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Reposted by Marcel Werner

Scaffidi Lab @scaffidilab.bsky.social · 8d

Histone acetylation - not always about transcriptional activation: H4K16ac safeguards the genome replication program by repressing premature replication of heterochromatin. Well done Marta Milan! tinyurl.com/yuy9m8t3

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Reposted by Marcel Werner

The Groth lab @grothlab.bsky.social · Aug 28

We have lift off!! 🚀 Yesterday was the official opening of EpiC! The DNRF Center for Epigenetic Cell Memory at the Danish Cancer Institute!
Our EpiC team with director Anja Groth @groth-anja.bsky.social, were joined by Jesper Fisker, CEO @cancer.dk & Niels Mejlgaar, CEO @dg.dk to celebrate 🎉

Image of Niels Mejlgaar (CEO of DNRF), Anja Groth (EpiC director) & Jesper Fisker (CEO of DCS).

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Marcel Werner @marcelwerner.bsky.social · Aug 17

Finally, also my family and friends who were always there for me and whose unvavering support made all of this possible in the first place!

Moving forward, I am excited to continue my research as a PostDoc in Copenhagen!

Marcel Werner @marcelwerner.bsky.social · Aug 17

I would like to thank everyone who supported me along the way. Especially Stephan, my supervisor, and all members of @hamperllab.bsky.social , as well as the whole @epihmgu.bsky.social. I could not have asked for a better team for this journey.

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Marcel Werner @marcelwerner.bsky.social · Aug 17

PhDone!

Last week, an incredible journey of 4.5 years came to an end when I defended my PhD at the LMU in Munich. I am tremendously grateful for all the fun moments throughout this chapter, full of learning and doing cool science.

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Marcel Werner @marcelwerner.bsky.social · Aug 4

Great work from @ioannistsirkas.bsky.social and the @hamperllab.bsky.social!

Hamperl Lab @hamperllab.bsky.social · Aug 4

Our latest research is online in the @biorxivpreprint.bsky.social! 🧬🎉

🔎 We have developed a novel, single-cell real-time approach to monitor R-loop generated TRCs, and we have shown R-loop-mediated, replisome-controlled transcription repression.

www.biorxiv.org/cgi/content/...

Replisome progression regulates R-loop mediated transcriptional repression

Maintaining cellular proliferation necessitates the synchronized activity of diverse molecular machineries operating in parallel on the genome. Wide-spread transcription and R-loop formation can inter...

www.biorxiv.org

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Marcel Werner @marcelwerner.bsky.social · Jul 29

Great overview on some of the recent work from my PhD lab! @hamperllab.bsky.social

European Research Council (ERC) @erc.europa.eu · Jul 29

🔬 Stephan Hamperl ‪uncovered how clashes between #gene reading & #DNA copying inside cells drive disease. Their tools reveal new insights into #cancer, ageing & development.

Read more 👉 europa.eu/!H7RtjQ

#FrontierResearch #GeneEditing #Genetics #Oncology @www.helmholtz-munich.de

Revealing cellular conflict role in disease and development

Understanding the conflicts that happen within our cells could shed new light not only on disease progression, but also on how our bodies...

europa.eu

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Marcel Werner @marcelwerner.bsky.social · Jun 20

If it is related to thesis submission just let me know. I still have all the information and forms saved.

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Reposted by Marcel Werner

Andreas Ingham @andreasingham.bsky.social · Jun 19

Linker histone expression is uniquely controlled by a specific pathway, which can be manipulated to increase TOP2i sensitivity! Proud to share first authorship on our story now out in @cp-molcell.bsky.social. www.cell.com/molecular-ce...

CRAMP1-dependent histone H1 biogenesis is essential for topoisomerase II inhibitor tolerance

Ingham et al. identify a dedicated H1 linker histone biogenesis pathway in human cells, driven by the protein CRAMP1 that functions as an H1 transcription factor. They demonstrate that defective CRAMP...

www.cell.com

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Reposted by Marcel Werner

ME Torres-Padilla @metorrespadilla.bsky.social · Jun 12

Are you @ the late stages of your postdoc ? Want to pursue a PI career ?

Then this 👇👇 is for you ! Apply for a spot @ our Talent Forum
www.helmholtz-munich.de/en/stem-cell...

Peer-networking / Career orientation and more !!!

