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Reposted by Henry McSorley

Jason Shepherd @jasonsynaptic.bsky.social · 1d

#goals

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Reposted by Henry McSorley

Dr Rebecca Coll @colllab.bsky.social · 2d

Yay immunology! Tregs FTW! www.nobelprize.org/prizes/medic...

Nobel Prize in Physiology or Medicine 2025

The Nobel Prize in Physiology or Medicine 2025 was awarded to Mary E. Brunkow, Fred Ramsdell and Shimon Sakaguchi “for their discoveries concerning peripheral immune tolerance.”

www.nobelprize.org

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Henry McSorley @henrymcsorley.bsky.social · 11d

real bravery

eileen chengyin chow @chowleen.bsky.social · 11d

The South Korean Ministry of Defense has awarded medals of merit to 11 officers for disobeying direct orders of superiors during the martial law fiasco, orders that they deemed to be contrary to the constitution and endangerment to democracy.
www.chosun.com/english/nati...

National Defense Ministry Honors 11 Soldiers for Refusing Illegal Orders

National Defense Ministry Honors 11 Soldiers for Refusing Illegal Orders Honored for rejecting illegal orders during martial law, Marine death probe

www.chosun.com

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Henry McSorley @henrymcsorley.bsky.social · 11d

Done! 7 laps, 67 km. To be clear, the race is still going on, IM done. 3000 calories - could eat… strava.app.link/8fs8DA6u0Wb

Henry McSorley @henrymcsorley.bsky.social · 11d

A Marshall just shouted “only 3 hours left!” And the look I gave him did this.

a man wearing glasses and a hat is laughing with his tongue out

ALT: a man wearing glasses and a hat is laughing with his tongue out

media.tenor.com

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Henry McSorley @henrymcsorley.bsky.social · 11d

Lap 5 update

a man with a mustache is laying on a couch and says screaming

ALT: a man with a mustache is laying on a couch and says screaming

media.tenor.com

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Henry McSorley @henrymcsorley.bsky.social · 11d

Lap 4 update: oh no

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Henry McSorley @henrymcsorley.bsky.social · 11d

Currently done lap 3 and has gone exactly as above, with a major crash due to overexcitement. (Bike and rider are fine)
I plan to learn nothing from this.

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Henry McSorley @henrymcsorley.bsky.social · 11d

My usual performance goes:
Lap 1: take it slow, pace yourself.
Lap 2: why is everyone so SLOW? I’m bored, imma overtake this group, and the next…
Lap 3: imma do a hot lap!
Lap4: oh no. I’m exhausted. How long has that been? [hour 2 of 7]. Oh no.
Lap 5: screaming, crying, throwing up

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Henry McSorley @henrymcsorley.bsky.social · 11d

Doing the Glentress 7 today - 7h mountain bike race. I plan to become a machine which turns peanut butter and jam sandwiches into laps.

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Reposted by Henry McSorley

Tara Sutherland @drtesutherland.bsky.social · 13d

We're looking for a Lead Scientist to join Flow Cytometry Centre in Aberdeen! Fantastic opportunity to deliver services, work with varied research groups, promote cytometry and further develop the facility. Aberdeen is a great place to live/work- APPLY NOW www.abdnjobs.co.uk/vacancy/cyto...

Cytometry Facility Lead Scientist (IMS313A) | University of Aberdeen

A Lead Cytometry expert post is available for a highly motivated flow cytometrist to deliver cytometry services, promote and develop the Iain Fraser Cytometry Centre (IFCC). This post is for a highly...

www.abdnjobs.co.uk

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Henry McSorley @henrymcsorley.bsky.social · 13d

Thats where the story ends at the moment - we would love to look at the in vivo effects of HpBoRB against RELM-beta (does it suppress RELM-beta's activity?) but we ran out of time in Viv's PhD. If anyone has any interesting RELM-beta assays they would like to try HpBoRB in, hit us up!

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Henry McSorley @henrymcsorley.bsky.social · 13d

We then confirmed this binding in a number of ELISA, SPR and gel filtration assays - it is a high-affinity (subnanomolar) interaction.

