Lightnews — Scholar-powered news

Reposted by hatzakislab

Achilles Kapanidis @achilleskap.bsky.social · 22d

What controls how/when growing RNA unblocks the "door" to exit RNA polymerase? Brilliant duo Anna Wang and Abhishek Majumder led a study in my lab - now out in NAR - on this. *Sequence* matters a lot! Read on... Super smFRET/dynamics work as well. Excited! academic.oup.com/nar/article/...

The displacement of the σ70 finger in initial transcription is highly heterogeneous and promoter-dependent

Abstract. Most bacterial sigma factors (σ) contain a highly conserved structural module, the ‘σ-finger’, which forms a loop that protrudes towards the RNA

academic.oup.com

5 13

Reposted by hatzakislab

DrLachie @drlachie.bsky.social · 22d

Check out the PyCon Au talk from my team member: @ishratz25.bsky.social on the challenges and solutions(?) of cell counting in whole-brain light sheet images! Also give her a follow, she's new here.
www.youtube.com/watch?v=ccLn...

"Big Brains, Small Targets: Whole-Brain Image Analysis with Python" - Ishrat Zaman (PyCon AU 2025)

YouTube video by PyCon AU

www.youtube.com

1 6 14

hatzakislab @hatzakislab.bsky.social · Jun 13

Thank you @krishnanyamuna.bsky.social

1

hatzakislab @hatzakislab.bsky.social · Jun 12

Yes indeed. That is exactly the feedback i got. So happy you could join us

1

Reposted by hatzakislab

Gerti Beliu @beliulab.bsky.social · Jun 12

Now it’s my turn! Excited to share our latest on GCE & click chemistry for live-cell and super-resolution microscopy 🧬🔬 From precise labeling to functional imaging — come by, join in, and let’s talk science! #CSSB25 #ClickChemistry #Bioimaging

@uniregensburg.bsky.social @uni-wuerzburg.de

1 2 11

hatzakislab @hatzakislab.bsky.social · Jun 12

What a fantastic (TED ) talk by @krishnanyamuna.bsky.social explain her trifecta of dna nanotech, chemistry and electrophysiology for ion transport in organelles You know a conference discussion is excellent when #keynote speaker actually uses the white board to explain . @isbuc.bsky.social

1 11

hatzakislab @hatzakislab.bsky.social · Jun 12

1st keynote talk of chemical solution to structural biology by #Nobel laureate Brian Kobilka. Fantastic conference organised by @isbuc.bsky.social and department of chemistry UCPH

1 8

hatzakislab @hatzakislab.bsky.social · Jun 12

Chemical solutions to structural biology kick off by #Nobel laureate Morten Meldal . So happy to organise and attend such a event
Check the amazing line up of speakers

isbuc.ku.dk/documents/CS...

1 2

hatzakislab @hatzakislab.bsky.social · Jun 11

Looking forward to have you here Sonja. Thank you for accepting our invitation

1 1

hatzakislab @hatzakislab.bsky.social · Jun 10

Very excited to attend the Mediterranean neuroscience meeting in chania, and present in the special event what we do in my lab in the #COE center of @novo-nordisk.bsky.social and the #nanopans project funded by @lundbeckfonden.bsky.social

#hatzakislab #machinelearning #singlemolecule

3

hatzakislab @hatzakislab.bsky.social · Jun 3

Sincere wishes for a swift recovery

1

hatzakislab @hatzakislab.bsky.social · Jun 2

Very excited to attend the #embo #febs lecture course and have a plenary on 4D microscopy and machine learning analysis of delivery of biologicals. A central part of the @coecenter.bsky.social funded by @novo-nordisk.bsky.social .

meetings.embo.org/event/25-phy...

Physical Virology: across length scales

!! Spam/phishing e-mails have been reported from some FEBS Advanced lecture courses. Please be alert and watch out for fraudulent emails offering to arrange registration, accommodation, or other ser…

meetings.embo.org

4

Reposted by hatzakislab

COE - Center for Optimized Oligo Escape and Control of Disease @coecenter.bsky.social · May 28

One more monthly COE meeting funded by the NNF Challenge Programme was held.

We discussed how material synthesized by KJJ lab are evaluated by all 3 groups and how #MachineLearning analysis by Hatzakis lab can propel #cardiomyocyte research of Carmos-Fonseca lab.

Hatzakis, KJJ, Kirchhausen and Carmo-Fonseca lab online on zoom.

KJJ and Hatzakis lab at the University of Copenhagen.

1 2

hatzakislab @hatzakislab.bsky.social · May 26

a fanstistc and long lasting collaboration with @kirchhausenlab.bsky.social spearheaded by @jacobkaestelhansen.bsky.social . the wok is funded by @novo-nordisk.bsky.social as well @villumfonden.bsky.social

hatzakislab @hatzakislab.bsky.social · May 26

See our recent article in @natmethods.nature.com on a machine learning model #DeepSPT to rapidly precisely and automatically analyze anomalous diffusion. The model predicted biological identity from diffusion alone indicating that motion beside structure defines function.

Nature Methods @natmethods.nature.com · May 8

Excited to announce this new paper from the Kirchhausen and Hatzakis labs on DeepSPT, a deep learning framework for single-particle/vesicle tracking. www.nature.com/articles/s41...

1 2 12

Reposted by hatzakislab

Nature Reviews Drug Discovery @natrevdrugdiscov.nature.com · Mar 21

For readers interested in siRNA drugs such as Alnylam's just-approved ATTR therapy vutrisiran, here's a comprehensive review
www.nature.com/articles/s41...
rdcu.be/eewvj

2 4

Reposted by hatzakislab

Steve Quinn @steve-quinn-lab.bsky.social · Mar 19

Blood biomarkers are beginning to revolutionize #Alzheimers diagnosis and have potential to offer early detection. Could emerging blood test technologies transform patiet care?

Check out my editorial, out now in @jprecmed.bsky.social
👇👇
tinyurl.com/nwk34t7k

#Biomarkers #Dementia #Diagnostics

The Urgent and Global Need for Democratized Blood-Based Biomarker Diagnostics in Alzheimer’s Disease

Alzheimer’s disease (AD) represents one of the most pressing healthcare challenges of the 21st century. As a leading cause of dementia, AD impacts over 55 million people worldwide, with this number pr...

tinyurl.com

2 1

hatzakislab @hatzakislab.bsky.social · Feb 21

Happy to see the great progress you guys are making

1

hatzakislab @hatzakislab.bsky.social · Feb 20

What a great few days in #bps2025. New interactions new collaborations and great times with a few of my group members

1 3

hatzakislab @hatzakislab.bsky.social · Feb 15

Excited to attend #bps2025 with multiple of my group members. Interested in #machinelearning single particle tracking ? Quantification of lipid nanoparticles heterogeneity in dimensions and mRNA loading ? Direct observation of #lnp entering cell ? Or single enzyme activity ? Just reach out

6

hatzakislab @hatzakislab.bsky.social · Feb 12

The registration Chemical solutions to structural biology symposium . Join us for 2 days and 30 speakers exploring state of the art science at the intersection of chemical and structural biology