Jamie Sugrue
@jamiesugrue.bsky.social
Visiting Scientist at the Page Lab, Whitehead Institute, MIT | MSCA funded postdoc at Institut Pasteur, Paris | Interferons | Systems Immunology | Data analytics
Reposted by Jamie Sugrue
7/ 📖 Monogenic disorders of immunity: Common variants are not so rare
Cell Genomics (2025)
🔗 www.cell.com/cell-genomic...
#Immunology #HumanGenetics #InbornErrorsOfImmunity #IEI #Genomics #PopulationGenetics #PrecisionMedicine
Cell Genomics (2025)
🔗 www.cell.com/cell-genomic...
#Immunology #HumanGenetics #InbornErrorsOfImmunity #IEI #Genomics #PopulationGenetics #PrecisionMedicine
Monogenic disorders of immunity: Common variants are not so rare
While monogenic disorders of immunity typically involve rare alleles, some arise from
alleles common in specific populations. Examples include IFNAR1/2 null alleles in
the Arctic/Pacific and PTCRA hyp...
www.cell.com
January 9, 2026 at 3:13 PM
7/ 📖 Monogenic disorders of immunity: Common variants are not so rare
Cell Genomics (2025)
🔗 www.cell.com/cell-genomic...
#Immunology #HumanGenetics #InbornErrorsOfImmunity #IEI #Genomics #PopulationGenetics #PrecisionMedicine
Cell Genomics (2025)
🔗 www.cell.com/cell-genomic...
#Immunology #HumanGenetics #InbornErrorsOfImmunity #IEI #Genomics #PopulationGenetics #PrecisionMedicine
Reposted by Jamie Sugrue
💥New paper alert!💥 What’s better than starting 2026 with an @annualreviews.bsky.social #Immunology, often a once-in-a-life honor ❤️?! Check it out if you want to know everything about type III interferons #IFN! Thanks to my wonderful team for their amazing work 🤗 doi.org/10.1146/annu...
Molecular, Cellular, Tissue, and Organismal Functions of Type III Interferons
Type III interferons are essential immune mediators playing pleiotropic roles during health and disease. In this review, we highlight the molecular and cellular pathways that lead to the production of...
doi.org
January 5, 2026 at 5:50 PM
💥New paper alert!💥 What’s better than starting 2026 with an @annualreviews.bsky.social #Immunology, often a once-in-a-life honor ❤️?! Check it out if you want to know everything about type III interferons #IFN! Thanks to my wonderful team for their amazing work 🤗 doi.org/10.1146/annu...
Reposted by Jamie Sugrue
🫀 How do we recreate organs in labs to study diseases?
Discover organoids research at Institut Pasteur
📅 Jan 26, 2026 | 9:20AM-6PM
📍 Paris | Free, registration required
Register: www.eventbrite.fr/e/translatio...
#Organoid #TranslationalResearch
Discover organoids research at Institut Pasteur
📅 Jan 26, 2026 | 9:20AM-6PM
📍 Paris | Free, registration required
Register: www.eventbrite.fr/e/translatio...
#Organoid #TranslationalResearch
January 6, 2026 at 1:55 PM
🫀 How do we recreate organs in labs to study diseases?
Discover organoids research at Institut Pasteur
📅 Jan 26, 2026 | 9:20AM-6PM
📍 Paris | Free, registration required
Register: www.eventbrite.fr/e/translatio...
#Organoid #TranslationalResearch
Discover organoids research at Institut Pasteur
📅 Jan 26, 2026 | 9:20AM-6PM
📍 Paris | Free, registration required
Register: www.eventbrite.fr/e/translatio...
#Organoid #TranslationalResearch
Reposted by Jamie Sugrue
Hadrian’s Wall meets Montezuma’s Revenge.
Ancient Romans Guarding Hadrian’s Wall Were Riddled with Worms and Parasites
Romans living in ancient Britain were plagued by intestinal parasites, all of which are spread by fecal contamination
www.scientificamerican.com
December 23, 2025 at 9:35 PM
Hadrian’s Wall meets Montezuma’s Revenge.
