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Hanieh Falahati

@haniehfalahati.bsky.social

490 followers 430 following 92 posts

Inspired by Jack-In-The-Box, living inside the box, trying to jump out of the box. @De Camilli lab @Yale. Formerly @Wieschaus lab @Princeton

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Hanieh Falahati @haniehfalahati.bsky.social · Dec 2

Our paper is out just in time for #EM_Monday! It is about a specialized neuron-specific ER, called the spine apparatus, which is found close to synapses and has a very peculiar shape. If you think neurons are special, the spine apparatus is their🦄 horn! But how does it form?!
doi.org/10.1016/j.cu...

Gif showing a spine containing spine apparatus, reconstructed from FIB-SEM images. ER: red, synapse: yellow, plasma membrane: blue

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Reposted by Hanieh Falahati

Andrés Guillén Samander @aguillensamander.bsky.social · Jul 26

One for the Apicomplexa peeps:
ever wonder how does the IMC grow so fast during progeny formation? Where do all the lipids come from? In our latest work on malaria RBC stages we implicate this monster protein (~6000 residues!) and ER contact sites.
Happy+proud to share and keen to hear thoughts!

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Hanieh Falahati @haniehfalahati.bsky.social · Aug 6

www.biorxiv.org/content/10.1...

Nucleation-dependent propagation of Polycomb modifications emerges during the Drosophila maternal to zygotic transition

During zygotic genome activation (ZGA) in Drosophila , broad domains of Polycomb-modified chromatin are rapidly established across the genome. Here, we investigate the spatial and temporal dynamics by...

www.biorxiv.org

Reposted by Hanieh Falahati

hanna-lab.bsky.social @hanna-lab.bsky.social · May 28

The Hanna lab opens this coming January in the Dept of Biochemistry and Molecular Biology at Penn State Uni! Follow us as we uncover the mechanisms that respond to lysosome damage

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Reposted by Hanieh Falahati

Michael Hanna @mike-hanna.bsky.social · May 28

A very special first post on Bluesky: I’m excited to share that I’ll be starting my lab at Penn State this coming January in the Dept of Biochemistry & Molecular Biology! I’ll be hiring at all levels soon. Check out updates, thoughts, and positions on the lab account: @hanna-lab.bsky.social

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Reposted by Hanieh Falahati

Casey Schneider-Mizell @csdashm.com · May 10

Mo and Hans's work here is truly a landmark in dense structural imaging, but the proof of the pudding is in the eating. Do yourself a favor and check out the Neuroglancer links and get an early glimpse at a technique I'm confident we'll see more and more over the next few years.

Light-microscopy-based connectomic reconstruction of mammalian brain tissue - Nature

A technique called LICONN (light-microscopy-based connectomics) allows mapping of brain tissue at synapse level and simultaneous measurement of molecular information, thus enabling quantification of c...

www.nature.com

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Hanieh Falahati @haniehfalahati.bsky.social · Apr 20

It was my pleasure :)

Hanieh Falahati @haniehfalahati.bsky.social · Apr 19

Earlier this month I had the honor of interviewing Dr. Zoncu @robzonculab.bsky.social during his visit to Yale. It was so inspiring- and also fun! Here is a link: medicine.yale.edu/cellbio/news...

Meet our Speakers: Dr. Roberto Zoncu

As a scientist, starting from my postdoc and continuing in my own lab, we have helped redefine the role of the lysosome. Historically, it was considered a

medicine.yale.edu

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Reposted by Hanieh Falahati

De Camilli Lab @pdc-lab.bsky.social · Apr 10

"The bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage" out now in Nature Cell Biology
rdcu.be/ehbaL

The bridge-like lipid transport protein VPS13C/PARK23 mediates ER–lysosome contacts following lysosome damage

Nature Cell Biology - Wang et al. show the recruitment of the lipid channel protein VPS13C and formation of VPS13C-dependent contacts between endoplasmic reticulum and lysosomes after lysosomal...

rdcu.be

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Hanieh Falahati @haniehfalahati.bsky.social · Apr 10

Congratulations! Such an inspiring work 😊

Reposted by Hanieh Falahati

Casey Schneider-Mizell @csdashm.com · Apr 9

It's been done for a while, accepted almost a year ago, but I'm happy to share that my first analysis of the MICrONs cubic mm dataset is online! nature.com/articles/s41...

Inhibitory specificity from a connectomic census of mouse visual cortex - Nature

Using volumetric electron microscopy, the authors map and analyze the structure of cortical inhibition with synaptic resolution across a column of visual cortex.

nature.com

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Hanieh Falahati @haniehfalahati.bsky.social · Apr 8

When the 1st Muslim ban was about to go into effect, I was toward the end of my PhD. I went to Eric’s office in tears to ask if I could still defend my thesis and get a PhD if my legal status was revoked. I was lucky but I am heartbroken that this is actually happening to some students now

Hanieh Falahati @haniehfalahati.bsky.social · Apr 4

Random small reason to be happy: I have got 777 citations today 😄 my favorite number is 7

Reposted by Hanieh Falahati

jon ben-menachem @jbenmenachem.com · Apr 2

Princeton has announced that it is considering selling approximately $320 million of taxable bonds. The bonds are a way for the University to raise short-term funds. The major credit-rating agencies rate University bonds AAA, the highest level of creditworthiness.

