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Reposted by Jeremy Wilkinson

Allison G @assemblerag.bsky.social · 7d

Here are a few highlights:
We first identified a 1.58 Mbp plasmid in an infant gut metagenome thanks to @pacbio.bsky.social sequencing. The average bacterial genome size in these communities is usually less than 5 Mbp so this was curious to us. We then found similar elements in other infants.

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Reposted by Jeremy Wilkinson

Allison G @assemblerag.bsky.social · 7d

Most plasmids described in E. coli are small compared to the megaplasmids we identified here! Check out the preprint if you want to learn about these mysterious large elements and their potential functions 🧬. I’m very grateful to have had the opportunity to work on this in @banfieldlab.bsky.social

bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 7d

Megaplasmids associate with Escherichia coli and other Enterobacteriaceae https://www.biorxiv.org/content/10.1101/2025.09.30.679422v1

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Jeremy Wilkinson @jewilki.bsky.social · 13d

In the latest issue of DDW Journal, I explore how long-read genomics is driving high-resolution microbiome profiling and why precision microbiomics is set to become the next foundational layer in the drug discovery toolkit. 🧬

Read the full article here. 👉 bit.ly/4mq1xwp

#microbiome #longreads

DDW Fall 2025 - Drug Discovery World (DDW)

The DDW Fall issue examines why there is a need for a universal pneumococcal vaccine, why China might be the next global biopharma powerhouse and looks at developments in microbiome research and the t...

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Jeremy Wilkinson @jewilki.bsky.social · 13d

Join us tomorrow if you can. Link below to register.

PacBio @pacbio.bsky.social · 13d

⏰ Last call! The human #microbiome webinar is tomorrow.

See how #PacBio HiFi sequencing delivers clarity with full-length 16S rRNA and shotgun metagenomics, revealing strain-level insights, novel taxa, and functional pathways.

Register now: bit.ly/46wBttB

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Reposted by Jeremy Wilkinson

PacBio @pacbio.bsky.social · 22d

Science award? (The Scientist’s Top Innovations 2025) ✅
Design award? (Fast Company’s Innovation by Design 2025) ✅

Sequencer that’s turning heads everywhere? Vega. 🔥

#Vega #PacBio #HiFiSequencing

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Reposted by Jeremy Wilkinson

PacBio @pacbio.bsky.social · 21d

Microbes may be small, but the discoveries they drive are huge! 🦠

This #InternationalMicroorganismDay, see how #PacBio HiFi sequencing is uncovering microbial mysteries, from mapping hidden HIV-1 reservoirs to revealing novel AMR pathways.

Details here: bit.ly/4mSgPeL

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Reposted by Jeremy Wilkinson

Hutlab @hutlab.bsky.social · 20d

Long and Kelsey just won the 2025 Microbiome SMRT Grant for HiFi shotgun metagenomics!! They will collaborate to optimize PacBio-compatible protocols for gut metagenomics, specifically generating high quality long-read data from IBD patients. Congrats to both! 🎉 🎉 www.pacb.com/blog/2025-mi...

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Reposted by Jeremy Wilkinson

PacBio @pacbio.bsky.social · 22d

The 2025 Long-Read Low Pass SMRT Grant for plant + animal sciences is now open! 🌱🐾

Apply to win free PacBio HiFi sequencing for your conservation or agricultural research.

Submit your 100-word proposal today: bit.ly/3IgrReu

#PacBio #SMRTGrant #HiFisequencing

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Reposted by Jeremy Wilkinson

Adam Ameur @adameur.bsky.social · 22d

Our first PacBio Revio run with over 140Gb average HiFi yield! This was for a pool of 16 human WGS libraries across 8 SMRTcells, giving >20x coverage per sample. We're running these samples as part of the "Genome of Sweden" project 🧬🇸🇪

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Reposted by Jeremy Wilkinson

Dan Portik @dportik.bsky.social · 28d

New #metagenome assembly comparison of PacBio, ONT, and Illumina in human gut #microbiomes.

- "HiFi generated more cMAGs than ONT at every depth with either assembly method"
- "HiFi cMAGs had significantly higher completeness and lower contamination than ONT"

doi.org/10.1016/j.ce...

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doi.org

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Jeremy Wilkinson @jewilki.bsky.social · 25d

So excited to see the results of these impactful human #microbiome studies and what can be accomplished with high accuracy #longread #metagenomics.

Congratulations to the winners and really looking forward to working with you.

PacBio @pacbio.bsky.social · 25d

We’re thrilled to announce the 2025 Microbiome SMRT Grant winners! 🎉 Four researchers from around the globe will use HiFi sequencing to push the boundaries of metagenomics.

See the awardees and their projects: bit.ly/3IiBrxq

#PacBio #Microbiome #Genomics #SMRTGrant

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Jeremy Wilkinson @jewilki.bsky.social · 26d

We’re at the @zymoresearch.bsky.social Biofestival at Johns Hopkins University. Come say hi if you’re here.

@pacbio.bsky.social

Reposted by Jeremy Wilkinson

PacBio @pacbio.bsky.social · 26d

#PacBio is proud to partner with Chulalongkorn and DKSH to launch Asia’s first clinical program using HiFi sequencing for precision health.

LIFE-SEQ will begin with newborn screening and rare disease detection, advancing care for families across Thailand.