Reposted by Jamie Sugrue
New preprint from our lab, spearheaded by @maelledaunesse.bsky.social and in collaboration with Diego Villar!
In which we ask, can we detect joint signatures suggestive of positive selection on transcriptomes and epigenomes?
In which we ask, can we detect joint signatures suggestive of positive selection on transcriptomes and epigenomes?
We've just released our new preprint! 🐀✨
doi.org/10.1101/2025...
How do gene expression and regulation evolve during adaptation? And how can we tell adaptive shifts apart from simple drift?
@camilleberthelot.bsky.social
👇 A short thread on what we found in African mole-rats.
doi.org/10.1101/2025...
How do gene expression and regulation evolve during adaptation? And how can we tell adaptive shifts apart from simple drift?
@camilleberthelot.bsky.social
👇 A short thread on what we found in African mole-rats.
Coordinated shifts in gene expression and regulation during mole-rat evolution
Changes in gene expression and regulation are central to mammalian phenotypic evolution. Yet, distinguishing adaptive gene expression shifts from neutral divergence remains challenging. Here, we integ...
doi.org
December 4, 2025 at 4:50 PM
New preprint from our lab, spearheaded by @maelledaunesse.bsky.social and in collaboration with Diego Villar!
In which we ask, can we detect joint signatures suggestive of positive selection on transcriptomes and epigenomes?
In which we ask, can we detect joint signatures suggestive of positive selection on transcriptomes and epigenomes?
Reposted by Jamie Sugrue
🏃♂️ 60 Pasteuriens sur la ligne de départ des 20km de Paris ce dimanche !
Depuis 17 ans, ils courent pour porter les valeurs de la recherche : persévérance, engagement, dépassement de soi.
#20kmDeParis #Pasteurdon
Depuis 17 ans, ils courent pour porter les valeurs de la recherche : persévérance, engagement, dépassement de soi.
#20kmDeParis #Pasteurdon
October 10, 2025 at 8:18 AM
🏃♂️ 60 Pasteuriens sur la ligne de départ des 20km de Paris ce dimanche !
Depuis 17 ans, ils courent pour porter les valeurs de la recherche : persévérance, engagement, dépassement de soi.
#20kmDeParis #Pasteurdon
Depuis 17 ans, ils courent pour porter les valeurs de la recherche : persévérance, engagement, dépassement de soi.
#20kmDeParis #Pasteurdon
Reposted by Jamie Sugrue
The American Association of Immunologists AAI meeting will be in Boston, April 15-19, 2026. Come join me and @chrysothemisbrown.bsky.social at this exciting Symposium on Early life immune development. Submit your abstracts by October 15th! immunology2026.aai.org/session/earl...
Early Life Immune Development and Function - IMMUNOLOGY2026™
Time: 8:00 - 11:30 AM Chairs: Chrysothemis C. Brown, Memorial Sloan Kettering Cancer Ctr., USA Petter Brodin, Imperial Col. London and Karolinska Inst., GBR, SWE
immunology2026.aai.org
September 22, 2025 at 3:23 PM
The American Association of Immunologists AAI meeting will be in Boston, April 15-19, 2026. Come join me and @chrysothemisbrown.bsky.social at this exciting Symposium on Early life immune development. Submit your abstracts by October 15th! immunology2026.aai.org/session/earl...
Reposted by Jamie Sugrue
Our latest study explains the link between the ABO blood type and its known associated differential susceptibility to thrombotic vascular diseases:
onlinelibrary.wiley.com/doi/10.1111/... lead by Tianai Lou @jamiesugrue.bsky.social with @darraghduffy.bsky.social & @clionaofarrelly.bsky.social
onlinelibrary.wiley.com/doi/10.1111/... lead by Tianai Lou @jamiesugrue.bsky.social with @darraghduffy.bsky.social & @clionaofarrelly.bsky.social
Altered DNA methylation of the ABO gene is associated with differential plasma levels of von willebrand factor and E‐selectin
Background The ABO blood group system is associated with differential susceptibility to thrombotic vascular diseases. ABO is also known to be a strong trans-protein quantitative trait locus for plas...
