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morganti.bsky.social
Josh Morganti
@morganti.bsky.social
550 followers 180 following 2 posts
Fascinated by all things astrocytes and microglia related to: aging, trauma, mixed dementia, and NeuroD processes in general. http://morgantilab.com
morgantilab.com
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morganti.bsky.social
Josh Morganti @morganti.bsky.social · 17d
🚨Fresh pre-print collab with @johnsonlab.bsky.social, Norton Healthcare, and our @uksbcoa.bsky.social collaborators. We report a coordinated CD8+ Tcell immunometabolic program associated with amyloid-related imaging abnormalities (ARIA) during lecanemab therapy👇

🔗 www.medrxiv.org/content/10.1...
Clonal expansion of cytotoxic CD8⁺ T cells in lecanemab-associated ARIA
Amyloid related imaging abnormalities (ARIA) remain the principal safety concern limiting adoption of anti amyloid therapies such as lecanemab, yet their underlying biology is poorly defined. To addre...
www.medrxiv.org
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morganti.bsky.social
Josh Morganti @morganti.bsky.social · May 16
New pre-print out:

www.biorxiv.org/content/10.1...

Surprise surprise 🤗, microglia proximity to AD pathology alters their immunometabolic signatures

Excellent work by Kai Saito and our team, along with our awesome collaborators Pete Nelson, @macauleylab.bsky.social, @johnsonlab.bsky.social
High-Resolution Spatial Profiling of Microglia Reveals Proximity Associated Immunometabolic Reprogramming in Alzheimers Disease
Single-cell RNA sequencing has demonstrated that the presence of parenchymal amyloid plaques and intracellular hyperphosphorylated tau pathology is associated with distinctive (and possibly disease-dr...
www.biorxiv.org
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Reposted by Josh Morganti
johnsonlab.bsky.social
Lance Johnson @johnsonlab.bsky.social · Dec 21
new preprint!

www.biorxiv.org/content/10.1...

a characterization of APOE effects on the lipid droplet-ome (turns out you see a lot of "AD-related" proteins!)

first authors Cassi Friday & Isaiah Stephens + great collaborators Scott Gordon, @cohenlaboratory.bsky.social @morganti.bsky.social
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Reposted by Josh Morganti
macauleylab.bsky.social
Shannon Macauley @macauleylab.bsky.social · Nov 15
Join us!
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Reposted by Josh Morganti
liddelowsa.bsky.social
Shane Liddelow @liddelowsa.bsky.social · Nov 14
go.bsky.app/Lyzro3M

!WELCOME!

thought we might need a starter pack for all those coming over from the birdhouse - here's a GliaSky list.

apologies for missing many of you - please do reply to get added

and remember to repost so the newbies can find us!
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Reposted by Josh Morganti
cohenlaboratory.bsky.social
Sarah Cohen @cohenlaboratory.bsky.social · Nov 12
Any of my #APOE buddies here yet? Abstract submissions are open for AAIC Advancements: APOE and #Lipid Biology, March 17-18, 2025 in Miami www.alz.org/apoe/overvie...
AAIC Advancements: APOE & Lipid Biology | alz.org
Neuroscience researchers should attend this Alzheimer's Association conference to discuss the role of APOE & lipid biology in neurodegenerative diseases.
www.alz.org
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