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Julie Carnesecchi

@jcarnesecchi.bsky.social

570 followers 610 following 17 posts

Digging in RNA & TF interplay - Exploring TF-RNA networks in cell fate - Fly pusher + CNRS Researcher + Mentorfirst https://www.igmm.cnrs.fr/en/team/integrative-rna-networks-in-development/

www.igmm.cnrs.fr

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Julie Carnesecchi @jcarnesecchi.bsky.social · Jul 4

🎉 Thrilled to share our new paper in @narjournal.bsky.social!
We uncover how the Hox TF Ultrabithorax controls alternative splicing to shape muscle patterning and homeotic identity 🧬 @igmm-montpel.bsky.social
🔗 doi.org/10.1093/nar/...

Synergistic DNA and RNA binding of the Hox transcription factor Ultrabithorax coordinates splicing and shapes in vivo homeotic functions

Abstract. The dual interaction of many transcription factors (TFs) with both DNA and RNA is an underexplored issue that could fundamentally reshape our und

doi.org

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Julie Carnesecchi @jcarnesecchi.bsky.social · 2d

@igmm-montpel.bsky.social @isemevol.bsky.social @umontpellier.bsky.social
www.linkedin.com/posts/julie-...

M2 interdisciplinary internship RNA, Hox, Evo-Devo | Julie Carnesecchi

Funded #M2 #Internship (6 months) — Montpellier | IGMM × ISEM We are recruiting a motivated M2 student to join a joint project on Hox factors beyond DNA, testing how RNA binding by conserved transcri...

www.linkedin.com

Julie Carnesecchi @jcarnesecchi.bsky.social · 2d

M2 internship (funded, 6months) in Montpellier — IGMM × ISEM with amazing @aigverte.bsky.social
Project: Hox factors beyond DNA: how RNA binding links molecules to body-plan evolution.
Start: early 2026
Apply: CV+motivation
#Master2 #Internship #Montpellier #RNA #Hox #EvoDevo #Drosophila #Bat

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Reposted by Julie Carnesecchi

Fillip Port @crisprflydesign.bsky.social · 3d

High levels of Cas9 are toxic in sensory neurons. Reducing Cas9 levels with uORFs avoids toxicity and is compatible with efficient editing. From @thompsonpeerlab.bsky.social. Fly lines @vdrc-flies.bsky.social

#CRISPR #Drosophila

www.biorxiv.org/content/10.1...

Figure from the preprint showing sensory neuron morphology with different levels of Cas9 expression.

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Reposted by Julie Carnesecchi

FlyBase @flybase.bsky.social · 5d

There's an update on the state of FlyBase on the FlyBase.org front page. You can contribute to FlyBase at this link wiki.flybase.org/wiki/FlyBase...
We express enormous gratitude to the people, labs, groups, and foundations who have already helped us.
#FlyBase #Drosophila

FlyBase Update – October 2025
The termination of the NIH/NHGRI FlyBase grant has placed the long-term sustainability of FlyBase at risk. However, thanks to the generous support of several key individuals and institutions, we are pleased to announce that FlyBase will remain operational through the coming year. We extend our deepest gratitude to Yukiko Yamashita, Cassandra Extavour, Hugo Bellen, Thom Kaufman, the Genetics Society of America / Drosophila Board, the Bloomington Drosophila Stock Center, an anonymous donor and the Wellcome Trust. We are especially thankful for a generous gift from Seemay Chou, Jed McCaleb, and The Navigation Fund. We also greatly appreciate the continued support from the broader Drosophila community – your donations and service fees have been vital in helping us stay afloat. Special thanks also go to Jessica Manning for her tireless administrative work at Harvard, to Ruth Lehmann, Hugo Bellen, and Paul Sternberg for advice and efforts, and to the Board of the European Drosophila Society for all their efforts. Sadly, we must also share that several long-standing FlyBase team members have recently moved on. We are immensely grateful to Susan Russo-Gelbart, Lynn Crosby, Gil dos Santos, Kris Broll, Victoria Jenkins, and TyAnna Lovato for their many years of dedicated service and contributions to FlyBase. Looking ahead, ensuring FlyBase’s sustainability beyond the next year – and successfully integrating with the Alliance – will require new funding sources. We kindly ask for your continued support:
• European labs: Please consider contributing to the Cambridge, U.K. FlyBase group
• U.S. and other non-European labs: Please consider contributing to the U.S. FlyBase groups
• Both U.K. and U.S. FlyBase are working diligently to establish an invoicing system. We appreciate your continued patience.
For more information on how to support us, please visit: Contribute to FlyBase wiki page https://wiki.flybase.org/wiki/FlyBase:Contribute_to_FlyBase

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Reposted by Julie Carnesecchi

EDRC2025 @edrc2025.bsky.social · 10d

That’s a wrap! We are done with #EDRC2025 and we look forward to seeing everyone again in 2027 for #EDRC2027 in Bonn!

