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Tom Longden

@talongden.bsky.social

230 followers 130 following 4 posts

Neurovascular physiologist | Assistant Professor at the University of Maryland Baltimore | Avid sci-fi nerd

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Tom Longden @talongden.bsky.social · Apr 8

Thanks for highlighting it Baptiste! Hope it is useful!!

Reposted by Tom Longden

Amreen Mughal @amreenmughal.bsky.social · Dec 11

New publication Alert: Delighted to share our latest work. We describe a unique relationship between electrical and Calcium signaling; 'Electro-Calcium Coupling' in brain capillary endothelial cells.
www.pnas.org/doi/10.1073/...

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Tom Longden @talongden.bsky.social · Dec 10

Congrats guys! Looking sharp also

Harry Pritchard @harry-pritchard.bsky.social · Dec 9

Last week we had the honour and surprise of winning the BHF Research Story of the Year award. The award was based off our work published last year, and was only possible due to an amazing group of scientist at the University of Manchester and the Geoffrey Jefferson Brain Research Centre.

Tom Longden @talongden.bsky.social · Dec 4

Thanks all! Super fun project and hopefully useful for the field 😀

Tom Longden @talongden.bsky.social · Dec 4

I am delighted to share the work of my amazing student Dominic Isaacs! Out today in PNAS (www.pnas.org/doi/10.1073/...), Dom beautifully used optogenetics to show that thin-strand pericytes in the brain can send long-range electrical signals to control arteriole diameter and brain blood flow.

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Reposted by Tom Longden

Hanieh Falahati @haniehfalahati.bsky.social · Dec 2

Our paper is out just in time for #EM_Monday! It is about a specialized neuron-specific ER, called the spine apparatus, which is found close to synapses and has a very peculiar shape. If you think neurons are special, the spine apparatus is their🦄 horn! But how does it form?!
doi.org/10.1016/j.cu...

Gif showing a spine containing spine apparatus, reconstructed from FIB-SEM images. ER: red, synapse: yellow, plasma membrane: blue

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Reposted by Tom Longden

Alexis Rohou @alexisrohou.bsky.social · Dec 2

Oh my. This is just gorgeous from Misha Kudryashev's lab (I don't think he's here yet?). Love to see it. V ATPase resolved directly in synaptic vesicles 🤤 Lots of other neat observations in there also. Congrats to all involved! www.pnas.org/doi/10.1073/...

Section through the 3D cryoET map of V-ATPase embedded in synaptic vesicle membrane at 17 Å resolution, as published in PNAS recently.

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Reposted by Tom Longden

Baptiste Lacoste @blacoste.bsky.social · Nov 29

www.biorxiv.org/content/10.1...

L-Type Ca2+ channels and TRPC3 channels shape brain pericyte Ca2+ signaling and hemodynamics throughout the arteriole to capillary network in vivo

Pericytes play a crucial role in regulating cerebral blood flow (CBF) through processes like vasomotion and neurovascular coupling (NVC). Recent work has identified different pericyte types at distinc...

www.biorxiv.org

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