Please distribute :) 🙂

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Reposted by Marcel Werner

Andreas Panagopoulos @apanagopoulos.bsky.social · May 21

Delighted to share that the results of my main postdoc project are now published in @nature.com

🔗 doi.org/10.1038/s415...

Multigenerational cell tracking of DNA replication and heritable DNA damage - Nature

A multigenerational single-cell tracking approach provides a framework to dissect phenotypic plasticity at the single-cell level, offering insights into cellular processes that may resemble early even...

doi.org

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Reposted by Marcel Werner

The Groth lab @grothlab.bsky.social · May 20

🚨 Postdoc wanted (🇳🇱NL based) for our exciting collaboration with the lab of Alexander van Oudenaarden @hubrechtinstitute.bsky.social in Utrecht, with collaborative visits to our lab Copenhagen 🇩🇰. We seek a computational scientist to model epigenetic inheritance, see more below 👇!

Jeroen van den Berg @jervdberg.bsky.social · May 16

🧬Postdoc position alert! 🚨 We're hiring a postoc in Computational Modeling of Epigenetic Inheritance at the Hubrecht Institute (Alexander van Oudenaarden, Utrecht 🇳🇱) & Danish Cancer Institute (Anja Groth, Copenhagen 🇩🇰).

Come work in our collaberative team of top scientists

shorturl.at/avBBy

Postdoctoral Researcher - Computational modeling of Epigenetic Inheritance - 38 hours p/w - Hubrecht Institute

About the Project Faithful inheritance of the epigenome in proliferating cells critically underpins human development and health. While DNA replication fidelity and DNA mutation rates are well underst...

shorturl.at

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Reposted by Marcel Werner

Jeroen van den Berg @jervdberg.bsky.social · May 16

🧬Postdoc position alert! 🚨 We're hiring a postoc in Computational Modeling of Epigenetic Inheritance at the Hubrecht Institute (Alexander van Oudenaarden, Utrecht 🇳🇱) & Danish Cancer Institute (Anja Groth, Copenhagen 🇩🇰).

Come work in our collaberative team of top scientists

shorturl.at/avBBy

Postdoctoral Researcher - Computational modeling of Epigenetic Inheritance - 38 hours p/w - Hubrecht Institute

About the Project Faithful inheritance of the epigenome in proliferating cells critically underpins human development and health. While DNA replication fidelity and DNA mutation rates are well underst...

shorturl.at

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Marcel Werner @marcelwerner.bsky.social · May 1

Thank you so much! 🤩

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Marcel Werner @marcelwerner.bsky.social · May 1

Delighted to share that I am joining @grothlab.bsky.social and @groth-anja.bsky.social at Danish Cancer Institute for my postdoc. 🇩🇰

I am looking forward to working on advancing our understanding of epigenome replication and maintenance. 🧬🧫

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Reposted by Marcel Werner

Apoorva Baluapuri @baluapuri.bsky.social · Apr 14

Thrilled to see my postdoc work at Adelman Lab @hms-bcmp.bsky.social on Integrator(INT) now out @cp-cell.bsky.social. We found that INT deficiency allows immature+unlicensed RNAPII to precociously enter genes. This immature RNAPII can transcribe short genes but terminates prematurely in long genes:

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Reposted by Marcel Werner

Lucas Farnung @lucas.farnunglab.com · Apr 6

🔬 New from the Farnung Lab: We established a fully in vitro reconstituted chromatin replication system and report the first cryo-EM snapshots of the human replisome engaging nucleosomes. Brilliant work by @felixsteinruecke.bsky.social with support from @jonmarkert.bsky.social! tinyurl.com/replisome

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Reposted by Marcel Werner

Epigenetics at Helmholtz Munich @epihmgu.bsky.social · Mar 25

🌟 SAVE THE DATE: Talent Forum 2025!

🗓️ November 18–19
📍 @www.helmholtz-munich.de‬, Germany

Showcase your research and network with global talents in #Epigenetics & Nucleic Acids Research!

Apply by July 31 for a speaker spot —travel & accommodation covered.

🔜 Website coming soon!

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Marcel Werner @marcelwerner.bsky.social · Apr 3

Goodbye @hamperllab.bsky.social and thank you for incredible 4.5 years! It has been a pleasure to work with all of you and I will miss you a lot. Thank you also to @epihmgu.bsky.social and the Munich chromatin community. I could not have picked a better place to do my PhD!