onlinelibrary.wiley.com
September 15, 2025 at 11:50 AM
Our latest study explains the link between the ABO blood type and its known associated differential susceptibility to thrombotic vascular diseases:
onlinelibrary.wiley.com/doi/10.1111/... lead by Tianai Lou @jamiesugrue.bsky.social with @darraghduffy.bsky.social & @clionaofarrelly.bsky.social
onlinelibrary.wiley.com/doi/10.1111/... lead by Tianai Lou @jamiesugrue.bsky.social with @darraghduffy.bsky.social & @clionaofarrelly.bsky.social
Reposted by Jamie Sugrue
What we need now, more torpor. I got a fever, and the only cure is more torpor. A synthetic torpor-like state, induced by ultrasound, to be precise. www.nature.com/articles/s42... 2
Synthetic torpor: advancing metabolic regulation for medical innovations - Nature Metabolism
Chen et al. provide an overview of historical and more recent approaches for the induction of synthetic torpor, and discuss their potential medical applications.
www.nature.com
July 31, 2025 at 9:29 PM
What we need now, more torpor. I got a fever, and the only cure is more torpor. A synthetic torpor-like state, induced by ultrasound, to be precise. www.nature.com/articles/s42... 2
Reposted by Jamie Sugrue
Good fun to contribute to this super paper from Yorgo Modis' lab where we looked at the impact of disease-associated MDA5 mutations on its structure, biochemistry and antiviral functions #immunosky www.cell.com/cell-reports...
Molecular basis of autoimmune disease protection by MDA5 variants
Loss-of-function MDA5 variants increase the risk of chronic inflammation but protect
against autoimmune disease. Singh et al. show that autoimmune-protective variants
impair MDA5 signaling via differe...
www.cell.com
May 31, 2025 at 1:45 PM
Good fun to contribute to this super paper from Yorgo Modis' lab where we looked at the impact of disease-associated MDA5 mutations on its structure, biochemistry and antiviral functions #immunosky www.cell.com/cell-reports...
Reposted by Jamie Sugrue
Steroid hormone levels vary with age, sex ... and lifestyle. A large-scale ten-year study conducted by @milieuinterieur.bsky.social on a thousand individuals has shed new light on #steroid hormones. ↘️
Steroid hormone levels vary with age, sex ... and lifestyle
A large-scale ten-year study conducted by the Institut Pasteur on a thousand individuals has shed new light on steroid hormones. Levels of these molecules, which play a crucial role in our health, var...
www.pasteur.fr
May 23, 2025 at 8:50 AM
Steroid hormone levels vary with age, sex ... and lifestyle. A large-scale ten-year study conducted by @milieuinterieur.bsky.social on a thousand individuals has shed new light on #steroid hormones. ↘️
Reposted by Jamie Sugrue
Join the 1st EFIS Sex Differences in Immunity Congress – October 23, 2025 @pasteur.fr @sexdiffimmunity.bsky.social Registration link lnkd.in/emerimQc abstracts welcome from all researchers, scientists, clinicians #immunosky
May 12, 2025 at 8:31 PM
Join the 1st EFIS Sex Differences in Immunity Congress – October 23, 2025 @pasteur.fr @sexdiffimmunity.bsky.social Registration link lnkd.in/emerimQc abstracts welcome from all researchers, scientists, clinicians #immunosky
Reposted by Jamie Sugrue
Delighted to have taken part in this project that was published today led by Tomas Ryan’s lab @tjryan.bsky.social @tcddublin.bsky.social @tbsi-tcd.bsky.social ….. mice remember cold 🐭📝❄️
Immunologists and neuroscientists collaborate to show experience of cold temps leaves a lasting impression on the brain. In Nature paper today by labs of Princeton's Lydia Lynch @lydialynch.bsky.social and Trinity College Dubin's Tomás Ryan @tjryan.bsky.social. molbio.princeton.edu/news/2025/co...
