Lightnews — Scholar-powered news

Ivano Legnini @ilegnini.bsky.social · 29d

Looking for a master student to help with a superexciting EU-funded project on mRNA metabolism. It'll involve cutting-edge sequencing and imaging techniques as well as computational workflows and modelling - great training opportunity! Get in touch if interested
humantechnopole.it/en/research-...

Legnini Group - Human Technopole

Laboratory for Molecular and Systems Biology of RNA The Legnini Group at Human Technopole combines molecular and systems biology approaches to study gene regulation. We use synthetic biology and opt...

humantechnopole.it

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Reposted by Ivano Legnini

FEBS Letters @febsletters.bsky.social · Aug 26

Immune responses need to be fast ⏱️ mRNA metabolism adapts rapidly via alternative splicing, polyadenylation & decay. Find out more: febs.onlinelibrary.wiley.com/doi/10.1002/...
#Immunology #RNA #mRNAmetabolism @ilegnini.bsky.social

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Reposted by Ivano Legnini

MDC-BIMSB @mdc-bimsb.bsky.social · Aug 7

Great opportunity! Up to 4 Group Leader positions at the NOVA Institute for Medical Systems Biology (NIMSB) in Computational & Experimental Medical Systems Biology
📍 Lisbon
⏳ Apply by Oct 8
🔗 nimsb.unl.pt/wp-content/u...

#Job #SciencePositions #JobOffer #GroupLeaders #Innovation #systemsbiology

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Ivano Legnini @ilegnini.bsky.social · Jul 27

Very cool stuff :)
Congrats Danny!

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Reposted by Ivano Legnini

Human Technopole @humantechnopole.bsky.social · Jul 25

🎉 A stellar wrap-up for the Milan #RNA Salon! On 18 July, 120+ scientists gathered at HT for the final event of the season.

🔬 Matthias Hentze @embl.org opened with a keynote on Riboregulation, followed by research talks from Laura Carpen (HT) and @mchiaragrieco.bsky.social @ceredalab.bsky.social

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Reposted by Ivano Legnini

Manuel Irimia @mirimiam.bsky.social · Jul 23

This job involve spending 1-2 years in Berlin and 1-2 years in Barcelona, a truly unique opportunity! 🌍

As the lead scientist, you will apply single-cell long-read sequencing, CRISPR interference, and small molecule modulation to dissect the molecular pathways underlying islet development.

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Reposted by Ivano Legnini

Manuel Irimia @mirimiam.bsky.social · Jul 23

🚨🚨🚨

Please RT!

We're looking for a postdoc to join an exciting joint project between our lab @upf.edu & @crg.eu (Barcelona) and the Sander lab @mdc-berlin.bsky.social (Berlin) investigating how alternative splicing and microexons influences the maturation of pancreatic islets.

Deadline: 30/09/25👇

www.upf.edu

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Reposted by Ivano Legnini

Kamil Lisek @klisek.bsky.social · Jul 22

We’re happy to share our new preprint form
@N_Rajewsky, with @tmpentimalli.bsky.social i.bsky.social @Ilan Theurillat
lab! 🎉
🧬 Spatiotemporal atlas of tumor–stroma crosstalk in a new TNBC model. Spatial transcriptomics (Open-ST), snRNA-seq, and functional validation.
🔗 biorxiv.org/content/10.1...

Spatiotemporal dynamics of tumor microenvironment remodeling

During tumorigenesis, interactions between tumor and stromal cells progressively remodel the tumor microenvironment (TME) towards pro-tumoral functions. Understanding early TME remodeling dynamics is ...

biorxiv.org

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Reposted by Ivano Legnini

Gregor Diensthuber @gdiensthuber.bsky.social · Jul 14

🚨 New preprint alert 🚨
We systematically benchmarked @nanoporetech.com 's modification-aware basecalling models released for RNA on sets of in vitro and in vivo sequences and made some curious observations 🧬🔍.
bit.ly/4lXqNul
Follow along for a little recap (1/12)

Systematic benchmarking of basecalling models for RNA modification detection with highly multiplexed nanopore sequencing

Nanopore direct RNA sequencing (DRS) holds promise for advancing our understanding of the epitranscriptome by detecting RNA modifications in native RNA molecules. Recently, Oxford Nanopore Technologie...

bit.ly

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Reposted by Ivano Legnini

EMBL Events @events.embl.org · Jul 9

‼️ Don't forget to submit your abstract for #EMBLSpatialBiology! The new deadline is 15 July 👉 https://s.embl.org/spb25-01-bl

📅 14–17 Oct
📍EMBL Heidelberg and Virtual

✨ ESSB will provide a fee subsidy for the top accepted abstracts. More info ➡️ https://s.embl.org/SPB25-01-practical-information

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Reposted by Ivano Legnini

Science News @sciencenews.bsky.social · Jul 12

Scientists 3-D printed objects inside of living cells for the first time. Naturally, they chose to print an elephant.

Scientists 3-D printed a tiny elephant inside a cell

The first structures ever 3-D printed inside living cells point to applications for biology research.

buff.ly

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Reposted by Ivano Legnini

Stegle Lab @steglelab.bsky.social · Jul 4

📢 Announcing the MOPITAS Autumn School on Spatial Transcriptomics Data Analysis – taking place November 12–14, in Munich. Don't miss this excellent opportunity to deepen your expertise in data science and multi-OMICS analysis - especially as a PhD student in the data science community.

