Lightnews — Scholar-powered news

MDC-BIMSB @mdc-bimsb.bsky.social · 9d

Passionate about #SystemsBiology and ready to lead your own research group?
Join us at the forefront of discovery — apply now to be a #GroupLeader at the NOVA Institute for Medical Systems Biology, in beautiful Lisbon, PT!

Appl. by Oct 8:
www.nature.com/naturecareer...

#ScienceJobs #JobOffer

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Reposted by MDC-BIMSB

Marc Appis @marclappis.bsky.social · 10d

Check out the latest #preprint by @ms-maren.bsky.social from our lab @leifludwig.bsky.social if you want to use frozen/archived tissues for mitochondrial scATAC-seq 👇

(With example data from #glioblastoma, #aortas, #als and #neuroblastoma 🤩)

@mdc-bimsb.bsky.social @bihatcharite.bsky.social

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CompCancer PhD programme @compcancer.bsky.social · 12d

Very dynamic poster sessions at the late summer school on tumor heterogeneity and treatment followed by a rooftop party. Thank you @mdc-bimsb.bsky.social for hosting us!

Impression of the poster session at bimsb, showing the staircase

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Max Delbrück Center @mdc-berlin.bsky.social · 21d

ADPKD affects 1 in 1,000 children – but only one drug exists, and it mainly targets symptoms.

Now, an international team led by #mdcBerlin / #mdcBIMSB's Michael Kaminski shows how base editing can restore protein function and shrink cysts in mice.

Full story:
👉 www.mdc-berlin.de/news/press/g... 👈

Scientific image with overlaid text: The image shows a stained tissue sample in shades of purple and white, displaying irregular structures and cell patterns. Overlaid text in white, all-caps sans-serif font inside a dark blue rectangular box is positioned at the top left. It reads: “GENE EDITING TO TREAT INHERITED KIDNEY DISEASE.”

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Max Delbrück Center @mdc-berlin.bsky.social · 23d

Cells use nonsense-mediated mRNA decay (NMD) to destroy faulty RNA before it can cause harm.

Researchers at the #mdcBerlin and the University of Cologne uncovered hidden RNA variants and built a free database for the field.

Check out the full story:
👉 www.mdc-berlin.de/news/press/h... 👈

Illustration with overlaid text: The image shows a close-up 3D rendering of a twisted, branch-like biological structure resembling a strand of mRNA, set against a blue gradient background. On the left side, white all-caps sans-serif text reads: “HOW CELLULAR QUALITY CONTROL WORKS.”

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Emanuel Wyler @ewyler.bsky.social · 23d

Job offer! We have a fully funded open PhD student position at the @mdc-bimsb.bsky.social as part of @deep-dv-for5200.bsky.social, on RNA-based molecular mechanisms in herpes simplex virus 1-infected cells. Please spread the word, and DM me in case of questions.

www.mdc-berlin.de/career/jobs/...

PhD student (m/f/d)

The Max Delbrück Center for Molecular Medicine in the Helmholtz Association aims to transform tomorrow’s medicine through our discoveries of today. At locations in Berlin-Buch, Berlin-Mitte, Heidelberg and Mannheim, our scientists collaborate across disciplines to unravel the complexities of disease at the systems level – from molecules and cells to organs and entire organisms. Through strong academic, clinical, and industry partnerships, as well as global networks, we translate biological insights into innovations for early detection, individualized therapies, and disease prevention.

www.mdc-berlin.de

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Reposted by MDC-BIMSB

Max Delbrück Center @mdc-berlin.bsky.social · 26d

Nearly 50 new cancer drugs are approved each year – but which one fits which patient?

At the #mdcBerlin, @al2na.bsky.social’s team built Flexynesis, a deep learning toolkit to guide precision cancer care.

Learn more:
👉 www.mdc-berlin.de/news/press/u... 👈

Illustration with overlaid text: The image shows a cancer cell in the bloodstream. The overlaid text appears in white, all-caps sans-serif font inside a dark blue rectangular box at the top left. It reads: “USING DEEP LEARNING FOR PRECISION CANCER THERAPY.” A small credit at the bottom right reads: “© Annie Cavanagh / Wellcome Collection.”

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Max Delbrück Center @mdc-berlin.bsky.social · 27d

🚀 Deadline approaching: apply by September 17 and become a GLOBAL POSTDOC FELLOW at the #mdcBerlin.

You'll co-develop projects with two supervising labs, tackling biomedical grand challenges – with full salary, modern infrastructure, and career support.

More:
👉 www.mdc-berlin.de/postdocs#t-g... 👈

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Max Delbrück Center @mdc-berlin.bsky.social · 29d

Researchers at the #mdcBerlin developed a new method called TESLA-seq that links gene regulatory elements to their targets – faster and more precisely.

