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Sheila Teves @sheilateves.bsky.social · 1d

How does a “universal” transcription factor evolve to do species-specific jobs?
Our new preprint reveals how divergence in TBP’s domains shapes transcriptional specialization across eukaryotes.

Read it here 👉

www.biorxiv.org/content/10.1...

#MolecularEvolution #Transcription

Molecular determinants underlying functional divergence of TBP homologs

The TATA-box binding protein (TBP) is a highly conserved basal transcription factor and a core component of the pre-initiation complex (PIC) for all three eukaryotic RNA polymerases (RNA Pols). Despit...

www.biorxiv.org

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Reposted by Dani León-Periñán 🇵🇸

Dr. Damien P. Williams Wants A Better Sociotechnical Paradigm @wolvendamien.bsky.social · 3d

Preliminary results show that the current framework of "AI" makes ppl less likely to help or seek help from other humans, or to seek to soothe conflict, and that people actively prefer that framework to any others, literally serving to make them more dependent on it.

Sycophantic AI Decreases Prosocial Intentions and Promotes Dependence

Both the general public and academic communities have raised concerns about sycophancy, the phenomenon of artificial intelligence (AI) excessively agreeing with or flattering users. Yet, beyond isolat...

arxiv.org

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Dani León-Periñán 🇵🇸 @danilexn.bsky.social · 3d

Israel is a terrorist state.

EL PAÍS @elpais.com · 3d

“Vivimos humillaciones e injusticias que nunca imaginé, ni en mis peores pesadillas”: la vida al límite de la población gazatí social.elpais.com/biv5q4

Dani León-Periñán 🇵🇸 @danilexn.bsky.social · 7d

Yes, reading it rn! Super cool, congrats!!!

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Dani León-Periñán 🇵🇸 @danilexn.bsky.social · 7d

Tweet only for Spanish native speakers

Dani León-Periñán 🇵🇸 @danilexn.bsky.social · 7d

SQLite que no pase hambre

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Reposted by Dani León-Periñán 🇵🇸

Merriam-Webster @merriam-webster.com · 7d

We are thrilled to announce that our NEW Large Language Model will be released on 11.18.25.

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Reposted by Dani León-Periñán 🇵🇸

Paul Medvedev @pashadag.bsky.social · Jun 12

1/4 Hash functions in genomic sequence analysis (tinyurl.com/4kk9ccmt) : a new survey written together with Ke Chen, Xiang Li, Qian Shi, and Mingfu Shao. Before submitting it, we are posting it online to get feedback from the community.

Dropbox

tinyurl.com

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Reposted by Dani León-Periñán 🇵🇸

EL PAÍS @elpais.com · 12d

🔴 ÚLTIMA HORA | La mayoría de los países abandonan la Asamblea General de la ONU a la llegada de Netanyahu social.elpais.com/njzv3

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Dani León-Periñán 🇵🇸 @danilexn.bsky.social · 12d

Mr. Big Ears said at the UN today, “Thanks to the efforts of our intelligence service, this message is being streamed to every Gazan’s phone.”

Reposted by Dani León-Periñán 🇵🇸

Yun S. Song @yun-s-song.bsky.social · 16d

We are excited to share GPN-Star, a cost-effective, biologically grounded genomic language modeling framework that achieves state-of-the-art performance across a wide range of variant effect prediction tasks relevant to human genetics.
www.biorxiv.org/content/10.1...
(1/n)

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Dani León-Periñán 🇵🇸 @danilexn.bsky.social · 16d

IMSLP (imslp.org; the biggest public library for classical music) generated >4 TB of data over the last 20 years.

Open-ST (rajewsky-lab.github.io/openst) can generate that from a 1x3x4 mm piece of human tissue in two days.

IMSLP: Free Sheet Music PDF Download

imslp.org

Reposted by Dani León-Periñán 🇵🇸

🧬Jacob L Steenwyk @jlsteenwyk.bsky.social · 25d

How come different people giving the same prompt to ChatGPT get different answers?

A new article from ThinkingMachines explains why LLMs are nondeterministic, and it largely comes down to how parallelization and precision are handled.

🧵

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Dani León-Periñán 🇵🇸 @danilexn.bsky.social · Sep 8

elpais.com/espana/2025-...