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Henry McSorley @henrymcsorley.bsky.social · 13d

We screened the CCP domain protein family to see if there were other host immune factor binders, using an AVEXIS protein-protein interaction screen. The screen confirmed that HpBARI binds ST2, and that TGM1 binds TGFBR2 (reassuring) and identified one new hit - a protein which bound RELM-beta.

Screen of parasite proteins binding to a range of host immune proteins

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Henry McSorley @henrymcsorley.bsky.social · 13d

This story started when we realised that all of the immunomodulators we had identified from Hpb (HpARI, HpBARI and TGM) were related in their domain structure - all consist of strings of CCP domains. Turns out the CCP domain family is massively (and uniquely) expanded in the Hpb genome.

Graph showing number of CCP domain proteins in different helminth genomes - H. polygyrus bakeri is an outlier with far more CCP domain proteins than any other worm.

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Henry McSorley @henrymcsorley.bsky.social · 13d

Latest McSorley lab paper is out! Led by Vivien @vshek.bsky.social, this is a story about the immunomodulators from H. polygyrus bakeri (Hpb), and how their analysis led to the identification of HpBoRB, a secreted protein which binds host RELM-beta www.sciencedirect.com/science/arti...

Graphic abstract of paper showing the identification of HpBoRB, a worm protein which binds RELM-beta

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Henry McSorley @henrymcsorley.bsky.social · 16d

Congratulations Tara, brilliant work!

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Reposted by Henry McSorley

Tara Sutherland @drtesutherland.bsky.social · 16d

Extremely happy to see our work out in #ScienceImmunology. We show allergen-induced ECM remodelling occurs independently of IL-13 or IL-17 driven inflammation. Rather chitinase-like proteins drive airway ECM accumulation & inhibition of Ym1 can remarkably reverse it. www.science.org/doi/10.1126/...

Allergen-induced airway matrix remodeling in mice can be prevented or reversed by targeting chitinase-like proteins

Allergic airway matrix remodeling occurs independently of IL-13 and IL-17A and is driven instead by chitinase-like proteins.

www.science.org

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Reposted by Henry McSorley

Becky Dodd @becky-dodd.bsky.social · 19d

Allergen-induced airway matrix remodeling in mice can be prevented or reversed by targeting chitinase-like proteins | Science Immunology www.science.org/doi/10.1126/... 🎉🎉
@hetompkins.bsky.social @drtesutherland.bsky.social @mattoburgess.bsky.social @james-ep.bsky.social
@profjudiallen.bsky.social

Allergen-induced airway matrix remodeling in mice can be prevented or reversed by targeting chitinase-like proteins

Allergic airway matrix remodeling occurs independently of IL-13 and IL-17A and is driven instead by chitinase-like proteins.

www.science.org

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Reposted by Henry McSorley

Barack Obama @barackobama.bsky.social · 18d

In a moment like this, when tensions are high, part of the job of the president is to remind us of the ties that bind us together.

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Reposted by Henry McSorley

Chris Washington 🧛‍♂️ @cwashington.bsky.social · 20d

Japan has a wrestling camp for kids where at the end they have a show match in front of their parents to show off what they learned.

Thought you'd enjoy this.

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Reposted by Henry McSorley

Alex Rubinsteyn @alexr.bsky.social · 20d

Hominid re-diversification

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Reposted by Henry McSorley

Michelle says: Be kind. Always. ❤️ @snarkysillysad.bsky.social · 26d

Pangolin taking a mud bath: #AGoodPlace

Source: www.reddit.com/r/NatureIsFu...

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Reposted by Henry McSorley

Dr Joanne Power @hanniepower.bsky.social · 27d

Save the dates!! @bspparasitology.bsky.social Spring Meeting 2026 will be in Bonnie Glasgow! 7-9 April 2026, with a drinks reception in Glasgow City Chambers on the 6th of April 2026!
Keep an eye on the BSP website for registration and abstract submission!
Logo by @shannaraeilean.bsky.social! 🦟

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Henry McSorley @henrymcsorley.bsky.social · 29d

I have marked 6 MSc theses in 2 days and I cant read any more words. No more words thank you.

Or acronyms. Especially acronyms.

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