The team mapped 200+ CaREs in the PHOX2B region, revealing new connections to disease-relevant genes.

More:
👉 www.mdc-berlin.de/news/press/u... 👈

Photo with overlaid text: The image shows a close-up of a lab pipette dispensing liquid onto a reflective surface, with a dark, out-of-focus background. The overlaid text is in white, all-caps sans-serif font inside a teal rectangular box, positioned in the top left corner. It reads: “NEW METHOD TO DISCOVER HOW DNA CONTROLS GENES.”

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MDC-BIMSB @mdc-bimsb.bsky.social · Sep 5

MDC-BIMSB is hiring a Science Program Manager & Coordinator - a pivotal role in our mission to integrate cutting-edge experimental & computational research in health & disease.
Ready to advance biomedical systems biology?
Apply by Sept 23: www.mdc-berlin.de/career/jobs/...
@mdc-berlin.bsky.social

Science Program Manager & Coordinator at the Berlin Institute for Medical Systems Biology (m/w/d)

The Max Delbrück Center for Molecular Medicine in the Helmholtz Association aims to transform tomorrow’s medicine through our discoveries of today. At locations in Berlin-Buch, Berlin-Mitte, Heidelberg and Mannheim, our scientists collaborate across disciplines to unravel the complexities of disease at the systems level – from molecules and cells to organs and entire organisms. Through strong academic, clinical, and industry partnerships, as well as global networks, we translate biological insights into innovations for early detection, individualized therapies, and disease prevention.

www.mdc-berlin.de

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Reposted by MDC-BIMSB

Max Delbrück Center @mdc-berlin.bsky.social · Sep 4

🎉 Congratulations to Markus Mittnenzweig on receiving an ERC Starting Grant!

With €1.5 million in funding from the @erc.europa.eu, he will investigate @mdc-bimsb.bsky.social how early-stage embryonic zebrafish cells become specialized tissues.

👉 Details:
www.mdc-berlin.de/news/press/m...

 #ERCStG

Portrait of a smiling man. Text: "Congrats! Markus Mittnenzweig"

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MDC-BIMSB @mdc-bimsb.bsky.social · Sep 4

Congratulations, Ashley! We look forward to the next chapter of innovation and discovery 🧬

Max Delbrück Center @mdc-berlin.bsky.social · Sep 3

🎉 Ashley Sanders has been awarded W3 professorship from Charité Berlin. Congratulations!

This honors her contributions to the field of #SingleCell #DNA sequencing, where she has helped redefine understanding of genomic structure and variability.

🔗 Details: www.mdc-berlin.de/news/news/pr...

Portrait of a woman. Text: "Congrats! Ashley Sanders"

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Reposted by MDC-BIMSB

Max Delbrück Center @mdc-berlin.bsky.social · Aug 29

📧 Sleeping #tumor cells, boosting #vaccine efficacy, and a sci-fi #podcast

Curious about the latest in biomedical research? Get our "Insights" #newsletter delivered to your inbox every month – sign up here:

👉 www.mdc-berlin.de/newsletter

Scientific images, text: "Insights August"

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Max Delbrück Center @mdc-berlin.bsky.social · Aug 28

📢 Interested in #immunology research? Join our “Afternoon for Immunology”! Scientists at all career stages will present their research.

📍 September 4, 15:00-18:00
Robert-Rössle-Str 10
Dendrit 2/3
13125 Berlin

🔗 www.mdc-berlin.de/Afternoonfor...

Poster for "Afternoon for Immunology" on 4 September 2025 at MDC-Campus Buch, featuring talks, coffee break, and networking.

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Reposted by MDC-BIMSB

Max Delbrück Center @mdc-berlin.bsky.social · Aug 7

🧬 How do immune cells talk – and what happens when they don’t?

A new technology by Simon Haas & Daniel Hübschmann maps millions of cell contacts 🔬
It shows how immune responses shift in disease & therapy.

📊 A step toward personalized medicine!

🔗 Read more: www.mdc-berlin.de/news/press/h...

Two immune cells interacting with glowing connection, illustrating cell communication.