Cold comforts: animals form memories about temperature
The experience of cold temperatures leaves a lasting impression on the brain, according to a new study published April 23, 2035 in the journal Nature. The study was conducted through a collaborative e...
molbio.princeton.edu
April 24, 2025 at 4:32 AM
Delighted to have taken part in this project that was published today led by Tomas Ryan’s lab @tjryan.bsky.social @tcddublin.bsky.social @tbsi-tcd.bsky.social ….. mice remember cold 🐭📝❄️
Reposted by Jamie Sugrue
Our second online seminar will take place next week:
🗓 Date: Friday, April 25th 2025
🕒 Time: 14:00 CET
💻 Location: Online
🗓 Date: Friday, April 25th 2025
🕒 Time: 14:00 CET
💻 Location: Online
April 19, 2025 at 12:00 PM
Our second online seminar will take place next week:
🗓 Date: Friday, April 25th 2025
🕒 Time: 14:00 CET
💻 Location: Online
🗓 Date: Friday, April 25th 2025
🕒 Time: 14:00 CET
💻 Location: Online
Reposted by Jamie Sugrue
Sex hormones and chromosomes work in tandem to impact immune responses, with estrogen influencing class-switched memory B cell frequency exclusively in humans with an XX chromosomal background. From @hlpeks.bsky.social, @bcellsrosser.bsky.social, Coziana Ciurtin et al. rupress.org/jem/article/...
March 28, 2025 at 1:12 PM
Sex hormones and chromosomes work in tandem to impact immune responses, with estrogen influencing class-switched memory B cell frequency exclusively in humans with an XX chromosomal background. From @hlpeks.bsky.social, @bcellsrosser.bsky.social, Coziana Ciurtin et al. rupress.org/jem/article/...
Reposted by Jamie Sugrue
A study published in Science advances, from @milieuinterieur.bsky.social consortium and led by @darraghduffy.bsky.social & @immunobladder.bsky.social, describes 17 #steroid hormone variability and associations with several lifestyle choices, aging, sex, genetics
institutcochin.fr/en/actualite...
institutcochin.fr/en/actualite...
April 4, 2025 at 4:12 PM
A study published in Science advances, from @milieuinterieur.bsky.social consortium and led by @darraghduffy.bsky.social & @immunobladder.bsky.social, describes 17 #steroid hormone variability and associations with several lifestyle choices, aging, sex, genetics
institutcochin.fr/en/actualite...
institutcochin.fr/en/actualite...
Reposted by Jamie Sugrue
New Milieu Intérieur study describing the causes of steroid hormone variability and associations with health & disease lead by @jamiesugrue.bsky.social Elizabeth Maloney & Léa Deltourbe between teams of @darraghduffy.bsky.social & @immunobladder.bsky.social www.science.org/doi/10.1126/...
April 1, 2025 at 11:16 AM
New Milieu Intérieur study describing the causes of steroid hormone variability and associations with health & disease lead by @jamiesugrue.bsky.social Elizabeth Maloney & Léa Deltourbe between teams of @darraghduffy.bsky.social & @immunobladder.bsky.social www.science.org/doi/10.1126/...
Reposted by Jamie Sugrue
Our new study quantifies sex steroid hormone changes with age in women & men, with strong impact of genetics, contraception, smoking, BMI & lifestyle often in sex specific ways @immunobladder.bsky.social @milieuinterieur.bsky.social @pasteur.fr
🧪#immunosky #medsky www.science.org/doi/epdf/10....
🧪#immunosky #medsky www.science.org/doi/epdf/10....
Steroid hormone levels vary with sex, aging, lifestyle, and genetics
You have to enable JavaScript in your browser's settings in order to use the eReader.
www.science.org
March 29, 2025 at 10:27 AM
Our new study quantifies sex steroid hormone changes with age in women & men, with strong impact of genetics, contraception, smoking, BMI & lifestyle often in sex specific ways @immunobladder.bsky.social @milieuinterieur.bsky.social @pasteur.fr
🧪#immunosky #medsky www.science.org/doi/epdf/10....
🧪#immunosky #medsky www.science.org/doi/epdf/10....
Reposted by Jamie Sugrue
Co-senior author from this study Prof Coziana Ciurtin will be talking alongside @petterbrodin.bsky.social in a RITA webinar on Sex Biases on Autoimmunity next Tuesday - should be a great discussion. Register 👇 #ImmunoSky #sexdifferences
register.gotowebinar.com/register/822...
register.gotowebinar.com/register/822...
