Lightnews — Scholar-powered news

Reposted by Anja Groth

Robert Hänsel-Hertsch @epistrucstab.bsky.social · Jul 28

🧪Move over CUT&Tag, there’s a new #TranscriptionFactor mapping method in town.
Our newly developed DynaTag is faster, cleaner, more sensitive than #ChIPseq, #CUT&RUN and #CUT&Tag.
🔗 Our @natcomms.nature.com paper: www.nature.com/articles/s41...
🧵Let’s break down what makes DynaTag so powerful (1/7)

Image credit: @gloglita.bsky.social‬ @lifescienceeditors.bsky.social‬ captured DynaTag in action: a pA-Tn5 probe (multicoloured) binds an antibody (white), which binds p53 DNA-binding domain (green) on DNA (blue) within 2 nucleosomes

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Journal of Cell Biology @jcb.org · Jul 16

Yadav, Jadhav, @hanasedlackova.bsky.social et al present a novel cell-permeable biotin-HaloTag ligand. The reported ligand expands the HaloTag toolbox by enabling in vivo labeling & providing capabilities for efficient affinity capture of protein variants from live cells rupress.org/jcb/article/...

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Tugce Aktas @aktast.bsky.social · Jun 30

We wrote a review on Transposable Elements (TEs) and almost all aspects of TE silencing and their roles in biological processes & disease.
www.nature.com/articles/s41...

Transcriptional and post-transcriptional regulation of transposable elements and their roles in development and disease - Nature Reviews Molecular Cell Biology

Transposable elements (TEs) comprise nearly half of the human genome. This Review discusses transcriptional and post-transcriptional mechanisms that repress TE activity, how TEs escape this suppressio...

www.nature.com

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Janet Iwasa @jiwasa.bsky.social · Jul 2

Check out this new review (with animations, natch) of mechanisms of licensing origins of DNA replication - a wonderful (and continuing!) collaboration with Bruce Stillman @cshlnews.bsky.social and John Diffley @crick.ac.uk! www.nature.com/articles/s41...

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Mathew Kiang @mathewkiang.com · Jun 25

Karolinska is looking for 20 (!!) assistant professors and offering 6 year appointments with ~1M USD startup packages.

ki.se/en/about-ki/...

Call for 20 Assistant Professor positions

Karolinska Institutet is a world-leading medical university with a long and proud history of ground-breaking research. We are now recruiting outstanding early-career researchers with particularly exce...

ki.se

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Alessandro Costa @costalaboratory.bsky.social · Jun 20

Postdoc positions open in my lab (Francis Crick Institute) to study

1. initiation of DNA replication.

2. chromatin replication/epigenetic inheritance.

Great for biochemists, biophysicists and cryo-EM/cryo-tomography scientists.

Deadline 3 August 2025.

crick.wd3.myworkdayjobs.com/External/job...

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Cees Dekker @ceesdekker.bsky.social · Jun 16

Latest #CDlab paper online now:
Cohesin supercoils DNA during loop extrusion
www.cell.com/cell-reports...

This extensive study was led by Jan Michael Peters at Vienna; our lab contributed mostly modeling of plasmid supercoiling (@romanbarth.bsky.social‬) and single-molecule data (Richard Janissen).

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Zha Lab @zhalab.bsky.social · Jun 15

Please join us celebrate the 5th year birthday of Social DNAing! Dr. Chapman will take the stage in the coming week. Sign up at cancer.columbia.edu/research/progr…

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ME Torres-Padilla @metorrespadilla.bsky.social · Jun 12

Are you @ the late stages of your postdoc ? Want to pursue a PI career ?

Then this 👇👇 is for you ! Apply for a spot @ our Talent Forum
www.helmholtz-munich.de/en/stem-cell...

Peer-networking / Career orientation and more !!!

Please distribute :) 🙂

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Anja Groth @groth-anja.bsky.social · Jun 12

Amazing accomplishment 👏👏 congrats Hiten and team 🎉

Hiten Madhani @hitenmadhani.bsky.social · Jun 11

Hey there,

Our latest paper is out in Cell.

We made a knockout collection in a human fungal pathogen, performed over 140 screens, and developed 6 follow up stories.

Phenotypic landscape of an invasive fungal pathogen reveals its unique biology

Share link:

authors.elsevier.com/c/1lFMiL7PXu...

authors.elsevier.com

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Anja Groth @groth-anja.bsky.social · Jun 6

Excellent advice!!

Science Magazine @science.org · Jun 6

#NextGenSci asked young scientists to write a rule that all principal investigators should be required to follow to improve the experience of young scientists in their lab.

Check out their answers on #NationalHigherEducationDay: scim.ag/45zsFEr

Illustration of two people, one holding a large pencil, the other walking along a path of diverging arrows. Hedline is "Rules all PIs should follow."

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EMBO @embo.org · Jun 5

From theory to practice — explore #computational approaches and #AI developments at EMBO Practical Course "Integrative modelling of biomolecular interactions" in Izmir, Türkiye, 28 September–3 October 2025

Deadline: 15 June

meetings.embo.org/event/25-bio...
#EMBObiomolInteractions #EMBOevents 🧪

Integrative modelling of biomolecular interactions

Experimental structural studies of interactions can be costly, low-throughput, and challenging. Therefore, computational methods aiming to model protein complexes are particularly valuable. The accur…

meetings.embo.org

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Anja Groth @groth-anja.bsky.social · Jun 5

Congratulations 🎉

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Mark A. Hanson @hansonmark.bsky.social · Jun 3

URGENT: FlyBase has lost practically all its funding overnight; even user fees are tied up in denied grant funding. 🤬🤯

Any lab using @flybase.bsky.social please donate using the link in post below.