Sánchez anuncia un decreto para legalizar el embargo total de armas a Israel y habla por primera vez de “genocidio” de los palestinos

España llama a consultas a su embajadora en Israel tras prohibir Netanyahu la entrada en el país de las ministras Yolanda Díaz y Sira Rego

elpais.com

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Reposted by Dani León-Periñán 🇵🇸

Proceedings of the National Academy of Sciences @pnas.org · Aug 28

A machine learning model can sort people with myalgic encephalomyelitis/chronic fatigue syndrome from healthy controls with 77% accuracy by sequencing the cell-free RNA in their plasma, suggesting a test for the condition may be on the horizon. In PNAS: www.pnas.org/doi/10.1073/...

Biological pathway analysis of myalgic encephalomyelitis/chronic fatigue syndrome. Heatmap of activated (blue) and inhibited (red) pathway marker genes for the selected pathways (n = 69 genes).

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Eric Topol @erictopol.bsky.social · Aug 28

This is how generative A.I. could be used to design far better, more potent mRNAs (linear and circular) for the future for genome editing, engineered T cells, cancer therapy, vaccines
www.science.org/doi/10.1126/...
@science.org

Deep generative models design mRNA sequences with enhanced translational capacity and stability

Despite the success of mRNA COVID-19 vaccines, extending this modality to more diseases necessitates substantial enhancements. We present GEMORNA, a generative RNA model that utilizes Transformer arch...

www.science.org

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Reposted by Dani León-Periñán 🇵🇸

bioRxivpreprint @biorxivpreprint.bsky.social · Aug 28

Adding layers of information to scRNA-seq data using pre-trained language models https://www.biorxiv.org/content/10.1101/2025.08.23.671699v1

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Reposted by Dani León-Periñán 🇵🇸

Manuel Álvarez @manuelalvarez.bsky.social · Aug 25

el futuro está siendo lo que siempre soñé que sería: que al buscar algo en google te salga arriba del todo una puta chorrada de mierda de los cojones.

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Nixa Sedes, MD @nixassedes.bsky.social · Aug 24

Deep-tissue transcriptomics and subcellular imaging at high spatial resolution🔓
pmc.ncbi.nlm.nih.gov/articles/PMC...

Deep-tissue transcriptomics and subcellular imaging at high spatial resolution

Limited color channels in fluorescence microscopy have long constrained spatial analysis in biological specimens. Here, we introduce cycleHCR, a method that integrates multicycle DNA barcoding with Hy...

pmc.ncbi.nlm.nih.gov

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The Matter Lab @thematterlab.bsky.social · Aug 21

We're excited to present our latest article in Nature Machine Intelligence - Boosting the predictive power of protein representations with a corpus of text annotations.

Link: www.nature.com/articles/s42...
[1/4]

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bioRxiv Bioinfo @biorxiv-bioinfo.bsky.social · Aug 22

SpatialFinder: A Human-in-the-Loop Vision-Language Framework for Prioritizing High-Value Regions in Spatial Transcriptomics https://www.biorxiv.org/content/10.1101/2025.08.16.670684v1

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Nature Biotechnology @natbiotech.nature.com · Aug 22

Stereo-cell is a DNA nanoball array-based method that enables scalable, spatially resolved single-cell sequencing across diverse cell types and sizes with multimodal integration capabilities. #NBThighlight www.science.org/doi/10.1126/...

Stereo-cell: Spatial enhanced-resolution single-cell sequencing with high-density DNA nanoball-patterned arrays

Single-cell sequencing technologies have advanced our understanding of cellular heterogeneity and biological complexity. However, existing methods face limitations in throughput, capture uniformity, c...

www.science.org

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Lucien Hinderling @lhinderling.bsky.social · Aug 21

Automated optogenetic control of hundreds of cells in parallel. Each cell is individually steered, collectively acting as a "tissue printer". Preprint & code out! www.biorxiv.org/content/10.1...

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AI x Bio Discovery @aixbiobot.bsky.social · Aug 20

Three-dimensional spatial transcriptomics at isotropic resolution enabled by generative deep learning [new]
AI maps 3D genes from 2D data. Modeling enables isotropic resolution, revealing gradients.

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bioRxiv Pathology @biorxiv-pathology.bsky.social · Aug 15

Novel Predictive Spatial Biomarker in Non-Small Cell Lung Carcinoma: The Diversity of Niches Unlocking Treatment Sensitivity (DONUTS) https://www.biorxiv.org/content/10.1101/2025.08.13.665980v1

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