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hovestadt.bsky.social
volker hovestadt
@hovestadt.bsky.social
68 followers 75 following 2 posts
official account of the hovestadt lab @danafarber.bsky.social @bostonchildrens.bsky.social @broadinstitute.org. we study childhood brain tumors and leukemia using genomics and computational biology. learn more at https://hovestadtlab.github.io.
hovestadtlab.github.io.
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hovestadt.bsky.social
volker hovestadt @hovestadt.bsky.social · 16d
Please see our new study on acute leukemia diagnostics using @nanoporetech.com methylation profiling, now out in @natgenet.nature.com ! many thanks to everyone involved !! summary by brilliant med student @til-steinicke.bsky.social below 👇
til-steinicke.bsky.social
Til Steinicke @til-steinicke.bsky.social · 16d
Epigenetic diagnosis of acute leukemia within two hours from sample receipt 🚀

Very happy to share the results of a great collaboration between @hovestadt.bsky.social and Griffin Labs, I co-led with @sbenfatto.bsky.social, published today in @natgenet.nature.com
📄 www.nature.com/articles/s41...
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Rapid epigenomic classification of acute leukemia - Nature Genetics
The authors present a molecular classification of acute leukemia using 5-methylcytosine signatures, together with a neural network-based classifier for clinical use.
www.nature.com
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Reposted by volker hovestadt
scienceinboston.com
Science in Boston @scienceinboston.com · 5d
Drs. Volker Hovestadt and Gabriel Griffin at @danafarber.bsky.social have developed a groundbreaking diagnostic tool, called MARLIN, that could transform the way acute #leukemia is identified and treated.

⚙️ Press release: https://bit.ly/4pUDBEt
🧪 Abstract: https://go.nature.com/48ea16t
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Reposted by volker hovestadt
natureportfolio.nature.com
Nature Portfolio @natureportfolio.nature.com · 10d
A paper in Nature Genetics presents a framework for rapid acute leukemia classification that complements and enhances standard-of-care diagnostics. go.nature.com/3IInDfM #medsky 🧬 🧪
This is figure 1, which shows DNA methylation-based classification of acute leukemia.
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Reposted by volker hovestadt
smcgrath.phd
Scott McGrath @smcgrath.phd · 15d
Dana-Farber's MARLIN tool uses AI to classify acute leukemia via DNA methylation in under two hours. It's not just faster; it also resolves diagnostic "blind spots" by identifying new epigenetic classes and cryptic genetic events. #MedAI #MedSky 🧬💻
Diagnostic tool enables rapid leukemia subtype classification
Researchers at Dana-Farber Cancer Institute have developed a diagnostic tool that could transform the way acute leukemia is identified and treated. The tool, called MARLIN (Methylation- and AI-guided…
medicalxpress.com
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hovestadt.bsky.social
volker hovestadt @hovestadt.bsky.social · 16d
Please see our new study on acute leukemia diagnostics using @nanoporetech.com methylation profiling, now out in @natgenet.nature.com ! many thanks to everyone involved !! summary by brilliant med student @til-steinicke.bsky.social below 👇
til-steinicke.bsky.social
Til Steinicke @til-steinicke.bsky.social · 16d
Epigenetic diagnosis of acute leukemia within two hours from sample receipt 🚀

Very happy to share the results of a great collaboration between @hovestadt.bsky.social and Griffin Labs, I co-led with @sbenfatto.bsky.social, published today in @natgenet.nature.com
📄 www.nature.com/articles/s41...
🧵1/n
Rapid epigenomic classification of acute leukemia - Nature Genetics
The authors present a molecular classification of acute leukemia using 5-methylcytosine signatures, together with a neural network-based classifier for clinical use.
www.nature.com
2 14
Reposted by volker hovestadt
natcancer.nature.com
Nature Cancer @natcancer.nature.com · Jun 4
New ARTICLE now online!

'Cellular hierarchies of embryonal tumors with multilayered rosettes are shaped by oncogenic microRNAs and receptor–ligand interactions'

✏️By Mariella Fillbin and colleagues

🔗 www.nature.com/articles/s43...
Cellular hierarchies of embryonal tumors with multilayered rosettes are shaped by oncogenic microRNAs and receptor–ligand interactions - Nature Cancer
Beck et al. conducted single-cell and spatial profiling of embryonal tumors with multilayered rosettes, finding that malignant cellular hierarchies are driven by developmental programs and specific me...
www.nature.com
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Reposted by volker hovestadt
sciencex.bsky.social
Science X / Phys.org @sciencex.bsky.social · May 26
FDA-approved FGFR inhibitors demonstrate potential as targeted therapy for embryonal tumor with multilayered rosettes, a rare and aggressive pediatric brain cancer driven by unique genetic alterations. doi.org/g9mb9g
FDA-approved FGFR inhibitors show promise against rare and aggressive pediatric brain tumor
A study led by researchers at Dana-Farber/Boston Children's Cancer and Blood Disorders Center and the Broad Institute of MIT and Harvard has uncovered critical insights into the biology of embryonal tumor with multilayered rosettes (ETMR), a rare and aggressive brain tumor affecting young children.
medicalxpress.com
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hovestadt.bsky.social
volker hovestadt @hovestadt.bsky.social · May 27
first post on bluesky, and it's a big one: our single-cell study on ETMR, a terrible brain tumor that occurs in young children, now out in @natcancer.nature.com: www.nature.com/articles/s43.... tremendous effort by @alexbeck, @lisagblr.bsky.social and many others. please check it out!
Cellular hierarchies of embryonal tumors with multilayered rosettes are shaped by oncogenic microRNAs and receptor–ligand interactions - Nature Cancer
Beck et al. conducted single-cell and spatial profiling of embryonal tumors with multilayered rosettes, finding that malignant cellular hierarchies are driven by developmental programs and specific me...
www.nature.com
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