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Reposted by MDC-BIMSB

Nature Biotechnology @natbiotech.nature.com · Jul 30

Shortcomings of silhouette in single-cell integration benchmarking - @uweohler.bsky.social @prauten.bsky.social @mdc-bimsb.bsky.social @mdc-berlin.bsky.social @humboldtuni.bsky.social go.nature.com/4fcQzZr

Shortcomings of silhouette in single-cell integration benchmarking - Nature Biotechnology

Silhouette score is unsuitable as a metric for single-cell data integration.

go.nature.com

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MDC-BIMSB @mdc-bimsb.bsky.social · Aug 7

Great opportunity! Up to 4 Group Leader positions at the NOVA Institute for Medical Systems Biology (NIMSB) in Computational & Experimental Medical Systems Biology
📍 Lisbon
⏳ Apply by Oct 8
🔗 nimsb.unl.pt/wp-content/u...

#Job #SciencePositions #JobOffer #GroupLeaders #Innovation #systemsbiology

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Max Delbrück Center @mdc-berlin.bsky.social · Aug 4

Lead your independent research project as a #postdoc in our 3-year #fellowship.

The program includes full-time employment with competitive salary, budget, structured co-supervision, mentoring and advanced training

Apply from August 4 to August 28
👉 www.mdc-berlin.de/postdocs#t-g...

Please share!

three scientists discuss. Text: "MDC Global Fellow postdoctoral program"

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MDC-BIMSB @mdc-bimsb.bsky.social · Jul 29

Thank you to all the organizers, speakers, and allies who made this event possible. Visibility and resilience go hand in hand — especially in times of uncertainty.
Let’s keep creating spaces where everyone feels seen, supported, and proud.
#MDCBerlin

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MDC-BIMSB @mdc-bimsb.bsky.social · Jul 29

Through inspiring talks, open conversations, and a joyful Pride After Hour @MDC-BIMSB, we celebrated the strength and diversity of our LGBTQIA+ community in science.

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MDC-BIMSB @mdc-bimsb.bsky.social · Jul 29

🏳️‍🌈🏳️‍⚧️ Celebrating #PrideMonthBerlin, the @mdc-berlin.bsky.social @mdc-bimsb.bsky.social hosted 'Pride at MDC – Resilience in Times of Change' — a powerful event that reminded us why inclusive science matters.

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Max Delbrück Center @mdc-berlin.bsky.social · Jul 24

We're taking a clear stand against sexism and strive to create a respectful environment where diversity is recognized and valued.

During #PrideMonthBerlin we launch an exhibition at @mdc-bimsb.bsky.social making the issue of sexism and sexual harassment visible.

www.mdc-berlin.de/about/values...

Posters explaining what sexism is and how it appears in everyday life, displayed on a hallway wall.

Posters discussing sexism's societal impact and its historical resistance, presented in an educational display.

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Reposted by MDC-BIMSB

Kamil Lisek @klisek.bsky.social · Jul 22

We’re happy to share our new preprint form
@N_Rajewsky, with @tmpentimalli.bsky.social i.bsky.social @Ilan Theurillat
lab! 🎉
🧬 Spatiotemporal atlas of tumor–stroma crosstalk in a new TNBC model. Spatial transcriptomics (Open-ST), snRNA-seq, and functional validation.
🔗 biorxiv.org/content/10.1...

Spatiotemporal dynamics of tumor microenvironment remodeling

During tumorigenesis, interactions between tumor and stromal cells progressively remodel the tumor microenvironment (TME) towards pro-tumoral functions. Understanding early TME remodeling dynamics is ...

biorxiv.org

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Reposted by MDC-BIMSB

Jacobo @jacobolcar.bsky.social · Jul 18

Don't miss our @mdc-berlin.bsky.social Pride Symposium starting at 13:00 today! I'll be moderating the panel discussion with @inanna-nalytica.bsky.social and others about resilience in the LGBTQ+ community.
#MDCdiversity
www.mdc-berlin.de/news/events/...

Pride at MDC - Resilience in Times of Change

TimeTitleSpeakers12:30-Cake 13:00-13:10OpeningOrganizing Committee13:10-13:15Welcome from MDC the directorate MDC Directors Session 1: Intersectionality13:15-13:30Queering Ag

www.mdc-berlin.de

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Emanuel Wyler @ewyler.bsky.social · Jul 14

Wir freuen uns sehr, am @mdc-bimsb.bsky.social zu dieser DFG-Forschungsgruppe beizutragen, in der wir molekulare Mechanismen von Herpes-, Polyoma- und Adenoviren untersuchen!

DEEP-DV FOR5200 @deep-dv-for5200.bsky.social · Jul 9

Yes! DEEP-DV geht in die Verlängerung! 🎉
Die DFG hat unserer Forschungsgruppe eine weitere Förderperiode bewilligt – 4 Jahre neue Ideen, Daten und Teamwork!
Danke an alle im Team für den starken Zusammenhalt und an DFG + Gutachter:innen für das Vertrauen in unsere Arbeit. Wir freuen uns riesig! 💪🔬

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