Lightnews — Scholar-powered news

Reposted by Michael Hanna

hanna-lab.bsky.social @hanna-lab.bsky.social · 1d

The Hanna lab has a website! 🖥️

Come check it out to see what we’ll be up to 😁

sites.psu.edu/hannalab

The Hanna Lab – Penn State Univeristy | Department of Biochemistry & Molecular Biology

sites.psu.edu

1 1

Michael Hanna @mike-hanna.bsky.social · 14d

Congrats on the fantastic work!

2

Reposted by Michael Hanna

Luis Bonet-Ponce @lysoluis.bsky.social · 14d

Much needed good news!! Our paper is just out in @jcb.org. We found a crazy antagonistic motor function that explains the elongation/retraction phenotype we see during LRRK2-dependent lysosomal tubulation. I am especially proud of Tsion, Nuria, Mia and Irene's contribution. Check it out!

Journal of Cell Biology @jcb.org · 14d

@lysoluis.bsky.social, @markrcookson.bsky.social et al. show how two distinct pRAB effectors and RHD members, JIP4 and RILPL1, provide antagonistic motor force to regulate #lysosome tubulation. rupress.org/jcb/article/...

1 6 11

Michael Hanna @mike-hanna.bsky.social · 26d

How delivery of new membrane lipids to lysosomes may limit or even repair damage remains unclear. This is a big emphasis for my future work!

Michael Hanna @mike-hanna.bsky.social · 26d

Loss of BLTP3A leads to increased lysosome fragility. Our working hypothesis is that CASM recruits BLTP3A to transfer lipids to damaged lysosomes in participation with other lipid transfer proteins.

1 1

Michael Hanna @mike-hanna.bsky.social · 26d

We find that BLTP3A, a lipid transfer protein structurally related to VPS13 and ATG2 proteins, plays a role in the response to lysosome damage as an effector of the CASM (conjugation of ATG8 to single membranes) pathway

1

Michael Hanna @mike-hanna.bsky.social · 26d

First, a special shout out to @helyrodriguez.bsky.social – a fantastic scientist who put in a tremendous effort on this manuscript

1 2

Michael Hanna @mike-hanna.bsky.social · 26d

New paper alert! I’m very excited to share our paper published in @embojournal.org! @pdc-lab.bsky.social @yaleneuro.bsky.social

The EMBO Journal @embojournal.org · 26d

Bridge-like lipid transfer protein 3A (BLTP3A) participates in endomembrane repair as an effector of #ATG8 conjugation to single membranes (CASM) - helping repair or minimize #lysosome damage
@mike-hanna.bsky.social et al, @pdc-lab.bsky.social
www.embopress.org/doi/full/10....

2 9 24

Reposted by Michael Hanna

Journal of Cell Biology @jcb.org · Sep 3

@anbangdai.bsky.social et al. @pdc-lab.bsky.social report the localization of BLTP2 in different human cell types & reveal binding partners that mediate its tethering to the PM & to PM-connected structures including certain #endosomes & #macropinosomes undergoing fusion rupress.org/jcb/article/...

6 10

Reposted by Michael Hanna

Aligning Science Across Parkinson's @asapresearch.parkinsonsroadmap.org · Aug 28

👏 We’re recognizing Ben Johnson (CRN Team De Camilli) as this month’s Open Science Champion!

Ben developed a color-coded Open Science compliance manual that makes ASAP policies easier to navigate and apply. Thank you for raising the bar for #OpenScience, Ben!

Check out the manual: bit.ly/46DuL6R

2 3

Reposted by Michael Hanna

Jeremy Baskin @jeremybaskin.bsky.social · Aug 25

Faculty opening in Cornell Chemistry at the Assistant Professor level in the area of chemical biology, broadly defined! academicjobsonline.org/ajo/jobs/30338 #chemjobs

Cornell University, Chemistry and Chemical Biology

Job #AJO30338, WDR-00054776 Assistant Professor - Chemistry and Chemical Biology, Cornell University (Ithaca, NY), Chemistry and Chemical Biology, Cornell University, Ithaca, New York, US

academicjobsonline.org

1 52 49

Reposted by Michael Hanna

Jeff Jones, PhD @jrjones.bsky.social · Jul 28

Thrilled to share that I’m starting my lab in the Department of Neuroscience at the University of Florida! We’ll study metabolism in brain aging to better understand Alzheimer’s disease. Excited to build, collab, and discover. Go Gators! 🐊
#Neuro #Aging #Alzheimers #UF
ufresearch.bsky.social‬

https://ufresearch.bsky.social‬

1 4

Reposted by Michael Hanna

Melanie McReynolds @drohsopretty.bsky.social · Jul 30

In a time as this— I am deeply thankful to be blessed with this honor. As a scientist and educator, the NSF CAREER award allows me to integrate the very core of who I am as a scientist and educator.

Forever grateful to past and present members of my lab for helping me accomplish this dream.

4 10 58

Reposted by Michael Hanna

Andrés Guillén Samander @aguillensamander.bsky.social · Jul 26

One for the Apicomplexa peeps:
ever wonder how does the IMC grow so fast during progeny formation? Where do all the lipids come from? In our latest work on malaria RBC stages we implicate this monster protein (~6000 residues!) and ER contact sites.
Happy+proud to share and keen to hear thoughts!

2 15 36

Michael Hanna @mike-hanna.bsky.social · Jul 26

Beautiful preprint from @aguillensamander.bsky.social who uncovered an essential role for a bridge-like lipid transfer protein (PfVPS13L1) on the growth of the inner membrane complex (IMC) in P. falciparum parasites: www.biorxiv.org/content/10.1...

A bridge-like lipid transfer protein is critical for generation of invasive stages in malaria parasites

Malaria blood stages build and maintain an intricate system of membranes during their cycle of rapid growth and schizogony (daughter-cell formation), requiring precise mechanisms of lipid synthesis an...

www.biorxiv.org

1 4

Michael Hanna @mike-hanna.bsky.social · Jul 1

Congrats, Anup!

1 1

Michael Hanna @mike-hanna.bsky.social · Jun 24

Check out this great new preprint by Sam Block et al. from @mvhlab.bsky.social @korylab.bsky.social uncovering how a range of neutral amino acids are transported in mitochondria www.biorxiv.org/content/10.1...

www.biorxiv.org

2