Princeton considers issuing bonds same day as federal government pauses grants

The University announced its consideration to sell approximately $320 million of taxable bonds on Tuesday, following a notification from government agencies about the suspension of research grants.

www.dailyprincetonian.com

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Reposted by Hanieh Falahati

Cahir O'Kane @cahirokane.bsky.social · Apr 2

Like the cultural revolution, when anyone smarter than the regime was fired and sent to the countryside. Mao-Tse Trump.

Katie Phang @katiephang.bsky.social · Apr 2

“Dr. Richard Youle, a leading researcher in the field of neurodegenerative disorders…including identifying mechanisms behind Parkinson’s disease” was one of several top scientists PURGED from the NIH today courtesy of Trump/Musk/DOGE.

www.wired.com/story/doctor...

Doctor Behind Award-Winning Parkinson’s Research Among Scientists Purged From NIH

Leading scientists at the National Institutes of Health, the US’s leading medical research agency, were swept up Tuesday in the Trump administration’s latest firing blitz.

www.wired.com

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Hanieh Falahati @haniehfalahati.bsky.social · Apr 1

My condolences …

Reposted by Hanieh Falahati

Cahir O'Kane @cahirokane.bsky.social · Mar 31

Worth following @fly-broadcast.bsky.social for new fly papers on PubMed. They deserve a lot more than 50 followers!
@bdsc.bsky.social @flybase.bsky.social @fly-eds.bsky.social @dgrc.bsky.social

fly paper broadcast @fly-broadcast.bsky.social · Mar 31

PDZD8 promotes autophagy at ER-lysosome membrane contact sites to regulate activity-dependent synaptic growth
#Drosophila

PDZD8 promotes autophagy at ER-lysosome membrane contact sites to regulate activity-dependent synaptic growth #Drosophila

PubMed link

pubmed.ncbi.nlm.nih.gov

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Reposted by Hanieh Falahati

Carolyn Bertozzi @carolynbertozzi.bskyverified.social · Mar 26

Check out our new review on induced proximity modalities (#TPD and a lot more!) aimed cell surface targets @naturebiotech.bsky.social, spearheaded by postdocs Nick Till and "Rahm" Ramanathan

www.nature.com/articles/s41...

Induced proximity at the cell surface - Nature Biotechnology

Technologies to modulate induced proximity at the cell surface advance the manipulation of diverse biological responses.

www.nature.com

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Reposted by Hanieh Falahati

Joachim Frank @joachim123.bsky.social · Mar 24

regarding Columbia University, I just learned about this (anonymous) account of negotiations of the Hitler regime in the 1930s with Frankfurt University -- Germany's most prestigious university at the time:

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Hanieh Falahati @haniehfalahati.bsky.social · Mar 12

Oh thank you ☺️

Hanieh Falahati @haniehfalahati.bsky.social · Mar 11

In this belated, crazy, #EM_Monday I am posting an image I took showing some organellar communications at a neuronal soma: a mitochondria contacting nuclear envelope, and Golgi going all the way from nuclear envelope to plasma membrane.

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Reposted by Hanieh Falahati

Sydney E. Cason, PhD @sydneyecason.bsky.social · Mar 11

Honored to be featured this week by @yaleneuro.bsky.social in honor of my Life Sciences Research Foundation @hhmi.org fellowship!

Yale Neuroscience @yaleneuro.bsky.social · Mar 11

This week’s ✨ #TraineeTuesday ✨ is the incredible Sydney Cason, a postdoc in the De Camilli lab who was recently awarded the Life Sciences Research Foundation Postdoc Fellowship 🏆 for her work exploring lipid transfer in neurons!

Let’s dive into her journey! [1/5]

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Reposted by Hanieh Falahati

Mark Peifer (He, him) @peiferlabunc.bsky.social · Mar 1

In a remarkable new paper, Qureshi and Duss use multi-colour single-molecule fluorescence microscopy to directly and simultaneously track transcription, translation & coupling 3/n
www.nature.com/articles/s41...

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Reposted by Hanieh Falahati

Amir Haji-Akbari @hajiakbari.bsky.social · Feb 18

Thrilled & honored to be a recipient of a Sloan Fellowship in Chemistry. Thanks for my mentors, colleagues and most importantly my students, for making this possible. #SloanFellow.

Alfred P. Sloan Foundation @sloanfoundation.bsky.social · Feb 18

🎉Congrats to the 126 early-career scientists who have been awarded a Sloan Research Fellowship this year! These exceptional scholars are drawn from 51 institutions across the US and Canada, and represent the next generation of groundbreaking researchers. sloan.org/fellowships/...

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Hanieh Falahati @haniehfalahati.bsky.social · Feb 24

So proud of @hajiakbari.bsky.social!!
news.yale.edu/2025/02/19/f...

Four Yale faculty members win Sloan Research Fellowships

Yale’s Amir Haji-Akbari, Tristan Geiller, Ian Moult, and Shreya Saxena have received 2025 Sloan Research Fellowships, which recognize outstanding early-career scientists and scholars.

news.yale.edu

Hanieh Falahati @haniehfalahati.bsky.social · Feb 17

And then comes the firing of scientists…

Hanieh Falahati @haniehfalahati.bsky.social · Jan 29

This current freeze of research funds in US reminds me of Iran’s cultural revolution en.m.wikipedia.org/wiki/Cultura...

Cultural Revolution in Iran - Wikipedia

en.m.wikipedia.org