This incredible community, on whose backs our #Drosophila labs depend, can't be left out to dry.

Marc Dionne @marcsdionne.bsky.social · Jun 3

My lab studies bacterial infections. We spend a lot of time looking at (or for) species-specific genetic and genomic databases for hosts and microbes. FlyBase is the best of all—there is literally no comparison. Its existence is under threat. Please donate.
www.philanthropy.cam.ac.uk/give-to-camb...

Drosophila Genetic Database

The Drosophila Genetic Database, FlyBase, is on the brink of collapse due to the sudden termination of the FlyBase NIH grant, which includes salaries for 5 literature curators based at the University ...

www.philanthropy.cam.ac.uk

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Fusion Conferences @fusionconf.bsky.social · May 28

⏰🚨FINAL DEADLINE APPROACHING

#BGFP25 's extended reg deadline is closing on 02 June 2025. This is your last chance to register and confirm your place at this fantastic conference 🧬!

Join us in sunny Portugal this July and register now: bit.ly/3AnsVZF

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Enhanced Genomics @enhancedgenomics.bsky.social · May 28

📢 Next speaker in our '3D Regulatory Genome' series: Dr. Alvaro Rada Iglesias (@radaiglesiaslab.bsky.social) presenting innovative enhancer research using transgenic mouse stem cells!

Moderated by @stefanschoenfelder.bsky.social
Register: us02web.zoom.us/webinar/regi...

#Genomics #VirtualSeminar

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Lopes_Lab @lopeslab.bsky.social · May 28

One more appointment with great science in a few days, one click away 👇

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Nature Cell Biology @natcellbio.nature.com · May 9

💫NEW: @jzylicz.bsky.social & co show that dimethyl α-ketoglutarate enhances the production and functional maturation of human #trophectoderm - like cells from embryonic #StemCells by regulating histone acetyltransferase activity and the pluripotency network.
bit.ly/3EGflmL

α-Ketoglutarate promotes trophectoderm induction and maturation from naive human embryonic stem cells - Nature Cell Biology

Van Nerum et al. show that dimethyl α-ketoglutarate enhances the production and functional maturation of human trophectoderm-like cells from embryonic stem cells by regulating histone acetyltransferas...

bit.ly

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EMBO @embo.org · May 8

Get to know Tuncay Baubec, former EMBO Young Investigator and EMBO Postdoctoral Fellow, who studied in #Austria, started his own group at University of Zurich and is now Professor at @utrechtuniversity.bsky.social: www.embo.org/people/the-f... 🧪 #LifeSciences #research #opportunities

The freedom to choose your own research focus – People – EMBO

Meet Tuncay Baubec, Professor at Utrecht University | Former EMBO Young Investigator and EMBO Postdoctoral Fellow

www.embo.org

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Lopes_Lab @lopeslab.bsky.social · May 1

Exciting science ahead! Hope to see many of you online on Tuesday 6th (just connect, no registration needed)

GIIN @genomeiinetwork.bsky.social · May 1

The Genome Integrity Webinar Series continues on Tuesday, May 6th at 5PM (Rome) / 11AM (New York) with an exciting discussion on DNA damage response and repair @kajastelab.bsky.social
Join via Zoom: uniroma1.zoom.us/j/95149984403

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Francesca Mattiroli @fmattiroli.bsky.social · May 4

Want to learn more about chromatin and its dynamics? Read this review by Charlotte and Jolijn in our lab, aimed at giving an overview on this and the ways this is dealt with during transcription, replication and damage repair. Thanks to Biochemistry for inviting us! doi.org/10.1021/acs....

Always on the Move: Overview on Chromatin Dynamics within Nuclear Processes

Our genome is organized into chromatin, a dynamic and modular structure made of nucleosomes. Chromatin organization controls access to the DNA sequence, playing a fundamental role in cell identity and...

doi.org

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The EMBO Journal @embojournal.org · Apr 25

Comprehensive mapping of protein-protein interactions in the Drosophila piRNA pathway reveals how adaptive evolution contributes to rapid diversification of this genome-defense mechanism
Peter Andersen @germline.bsky.social and collaborators
www.embopress.org/doi/full/10....

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EMBO @embo.org · Apr 23

Co-organized by EMBL, EMBO and EMBO Press, the EMBL Science and Society Conference "In science we trust?" will explore the importance of public trust in science and the role we all play in shaping its future. 🧪 Register by 5 May: www.embl.org/about/info/c... #LifeSciences @embl.org @embopress.org

In science we trust?

EMBL Science and Society Conference

www.embl.org

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Journal of Cell Science @jcellsci.bsky.social · Apr 21

Cell scientist to watch – Hana Polasek-Sedlackova @hanasedlackova.bsky.social

In this interview, we learn about Hana’s career, her insights on collaborative research and her engineering hobby.
journals.biologists.com/jcs/article/...

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Vijay Ramani @vram142.bsky.social · Apr 16

To the top of the "to-read" list. Looks like a heroic amount of work from the Hahn lab (large-scale ChEC-seq compendium!) www.nature.com/articles/s41...

Low overlap of transcription factor DNA binding and regulatory targets - Nature

A near-complete survey of transcription factor activities in Saccharomyces cerevisiae reveals that most transcription factors have both activator and repressor activities and limited overlap between t...

www.nature.com

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