DNA replication requires precise coordination between DNA unwinding and DNA synthesis. In all domains of life, protein–protein interactions at the ...

Nobel prize winner shaped medicine, crimefighting and genealogy but later years marred by racist remarks James D Watson, whose co-discovery of the twisted-ladder structure of DNA in 1953 helped light the long fuse on a revolution in medicine, crimefighting, genealogy and ethics, has died, according to his former research lab. He was 97. The breakthrough – made when the brash, Chicago-born Watson was just 24 – turned him into a hallowed figure in the world of science for decades. But near the end of his life, he faced condemnation and professional censure for offensive remarks, including saying Black people were less intelligent than white people. Continue reading...

Koo et al. apply genome-scale double-CRISPRi to map cell envelope gene interactions in Bacillus subtilis, revealing >1,000 genetic interactions and uncovering gene networks in envelope biogenesis and ...

This Perspective introduces a framework for defining, measuring and reporting resolution in super-resolution microscopy and details the current state of the art in using fluorescence microscopy for st...

The ATP- and CTP-dependent ParA-ParB-parS segrosome is a macromolecular complex that segregates chromosomes/plasmids in most bacterial species. CTP...

Our ability to use engineered bacteria for cancer therapy is rapidly expanding. A survey of preclinical, clinical and commercial efforts provides an overview of the state of the field, revealing trend...