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Reposted by Jackson Hoffman

Lindsay K Pino @lindsaykpino.com · 2d

Still got our latest preprint bookmarked in an unread tab of your browser? We got you. @afederation.bsky.social presenting @talusbio.bsky.social's work-in-progress on Wednesday! 🧬 🖥️ 🧪 #MassSpectrometry #Proteomics

FragileNucleosome @fnucleosome.bsky.social · 2d

🎃 🥁This Wednesday in our 1st session of spookiest month👻 at #FragileNucleosome seminar, we are excited to host @sanimr.bsky.social & Alex Federation!
Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...

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Reposted by Jackson Hoffman

Raquel Fueyo @fueyoraquel.bsky.social · 2d

⚡⚡Excited to announce I'll be starting my lab at the Max Planck Institute of Molecular Genetics (@molgen.mpg.de) in Berlin in December! Leaving sunny California to join a fantastic environment with colleagues who do super cool work.
🔬🦠I'm hiring at all levels! 🔬🦠Check: www.molgen.mpg.de/fueyo-lab

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Reposted by Jackson Hoffman

FragileNucleosome @fnucleosome.bsky.social · 2d

🎃 🥁This Wednesday in our 1st session of spookiest month👻 at #FragileNucleosome seminar, we are excited to host @sanimr.bsky.social & Alex Federation!
Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...

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Reposted by Jackson Hoffman

Raquel Fueyo @fueyoraquel.bsky.social · 7d

Today in @nature.com, we present our work leveraging functional genomics and human blastoids to uncover a human-specific mechanism in preimplantation development driven by the endogenous retrovirus HERVK.
Special thanks to the reviewers whose comments improved our manuscript a lot! rdcu.be/eI3tD

A human-specific regulatory mechanism revealed in a pre-implantation model

Nature - Genetic manipulation of blastoids reveals the role of recently emerged transposable elements and genes in human development.

rdcu.be

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Reposted by Jackson Hoffman

Canadian Epigenetics @ceehrc.bsky.social · 9d

FINAL REGISTRATION DEADLINE!

Last day to register for the CEEHRC Annual Meeting is FRIDAY, OCTOBER 10!

Abstracts still being accepted for the poster sessions.

Speaker lineup and other details can be found at event.fourwaves.com/...

#epigenetics #epigenomics #ceehrc

CEEHRC 11th Annual Canadian Conference on Epigenetics

Fourwaves - CEEHRC 11th Annual Canadian Conference on Epigenetics

event.fourwaves.com

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Reposted by Jackson Hoffman

Connor Rogerson @doctorconnor.bsky.social · 13d

We have space for two postdoctoral fellows in the Taipale Lab at the @sangerinstitute.bsky.social. This is a core-funded open position! Come with your ideas and interests and we can develop a project together.

sanger.wd103.myworkdayjobs.com/en-US/Wellco...

Postdoctoral Fellow - Gene Regulation and Functional Genomics

Do you want to help us improve human health and understand life on Earth? Make your mark by shaping the future to enable or deliver life-changing science to solve some of humanity’s greatest challenge...

sanger.wd103.myworkdayjobs.com

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Jackson Hoffman @jxhoffman.bsky.social · 14d

Starting in 3 hours!!

FragileNucleosome @fnucleosome.bsky.social · 16d

This Wednesday at #FragileNucleosome seminar, we are excited to host Ali Wilkening and @schvartzman.bsky.social to tell us about amazing work they are doing!
Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...

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Reposted by Jackson Hoffman

Serena Sanulli Lab at Stanford Genetics @serenasanulli.bsky.social · 15d

If you want to learn more about Ali's exciting work, register for the fragile nucleosome seminar! tomorrow 9AM PDT

FragileNucleosome @fnucleosome.bsky.social · 16d

This Wednesday at #FragileNucleosome seminar, we are excited to host Ali Wilkening and @schvartzman.bsky.social to tell us about amazing work they are doing!
Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...

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Reposted by Jackson Hoffman

FragileNucleosome @fnucleosome.bsky.social · 16d

This Wednesday at #FragileNucleosome seminar, we are excited to host Ali Wilkening and @schvartzman.bsky.social to tell us about amazing work they are doing!
Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...