#PrecisionHealth #RareDisease #Genomics

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Reposted by Jeremy Wilkinson

Falk Hildebrand @bioinf.bsky.social · 29d

How do you long-read sequence metagenomes? I would argue it starts with the right sample storage & DNA extraction, to enable efficient @nanoporetech.com /@pacbio.bsky.social sequencing, which we investigated in our new paper: www.biorxiv.org/content/10.1...

Massive thanks to Klara for driving this

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Jeremy Wilkinson @jewilki.bsky.social · 29d

Join me for this webinar on the human #microbiome! Register below.

PacBio @pacbio.bsky.social · 29d

The human #microbiome holds enormous potential, but only if we can see it clearly.

Join this webinar to learn how #PacBio HiFi sequencing delivers accurate, high-resolution insights with 16S rRNA sequencing and shotgun metagenomics.

Secure your spot: bit.ly/4mYmK1G

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Reposted by Jeremy Wilkinson

PacBio @pacbio.bsky.social · Aug 20

🚩 Short reads for big SVs
🚩 Long reads with tradeoffs
🟢 Tech with large variant detection, haplotyping, epigenetics + exceptional accuracy.

See how to get green flags from the start...There's HiFi for That: bit.ly/3JminPa

#PacBio #ScienceHumor #TheresHiFiForThat #HiFisequencing

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Reposted by Jeremy Wilkinson

Physalia-courses@Online @physaliacourses.bsky.social · Aug 19

Do not miss this course with @marcelauliano.bsky.social & Joao if you are interested in Genome Assembly using #longreads @pacbio.bsky.social data #ESEB25

EvolDir @evoldir.bsky.social · Aug 19

Join the online course "Eukaryotic Genome Assembly Using PacBio and Hi-C" from Nov 10-14. Learn assembly techniques and get hands-on experience. More details: https://www.physalia-courses.org/courses-workshops/pacbio/ #course

Eukaryotic genome assembly using Pacbio and Hi-C

Dates 10-14 November 2025 To foster international participation, this course will be held online

www.physalia-courses.org

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Reposted by Jeremy Wilkinson

PacBio @pacbio.bsky.social · Aug 19

Too many tabs.
Password resets.
47 unread notifications before 9 a.m.

Some struggles are inevitable. The ones in your lab? You can fix those with #PacBio.

#TheresHiFiForThat launches today with free tools, guides, and a shot at a 2026 genomics conference.

🔗Join in: bit.ly/3JminPa

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Reposted by Jeremy Wilkinson

andorjkiss.bsky.social @andorjkiss.bsky.social · Aug 18

And just like that, our first sequencing run has started on our @pacbio.bsky.social #VEGA, libraries and run started entirely by first time graduate student user. @miamiuniversity.bsky.social #CBFG #Longreads #HiFi #epigenetics

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Jeremy Wilkinson @jewilki.bsky.social · Aug 18

@dportik.bsky.social and I wrote a book chapter on highly accurate #longread @pacbio.bsky.social HiFi sequencing for #microbiome and #metagenomic applications in "Metagenomics for Microbiology (Second Edition)" that is now published! Check it out here:
www.sciencedirect.com/science/arti...

www.sciencedirect.com

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Reposted by Jeremy Wilkinson

PacBio @pacbio.bsky.social · Aug 11

Curious how long-read sequencing is shaping drug discovery and development? Hear it from the experts.

Join panelists from Pfizer, AstraZeneca, GSK, and more as they share how #PacBio HiFi sequencing is transforming the #biopharma industry.

Register now: bit.ly/4m3L7KJ

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Reposted by Jeremy Wilkinson

Cameron Thrash @jcamthrash.bsky.social · Aug 11

Comparative evaluation of sequencing platforms: Pacific Biosciences, Oxford Nanopore Technologies, and Illumina for 16S rRNA-based soil microbiome profiling www.frontiersin.org/journals/mic... #jcampubs

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Jeremy Wilkinson @jewilki.bsky.social · Aug 11

" @pacbio.bsky.social #HiFi #metagenomic assembly achieves a level of precision approaching that of isolated genomes derived from the same sample. This benchmarking establishes HiFi as a robust approach for generating #MAGs rivaling isolated genome quality."

onlinelibrary.wiley.com/doi/full/10....

HiFi based metagenomic assembly strategy provides accuracy near isolated genome resolution in MAG assembly

Recovering high-contiguity, circular bacterial genomes from complex microbiomes (e.g., gut) is challenged by limitations of short-read and error-prone long-read sequencing. This study comprehensively...

onlinelibrary.wiley.com

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Reposted by Jeremy Wilkinson

PacBio @pacbio.bsky.social · Jul 31

European genomics is leveling up, thanks to Dr. Ibrahim Bitar’s work with #Vega in the Czech Republic.
📖 Read his story: bit.ly/3Jda9sg
#HiFiSequencing #TheresHiFiForThat

Customer success story: How Dr. Ibrahim Bitar is doubling his research impact while leading the future of European genomics from the Czech Republic - PacBio

Dr. Bitar is a true champion of innovation, bringing PacBio HiFi sequencing to some of the most difficult-to-sequence samples.

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Reposted by Jeremy Wilkinson

PacBio @pacbio.bsky.social · Jul 17

🚨Last call!🚨

Submit your 100-word proposal for the 2025 Microbial #PacBio SMRT Grant by tomorrow, Friday, July 18. Win free HiFi long-read sequencing for your microbial or metagenomics project—including library construction + Revio SMRT Cells.

Apply now: bit.ly/40XcH3T

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