Lightnews — Scholar-powered news

Reposted by Hattie Chung

Leif S. Ludwig @leifludwig.bsky.social · 14d

🚨 New preprints from our lab! First, we introduce Cryo-mtscATAC-seq, led by Maren (@ms-maren.bsky.social ), enabling high-throughput clonal tracing from frozen human samples by isolating nuclei with their mitochondria (“CryoCells”). 👉 www.biorxiv.org/content/10.1...

Cryo-mtscATAC-seq for single-cell mitochondrial DNA genotyping and clonal tracing in archived human tissues

High-throughput clonal tracing of primary human samples relies on naturally occurring barcodes, such as somatic mitochondrial DNA (mtDNA) mutations detected via single-cell ATAC-seq (mtscATAC-seq). Fr...

www.biorxiv.org

2 10 22

Reposted by Hattie Chung

Society for Developmental Biology @socdevbio.bsky.social · Aug 22

✨If Monet studied mouse ovaries 🎨 Stromal cells 💜 Follicular cells 🔵 and Fatty Cells 🟡. Together, they reveal the cellular architecture and functional zones of the ovary 🔬 Image provided by @shmimberly.bsky.social 🧪 #FluorescenceFriday #ReproductiveBiology

15 78

Hattie Chung @hattaca.bsky.social · Aug 21

I'm so sorry Anders 🤯

1

Reposted by Hattie Chung

Bluma Lesch @ambystoma22.bsky.social · Aug 20

New paper on the role of H3K4me3 at enhancers! We (led by Haoming Yu) used dCas9 epigenome editing to add H3K4me3 to intergenic enhancers. This was (1) sufficient to turn up transcription at open, active regions and (2) has no effect on target gene transcription. genesdev.cshlp.org/content/earl...

H3K4me3 amplifies transcription at intergenic active regulatory elements

A biweekly scientific journal publishing high-quality research in molecular biology and genetics, cancer biology, biochemistry, and related fields

genesdev.cshlp.org

3 33 83

Hattie Chung @hattaca.bsky.social · Aug 8

A world of possibilities contained in the ovary :)

1

Hattie Chung @hattaca.bsky.social · Aug 8

One of our favorite ovary images

1 7

Hattie Chung @hattaca.bsky.social · Aug 8

Our lab at Yale @yalemedicine.bsky.social seeks #postdocs with in vivo expertise to pioneer research at the intersection of tissue remodeling & aging. Work with us to uncover immunological & vascular drivers of ovarian aging, applying single-cell, spatial omics, and ML! jobrxiv.org/job/yale-uni...

Postdoctoral Fellow, Hattie Chung Lab (Yale School of Medicine)

Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

jobrxiv.org

1 8 10

Reposted by Hattie Chung

Paul Macklin @mathcancer.bsky.social · Jul 28

Really excited to share our new @cellpress.bsky.social Cell paper with @fertiglab.bsky.social and colleagues. 1/n

www.cell.com/cell/fulltex...

@jktgfoundation.bsky.social @itcrtraining.bsky.social @smbmathbiology.bsky.social #mathbio #mathonco @mathonco.bsky.social @deniswirtz.bsky.social

Human interpretable grammar encodes multicellular systems biology models to democratize virtual cell laboratories

We developed a plain text modeling language—a cell behavior hypothesis grammar—to easily build virtual cell models and connect them to data, helping scientists to unlock the hidden dynamics of tissues...

www.cell.com

3 20 55

Hattie Chung @hattaca.bsky.social · Aug 1

Thank you Jenn!!

Hattie Chung @hattaca.bsky.social · Aug 1

Thank you Haiqi!

1

Hattie Chung @hattaca.bsky.social · Jul 31

Excited to share that we've received an NIH R35 MIRA! This grant will support our work building tools to study how cell states change over space and time in disease. Grateful to our community, and especially the wonderful team I get to work with.

@yalecvrc.bsky.social

4 2 39

Reposted by Hattie Chung

Amy Diehl, Ph.D. @amydiehl.bsky.social · Jul 7

In a study of professors, women got 378 new work requests over 4 weeks vs 118 for men. Women spent more time on service, advising & teaching; men on research. Orgs should track who is taking extra duties & ensure they are rewarded and distributed fairly. www.forbes.com/sites/kimels...

Being Too Helpful At Work Can Hurt Your Career—Here’s How To Say No

Women are more likely to take on behind-the-scenes duties at work—extra tasks like onboarding or event planning—and it's hurting their careers. Here's how to say no.

www.forbes.com

31 600 1.5K

Reposted by Hattie Chung

Rita Strack @ritastrack.bsky.social · Jun 6

Pluripotent stem cells that differentiate into vascularized cardiac and hepatic organoids. Wow! www.science.org/doi/10.1126/...

Gastruloids enable modeling of the earliest stages of human cardiac and hepatic vascularization

Although model organisms have provided insight into the earliest stages of cardiac and hepatic vascularization, we know very little about this process in humans because of ethical restrictions and the...

www.science.org

8 30

Reposted by Hattie Chung

Eric Topol @erictopol.bsky.social · Jun 4

Microvascular obstruction is known to be a #LongCovid feature. Now a potential mechanism found for the obstruction induced by death of endothelial cells->sticky red blood cells. Which wouldn't respond to blood thinners or anti-platelet Rx
www.nature.com/articles/d41...
www.nature.com/articles/s41...