March 28, 2025 at 6:04 PM
Co-senior author from this study Prof Coziana Ciurtin will be talking alongside @petterbrodin.bsky.social in a RITA webinar on Sex Biases on Autoimmunity next Tuesday - should be a great discussion. Register 👇 #ImmunoSky #sexdifferences
register.gotowebinar.com/register/822...
register.gotowebinar.com/register/822...
Reposted by Jamie Sugrue
The EFIS Sex Differences in Immunity group is organising a small congress this fall. We want to make it free to facilitate access. But we need to evaluate attendance interest. We kindly ask you to fill in this form if you would be interested in attending.
forms.office.com/e/2cEmKbVurx
forms.office.com/e/2cEmKbVurx
Microsoft Forms
forms.office.com
March 19, 2025 at 4:44 PM
The EFIS Sex Differences in Immunity group is organising a small congress this fall. We want to make it free to facilitate access. But we need to evaluate attendance interest. We kindly ask you to fill in this form if you would be interested in attending.
forms.office.com/e/2cEmKbVurx
forms.office.com/e/2cEmKbVurx
Reposted by Jamie Sugrue
📢Aujourd'hui l'Institut Pasteur se mobilise pour la science, l'inclusion & l'avenir du savoir avec l'organisation du symposium «Excellence Scientifique : et si l'inclusion était la clé ?» en écho avec la Journée Internationale des Droits des Femme & la participation au mouvement #StandUpForScience !
March 7, 2025 at 2:23 PM
📢Aujourd'hui l'Institut Pasteur se mobilise pour la science, l'inclusion & l'avenir du savoir avec l'organisation du symposium «Excellence Scientifique : et si l'inclusion était la clé ?» en écho avec la Journée Internationale des Droits des Femme & la participation au mouvement #StandUpForScience !
Being at @pasteur.fr has its perks sometimes
March 8, 2025 at 1:01 AM
Being at @pasteur.fr has its perks sometimes
Reposted by Jamie Sugrue
Now available online: our recent work showing that the maternal adaptive immune system promotes optimal lactogenesis. @dancrrl.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Mammary intraepithelial lymphocytes promote lactogenesis and offspring fitness
Mammary intraepithelial lymphocytes enhance mammary gland differentiation during pregnancy,
thereby promoting offspring fitness.
www.cell.com
February 20, 2025 at 9:20 AM
Now available online: our recent work showing that the maternal adaptive immune system promotes optimal lactogenesis. @dancrrl.bsky.social
www.cell.com/cell/fulltex...
www.cell.com/cell/fulltex...
Reposted by Jamie Sugrue
🔬 What Makes Us React Differently to Viruses? #MyPhDAtTheInstitutPasteur
This is the question Yann Aquino explored in his PhD at the Institut Pasteur & how factors like genetics and environment shape the response to infection by viruses like SARS-CoV-2.
Read his thesis 👉 bit.ly/YAPhD
@pasteur.fr
This is the question Yann Aquino explored in his PhD at the Institut Pasteur & how factors like genetics and environment shape the response to infection by viruses like SARS-CoV-2.
Read his thesis 👉 bit.ly/YAPhD
@pasteur.fr
What Makes Us React Differently to Viruses? | My PhD at the Institut Pasteur – Yann Aquino
YouTube video by Institut Pasteur EDUCATION
youtube.com
February 21, 2025 at 2:15 PM
🔬 What Makes Us React Differently to Viruses? #MyPhDAtTheInstitutPasteur
This is the question Yann Aquino explored in his PhD at the Institut Pasteur & how factors like genetics and environment shape the response to infection by viruses like SARS-CoV-2.
Read his thesis 👉 bit.ly/YAPhD
@pasteur.fr
This is the question Yann Aquino explored in his PhD at the Institut Pasteur & how factors like genetics and environment shape the response to infection by viruses like SARS-CoV-2.
Read his thesis 👉 bit.ly/YAPhD
@pasteur.fr
True joy as we enter week two of vacances scolaire. ie. A palatable morning metro journey
February 25, 2025 at 6:52 AM
True joy as we enter week two of vacances scolaire. ie. A palatable morning metro journey