🚨Fresh pre-print collab with @johnsonlab.bsky.social, Norton Healthcare, and our @uksbcoa.bsky.social collaborators. We report a coordinated CD8+ Tcell immunometabolic program associated with amyloid-related imaging abnormalities (ARIA) during lecanemab therapy👇

🔗 www.medrxiv.org/content/10.1...

new preprint from @iostephens.bsky.social describes the potential benefits of increasing lipid turnover in microglia by eliminating PLIN2 from their surface

Are you an ATP!?!

We are hosting our 2nd annual CNS MET Symposium 12/3/25 and are searching for early-career researchers to highlight as All-star Trainee Presentations (ATPs).

Up to 4 individuals will be invited for an all-expense paid trip to beautiful Lexington KY.

Apply here! rb.gy/3zk4cm

Shoutout to Sanders-Brown trainees as they met with legislators on Capitol Hill during the @alzassociation.bsky.social Advocacy Forum!
medicine.uky.edu/news/kentuck...
@ukresearch.bsky.social @universityofky.bsky.social @johnsonlab.bsky.social @bachstetterlab.bsky.social @mpmurphy.bsky.social

What does the APOE 'lipid droplet-ome' look like???

Check out our new paper to find out!
www.sciencedirect.com/science/arti...

Thanks to first authors @cassifriday.bsky.social and @iostephens.bsky.social

+help from Scott Gordon @morganti.bsky.social and @cohenlaboratory.bsky.social labs

Kudos to 𝐒𝐭𝐞𝐯𝐞 𝐌𝐚𝐜𝐋𝐞𝐚𝐧, a T32 in the @johnsonlab.bsky.social who does outstanding work!
medicine.uky.edu/centers/sbco...
@ukresearch.bsky.social @universityofky.bsky.social
#APOE

I cannot wait for @erinmgibson.bsky.social visit to Univeristy of Kentucky next week!!!! How lucky are we!!! 🤩🤩🤩

New pre-print out:

www.biorxiv.org/content/10.1...

Surprise surprise 🤗, microglia proximity to AD pathology alters their immunometabolic signatures

Excellent work by Kai Saito and our team, along with our awesome collaborators Pete Nelson, @macauleylab.bsky.social, @johnsonlab.bsky.social

As NIH and university funding in the US is dismantled and as this admin revokes international student visas for no reason…we need to make a stand. Thanks @ardemp.bskyverified.social for being vocal about what’s at stake! www.cnn.com/2025/04/09/h...

Congratulations to #APOE25 Award Winners Lesley Golden, Ph.D., and Aura Ramirez, Ph.D. on their work to advance dementia science. #AAICAdvancements

Our latest in PNAS! 🎉

ATP-sensitive potassium channels alter glycolytic flux to modulate cortical activity and sleep

Take home message?

KATP channels are metabolic sensors under circadian control that gate glycolytic flux, arousal, & sleep/wake transitions.

www.pnas.org/doi/10.1073/...

Grateful to The Scientist for listening to my story and amplifying our concerns regarding bans on NIH communication and govt funding. www.the-scientist.com/freeze-on-ni...

new preprint!

www.biorxiv.org/content/10.1...

a characterization of APOE effects on the lipid droplet-ome (turns out you see a lot of "AD-related" proteins!)

first authors Cassi Friday & Isaiah Stephens + great collaborators Scott Gordon, @cohenlaboratory.bsky.social @morganti.bsky.social

For my first post, an invitation to join us in Miami! A lot of thing on ApoE and lipids are moving fast, catch up!

Abstract submission is now open!

😂 as long as we can use the term "study" loosely, I should be fine

@rikvanderkant.bsky.social @macauleylab.bsky.social hook it up, yo

can't have @morganti.bsky.social gloating about how he has more followers than me

Tal, can I join the APOE family? :)