Abstract. The nucleosome remodeler Chd1 is required for the re-establishment of nucleosome positioning in the wake of transcription elongation by RNA Polym

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Abstract. The dual interaction of many transcription factors (TFs) with both DNA and RNA is an underexplored issue that could fundamentally reshape our und

Transposable elements (TEs) comprise nearly half of the human genome. This Review discusses transcriptional and post-transcriptional mechanisms that repress TE activity, how TEs escape this suppressio...

In the June 12th issue of Cell, Baluapuri et al. report that loss of the Integrator (INT) complex triggers cellular stress by unleashing aberrant transcription, resulting in production of immunogenic double-stranded RNA. Dissecting early and late consequences of INT depletion, the study exemplifies how transcriptional dysregulation can culminate in profound physiological outcomes.

Study solves riddle of how mutations in Integrator complex relate to neurodegeneration, cancer

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Control over protein phosphorylation timing is crucial for faithful cell cycle progression. Takacs et al. revisit existing qualitative and quantitative models for cyclin-dependent kinase (Cdk) control of the cell cycle. They provide evidence of a third mechanism in which the substrates themselves contribute to controlling their phosphorylation timing.