Lightnews — Scholar-powered news

Kamil Lisek

@klisek.bsky.social

67 followers 160 following 6 posts

Breast Cancer Biology, PhD, Lab of Nikolaus Rajewsky, MDC, BIMSB, Berlin

Posts Media Videos Starter Packs

Reposted by Kamil Lisek

Max Delbrück Center @mdc-berlin.bsky.social · 7d

We believe in fostering a community through exchange, dialogue, and mutual respect. 💙

Our "Town Hall Meetings" are a cornerstone of #mdcBerlin's culture. Colleagues from all over the institute come together to share ideas, ask questions, and celebrate progress. Today’s theme: Innovation @ Work

Four people standing in front of an audience in what appears to be a lecture hall. One is talking into a microphone, the other three are each holding a microphone and note cards.

Several dozen people sitting inside a large lecture hall. Most are facing the stage with four people on it, while a presentation is visible on a screen above the stage. Steps are leading away from the camera towards the stage.

Two people with microphones are standing on a stage in what appears to be a lecture hall.

Reposted by Kamil Lisek

Johanna Joyce @johannajoyce.bsky.social · 7d

Dr. Jane Goodall, 1934-2025

An exceptional scientist, and a singular woman in science

#WomeninScience 🐒

www.nytimes.com/2025/10/01/o...

Jane Goodall, Eminent Primatologist Who Chronicled the Lives of Chimps, Dies at 91

www.nytimes.com

Reposted by Kamil Lisek

German Stem Cell Network GSCN @gscnoffice.bsky.social · 12d

Join us for the hybrid GSCN Stem Cell Club on 2 Oct. at 16:15 h online: all info here: www.gscn.org

Reposted by Kamil Lisek

Barbara Marte @barbmarte.bsky.social · 12d

new out in Nature www.nature.com/articles/s41...

SPP1 is required for maintaining mesenchymal cell fate in pancreatic cancer - Nature

Mutual paracrine regulation of the cytokines GREM1 and SPP1 mediate mesenchymal and epithelial cell fate in pancreatic cancer.

Reposted by Kamil Lisek

Barbara Marte @barbmarte.bsky.social · 12d

new out in Nature www.nature.com/articles/s41...

Reprogramming neuroblastoma by diet-enhanced polyamine depletion - Nature

Enhanced polyamine depletion in neuroblastoma models decreases translation of mRNA codons with adenosine in the third position, reprogramming the tumour proteome away from cell cycle progression and towards differentiation.

Reposted by Kamil Lisek

Denis Wirtz @deniswirtz.bsky.social · 16d

We have developed a new workflow to map whole human organs at single-cell resolution, while integrating spatial transcriptomics, proteomics, and metabolomics.

We applied this workflow to map precancerous lesions of the fallopian tubes.

More here: www.biorxiv.org/content/10.1...

Reposted by Kamil Lisek

Johanna Joyce @johannajoyce.bsky.social · Jul 21

As conference organisers, we just love to receive feedback like this anonymous comment from a trainee at our recent #EACR2025 Congress in Lisbon 😊

#WomeninSTEM #WomeninScience 🧪🔬👩🏻‍🔬👩🏼‍💻👩🏾‍⚕️👩‍🔬👩🏿‍🔬

@helloeacr.bsky.social

White text on a black background:

For me, the most inspiring part was seeing how many women are now leading the field of cancer research. I’ve attended conferences before, but this time, it felt different; there was a strong presence of women not just as attendees, but as keynote speakers, session chairs, and award recipients. It made me pause and realize how much the landscape is changing. As a young woman in science, it felt both empowering and motivating. It reminded me that we’re not just contributing, we’re also shaping the future of this field in a real and visible way.

Kamil Lisek @klisek.bsky.social · Jul 22

A collaborative effort: 🇩🇪 🇵🇱 🇫🇷 🇮🇹 🇬🇷 🇮🇱 🇷🇴 🇵🇹 🇨🇭
Many thanks to the whole
@N_Rajewsky lab,
@nukappa.bsky.social,
@danilexn.bsky.social, our institutions
@mdc-bimsb.bsky.social, @mdc-berlin.bsky.social, and personally to @DeutscheKrebshilfe for their generous support.

