Jaiden Mazefsky
@jaidenmaze.bsky.social
Student Pharmacist at University of Pittsburgh School of Pharmacy 💊
New strategies for a vexing problem: injectables to the rescue for people with Multidrug-Resistant HIV
✅ Just Accepted
🔗 https://bit.ly/4ovrYCU
✅ Just Accepted
🔗 https://bit.ly/4ovrYCU
November 10, 2025 at 3:38 AM
Emerging Risk of Campylobacter spp. Infection Associated with Anti-BCMA and Anti-GPRC5D Bispecific Antibodies
✅ Just Accepted
🔗 https://bit.ly/3LsCGeP
✅ Just Accepted
🔗 https://bit.ly/3LsCGeP
November 10, 2025 at 3:38 AM
New Research
Long-term consequences of monkeypox virus infection or modified vaccinia virus Ankara vaccination in Belgium (MPX-COHORT and POQS-FU-PLUS): a 24-month prospective and retrospective cohort study
www.thelancet.com/journals/lan...
Long-term consequences of monkeypox virus infection or modified vaccinia virus Ankara vaccination in Belgium (MPX-COHORT and POQS-FU-PLUS): a 24-month prospective and retrospective cohort study
www.thelancet.com/journals/lan...
Long-term consequences of monkeypox virus infection or modified vaccinia virus Ankara vaccination in Belgium (MPX-COHORT and POQS-FU-PLUS): a 24-month prospective and retrospective cohort study
Individuals previously infected with MPXV show strong and durable immunological memory
lasting up to 2 years after infection, in contrast to the less robust and shorter-lived
response observed after M...
www.thelancet.com
November 10, 2025 at 3:37 AM
Insights into the Role of Rifampicin Exposure and Clinical Baseline Covariates on the Response to Pulmonary Tuberculosis Treatment
✅ Just Accepted
#IDSky
🔗 https://bit.ly/3Ws4x0Q
✅ Just Accepted
#IDSky
🔗 https://bit.ly/3Ws4x0Q
November 4, 2025 at 6:17 PM
Consequences of Delaying Surgical Intervention in Patients with Native Joint Septic Arthritis
✅ Just Accepted
#IDSky
✅ Just Accepted
#IDSky
Consequences of Delaying Surgical Intervention in Patients with Native Joint Septic Arthritis
AbstractBackground. Although recent guidance recommends early surgical debridement for native joint septic arthritis (NJSA), supporting data, particularly
bit.ly
November 4, 2025 at 6:09 PM
Resistance Analyses of Lenacapavir, Emtricitabine/Tenofovir Alafenamide and Emtricitabine/Tenofovir Disoproxil Fumarate in the PURPOSE 1 and 2 Studies
✅ Just Accepted
#IDSky
🔗 https://bit.ly/4og9whx
✅ Just Accepted
#IDSky
🔗 https://bit.ly/4og9whx
October 29, 2025 at 12:56 AM
A Quality Improvement Pilot to Increase Hepatitis B Screening and Optimize Patient Selection for Switch to Two-Drug Antiretroviral Regimens in People with HIV
✅ Just Accepted
#IDSky
🔗 https://bit.ly/48QNZqJ
✅ Just Accepted
#IDSky
🔗 https://bit.ly/48QNZqJ
October 29, 2025 at 12:56 AM
Community-acquired pneumonia is the leading infectious cause of morbidity and mortality globally.
Yet, there are several challenges associated with diagnosis, treatment, and long-term management of Community-acquired pneumonia.
Find out more in a new Seminar: tinyurl.com/hd2fwz7n
Yet, there are several challenges associated with diagnosis, treatment, and long-term management of Community-acquired pneumonia.
Find out more in a new Seminar: tinyurl.com/hd2fwz7n
October 23, 2025 at 12:01 AM
Effects of Semaglutide on Cognitive Function in People with HIV: A Randomized Controlled Trial
✅ Just Accepted
#IDSky
✅ Just Accepted
#IDSky
Effects of Semaglutide on Cognitive Function in People with HIV: A Randomized Controlled Trial
AbstractBackground. People with HIV (PWH) are at higher risk for visceral adiposity, enhanced inflammation, and cognitive decline than HIV-negative control
bit.ly
October 22, 2025 at 11:59 PM
Long-term clinical, immunologic, and viral reservoir outcomes in children treated with VRC01LS and 10-1074 monoclonal antibodies in the Tatelo Study
✅ Just Accepted
#IDSky
🔗 https://bit.ly/3WF11QL
✅ Just Accepted
#IDSky
🔗 https://bit.ly/3WF11QL
October 17, 2025 at 11:11 AM
Single-cell transcriptome profiling reveals the immune dysregulation characteristics of mice infected by Brucella abortus
✅ Just Accepted
#IDSky
🔗 https://bit.ly/4nPugfH
✅ Just Accepted
#IDSky
🔗 https://bit.ly/4nPugfH
October 17, 2025 at 11:10 AM
Pregnancy doubles the risk of severe COVID-19.
