banner
hamperllab.bsky.social
Hamperl Lab
@hamperllab.bsky.social
150 followers 150 following 9 posts
We are professional DNA traffic controllers and study how transcription and replication are moving smoothly (most of the time).
Posts Media Videos Starter Packs
hamperllab.bsky.social
Hamperl Lab @hamperllab.bsky.social · Aug 4
Additionally, Tsirkas et al. show that R-loops, under specific conditions, can be beneficial for cells, by reducing excessive RNAPII load on highly-transcribing genes, thus preventing potential TRCs.

We are very happy to see this project led by @ioannistsirkas.bsky.social reach the final stages! 🥳
1
hamperllab.bsky.social
Hamperl Lab @hamperllab.bsky.social · Aug 4
Our latest research is online in the @biorxivpreprint.bsky.social! 🧬🎉

🔎 We have developed a novel, single-cell real-time approach to monitor R-loop generated TRCs, and we have shown R-loop-mediated, replisome-controlled transcription repression.

www.biorxiv.org/cgi/content/...
Replisome progression regulates R-loop mediated transcriptional repression
Maintaining cellular proliferation necessitates the synchronized activity of diverse molecular machineries operating in parallel on the genome. Wide-spread transcription and R-loop formation can inter...
www.biorxiv.org
1 5 17
hamperllab.bsky.social
Hamperl Lab @hamperllab.bsky.social · Aug 4
Such a nice review for one of our latest research works!
erc.europa.eu
European Research Council (ERC) @erc.europa.eu · Jul 29
🔬 Stephan Hamperl ‪uncovered how clashes between #gene reading & #DNA copying inside cells drive disease. Their tools reveal new insights into #cancer, ageing & development.

Read more 👉 europa.eu/!H7RtjQ

#FrontierResearch #GeneEditing #Genetics #Oncology @www.helmholtz-munich.de
Revealing cellular conflict role in disease and development
Understanding the conflicts that happen within our cells could shed new light not only on disease progression, but also on how our bodies...
europa.eu
2 5
hamperllab.bsky.social
Hamperl Lab @hamperllab.bsky.social · Apr 8
Wishing you all the best as you move on to your next adventure, we are so proud of you! It’s been great having you in the lab — we’ll miss you!
1
hamperllab.bsky.social
Hamperl Lab @hamperllab.bsky.social · Mar 24
Two days of science, international cooking, and breathtaking hikes in the Bavarian Alps—our lab retreat in Mittenwald had it all! Great discussions, great food, and even better company.
2 14
Reposted by Hamperl Lab
epihmgu.bsky.social
Epigenetics at Helmholtz Munich @epihmgu.bsky.social · Mar 18
🚨Paper Alert!

👏 Big congrats to @marcelwerner.bsky.social, ManuelTrauner & rest of @hamperllab.bsky.social team for this brilliant work!

🧬 Check out their amazing research diving into how #TRCs and DOT1L impact genome stability.

A must-read 🧵 for #transcription, #replication & #epigenetics fans👇!
marcelwerner.bsky.social
Marcel Werner @marcelwerner.bsky.social · Feb 20
I am delighted to share the main work of my PhD project in the @hamperllab.bsky.social now out in @narjournal.bsky.social. TRCs drive R-loop-dependent nucleosome eviction and require DOT1L activity for transcription recovery.
academic.oup.com/nar/article/...

#TRC #r-loop #chromatin

More below 👇
Transcription-replication conflicts drive R-loop-dependent nucleosome eviction and require DOT1L activity for transcription recovery
Abstract. Progressing transcription and replication machineries profoundly impact their underlying chromatin template. Consequently, transcription-replicat
academic.oup.com
4 10
hamperllab.bsky.social
Hamperl Lab @hamperllab.bsky.social · Feb 21
Thank you, Umberto!
hamperllab.bsky.social
Hamperl Lab @hamperllab.bsky.social · Feb 21
Happy to hear it, thank you Marcelo!
hamperllab.bsky.social
Hamperl Lab @hamperllab.bsky.social · Feb 21
Thank you, Daphne!
1
Reposted by Hamperl Lab
antonio-scialdone.bsky.social
Antonio Scialdone @antonio-scialdone.bsky.social · Feb 12
How can we improve gene regulatory network inference from noisy scRNA-seq data? Our new review in @molsystbiol.org explores the latest methods integrating prior knowledge to enhance reliability. Plus, some suggestions on how to improve benchmarking!
www.embopress.org/doi/full/10....
Leveraging prior knowledge to infer gene regulatory networks from single-cell RNA-sequencing data | Molecular Systems Biology
EMBO Press is an editorially independent publishing platform for the development of EMBO scientific publications.
www.embopress.org
2 14 25
hamperllab.bsky.social
Hamperl Lab @hamperllab.bsky.social · Feb 20
Proud to share our latest publication in @narjournal.bsky.social! A fantastic team effort led by @marcelwerner.bsky.social and Manuel T., where we explore the chromatin dynamics at transcription-replication conflicts (TRC) sites and their impact on genome stability using a novel TRC reporter system.
marcelwerner.bsky.social
Marcel Werner @marcelwerner.bsky.social · Feb 20
I am delighted to share the main work of my PhD project in the @hamperllab.bsky.social now out in @narjournal.bsky.social. TRCs drive R-loop-dependent nucleosome eviction and require DOT1L activity for transcription recovery.
academic.oup.com/nar/article/...

#TRC #r-loop #chromatin

More below 👇
Transcription-replication conflicts drive R-loop-dependent nucleosome eviction and require DOT1L activity for transcription recovery
Abstract. Progressing transcription and replication machineries profoundly impact their underlying chromatin template. Consequently, transcription-replicat
academic.oup.com
3 5 21
Reposted by Hamperl Lab
epihmgu.bsky.social
Epigenetics at Helmholtz Munich @epihmgu.bsky.social · Jan 15
Best first bsky post posible 4us:

2025 INTERNSHIP CALL IS NOW OPEN!

Ready for an adventure this summer?

Join our 2025 #Epigenetics #SummerInternship at Helmholtz Munich! Dive into AI, stem cells, nutrition and cutting-edge research, while gaining hands-on experience.

Apply now! 👉 bit.ly/40g1BWL
3 15 19