Kamil Lisek @klisek.bsky.social · Jul 22

🎯 Tumor-derived TGFβ initiated TME remodeling: → iCAFs → macrophage recruitment
💪 Later, myCAFs remodeled ECM & interacted with EMT tumor cells
These niches are conserved in human TNBC PDXs and functionally validated.

Kamil Lisek @klisek.bsky.social · Jul 22

📸 Tumor and stromal cells form spatially organized neighborhoods.
Aligning tumors by progression revealed how cell states, signaling, and ECM features remodel dynamically at the tumor–stroma interface.

Kamil Lisek @klisek.bsky.social · Jul 22

🐁 Our model develops asynchronous tumors across glands. Using Open-ST and snRNA-seq, we profiled 100+ ducts in situ and treated them as replicates reconstructing tumor evolution from healthy tissue to invasion in native context.

Kamil Lisek @klisek.bsky.social · Jul 22

We’re happy to share our new preprint form
@N_Rajewsky, with @tmpentimalli.bsky.social i.bsky.social @Ilan Theurillat
lab! 🎉
🧬 Spatiotemporal atlas of tumor–stroma crosstalk in a new TNBC model. Spatial transcriptomics (Open-ST), snRNA-seq, and functional validation.
🔗 biorxiv.org/content/10.1...

Spatiotemporal dynamics of tumor microenvironment remodeling

During tumorigenesis, interactions between tumor and stromal cells progressively remodel the tumor microenvironment (TME) towards pro-tumoral functions. Understanding early TME remodeling dynamics is ...

Reposted by Kamil Lisek

bioRxivpreprint @biorxivpreprint.bsky.social · Jul 18

Spatiotemporal dynamics of tumor microenvironment remodelling https://www.biorxiv.org/content/10.1101/2025.07.15.662972v1

Reposted by Kamil Lisek

Max Delbrück Center @mdc-berlin.bsky.social · Jun 3

🔷 @www.helmholtz.de is building powerful #AI for science. 🔷

From cells to solar tech, Foundation Models help tackle complex data across various fields.

1️⃣2️⃣ centers, including the #mdcBerlin, are working on 7️⃣ pilot projects to make this technology work for science and society.

More: 👇 #Helmholtz30

Reposted by Kamil Lisek

Nature @nature.com · Apr 13

Evidence for a previously overlooked route for microplastics to enter crops and reach plant tissues has implications for ecology and human health

https://go.nature.com/4iblIwc

Airborne microplastics enter plant leaves and end up in our food

Evidence for a previously overlooked route for microplastics to enter crops and reach plant tissues has implications for ecology and human health.

Reposted by Kamil Lisek

Dani León-Periñán 🇵🇸 @danilexn.bsky.social · Apr 11

Excited to introduce Malva publicly for the first time - our sequence-centric search engine for instant exploration of spatial and single-cell data at unprecedented scale.

#bioinformatics #singlecell

Max Delbrück Center @mdc-berlin.bsky.social · Apr 10

From an #AI-powered search engine for omics data to a scalable drug screening platform for neuromuscular diseases – 4 of our labs present their projects at @biovaria.bsky.social #techtransfer networking event!
www.biovaria.org/

@danilexn.bsky.social@nukappa.bsky.social @garyrlewin.bsky.social

Technology Transfer: Our innovations at Biovaria. Munich, 28 - 29 April

Reposted by Kamil Lisek

Denis Wirtz @deniswirtz.bsky.social · Mar 6

These are extremely challenging times for early-career faculty. Here is my office's small contribution to make their hard and important work a bit easier:

Download our curated and comprehensive database of funding opportunities for early-career faculty.

Here: research.jhu.edu/rdt/funding-...