Infants < 6 months old have approx = risk of severe disease as those 65-74 yrs old.
➡️ Pregnancy = priority for COVID 💉
Modeling the Health Impact of Discontinuing COVID-19 Vaccination During Pregnancy in the US : jamanetwork.com/journals/jam...
Infants < 6 months old have approx = risk of severe disease as those 65-74 yrs old.
➡️ Pregnancy = priority for COVID 💉
Modeling the Health Impact of Discontinuing COVID-19 Vaccination During Pregnancy in the US : jamanetwork.com/journals/jam...
Modeling the Health Impact of Discontinuing COVID-19 Vaccination During Pregnancy in the US
This decision analytical model study estimates the number of avertable COVID-19 hospitalizations in US infants younger than 6 months and pregnant persons with vaccinations during pregnancy.
jamanetwork.com
October 13, 2025 at 11:26 PM
Exploring the interaction between injection site and biological sex on the real-world population pharmacokinetics of long acting cabotegravir and rilpirivine in people living with HIV
✅ Just Accepted
#IDSky
🔗 https://bit.ly/4obm2ya
✅ Just Accepted
#IDSky
🔗 https://bit.ly/4obm2ya
October 13, 2025 at 11:25 PM
Whole genome sequencing of hepatitis B virus genotypes E and A in Zambia reveals limited viral diversity in HIV coinfection
✅ Just Accepted
#IDSky
🔗 https://bit.ly/4mTnDHV
✅ Just Accepted
#IDSky
🔗 https://bit.ly/4mTnDHV
October 13, 2025 at 11:25 PM
Noninferiority Study of Purified Vero Rabies Vaccine—Serum Free in 3-dose and 2-dose Preexposure Prophylaxis Regimens in Comparison With Licensed Rabies Vaccines
#IDSky
#IDSky
Validate UserNoninferiority Study of Purified Vero Rabies Vaccine—Serum Free in 3-dose and 2-dose Preexposure Prophylaxis Regimens in Comparison With Licensed Rabies Vaccines
A next-generation, serum-free, highly purified Vero cell rabies vaccine, PVRV-NG2, is in development.
bit.ly
October 13, 2025 at 11:24 PM
Reducing Household Tuberculosis Transmission: A Pilot Cluster-Randomized Controlled Trial
✅ Just Accepted
#IDSky
🔗 https://bit.ly/4gPh0oz
✅ Just Accepted
#IDSky
🔗 https://bit.ly/4gPh0oz
Reducing Household Tuberculosis Transmission: A Pilot Cluster-Randomized Controlled Trial
AbstractBackground. The duration of infectiousness following pulmonary tuberculosis treatment initiation remains uncertain. We aimed to assess whether a bu
bit.ly
September 30, 2025 at 7:30 PM
Real-world prevalence of non-integrase InSTI resistance-associated mutations and virological outcomes in people who have recently acquired HIV-1 in the UK
✅ Just Accepted
#IDSky
🔗 https://bit.ly/4pIP2Pr
✅ Just Accepted
#IDSky
🔗 https://bit.ly/4pIP2Pr
Real-world prevalence of non-integrase InSTI resistance-associated mutations and virological outcomes in people who have recently acquired HIV-1 in the UK
Integrase strand transfer inhibitors(INSTIs) are the mainstay of antiretroviral therapy(ART) globally. Virological breakthrough is uncommon but often manifests as low level viraemia and only 50% of cases have identified drug resistance mutations in the integrase gene.
bit.ly
September 30, 2025 at 7:29 PM
SLC22A1 Resists Hepatitis B Virus by Activating the JAK/STAT Pathway and Predicts the Effect of Pegylated Interferon α–Based Therapy on Chronic Hepatitis B
#IDSky
#IDSky
SLC22A1 Resists Hepatitis B Virus by Activating the JAK/STAT Pathway and Predicts the Effect of Pegylated Interferon α–Based Therapy on Chronic Hepatitis B
The association between SLC22A1 and chronic hepatitis B (CHB) was elucidated. Hepatitis B virus (HBV) down-regulated SLC22A1, which in turn suppressed HBV
bit.ly
September 22, 2025 at 2:29 PM
Streptococcus pyogenes Surveillance Through Surface Swab Samples to Track the Emergence of Streptococcal Toxic Shock Syndrome in Rural Japan
#IDSky
#IDSky
Streptococcus pyogenes Surveillance Through Surface Swab Samples to Track the Emergence of Streptococcal Toxic Shock Syndrome in Rural Japan
Japan recently experienced a record surge in streptococcal toxic shock syndrome. Our environmental surveillance study reveals that Streptococcus pyogenes persists seasonally, peaking in autumn and winter in rural Japan.
