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James Gagnon

@james-gagnon.bsky.social

450 followers 400 following 40 posts

I'm an associate professor @UofUBiology, Utah, USA gagnonlab.org | fish stuff in and out of the tank

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James Gagnon @james-gagnon.bsky.social · Jun 2

To dissect the gene regulatory networks used to build organisms, we need Perturb-seq-like tools that work in whole animals.

For this purpose, we developed MIC-Drop-seq, a tool that couples high-throughput CRISPR in zebrafish embryos with single-cell RNAseq.

www.biorxiv.org/content/10.1...

MIC-Drop-seq: Scalable single-cell phenotyping of mutant vertebrate embryos

Pooled perturbation screens can reveal cellular regulatory networks, yet scaling these techniques for large-scale screens in animals remains challenging. To address this, we developed MIC-Drop-seq, wh...

www.biorxiv.org

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Reposted by James Gagnon

Matthew Neville @mattneville.bsky.social · 20h

Now published! Our paper on:
(1) Accurate sequencing of sperm at scale
(2) Positive selection of spermatogenesis driver mutations across the exome
(3) Offspring disease risks from male reproductive aging
[1/n]
www.nature.com/articles/s41...

Sperm sequencing reveals extensive positive selection in the male germline - Nature

A combination of whole-genome NanoSeq with deep whole-exome and targeted NanoSeq is used to accurately characterize mutation rates and genes under positive selection in sperm cells.

www.nature.com

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James Gagnon @james-gagnon.bsky.social · 8d

Awesome, congratulations!

James Gagnon @james-gagnon.bsky.social · 8d

we will find out ...

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James Gagnon @james-gagnon.bsky.social · 8d

FY2023
NIGMS R01 23.2% funded
NIGMS R35 53.1% funded

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Reposted by James Gagnon

D. Allan Drummond @dadrummond.art · 8d

Cat flea, homage to Hooke. Micron in Moleskine. 🔬🖊️

A cat flea in mid-jump, drawn with Micron pens using a crosshatched technique. The drawing is in a sketchbook, which is on a wooden table with glasses, pens, and eraser next to it.

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James Gagnon @james-gagnon.bsky.social · 8d

You can get denominators from Table 205A.

FY2024
NIGMS R01 14.4% funded
NIGMS R35 49.7% funded

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Reposted by James Gagnon

Josh Currie @joshcurrie.bsky.social · 20d

💥OUR LAB IS HIRING!!💥

We are hiring a research assistant/lab manager to assist with managing our axolotl colony and enabling some kick-ass science! Looking for high levels of organization, collaboration, problem solving and curiosity.

Application link: tinyurl.com/3tpvphpm
#SciJob #JobAlert

One of your future coworkers in the Currie Lab, an adorable axolotl.

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Reposted by James Gagnon

Mathieu Preußner @mathpreu.bsky.social · 21d

1🧵
Excited to share my first PhD paper, published in @dev-journal.bsky.social
What if fish gills —often overlook —hold secrets about development, patterning, and function?
We uncovered how early patterning shapes adult gill architecture.
journals.biologists.com/dev/article/...

#DevBio #Zebrafish

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Reposted by James Gagnon

Martin Haesemeyer @haesemeyerlab.bsky.social · 22d

Come be my colleague in the department of neuroscience at OSU. We are hiring for an open rank tenure track faculty position in several focus areas.

neurojobs.sfn.org/job/39081/te...

Tenure-track faculty positions in Neuroscience - Columbus, Ohio job with The Ohio State University, Dept of Neuroscience | 39081

Faculty studying mechanisms underlying normal nervous system function and/or how these mechanisms and interactions are affected by disease or injury

neurojobs.sfn.org

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Reposted by James Gagnon

pikaole @pikaole.bsky.social · Sep 2

Just keep thinking about fish

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Reposted by James Gagnon

Maxwell Shafer @maxshafer.bsky.social · Aug 28

Now published @natecoevo.nature.com with @annika-nichols.bsky.social, our latest on the evolution of 𝘴𝘭𝘦𝘦𝘱 across 𝟲𝟬 𝘀𝗽𝗲𝗰𝗶𝗲𝘀 of cichlid fishes! doi.org/10.1038/s415...
with members of the @schierlab.bsky.social and Salzburger labs, as well as the burgeoning Shafer lab @uoftcellsysbiol.bsky.social

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James Gagnon @james-gagnon.bsky.social · Aug 22

Welcome back!!! Let me know if you'd like to get a coffee any time, I'm on sabbatical in Human Genetics, one building over :)

James Gagnon @james-gagnon.bsky.social · Jul 31

I must have watched this a hundred times over the years. So good

James Gagnon @james-gagnon.bsky.social · Jul 31

maybe that is cheating with a cartoon

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James Gagnon @james-gagnon.bsky.social · Jul 31

Ooo fun! How about hox conservation

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James Gagnon @james-gagnon.bsky.social · Jul 18

Woo! Keep up the great work !

Reposted by James Gagnon

The Salt Lake Tribune @sltrib.com · Jul 8

Proposed cuts to the National Institutes of Health and the National Science Foundation “would cause immense and largely irreversible damage to the successful American scientific enterprise,” write Jerry Kaplan and Dana Carroll in an op-ed.

Voices: Federal funding cuts to genetic research will be devastating for years to come

www.sltrib.com

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James Gagnon @james-gagnon.bsky.social · Jul 8

Woohoo congratulations!!! This is so exciting! Let me know if you need anything or visit before January!!

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James Gagnon @james-gagnon.bsky.social · Jun 26

You Rock, Kevin 🐟

James Gagnon @james-gagnon.bsky.social · Jun 24

but did you get the proofs back in time????

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Reposted by James Gagnon

John Murray @jisaacmurray.bsky.social · Jun 20

Happy to announce our paper comparing embryonic gene expression between C. elegans and C. briggsae, work led by Christopher Large with Rupa Khanal and in collaboration with Junhyong Kim and Bob Waterston. www.science.org/doi/10.1126/...

Lineage-resolved analysis of embryonic gene expression evolution in C. elegans and C. briggsae

The constraints that govern the evolution of gene expression patterns across development remain unclear. Single-cell RNA sequencing can detail these constraints by systematically profiling homologous ...

www.science.org

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James Gagnon @james-gagnon.bsky.social · Jun 11

haha congrats! a win

James Gagnon @james-gagnon.bsky.social · Jun 5

Welcome to Utah!! I'm psyched you are joining us.

Reposted by James Gagnon

International Zebrafish Society @izfs.bsky.social · Jun 3

We are excited to announce the winner of the Chi-Bin Chien Award, Dr. Victoria Deneke! See more about Dr. Deneke and the CBC Award here: www.izfs.org/news/congrat...

@impvienna.bsky.social @vdeneke.bsky.social

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James Gagnon @james-gagnon.bsky.social · Jun 3

🎤🫳 !!!