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Jaime Grutzendler @jgrutzendler.bsky.social · Jul 25

Truly beautiful myelin imaging Bobby, Congrats!!

Robert Hill @bobalhill.bsky.social · Jul 18

We had fun assembling images and describing approaches for imaging oligodendrocytes and myelin in vivo, in organotypic slices, and in fixed tissues. This work started in the lab of @jgrutzendler.bsky.social over 10 years ago and continues to keep us busy.
www.nature.com/articles/s44...

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Reposted by Jaime Grutzendler

Nature Neuroscience @natneuro.nature.com · Jun 20

At the myelin-axon interface, axon-glial signaling, paranodal architecture, and β-amyloid aggregation are altered in Alzheimer's disease, implicating myelin-axon disruption in disease progression

@jgrutzendler.bsky.social @yifeicai.bsky.social

www.nature.com/articles/s41...

Myelin–axon interface vulnerability in Alzheimer’s disease revealed by subcellular proteomics and imaging of human and mouse brain - Nature Neuroscience

In Alzheimer’s disease (AD), disruptions in myelin and axonal structures occur, although the underlying mechanisms remain unclear. Here the authors show that, at the myelin–axon interface, axon–glial ...

www.nature.com

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Jaime Grutzendler @jgrutzendler.bsky.social · Jun 16

Hi Yifei, i gave full credit to you; this study would have not been possible without your fearless and collaborative approach!

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Jaime Grutzendler @jgrutzendler.bsky.social · Jun 16

Hi Yifei, i gave full credit to you; this study would have not been possible without your fearless and collaborative approach!

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Jaime Grutzendler @jgrutzendler.bsky.social · Jun 16

very appreciative of this collaboration!! @reimand.bsky.social

Jüri Reimand @reimand.bsky.social · Jun 16

Very happy to have contributed to this comprehensive study on myelin–axon interface vulnerability in Alzheimer’s disease by @yifeicai.bsky.social @jgrutzendler.bsky.social. @mslob95 led our integrative pathway analyses. All started from a brief posterside chat at CSHL www.nature.com/articles/s41...

Myelin–axon interface vulnerability in Alzheimer’s disease revealed by subcellular proteomics and imaging of human and mouse brain - Nature Neuroscience

In Alzheimer’s disease (AD), disruptions in myelin and axonal structures occur, although the underlying mechanisms remain unclear. Here the authors show that, at the myelin–axon interface, axon–glial ...

www.nature.com

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Jaime Grutzendler @jgrutzendler.bsky.social · Jun 14

thank you Ethan, i hope all is well!

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Jaime Grutzendler @jgrutzendler.bsky.social · Jun 14

great, hopefully you enjoy it :)

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Jaime Grutzendler @jgrutzendler.bsky.social · Jun 14

Happy to share our latest publication on subcellular myelin proteomics and structural changes in Alzheimer disease www.nature.com/articles/s41...

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Jaime Grutzendler @jgrutzendler.bsky.social · Mar 11

thank Junjie!

Jaime Grutzendler @jgrutzendler.bsky.social · Mar 10

We appreciate the contributions of our collaborators Angus Nairn, Kristen Brennand (@kristenbrennand.bsky.social), Evangelia Petsalaki (@e_petsalaki.bsky.social), and all coauthors.

#Alzheimers #Neuroscience #Proteomics #Neurodegeneration

Jaime Grutzendler @jgrutzendler.bsky.social · Mar 10

To further investigate PAAS formation and modulation, we optimized an iPSC-derived AD model that develops spheroids closely resembling those in human brains. Inhibiting mTOR reduced PAAS pathology in cultures and in mice, suggesting that some axonal alterations in AD may be reversible.

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Jaime Grutzendler @jgrutzendler.bsky.social · Mar 10

Using proximity labeling proteomics, we identified abnormalities in protein turnover, cytoskeleton organization, and lipid transport, all linked to PI3K/AKT/mTOR pathway activation.

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Jaime Grutzendler @jgrutzendler.bsky.social · Mar 10

We previously showed that PAASs (dystrophic neurites) form in hundreds of axons around each amyloid plaque, blocking action potential conduction and disrupting neural circuits (www.nature.com/articles/s41...). However, their molecular composition remained unclear.

PLD3 affects axonal spheroids and network defects in Alzheimer’s disease - Nature

Amyloid-plaque-associated axonal spheroids are prominent contributors to neural network dysfunction in an Alzheimer’s model and can be reversed by endolysosomal modulation.

www.nature.com

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Jaime Grutzendler @jgrutzendler.bsky.social · Mar 10

Happy to share our latest study, led by @YifeiCai_. We applied Antibody-Driven Proximity Labeling to analyze postmortem human brain tissue, mapping the molecular architecture of plaque-associated axonal spheroids (PAASs) in Alzheimer’s disease.