bit.ly
September 22, 2025 at 2:28 PM
Annual Variant-Targeted Vaccination to Prevent Severe COVID-19 in Cohorts With Vaccine-Derived and Hybrid Immunity
#IDSky
#IDSky
Annual Variant-Targeted Vaccination to Prevent Severe COVID-19 in Cohorts With Vaccine-Derived and Hybrid Immunity
Among US Veterans with hybrid immunity for COVID-19, annual variant-targeted booster vaccination yielded modest but significant gains in protection against
bit.ly
September 18, 2025 at 2:00 PM
Using the antibiotic doxycycline used as post-exposure & pre-exposure prophylaxis (doxyPEP/PrEP) can prevent #STI
Even though it's currently not recommended in the Netherlands, 15% of 1,633 survey participants stated recent informal use without prescription
#SexualHealth #IDSky #AMR #PublicHealth
Even though it's currently not recommended in the Netherlands, 15% of 1,633 survey participants stated recent informal use without prescription
#SexualHealth #IDSky #AMR #PublicHealth
Benefits and risks: informal use of antibiotics to prevent sexually transmitted infections on the rise in key populations in the Netherlands
Survey data from the Netherlands show high interest and intention to use antibiotics to prevent sexually transmitted infections (STIs). A new approach to prevent bacterial sexually transmitted infecti...
www.eurekalert.org
September 18, 2025 at 1:59 PM
Systematic #Corticosteroids Treatment Among Patients With #HIV and #Tuberculosis: This meta-analysis of 1410 HIV-positive TB patinete found that corticosteroid treatment neither significantly reduced all-cause mortality nor increased serious adverse events.
url: academic.oup.com/cid/article-...
url: academic.oup.com/cid/article-...
Efficacy and Safety of Systematic Corticosteroids Treatment Among Patients With HIV and Tuberculosis: A Systematic Review and Meta-analysis of Randomized Controlled Trials
This meta-analysis demonstrated corticosteroid treatment neither significantly reduced all-cause mortality nor increased serious adverse events.
academic.oup.com
September 12, 2025 at 1:37 PM
Linezolid (n=43) vs Clinda + Vanc (n=199) for NSTI
No difference in # of surgical debridements between groups nor AKI, ICU LOS, antibiotic duration
No reporting on mortality or CDiff?
Always happy to see more on this topic!
#IDSky #TeamLinezolidNow 💰
www.liebertpub.com/doi/abs/10.1...
No difference in # of surgical debridements between groups nor AKI, ICU LOS, antibiotic duration
No reporting on mortality or CDiff?
Always happy to see more on this topic!
#IDSky #TeamLinezolidNow 💰
www.liebertpub.com/doi/abs/10.1...
Assessment of Therapeutic Approaches: Necrotizing Soft Tissue Infections and the Choice Between Vancomycin + Clindamycin and Linezolid | Surgical Infections
Background: Necrotizing skin and soft tissue infections (NSTIs) are life threatening, requiring antibiotic agents and surgical intervention. Clindamycin or linezolid is recommended as an adjunct thera...
www.liebertpub.com
September 12, 2025 at 1:35 PM
Osivax is developing a vaccine candidate that could be effective against all strains of the influenza A virus. cen.acs.org/pharmaceutic... #chemsky 🧪
BARDA provides Osivax with $19.5 million for universal flu vaccine
Despite US pushback on vaccines, the government research agency is preparing for a potential influenza pandemic
cen.acs.org
September 9, 2025 at 2:59 AM
Development of a comprehensive program for the early diagnosis and treatment of severe infections in a tertiary hospital in Spain
✅ Just Accepted
#IDSky
✅ Just Accepted
#IDSky
Development of a comprehensive program for the early diagnosis and treatment of severe infections in a tertiary hospital in Spain
To assess the impact of the Rapid Diagnosis and Treatment of Severe Infections (rDTSI) program on diagnostic and clinical outcomes in patients with severe infections.
bit.ly
September 9, 2025 at 2:58 AM