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Reposted by Julie Carnesecchi

Junior European Drosophila Investigators @fly-jedi.bsky.social · 10d

Update from #EDRC2025! Four days of amazing talks and poster sessions and JEDIs have reconnected across geographical boundaries. Dinner was fun and we are looking forward to everyone at the next #Drosophila conference!

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Reposted by Julie Carnesecchi

Lucas Waltzer @lucaswaltzer.bsky.social · 11d

#edrc2025 European #drosophila Society meeting announces the 2029 meeting location : see you all in Szeged (and Bonn in 2027 of course)!

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Reposted by Julie Carnesecchi

EDRC2025 @edrc2025.bsky.social · 11d

We are on day 3 of #EDRC2025 continuing with excellent #Drosophila science

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Reposted by Julie Carnesecchi

Junior European Drosophila Investigators @fly-jedi.bsky.social · 12d

Dear JEDIs,
as we are self-organizing using the #EDRC as a nucleator we decided it is time for a JEDI database to boost our network! If you identify as a JEDI, please contact us here or send a mail to [email protected] to be added to our database.
#Drosophila
@fly-eds.bsky.social

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Reposted by Julie Carnesecchi

EDRC2025 @edrc2025.bsky.social · 12d

Welcome to the second day of #EDRC2025 starting with two great keynote lectures by Cassandra Extavour from Harvard University and Yulong Li from Peking University

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Reposted by Julie Carnesecchi

EDRC2025 @edrc2025.bsky.social · 13d

3, 2, 1 and we are on!!! #EDRC2025 is starting! Welcome to our more than 740 participants from more than 40 countries! Thank you to all our sponsors!

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Reposted by Julie Carnesecchi

EDRC2025 @edrc2025.bsky.social · 13d

Welcome to the #EDRC2025 pre-opening workshops! #ECM #Drosophila

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Reposted by Julie Carnesecchi

EDRC2025 @edrc2025.bsky.social · 14d

Only a few hours left before our meeting starts! Are you travelling to #EDRC2025 now? Let us know by using the oficial #EDRC2025 hashtag!

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Reposted by Julie Carnesecchi

GW Gant Luxton @gwgl.bsky.social · 15d

🧬 NEW Starr-Luxton Lab PREPRINT: Our 🌠grad student
@XiangyiDing
figured out why muscular dystrophy mutations cause such widespread cellular chaos. The answer wasn't what we expected - and it changes how we think about the disease. Thread🧵 (1/6). www.biorxiv.org/content/10.1...

www.biorxiv.org

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Reposted by Julie Carnesecchi

Junior European Drosophila Investigators @fly-jedi.bsky.social · 19d

Dear JEDIs, the #EDRC meeting is coming soon! Who is joining? Looking forward to meeting everyone next week!

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Julie Carnesecchi @jcarnesecchi.bsky.social · 19d

Coming 👍

Reposted by Julie Carnesecchi

paveltomancak.bsky.social @paveltomancak.bsky.social · Sep 4

We are all super happy and proud to see our work on the function and evolution of the #cephalic #furrow published in @nature.com. Let me say a few things about the background and history of this work on the #Evolution_of_Morphogenesis (1/12)

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Reposted by Julie Carnesecchi

PLOS Biology @plosbiology.org · 23d

The #Drosophila Dscam1 gene generates 10000s of isoforms, but only a small fraction supports neuronal functions. This study shows that #fitness & #immunity are the likely primary evolutionary drivers of Dscam1 isoform diversity in #arthropods @plosbiology.org 🧪 plos.io/4gp8cWd

