been to scientifically study how our food environment affects what we eat, and how what we eat affects our physiology.

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Stephen O'Rahilly @stephenorahilly.bsky.social · Apr 17

www.thefp.com/p/carole-hoo.... While I applaud Harvard for standing up to the Trump government, this article is mandatory reading for anyone who doesn’t understand how it got to this point.

Carole Hooven: Why I Left Harvard

After I stated banal facts about human biology, I found myself caught in a DEI web, without the support to do the job I loved. The only way out was to leave it.

www.thefp.com

Stephen O'Rahilly @stephenorahilly.bsky.social · Apr 16

UK’s supreme court rules that legal definition of woman is based on biological sex. This is a hugely important decision. Unanimous .I hope it will open up rational debate in other countries.

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Stephen O'Rahilly @stephenorahilly.bsky.social · Apr 13

Thanks so much Brent. I hope I made it clear in my talk that the discovery of the role of GDF15 in pregnancy sickness was very much an international collaborative effort

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Stephen O'Rahilly @stephenorahilly.bsky.social · Apr 2

I really enjoyed recording one of these with you several years ago. Wishing you well with whatever your next venture will be.

Ushma Neill @ushmaneill.bsky.social · Apr 1

All good things must come to an end, including this brilliant series that I was delighted to have hosted. Hope you all have enjoyed it as much as I did! Thank you @jclinical-invest.bsky.social ! And all the Giants who trusted me to help tell their stories.

Journal of Clinical Investigation @jci.org · Apr 1

Thanks to @UshmaNeill for running the Conversation of Giants in Medicine series for over a decade. Since its inception in 2012, this series has spanned 74 interviews with 80 pioneer scientists: jci.org/videos/cgms

Last but not least episode:
Video: buff.ly/LF6DMYz
Article: jci.org/articles/vie...

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Stephen O'Rahilly @stephenorahilly.bsky.social · Mar 29

Almut Gadow v Open University genderblog.net/almut-gadow-... This piece is from Nick Wallis, the journalist whose doigged research exposed the Post Office Scandal. He is now taking a serious interest in an area that is increasingly affecting UK universities.Worth a read

Almut Gadow v Open University

Almut Gadow Dr Almut Gadow has a personality similar to those I’ve stumbled across a lot whilst talking to people about gender ideology. She’s fiercely intelligent, does not back down a…

genderblog.net

Reposted by Stephen O'Rahilly

Laura Dearden @lauradearden.bsky.social · Mar 25

Come and study with us for a Masters!

Institute of Metabolic Science-Metabolic Research Laboratories @ims-mrl.bsky.social · Mar 25

@ims-mrl.bsky.social @uniofcam.bsky.social full-time taught MPhil in Obesity, Endocrinology and Metabolism for 2025/2026

Application deadline 4th April!!!

High quality postgrad training in physiology & pathophysiology of energy balance & metabolism.

🛜 mrl.ims.cam.ac.uk/study-us/tau...