25 140 380

Reposted by Hattie Chung

Eric Topol @erictopol.bsky.social · Jun 2

Our ability to accurately determine an individual's risk for heart and vascular disease is getting transformed
—New A.I. transformer model
www.thelancet.com/journals/lan...
—Meta-prediction
www.nature.com/articles/s41...

3 18 94

Reposted by Hattie Chung

Lars Velten @larsplus.bsky.social · May 21

Out @nature.com: Clonal tracing with somatic epimutations

🧬 Single cell methylome encodes cell state & clonal identity

🔨 EPI-Clone reads out both (+mutations, +RNA) at scale

🩸 Clonal expansions of HSCs are universal from age 50, not driven by CH mutations

doi.org/10.1038/s415...
🧵

Clonal tracing with somatic epimutations reveals dynamics of blood ageing - Nature

The discovery that DNA methylation of different CpG sites can serve as digital barcodes of clonal identity led to the development of EPI-Clone, an algorithm that enables single-cell lineage tracing th...

doi.org

7 42 130

Reposted by Hattie Chung

Caroline Bartman @cbartman.bsky.social · May 20

title of assistant professor's talk: amino acid metabolism of effector T cells in LCMV infection

title of senior full professor's talk: Why do cells eat?

7 9 82

Reposted by Hattie Chung

Eric Topol @erictopol.bsky.social · May 10

Cells as living drugs is a big part of future medical approaches.
There's been so much about engineering T cells (CAR-T) for treatment of cancer and autoimmune diseases. But engineering macrophages (CAR-M) is next up for blocking inflammation.
www.nature.com/articles/s41...

Targeting inflammation with chimeric antigen receptor macrophages using a signal switch - Nature Biomedical Engineering

Anti-TNF CAR macrophages show anti-inflammatory efficacy in both acute and chronic inflammatory disease mouse models.

www.nature.com

2 40 190

Hattie Chung @hattaca.bsky.social · Apr 21

A wonderful interview with our @yalecvrc.bsky.social colleague Martin Schwartz! Where science is like art: learning to define your taste in questions

Itai Yanai @itaiyanai.bsky.social · Apr 21

In today's episode of the Night Science Podcast we talk with Martin Schwartz from Yale about the importance of stupidity in science: while learning science makes you feel smart, true scientific discovery often involves feeling stupid, because it means venturing into the unknown.

2 22

Reposted by Hattie Chung

Itai Yanai @itaiyanai.bsky.social · Apr 21

In today's episode of the Night Science Podcast we talk with Martin Schwartz from Yale about the importance of stupidity in science: while learning science makes you feel smart, true scientific discovery often involves feeling stupid, because it means venturing into the unknown.

3 56 200

Reposted by Hattie Chung

David van Dijk @vandijklab.bsky.social · Apr 18

What if LLMs could “read” & “write” biology? 🤔
Introducing C2S‑Scale—a Yale and Google collab: we scaled LLMs (up to 27B!) to analyze & generate single‑cell data 🧬 ➡️ 📝
🔗 Blog: research.google/blog/teachin...
🔗 Preprint: biorxiv.org/content/10.1...

Teaching machines the language of biology: Scaling large language models for next-generation single-cell analysis

research.google

2 9 17

Reposted by Hattie Chung

Paul Francois @pfrancois.bsky.social · Apr 14

As promised, a 'skeet' -orial on our paper published last week !

Cell - a Cell Press journal @cp-cell.bsky.social · Apr 11

Now online! Engineering TCR-controlled fuzzy logic into CAR T cells enhances therapeutic specificity

Engineering TCR-controlled fuzzy logic into CAR T cells enhances therapeutic specificity

Robot-assisted analysis and theoretical modeling of TCR/CAR crosstalk enable the design of adoptive T cell therapies that maximize anti-tumor activity and minimize toxicity in healthy tissues.

dlvr.it

1 10 29

Reposted by Hattie Chung

Albert Vilella, PhD. @albertvilella.bsky.social · Apr 16

Ranking of Variant Effect Predictor (VEP) in-silico tools from a recently published review, based on Relative performance with rate on MAVE data)
1. CPT-1 (Broad Institute)
2. AlphaMissense (Google DeepMind and cols.)
3. ESCOTT (Sorbonne/INSERM France)

4 23

Hattie Chung @hattaca.bsky.social · Apr 2

jobrxiv.org/job/yale-uni...

Postdoctoral Associate at Hattie Chung Lab

Post a job in 3min, or find thousands of job offers like this one at jobRxiv!

jobrxiv.org

Hattie Chung @hattaca.bsky.social · Apr 2

🚨 Job alert! 🚨
The Chung Lab @ Yale seeks a motivated, creative postdoc to examine tissue remodeling in health and disease. We study ovarian aging and cardiovascular disease in human samples and animal models. Passionate about single-cell, spatial genomics, machine learning & therapeutics? Join us!

1 7 9