To new adventures! 🇩🇰

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Reposted by Marcel Werner

Anja Groth @groth-anja.bsky.social · Mar 28

A few days left to apply for exciting PhD and Postdoc opportunities in wonderful Copenhagen and join our efforts in understanding Epigenetic Cell Memory.

The Groth lab @grothlab.bsky.social · Feb 12

🚨𝐌𝐚𝐣𝐨𝐫 𝐉𝐨𝐛 𝐀𝐥𝐞𝐫𝐭!🚨The Groth @groth-anja.bsky.social, Mailand, Nilsson @nilssonlab.bsky.social & Krietenstein @nilskrietenstein.bsky.social labs are hiring 𝟔 𝐏𝐡𝐃&𝐩𝐨𝐬𝐭𝐝𝐨𝐜𝐬 to join the new Center for Epigenetic Cell Memory (EpiC) in Copenhagen, Denmark. Apply here: tinyurl.com/yvd93na2 & please share!

6 Postdoctoral and PhD positions in Center for Epigenetic Cell Memory (EpiC)

The Center for Epigenetic Cell Memory (EpiC) is a new Center of Excellence that will be established based on funding by the Danish National Research Foundation.

tinyurl.com

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Reposted by Marcel Werner

Hamperl Lab @hamperllab.bsky.social · Mar 24

Two days of science, international cooking, and breathtaking hikes in the Bavarian Alps—our lab retreat in Mittenwald had it all! Great discussions, great food, and even better company.

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Reposted by Marcel Werner

Epigenetics at Helmholtz Munich @epihmgu.bsky.social · Mar 18

🚨Paper Alert!

👏 Big congrats to @marcelwerner.bsky.social, ManuelTrauner & rest of @hamperllab.bsky.social team for this brilliant work!

🧬 Check out their amazing research diving into how #TRCs and DOT1L impact genome stability.

A must-read 🧵 for #transcription, #replication & #epigenetics fans👇!

Marcel Werner @marcelwerner.bsky.social · Feb 20

I am delighted to share the main work of my PhD project in the @hamperllab.bsky.social now out in @narjournal.bsky.social. TRCs drive R-loop-dependent nucleosome eviction and require DOT1L activity for transcription recovery.
academic.oup.com/nar/article/...

#TRC #r-loop #chromatin

More below 👇

Transcription-replication conflicts drive R-loop-dependent nucleosome eviction and require DOT1L activity for transcription recovery

Abstract. Progressing transcription and replication machineries profoundly impact their underlying chromatin template. Consequently, transcription-replicat

academic.oup.com

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Reposted by Marcel Werner

The Groth lab @grothlab.bsky.social · Mar 6

𝐍𝐞𝐰 𝐦𝐞𝐜𝐡𝐚𝐧𝐢𝐬𝐭𝐢𝐜 𝐢𝐧𝐬𝐢𝐠𝐡𝐭𝐬 𝐢𝐧𝐭𝐨 𝐭𝐡𝐞 𝐫𝐞𝐠𝐮𝐥𝐚𝐭𝐢𝐨𝐧 𝐨𝐟 𝐡𝐢𝐬𝐭𝐨𝐧𝐞 𝐬𝐮𝐩𝐩𝐥𝐲! Excited to share our latest collaboration led by tkjeong.bsky.social and ciaranfrater.bsky.social! Structural determination of the histone chaperone ASF1 and its regulator CODANIN-1 uncovers how CODANIN-1 counters ASF1 activity. 🧵👇

CODANIN-1 sequesters ASF1 by using a histone H3 mimic helix to regulate the histone supply

Nature Communications - CODANIN-1 negatively regulates the function of ASF1, the key chaperone for histone H3-H4 supply. Here the authors present the cryo-EM structure of the CODANIN-1_ASF1A...

rdcu.be

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Reposted by Marcel Werner

Anja Groth @groth-anja.bsky.social · Feb 26

SAVE THE DATE! The next EMBO | EMBL Symposium on 'DNA replication and genome maintenance: from basic biology to disease' will be held October 20-23, 2026.

Organized by Helle Ulrich (IMB), Johannes Walter (Harvard) and Anja Groth (Danish Cancer Institute).

www.embl.org/about/info/c...

DNA replication and genome maintenance: from basic biology to disease

www.embl.org

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Marcel Werner @marcelwerner.bsky.social · Feb 21

Thanks a lot, Alva! See you in May!