Reposted by Kamil Lisek

Stand Up for Science! @standupforscience.bsky.social · Mar 6

SPEAKER LINEUP FOR STAND UP FOR SCIENCE ☀️

Here's our list of current speakers—and it's still growing! Come tomorrow to hear some amazing speakers talk about science, their experiences, and the future.

#standupforscience2025

Speaker lineup for stand up for science -

Bill Nye, Dr. Atul Gawande, Dr. Phil Plait, Dr. Michael Mann, Dr. Itai Yanai
Dr. Francis Collins, Dr. Victor Ambros, Dr. Nate Brought, Bill Nelson, JD
Dr. Ticora V Jones, Dr. Gretchen Goldman, Dr. Haley Chatelaine
Dr. Bonnielinn Swenor, Dr. Allison Agwu, Dr. Patrick Sullivan, Andrew Eneim
Dr. Nathaniel Kupperman, Bridget Nelson, MPH, Samantha Jade Duran
Denali Kincaid, Connor Phillips, Gabriella Amaya, Emily Whitehead
Sarah Aleman Senator Chris Van Hollen (MD), Rep. Bill Foster (IL-11)
Rep. Suhas Subramanyam (VA-10), Rep. Jamie Raskin (MD-8)
Rep. Glenn Ivey (MD-4), Former Rep. Fred Upton (MI-6)

Reposted by Kamil Lisek

Nature Cancer @natcancer.nature.com · Feb 12

ONLINE NOW! @naturecancer.bsky.social

'Spatially resolved transcriptomics and graph-based #deeplearning improve accuracy of routine #CNStumor #diagnostics'

✏️By Dieter Henrik Heiland & Felix Sahm and colleagues

🔗 www.nature.com/articles/s43...

#spatialtranscriptomics

Spatially resolved transcriptomics and graph-based deep learning improve accuracy of routine CNS tumor diagnostics - Nature Cancer

Ritter et al. present a spatial transcriptomics and deep learning-based approach named NePSTA (neuropathology spatial transcriptomic analysis) and leverage it to improve neuropathological diagnostics ...

Kamil Lisek @klisek.bsky.social · Feb 10

it is not β-Catenin but rather a mysterious gene called CTNNB1 :D

Reposted by Kamil Lisek

Max Delbrück Center @mdc-berlin.bsky.social · Feb 4

Each cancer is different, and so are the specific treatment options. "Onconaut," an #AI-based tool developed by #mdcBerlin's @al2na.bsky.social and his team, is designed to navigate through the maze of options more efficiently.

More: www.mdc-berlin.de/news/news/na... #WorldCancerDay #UnitedByUnique

A microscopic image of cancer cells in shades of purple, overlaid with two hashtag boxes: #WorldCancerDay written in white letters on a dark magenta text box at the top, #UnitedByUnique in a light pink box at the bottom.

Reposted by Kamil Lisek

Human Technopole @humantechnopole.bsky.social · Feb 4

🎗️ Cancer is often described as an “evolving disease” due to its ability to adapt and progress over time.

#WorldCancerDay

Reposted by Kamil Lisek

Johanna Englund @johannaienglund.bsky.social · Jan 20

Are you working on #ECM or mechanobiology in the mammary gland or in breast cancer? Together with Jason Northey we are guest editing a collection on the topic for the Journal of Mammary gland biology and Neoplasia. Submission of articles is now open! link.springer.com/collections/...

Mammary tumor tissue stained with collagen (green) and nuclei (red)

Reposted by Kamil Lisek

Max Delbrück Center @mdc-berlin.bsky.social · Jan 9

Science meets society: How do we deal with change?

Join us at #SalonSC at @bbaw.bsky.social – Nikolaus Rajewsky and Katja Simon will share insights:
⚕️ Future Medicine
🧬 Life, Aging, and Death of Our Cells

🗓️ 18.01.2025, Markgrafenstr. 38, 10117 Berlin
Program: salon.bbaw.de

Salon Sophie Charlotte
January 18, 2025