🔗 Read here: www.nature.com/articles/s43...

Subcellular proteomics and iPSC modeling uncover reversible mechanisms of axonal pathology in Alzheimer’s disease - Nature Aging

Axonal spheroids disrupt neural circuits in Alzheimer’s disease. In this study, using subcellular proximity labeling proteomics in human brain and iPSC modeling, the authors link spheroid formation to...

www.nature.com

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Jaime Grutzendler @jgrutzendler.bsky.social · Jan 20

www.science.org/doi/10.1126/...

A petavoxel fragment of human cerebral cortex reconstructed at nanoscale resolution

To fully understand how the human brain works, knowledge of its structure at high resolution is needed. Presented here is a computationally intensive reconstruction of the ultrastructure of a cubic mi...

www.science.org

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Jaime Grutzendler @jgrutzendler.bsky.social · Jan 8

Our lab at Yale U/Wu Tsai Institute has a postdoctoral position on neurodegeneration, neuro-glial-vascular biology using 2photon, calcium/voltage imaging, gene editing,transcriptome/proteome, 3D EM, translational neurosci/chemistry. Email me if interested. Forward to those interested pls

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Reposted by Jaime Grutzendler

Mike Greicius @mikegreicius.bsky.social · Dec 14

🧪Thanks to @rbaltman.bsky.social for having me on The Future of Everything podcast to talk about treatments for Alzheimer's disease. Give a listen if you're interested in an (anti)anti-amyloid antibody argument and some promising new drug targets. #Alzheimers
engineering.stanford.edu/news/future-...

The future of Alzheimer's treatment

A neurologist who studies Alzheimer’s disease says hopes are on the rise for new treatments that target tau proteins.

engineering.stanford.edu

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Jaime Grutzendler @jgrutzendler.bsky.social · Dec 14

interested!

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Reposted by Jaime Grutzendler

Luke Sjulson @lukesjulson.bsky.social · Dec 13

Neuroscience students asked us to teach a PRACTICAL course on experimental methods, and it is now on YouTube!

Please like and repost to help us get the word out!

www.youtube.com/playlist?lis...

Lecture 1: Signals and data acquisition
Focusing on hardware, digital/analog I/O, synchronization
🧵

Neuroscience methods - YouTube

Nanocourse: Approaches to Study Neural Circuits This course was taught by Anita Autry, Tiago Gonçalves, and Luke Sjulson at Albert Einstein College of Medici...

www.youtube.com

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Jaime Grutzendler @jgrutzendler.bsky.social · Dec 10

likewise, happy to have contributed to the comprehensive update on this important topic

Gabor Petzold @gaborpetzold.bsky.social · Dec 9

Too many authors to list here, but very happy to have contributed to this review‬⁩ led by Michael Heneka on #neuroinflammation in #Alzheimer‘s disease, now out in @natrevimmunol.bsky.social. @dzne.bsky.social

www.nature.com/articles/s41...

Neuroinflammation in Alzheimer disease - Nature Reviews Immunology

This Review provides an in-depth examination of how inflammation contributes to neurodegeneration in Alzheimer disease. The authors explore the impact of extrinsic factors, such as brain trauma, diet ...

www.nature.com

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Reposted by Jaime Grutzendler

Tom Longden @talongden.bsky.social · Dec 4

I am delighted to share the work of my amazing student Dominic Isaacs! Out today in PNAS (www.pnas.org/doi/10.1073/...), Dom beautifully used optogenetics to show that thin-strand pericytes in the brain can send long-range electrical signals to control arteriole diameter and brain blood flow.

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Reposted by Jaime Grutzendler

Eduardo Zimmer @erzimmer.bsky.social · Dec 5

What a great initiative! 👉 Highlighting an outstanding paper by another researcher. 👉 Below is a must-read by @jgrutzendler.bsky.social and team 👇

www.science.org/doi/full/10....

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Jaime Grutzendler @jgrutzendler.bsky.social · Dec 5

many thanks Eduardo for highlighting our paper. I agree, this is. great initiative!

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Reposted by Jaime Grutzendler

Alice Ting @aliceyting.bsky.social · Dec 4

Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation..

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Jaime Grutzendler @jgrutzendler.bsky.social · Dec 1

go.bsky.app/5Pz9Cp3

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