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Reposted by Jeff Jones, PhD

Elinne Becket, PhD @bielleogy.bsky.social · 9d

I'm still mad someone decided to call them H2A, H2B, H3, H4.

Jeff Jones, PhD @jrjones.bsky.social · Jul 28

Thrilled to share that I’m starting my lab in the Department of Neuroscience at the University of Florida! We’ll study metabolism in brain aging to better understand Alzheimer’s disease. Excited to build, collab, and discover. Go Gators! 🐊
#Neuro #Aging #Alzheimers #UF
ufresearch.bsky.social‬

https://ufresearch.bsky.social‬

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Reposted by Jeff Jones, PhD

ahellab.bsky.social @ahellab.bsky.social · Jul 10

A few years back we discovered a dual hybrid protein modification composed of ADP-ribose dinucleotide and ubiquitin (ADPr-Ub). Now we reveal that ADPr-Ub can be further ubiquitinated by the E3 ubiquitin ligase RNF114!
www.nature.com/articles/s41...

www.science.org/doi/10.1126/...

Identification of RNF114 as ADPr-Ub reader through non-hydrolysable ubiquitinated ADP-ribose - Nature Communications

Deltex E3s modify ADP-ribosylated targets with ubiquitin, creating a hybrid modification whose readers remains unknown. Here, the authors synthesise a non-hydrolysable probe that mimics the modificati...

www.nature.com

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Jeff Jones, PhD @jrjones.bsky.social · Jun 27

Reminds me the sentinels from The Matrix

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Jeff Jones, PhD @jrjones.bsky.social · Jun 23

"Take Me Back" is such a vibe

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Jeff Jones, PhD @jrjones.bsky.social · Jun 9

this is AI

Reposted by Jeff Jones, PhD

Eric Topol @erictopol.bsky.social · May 25

Front page, NYT today
Nothing has been proven to reverse Alzheimer’s disease, including this false claim
gift link www.nytimes.com/2025/05/21/w...

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Reposted by Jeff Jones, PhD

The Conversation U.S. @us.theconversation.com · May 18

The NSF helped fund the tech in your phone, the models that forecast deadly storms and 268 Nobel prize-winners.

The Trump Administration has proposed cutting its budget by 55% – and 1400+ grants are already terminated.

Unprecedented cuts to the National Science Foundation endanger research that improves economic growth, national security and your life

The Trump administration has terminated hundreds of federal grants that support engineering, biology, geology, computer science, STEM education and much more.

buff.ly

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Jeff Jones, PhD @jrjones.bsky.social · May 13

Great paper out today by my friend and colleague James Tucker! I'm hopeful that some of these scaffolds have therapeutic value.
www.sciencedirect.com/science/arti...

Scaffold hopping and sidechain modification from a flavone scaffold lead to discovery of potent, selective CK2A2 inhibitors with favorable properties for CNS activity

The human protein kinase CK2 has long been of interest as a target in oncology, but new evidence is emerging of its role in central nervous system (CN…

www.sciencedirect.com

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Reposted by Jeff Jones, PhD

Eric Topol @erictopol.bsky.social · May 4

Good summary of this important study linking blood pressure control and reduced dementia
www.nature.com/articles/s41...

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Jeff Jones, PhD @jrjones.bsky.social · Apr 29

spot on

Reposted by Jeff Jones, PhD

Astronomy 🔭 @astronomy.bsky.social · Apr 18

Albert Einstein died on this day, April 18, 1955.

It is incredible to hear Albert Einstein explain his famous formula, E=mc².

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Oregon 🕎🎲 @oregonthedm.bsky.social · Apr 9

Biggest commitment to a 3 second joke I've ever seen

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Jeff Jones, PhD @jrjones.bsky.social · Apr 1

My annual post for today:
In the era of rampant misinformation, April Fools just doesn't seem appropriate or funny

Jeff Jones, PhD @jrjones.bsky.social · Mar 31

Conda users will get this
Solving Environment: \

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Reposted by Jeff Jones, PhD

Mark Cuban @mcuban.bsky.social · Mar 22

From 2010 to 2016 (latest data I have ), NIH research contributed to EVERY drug approved by the FDA

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Jeff Jones, PhD @jrjones.bsky.social · Mar 20

What?

Reposted by Jeff Jones, PhD

Society for Neuroscience @sfn.org · Mar 18

Success often requires community support.

Discuss practical approaches to creating more accessible & inclusive research settings in this webinar w/ @umarchatterjee.bsky.social, Kimberly Fiock, PhD, Billie Goolsby, BA, @brittgratreak.bsky.social, & @dwwilliamslab.bsky.social.

#NeuroSky

SfN Neuronline Professional Development Webinar - Disabled in Neuroscience: Promoting Equitable and Accessible Research for All. March 19, noon-1:30 p.m. EDT. Colorful scientific image background.

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Eric Topol @erictopol.bsky.social · Mar 13

More than 2 decades ago the PINK1 protein was found to be linked to Parkinson's disease, but its structure and how it was activated was not known. Until @science.org today. A triumph for cryo-EM and structural biology, introducing new targets for drug intervention.
www.science.org/doi/10.1126/...

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Jeff Jones, PhD @jrjones.bsky.social · Mar 12

Yep! But if you had tick marks the effect wouldn't look as large at first glance

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Jeff Jones, PhD @jrjones.bsky.social · Mar 12

Strict regulations on money and religious influence on govt. Publicly funded elections, a random element to picking candidates and compulsory participation in elections / govt. Ranked choice voting. This would go a long way.

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Jeff Jones, PhD @jrjones.bsky.social · Mar 12

NYT gets to decide when to use a Y axis I guess.

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Jeff Jones, PhD @jrjones.bsky.social · Mar 11

He would see the entire world burn just to be the king of ashes

Reposted by Jeff Jones, PhD

Science Magazine @science.org · Mar 7

Breaking news: Thousands of researchers and their supporters, including recently fired federal workers, have gathered across the U.S. in response to layoffs and funding cuts ordered by the Trump administration. scim.ag/41zlPv4

Thousands gather across U.S. in Stand Up for Science events

Scientists rally across the country in response to layoffs and funding cuts ordered by the Trump administration

scim.ag

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Reposted by Jeff Jones, PhD

Technology Connections @techconnectify.bsky.social · Mar 3

A really clarifying question that I think should be asked of basically every politician out there is "what do you imagine power to be and why do you want it?"

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