Top: Dscam1 gene structure and isoform diversity in pancrustacean species. Top: Schematic diagrams of Drosophila melanogaster Dscam1 gene and protein structure. The variable exons or domains are shown in color, while the constant exons or domains are shown in gray. Middle: Phylogenetic distribution of Dscam1 isoform diversity. A phylogenetic tree of Pancrustacean species is shown in the lower panel. The upper panel shows distribution of the number of exons in variable exon 4, exon 6, or exon 9 clusters in Pancrustacean species, with variable exon clusters shown in different colors. The middle panel shows distribution of the number of potential ectodomains diversity, where species with a special number of diversities are highlighted. Bottom: Reducing the Dscam1 diversity affects adult survival upon Beauveria bassiana infection. Survival curves after Triton or B. bassiana infection for wild-type and exon 4 (left), exon 6 (middle), and exon 9 (right) mutants are shown, respectively. The Triton groups (control) are represented by solid lines, while the B. bassiana groups are represented by dashed lines.

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Reposted by Julie Carnesecchi

Hadi Boukhatmi @muscleflylab.bsky.social · Aug 30

Our new preprint is out !
We uncover how adult Drosophila muscles respond to injury through a coordinated dialogue between hemocytes, tracheal cells, and muscles.
Check it out and please share
@igdrennes.bsky.social

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Julie Carnesecchi @jcarnesecchi.bsky.social · Sep 2

Hello #Drosophila & #insect people!
I am searching for libraries of ORF/RNA from Tribolium castaneum and Bombyx mori for cloning cDNA/proteins (or insects with unusual body plans).
Is there an existing resource centre where I can find them, please?
Thanks very much in advance for your help!

Julie Carnesecchi @jcarnesecchi.bsky.social · Aug 29

We are recruiting an enthusiastic engineer to work on the core project of our lab: identifying Hox protein-RNA networks in Drosophila
@igmm-montpel.bsky.social

Interested in BioID, UV-RIP and muscle development? Apply: emploi.cnrs.fr/Offres/CDD/U...

Please share! #jobOffer #RNA #hox #Drosophila

Portail Emploi CNRS - Offre d'emploi - Engineer in molecular biology (M/F)

emploi.cnrs.fr

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Reposted by Julie Carnesecchi

Andreas Prokop @poppi62.bsky.social · Aug 25

Dear [email protected], dear [email protected],
to learn more about the importance of #Drosophila and crucial role of @flybase.bsky.social, and how it gave rise to at least 9 Nobel laureates in Physiology and Medicine, please see this link:
droso4schools.wordpress.com/why-fly/

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Reposted by Julie Carnesecchi

Evelina Tutucci @anilevetu.bsky.social · Aug 22

A time-resolved framework for the recruitment of mRNP processing and assembly factors to a site of transcription.

Great work by the Montpetit lab!
#RNAbiology #RNAprocessing #mRNP
doi.org/10.1093/nar/...

Validate User

doi.org

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Julie Carnesecchi @jcarnesecchi.bsky.social · Aug 19

French only: article vulgarisé de nos premiers travaux d'équipe @igmm-montpel.bsky.social @wxiang007c.bsky.social #RNA #Hox #muscle
Merci pour votre soutien a notre recherche fondamentale 🙏 @afm-telethon.bsky.social @agencerecherche.bsky.social

CNRS Biologie @cnrsbiologie.bsky.social · Aug 19

#ResultatScientifique🔎| Les facteurs Hox ne lisent pas seulement l’ADN : ils dialoguent aussi avec l’ARN ! 🧬
🤝 @cnrs.fr @cnrsoccitanieest.bsky.social @umontpellier.bsky.social
✍️ @jcarnesecchi.bsky.social
📕 @narjournal.bsky.social

Quand le plan du corps s’écrit à deux voix : ADN et ARN, une nouvelle partition de la régulation génique

Les facteurs de transcription Hox, longtemps considérés comme des lecteurs d’ADN, s’avèrent aussi interagir directement avec

buff.ly

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Reposted by Julie Carnesecchi

Alex Gould Lab @alexgouldlab.bsky.social · Aug 14

Drosophila research without FlyBase would be untenable. Time for all labs who can afford it to step up.

Mark A. Hanson @hansonmark.bsky.social · Aug 14

A reminder you/your lab can support FlyBase at Cambridge through the following link. Every bit helps. Please share if you yourself can't donate.

www.philanthropy.cam.ac.uk/give-to-camb...

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