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Reposted by Jackson Hoffman

mathiaseder.bsky.social @mathiaseder.bsky.social · 19d

✨Exciting news: the main story of my PhD is out in Science!

Together with Christine Moene @cmoene.bsky.social, we explored what happens when you scramble the genome—revealing how Sox2’s position shapes enhancer activation.

📖 Read the full story here: www.science.org/doi/10.1126/...

Functional maps of a genomic locus reveal confinement of an enhancer by its target gene

Genes are often activated by enhancers located at large genomic distances, and the importance of this positioning is poorly understood. By relocating promoter-reporter constructs into thousands of alt...

www.science.org

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Reposted by Jackson Hoffman

Melvin Noe Gonzalez @melv-noe-gonzalez.bsky.social · 19d

It is my pleasure to share with you the latest from @jsvejstrup.bsky.social lab, where we look at how the reduction of RNAPII levels has a severe, yet organized transcriptional response in the cell.

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Reposted by Jackson Hoffman

Jan Żylicz @jzylicz.bsky.social · 20d

Genes are not On/Off switches. In a new preprint we show that HDAC3 is key to establish correct transcriptional dose in development. Gr8 work from N. Stamidis @ucph.bsky.social and collab. @jamiehackett.bsky.social @gregersenlab.bsky.social . Huge thx to all authors! www.biorxiv.org/content/10.1...

HDAC3 prevents enhancer hyperactivation to enable developmental transitions

Dynamic gene regulation requires precise cooperation between transcription factors and chromatin modifiers at regulatory elements to achieve not only activation or repression, but also appropriate tra...

www.biorxiv.org

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Reposted by Jackson Hoffman

FragileNucleosome @fnucleosome.bsky.social · 28d

We're getting started in ~90 minutes!

In addition to watching the seminars, remember you can join us on Discord to chat about transcription and chromatin whenever you want! discord.com/invite/dXqT89r

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Reposted by Jackson Hoffman

Pedro Rocha @pedroprocha.bsky.social · Sep 8

🚨🚨🚨 Please repost
We are looking for postdocs to join our lab at NIH.
Apply:
www.nichd.nih.gov/research/atNICHD/Investigators/rocha/apply
Learn more about training at NIH :
www.training.nih.gov/research-tra...

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Jackson Hoffman @jxhoffman.bsky.social · Sep 8

Really excited to get our seminars back up and running. @gracebower.bsky.social is going 1st and if you haven't read her range extender story, you're in for a treat!
+
@creminslab.bsky.social has the 2nd talk and will tell us about the amazing work happening in her lab!

FragileNucleosome @fnucleosome.bsky.social · Sep 5

Let’s kickstart new series of #FragileNucleosome seminars! We are delighted to have @gracebower.bsky.social from Kvon lab and @creminslab.bsky.social to present their work!
Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...

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Reposted by Jackson Hoffman

FragileNucleosome @fnucleosome.bsky.social · Sep 5

Let’s kickstart new series of #FragileNucleosome seminars! We are delighted to have @gracebower.bsky.social from Kvon lab and @creminslab.bsky.social to present their work!
Register here for upcoming session and the entire series:
us06web.zoom.us/webinar/regi...

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Reposted by Jackson Hoffman

Hanneke Vlaming @hannekevlaming.bsky.social · Sep 4

As part of this grant, I have a vacancy out for a PhD student to join our super nice team. It closes on September 9 (Tuesday).
If you are or know a good prospective PhD student, excited about studying transcription, please (suggest them to) apply here: www.uu.nl/en/organisat...

PhD position in Gene Regulation

Are you excited about studying the crucial process of transcription? Join our supportive, young and growing team!

www.uu.nl

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Jackson Hoffman @jxhoffman.bsky.social · Sep 4

Awesome! Congrats Hanneke!

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Jackson Hoffman @jxhoffman.bsky.social · Sep 3

Congrats Charly!!!

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Reposted by Jackson Hoffman

Carlos Guardia @charlyguardia.bsky.social · Sep 3

Excited to share the first paper from the lab! 🥳 The ATG9 and lipid droplets saga continues! Open source!

