aktast.bsky.social
Tugce Aktas
@aktast.bsky.social
420 followers 180 following 7 posts
Max Planck Research Group Leader at MPI for Molecular Genetics, Berlin, Germany. working on: RNA | Transposable Elements | Genome Evolution
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aktast.bsky.social
Tugce Aktas @aktast.bsky.social · Jun 30
We wrote a review on Transposable Elements (TEs) and almost all aspects of TE silencing and their roles in biological processes & disease.
www.nature.com/articles/s41...
Transcriptional and post-transcriptional regulation of transposable elements and their roles in development and disease - Nature Reviews Molecular Cell Biology
Transposable elements (TEs) comprise nearly half of the human genome. This Review discusses transcriptional and post-transcriptional mechanisms that repress TE activity, how TEs escape this suppressio...
www.nature.com
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Reposted by Tugce Aktas
canaztekin.bsky.social
canaztekin.bsky.social @canaztekin.bsky.social · 23d
🚀 Looking for a Bioinformatician / Data Scientist to join our crew and explore regeneration through single-cell genomics & evolutionary biology! @mpi-bio-fml.bsky.social
📩 Questions? Contact us ✉️
🔗 Apply here: www.mpg.de/25243280/bio...
Bioinformatician / Data Scientist (m/f/d)
Bioinformatician / Data scientist position in the Aztekin Lab focusing on Structural Regeneration and support the working group together with the other members
www.mpg.de
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Reposted by Tugce Aktas
ilegnini.bsky.social
Ivano Legnini @ilegnini.bsky.social · 28d
Looking for a master student to help with a superexciting EU-funded project on mRNA metabolism. It'll involve cutting-edge sequencing and imaging techniques as well as computational workflows and modelling - great training opportunity! Get in touch if interested
humantechnopole.it/en/research-...
Legnini Group - Human Technopole
Laboratory for Molecular and Systems Biology of RNA   The Legnini Group at Human Technopole combines molecular and systems biology approaches to study gene regulation. We use synthetic biology and opt...
humantechnopole.it
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aktast.bsky.social
Tugce Aktas @aktast.bsky.social · Jul 9
Transposon enthusiats: you don't want to miss this story.
julianeg.bsky.social
Juliane Glaser @julianeg.bsky.social · Jul 9
Finally out! 🥳 Our paper showing how a transposable element (TE) insertion can cause developmental phenotypes is now published @natgenet.nature.com 🧬🦠🐁
Below is a brief description of the major findings. Check the full version of the paper for more details: www.nature.com/articles/s41588-025-02248-5
Enhancer adoption by an LTR retrotransposon generates viral-like particles, causing developmental limb phenotypes - Nature Genetics
Activation of an LTR retrotransposon inserted upstream of the Fgf8 gene produces viral-like particles in the mouse developing limb, triggering apoptosis and causing limb malformation. This phenotype c...
www.nature.com
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Reposted by Tugce Aktas
natrevmcb.nature.com
Nature Reviews Molecular Cell Biology @natrevmcb.nature.com · Jun 30
New Online! Transcriptional and post-transcriptional regulation of transposable elements and their roles in development and disease
Transcriptional and post-transcriptional regulation of transposable elements and their roles in development and disease
Nature Reviews Molecular Cell Biology, Published online: 30 June 2025; doi:10.1038/s41580-025-00867-8Transposable elements (TEs) comprise nearly half of the human genome. This Review discusses transcriptional and post-transcriptional mechanisms that repress TE activity, how TEs escape this suppression and regulate endogenous genes in development and disease, and emerging therapeutic strategies that exploit TE derepression.
bit.ly
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aktast.bsky.social
Tugce Aktas @aktast.bsky.social · Jun 30
With such a large scope you need excellent partners, so we are happy to have teamed up with @zz-zhang.bsky.social & @vincent-yangxu-phd.bsky.social
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aktast.bsky.social
Tugce Aktas @aktast.bsky.social · Jun 30
We wrote a review on Transposable Elements (TEs) and almost all aspects of TE silencing and their roles in biological processes & disease.
www.nature.com/articles/s41...
Transcriptional and post-transcriptional regulation of transposable elements and their roles in development and disease - Nature Reviews Molecular Cell Biology
Transposable elements (TEs) comprise nearly half of the human genome. This Review discusses transcriptional and post-transcriptional mechanisms that repress TE activity, how TEs escape this suppressio...
www.nature.com
2 69 140
Reposted by Tugce Aktas
molgen.mpg.de
Max Planck Institute for Molecular Genetics @molgen.mpg.de · Jun 13
📢 Don't miss!
Wayo Matsushima of École polytechnique fédérale de Lausanne (EPFL) will speak at our #DahlemColloquium!
📜 Gene regulatory evolution driven by transposable elements and their controllers
📆 20. JUN, 11:00 AM (CET)
📍MPIMG, Berlin
🔗 www.molgen.mpg.de/events/41978...
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Reposted by Tugce Aktas
molgen.mpg.de
Max Planck Institute for Molecular Genetics @molgen.mpg.de · Jun 6
In @nature.com Yaotian Zhang and @henriniskanen.bsky.social from the Hnisz Lab discovered a micropeptide, the "Killswitch," which alters the physical state of biomolecules in condensates. This tool solidifies dynamic, liquid-like droplets, affecting their function.
--> www.molgen.mpg.de/4884827
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aktast.bsky.social
Tugce Aktas @aktast.bsky.social · Jun 4
Congratulations neighbors!
We are very happy to be part of this story and looking forward to the future work we'll be doing with the Hnisz lab 😉
henriniskanen.bsky.social
Henri Niskanen @henriniskanen.bsky.social · Jun 4
What controls condensate composition and function beyond binding stoichiometry? We show that condensate microenvironments play a key role, and can be probed by a micropeptide killswitch in live cells. www.nature.com/articles/s41... in @nature.com ‬ with @yaotianzhang.bsky.social Denes Hnisz & team.
www.nature.com
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aktast.bsky.social
Tugce Aktas @aktast.bsky.social · May 26
I wish you a speedy recovery 🙏
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Reposted by Tugce Aktas
bulutkarslioglu.bsky.social
Aydan Bulut-Karslioglu @bulutkarslioglu.bsky.social · Apr 28
The awesome Helene Kretzmer and I are looking to recruit a join computational PhD student. Applications will be evaluated on a rolling basis, so don't wait! Any questions get in touch. We are looking forward.
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Reposted by Tugce Aktas
koenig-lab.bsky.social
König Lab @koenig-lab.bsky.social · Mar 26
How to find binding sites or your favorite #RNA binding protein?