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Ivano Legnini @ilegnini.bsky.social · Jul 1

🤩🍾

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Ivano Legnini @ilegnini.bsky.social · Jun 26

🧡

Alessandra Zappulo @azappulo.bsky.social · Jun 26

Science, Nature,Friends….the Legnini Lab retreat was an amazing experience! @ilegnini.bsky.social @lindamasante.bsky.social @fmarcuccio.bsky.social ❤️

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Reposted by Ivano Legnini

Mireya Plass @mireyaplass.bsky.social · Jun 25

🚨We are looking for post-doctoral candidates to apply for a MSCA fellowship.

Projects on gene regulation in neural development or neurdegenerative diseases using single-cell omics.

Computational & wet-lab candidates are welcomed! #postdoc #MSCA #Barcelona #singlecell.

Postdoctoral Fellowships

The information provided on this page is a summary of the main rules and requirements for Postdoctoral Fellowships (PFs) and who can apply for them.

marie-sklodowska-curie-actions.ec.europa.eu

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Reposted by Ivano Legnini

Danny IncaRNAto @incarnatolab.bsky.social · Jun 19

#RNA Framework 2.9.3 is out! Lots of improvements! Check it out: github.com/dincarnato/R... & see the CHANGELOG (raw.githubusercontent.com/dincarnato/R...) for the details!

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Reposted by Ivano Legnini

Science Magazine @science.org · Jun 19

In Science, researchers present a new method to safely and preferentially generate CAR T cells directly inside the body using targeted lipid nanoparticles that deliver mRNA directly to T cells.

Learn more: scim.ag/4jVfcuk
#SciencePerspective: scim.ag/3STvdWC

Graphic depicting in vivo generation of CAR T cells

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Reposted by Ivano Legnini

Human Technopole @humantechnopole.bsky.social · Jun 17

🧬 Ageing, immunity & chronic diseases: HT wins €2.5M @erc.europa.eu Advanced Grant for a 5-year project led by @nicolesoranzo.bsky.social. Using AI & big data, the group will decode how our immune system weakens over time. A huge step for precision medicine!

humantechnopole.it/en/news/agei...

Ageing and Chronic Diseases: Europe Rewards Human Technopole’s Research - Human Technopole

The ERC has awarded HT a €2.5 million grant for a study investigating how lifestyle, biology and environmental exposures weaken the immune system over the course of life and increase vulnerability to ...

humantechnopole.it

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Reposted by Ivano Legnini

Sebastian Kadener @skadener.bsky.social · Jun 9

But this is happening to people around us: foreign professors, teachers, students, postdocs, neighbors. And sometimes much worse. Please don’t assume this can’t happen where you live. And if you witness it, say something. Silence is complicity.

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Reposted by Ivano Legnini

Coscia Lab @coscialab.bsky.social · Jun 5

Thrilled to share our latest preprint describing an optimized spatial tissue proteomics workflow for the preparation and analysis of >100 proteomes / day at high spatial resolution.
Kudos to @melissaklingeberg.bsky.social 🥳 and big thanks to all our collaborators! bit.ly/3SCARw4

An ultrasensitive spatial tissue proteomics workflow exceeding 100 proteomes per day

Achieving high-resolution spatial tissue proteomes requires careful balancing and integration of optimized sample processing, chromatography, and MS acquisition. Here, we present an advanced cellenONE...

bit.ly

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Reposted by Ivano Legnini

Manolis Maragkakis @manolis-maragkakis.bsky.social · Jun 4

🚨 We’re looking for a curious mind to join our lab at the NIH!
Passionate about #RNA biology, #MachineLearning, and the #genomics of #aging?

Interested in a postdoc or a PhD research visit at NIH? Let’s connect.
📩 DM or email for details!

#Bioinformatics #AI #ComputationalBiology

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Reposted by Ivano Legnini

Max Delbrück Center @mdc-berlin.bsky.social · Jun 3

Organoids are becoming a valid alternative, but they can’t fully replace animal research – yet. At the #mdcBerlin, we’re working on better models and transparent communication. That's what @eara.eu's #BOARD25 is all about!

More on our organoid research:
🔗 www.mdc-berlin.de/themen/organ...

Spatial transcriptomic characterization of human cerebral organoids. Different colored dots indicate transcripts of different genes recorded with Molecular Cartography (Resolve Biosciences). © Ivano Legnini / Agnieszka Rybak-Wolf, Max Delbrück Center

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Reposted by Ivano Legnini

Stefano Cacciatore @tkcaccia.bsky.social · Jun 2

KODAMA goes spatial.
doi.org/10.1101/2025...
#spatialtranscriptomics #visium #visiumhd #seurat #giotto

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Reposted by Ivano Legnini

Mark A. Hanson @hansonmark.bsky.social · Jun 3

URGENT: FlyBase has lost practically all its funding overnight; even user fees are tied up in denied grant funding. 🤬🤯

Any lab using @flybase.bsky.social please donate using the link in post below.

This incredible community, on whose backs our #Drosophila labs depend, can't be left out to dry.

Marc Dionne @marcsdionne.bsky.social · Jun 3

My lab studies bacterial infections. We spend a lot of time looking at (or for) species-specific genetic and genomic databases for hosts and microbes. FlyBase is the best of all—there is literally no comparison. Its existence is under threat. Please donate.
www.philanthropy.cam.ac.uk/give-to-camb...

Drosophila Genetic Database

The Drosophila Genetic Database, FlyBase, is on the brink of collapse due to the sudden termination of the FlyBase NIH grant, which includes salaries for 5 literature curators based at the University ...

www.philanthropy.cam.ac.uk

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Reposted by Ivano Legnini

Arnau Sebé-Pedrós @arnausebe.bsky.social · May 7

Check out our latest work on the evolution of animal genome regulation out today in @nature.com. Nicely summarized below by @ianakim.bsky.social.
www.nature.com/articles/s41...

This is a major output from our ERC-StG project Evocellmap @erc.europa.eu at @crg.eu

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