Liver-specific loss of Atg9a perturbs lipid metabolism and hepatocyte integrity

The autophagy-related protein ATG9A is integral to cellular autophagy and lipid mobilization, yet its importance in mammalian physiology remains underexplored. Using a liver-specific conditional At...

doi.org

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Reposted by Jackson Hoffman

María Mariner @mariamafau.bsky.social · Sep 2

Honoured to be part of this awesome lineup 😍! @fnucleosome.bsky.social thanks for the opportunity! A very exciting Fall Season is about to start, I wouldn't miss it 😌🧬

FragileNucleosome @fnucleosome.bsky.social · Sep 1

We're super excited to announce the entire lineup for the Fall season of Fragile Nucleosome Seminars, starting on Sept 10th at 1200 EDT / 1600 UTC with @gracebower.bsky.social and @creminslab.bsky.social!

register here for the entire series: us06web.zoom.us/webinar/regi...

Fragile Nucleosome Fall Seminars:
September 10 Grace Bower, Kvon Lab @ UC Irvine, USA
Jennifer Phillips-Cremins, UPenn, USA

September 24 Ali Wilkening, Sanulli Lab @ Stanford, USA
Juanma Schvartzman, Columbia University, USA

October 8 Sanim Rahman, Greenberg Lab @ UPenn, USA
Alex Federation, Talus Bio, USA

October 22 Alice Laigle, Croll Lab @ University of Neuchâtel, Switzerland
Seungsoo Kim, UC Irvine, USA

November 5 Hannah Long, University of Edinburgh, UK
Jeff Vierstra, Altius Institute, USA

November 19 Ishtiaque Hossain, Pastor Lab @ McGill, Canada
Sarah Teichmann, University of Cambridge, UK

December 3 María Mariner Faulí, Rada Iglesias Lab @ IBBTEC, Spain
Jonathan Henninger, Carnegie Mellon, USA

December 17 Rebecca Berrens, Oxford University, UK
Jean-Benoit Lalanne, University of Montreal, Canada

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Reposted by Jackson Hoffman

Evgeny Kvon @evgenykvon.bsky.social · Sep 1

Join the Fragile Nucleosome Seminar featuring @gracebower.bsky.social, who will discuss our recent discovery of the Range Extender Element. (www.nature.com/articles/s41...)

FragileNucleosome @fnucleosome.bsky.social · Sep 1

We're super excited to announce the entire lineup for the Fall season of Fragile Nucleosome Seminars, starting on Sept 10th at 1200 EDT / 1600 UTC with @gracebower.bsky.social and @creminslab.bsky.social!

register here for the entire series: us06web.zoom.us/webinar/regi...

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Reposted by Jackson Hoffman

Surfin' NuRD @surfinnurd.bsky.social · Sep 1

What a job done by the @fnucleosome.bsky.social organisers. Awesome autumn lineup of speakers!

FragileNucleosome @fnucleosome.bsky.social · Sep 1

We're super excited to announce the entire lineup for the Fall season of Fragile Nucleosome Seminars, starting on Sept 10th at 1200 EDT / 1600 UTC with @gracebower.bsky.social and @creminslab.bsky.social!

register here for the entire series: us06web.zoom.us/webinar/regi...

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Reposted by Jackson Hoffman

Surfin' NuRD @surfinnurd.bsky.social · Aug 30

Check it out, Chromatin Kids!

Chromatin remodeller does stuff to Transcription Factors!

Functions where it is seldom seen!

Both decreases and increases chromatin accessibility!

How cool is that?

bioRxiv Molecular Biology @biorxiv-molbio.bsky.social · Aug 30

The chromatin remodeller CHD4 controls both nucleosome integrity and transcription factor binding to promote activity of active regulatory elements and to prevent activation of silent enhancers https://www.biorxiv.org/content/10.1101/2025.08.29.672645v1

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Reposted by Jackson Hoffman

Rogatsky Lab @rogatskylab.bsky.social · Aug 29

It's been a great & productive summer, we had fantastic #undergraduates :) but September is HERE and we are looking for new #POSTDOCS - effective immediately! please spread the word and if interested - let us know! We are into #transcription #inflammation #epigenomics #NuclearReceptors #macrophages

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