Hanneke Vlaming
@hannekevlaming.bsky.social
260 followers 160 following 10 posts
Assistant Prof at Utrecht University, studying the process of transcription elongation vs early termination. (she/her)
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hannekevlaming.bsky.social
And for you!! Congratulations!
There have now been at least 3 starting grants earned by participants of that one Epigenetics course in Paris in 2011, with maybe 20-25 participants? Pretty impressive!
hannekevlaming.bsky.social
Getting this grant took several attempts and lots of support from my past advisors, current colleagues and many other science friends. Thank you to everyone who helped me prepare by proofreading, doing practice talks or sharing advice or encouragement!!
hannekevlaming.bsky.social
As part of this grant, I have a vacancy out for a PhD student to join our super nice team. It closes on September 9 (Tuesday).
If you are or know a good prospective PhD student, excited about studying transcription, please (suggest them to) apply here: www.uu.nl/en/organisat...
PhD position in Gene Regulation
Are you excited about studying the crucial process of transcription? Join our supportive, young and growing team!
www.uu.nl
hannekevlaming.bsky.social
Thrilled to be one of the ERC StG awardees this year! It will allow my team to further delve into the puzzle of what regulates the fate of RNA Polymerase II during early elongation: will it terminate early, or elongate happily ever after?
erc.europa.eu
📣 The ERC Starting Grant call results are out!

Find out which early-career researchers will receive funding this year, what they will be investigating, where they will be based... plus lots of other #ERCStG facts & figures for 2025!

➡️ buff.ly/IsafuFh

#FrontierResearch 🇪🇺#EUfunded #HorizonEurope
Reposted by Hanneke Vlaming
basvansteensellab.bsky.social
Very proud of our paper on "scrambling-by-hopping" LADs, which was just published: www.nature.com/articles/s41.... Congrats to Lise Dauban and the rest of the team – this was a real tour-de-force!
Reposted by Hanneke Vlaming
fnucleosome.bsky.social
We're super excited to announce the entire lineup for the Fall season of Fragile Nucleosome Seminars, starting on Sept 10th at 1200 EDT / 1600 UTC with @gracebower.bsky.social and @creminslab.bsky.social!

register here for the entire series: us06web.zoom.us/webinar/regi...
Fragile Nucleosome Fall Seminars:
September 10    Grace Bower, Kvon Lab @ UC Irvine, USA
    Jennifer Phillips-Cremins, UPenn, USA

September 24    Ali Wilkening, Sanulli Lab @ Stanford, USA
    Juanma Schvartzman, Columbia University, USA

October 8    Sanim Rahman, Greenberg Lab @ UPenn, USA
    Alex Federation, Talus Bio, USA

October 22    Alice Laigle, Croll Lab @ University of Neuchâtel, Switzerland
    Seungsoo Kim, UC Irvine, USA

November 5    Hannah Long, University of Edinburgh, UK
    Jeff Vierstra, Altius Institute, USA

November 19    Ishtiaque Hossain, Pastor Lab @ McGill, Canada
    Sarah Teichmann, University of Cambridge, UK

December 3    María Mariner Faulí, Rada Iglesias Lab @ IBBTEC, Spain
    Jonathan Henninger, Carnegie Mellon, USA

December 17    Rebecca Berrens, Oxford University, UK
    Jean-Benoit Lalanne, University of Montreal, Canada
Reposted by Hanneke Vlaming
lucas.farnunglab.com
🧬 Transcription elongation by RNA polymerase II relies on a web of elongation factors. Our new work shows how IWS1 acts as a modular scaffold to stabilize & stimulate elongation. Fantastic work by Della Syau! www.biorxiv.org/content/10.1...
hannekevlaming.bsky.social
Could you add me too? Thanks!
Reposted by Hanneke Vlaming
kasitc.bsky.social
Activity of most genes is controlled by multiple enhancers, but is there activation coordinated? We leveraged Nanopore to identify a specific set of elements that are simultaneously accessible on the same DNA molecules and are coordinated in their activation. www.biorxiv.org/content/10.1...
hannekevlaming.bsky.social
The Vlaming lab is expanding! If you are or know a good prospective PhD student, excited about studying transcription, please (suggest them to) apply here: www.uu.nl/en/organisat...
My biased opinion: exciting topic, super nice colleagues, and great research environment in a lovely city.
PhD position in Gene Regulation
Are you excited about studying the crucial process of transcription? Join our supportive, young and growing team!
www.uu.nl
Reposted by Hanneke Vlaming
mgkopczynska.bsky.social
🚨 New preprint from our labs (STOP lab @stoplab.bsky.social & Nojima lab @pol2rna.bsky.social @pyrolyn.bsky.social)! We've been digging into how chromatin remodeler SETD2 controls the start and end of transcription 👇 www.biorxiv.org/cgi/content/... (1/5)
Reposted by Hanneke Vlaming
suyangzhang.bsky.social
Excited to share our latest work! We found transcription factor SPT6 and phosphorylated Pol II CTD help recruit U1 snRNP to elongating Pol II, allowing efficient co-transcriptional splicing.

Glad to be featured in the Editors’ Highlights!

www.nature.com/articles/s41...

#splicing #cryoEM
hannekevlaming.bsky.social
Big thank you to co-lead @camimoso.bsky.social and to @adelmanlab.bsky.social. Further support from Nathalie in my group (first paper with @utrechtuniversity.bsky.social affiliation 🤩!) and Allison.
hannekevlaming.bsky.social
This manuscript was a long time in the making (started while Claudia and I were both still in the Adelman lab), but thankfully going from preprint to published in @genesdev.bsky.social was a smooth process!
hannekevlaming.bsky.social
Happy to share this paper! We uncovered that good 5' splice sites protect against ZC3H4/Restrictor's promiscuous role, and that its role is to suppress elongation and indirectly cause termination. Looking forward to learning more about this protein in the future!
genesdev.bsky.social
In this study, Mimoso et al. show that Restrictor serves as a transcriptional safeguard that suppresses the spurious transcription of non-coding RNAs, while preserving mRNA transcription.

Learn more here:
➡️ tinyurl.com/gd352654
hannekevlaming.bsky.social
Finally joined this platform! Looking forward to reconnect with many old friends and colleagues, and connect with new people too! Now let's see if I can moderate my 'intake', haha.