Join us for the EMBO practical course "iCLIP2, mapping protein RNA interactions: from A to Z". from 7.-12. September in Genoa, Italy

Learn more and register here:
meetings.embo.org/event/25-icl...

@embo.org @mixmue.bsky.social
iCLIP2, mapping protein-RNA interactions: from A to Z
RNA is increasingly recognized as a key therapeutic target , driving the development of RNA-based therapeutics for a broad spectrum of diseases. RNA-binding proteins (RBPs) play a fundamental ro…
meetings.embo.org
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Reposted by Tugce Aktas
retrogenomics.bsky.social
Gael Cristofari @retrogenomics.bsky.social · Feb 7
Don't miss the first edition of the CSH-Asia meeting on "The Repetitive and Mobile Genome" taking place in Suzhou, China.
📅 Abstract submission deadline extended: Feb 21, 2025
👉 www.csh-asia.org?content/2544
#transposon #mobileDNA #TEsky
CSH-Asia "The Repetitive and Mobile Genome" meeting announcement poster
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aktast.bsky.social
Tugce Aktas @aktast.bsky.social · Jan 18
Thank you 🤓
Reposted by Tugce Aktas
brancolab.bsky.social
Miguel Branco @brancolab.bsky.social · Jan 9
CSH Asia is organising its first transposon meeting. Don't miss out on some great science and a fantastic trip. Abstract deadline fast approaching.
www.csh-asia.org?content/2544
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Reposted by Tugce Aktas
canaztekin.bsky.social
canaztekin.bsky.social @canaztekin.bsky.social · Dec 20
🎉 Excited to announce job openings in our new lab @mpi-bio-fml.bsky.social in Tübingen!🇩🇪Looking for enthusiastic colleagues to explore regeneration together! We have positions for:
🔬 Research Technician
💻 Bioinformatician
🎓 PhD Studentship
🧪🔬📖 Postdocs
Details and links below👇
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aktast.bsky.social
Tugce Aktas @aktast.bsky.social · Dec 18
We are very happy to have Zack with us. Looking forward to all the cool transposons related projects we will be doing together.
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Reposted by Tugce Aktas
deborahbourchis.bsky.social
Deborah Bourc’his @deborahbourchis.bsky.social · Nov 28
The international Curie « Noncoding Genome » course has been revamped! 👉 Dark genome in cell plasticity and heterogeneity. A session on TEs #TEsky with M.E. Torres Padilla, D.Trono and @aktast.bsky.social. Master, PhD and postdoc fellows, a week in Paris during the Spring?
Apply before Feb 15th
📌
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