Lightnews — Scholar-powered news

Reposted by Alexis Rohou

Alejandro Llorente, Ph.D. @llorentealejandro.bsky.social · 3h

1/9 🚀 Big news! As a result of 5 years of my PhD, building on a 30-year dream of my PI Dr. Nancy Carrasco, we think we've found a new way to treat cancer! We’ve released our preprint & I'm so excited to share this story! 🧵
www.biorxiv.org/content/10.1...
#Science #proteinengineering #proteindesing

Engineering substrate selectivity in the human sodium/iodide symporter (NIS)

Iodide (I-) uptake mediated by the Na+/I- symporter (NIS) is the first step in the biosynthesis of the thyroid hormones, of which I- is an essential constituent. NIS couples the inward transport of I-...

www.biorxiv.org

1 3 4

Alexis Rohou @alexisrohou.bsky.social · 8h

Congratulations!!

Reposted by Alexis Rohou

Oded Rechavi @odedrechavi.bsky.social · 1d

Fwd: Fwd: “I hope this email finds you well”

7 50 280

Reposted by Alexis Rohou

Michael Gilman @gilman.bsky.social · 2d

Love this story about one of today's Nobel winners, Mary Brunkow.

(She and colleague Fred Ramsdell, working at Celltech (RIP), uncovered the role of Foxp3 in the development of Tregs.)

5 34 130

Reposted by Alexis Rohou

Science Magazine @science.org · 2d

This year’s #NobelPrize in Physiology or Medicine has been awarded to three scientists for discovering how the immune system distinguishes friend from foe. https://scim.ag/3Wt5rdi

Medicine Nobel goes to three researchers who identified immune system’s security guards

Mary Brunkow, Fred Ramsdell, and Shimon Sakaguchi discovered regulatory T cells that prevent autoimmune disease

scim.ag

47 140

Reposted by Alexis Rohou

Aman Husbands @husbandslab.bsky.social · 5d

RIP to the legend

Ma$on @masonfromtwitter.bsky.social · 5d

It's pronounced "bouquet"

3 8

Alexis Rohou @alexisrohou.bsky.social · 8d

I hadn't realized Robert Oppenheimer was a francophone. A few pearls in there. Last question: "Einstein is often quoted as saying if he had to do it all over again he'd be a plumber... what about you?" Oppenheimer: "I am very glad that the human condition means one never has to answer this question"

1958 : Entretien avec Oppenheimer, le père de la bombe atomique | Archive INA

YouTube video by INA Histoire

www.youtube.com

Alexis Rohou @alexisrohou.bsky.social · 10d

The end of an era. An outstanding body of broadcasting work.

Melvyn Bragg steps down from BBC Radio 4's In Our Time after 26 years

The veteran presenter has hosted more than 1,000 epsiodes of the programme over the past 26 years.

www.bbc.com

Alexis Rohou @alexisrohou.bsky.social · 14d

Wow. This seems excellent. I assume it will force some journals to change policies regarding embargoes (revised preprint must be published after peer review but before publication).

Richard Sever @richardsever.bsky.social · 14d

HHMI adopts Plan U journals.plos.org/plosbiology/...

4

Reposted by Alexis Rohou

Rebecca R Helm @rebeccarhelm.bsky.social · 14d

I get that the news cycle is packed right now, but I just heard from a colleague at the Smithsonian that this is fully a GIANT SQUID BEING EATEN BY A SPERM WHALE and it’s possibly the first ever confirmed video according to a friend at NOAA

10 YEAR OLD ME IS LOSING HER MIND (a thread 🧵)

730 10K 30K

Alexis Rohou @alexisrohou.bsky.social · 14d

Would someone care to write a summary thread for the lazy among us?

Alexis Rohou @alexisrohou.bsky.social · 15d

What?!? I’m sorry that’s happening to you two. Grrrrrrrr.

Alexis Rohou @alexisrohou.bsky.social · 18d

www.uscis.gov/sites/defaul...

Actually will only affect new H1B petitions.

www.uscis.gov

1 1

Alexis Rohou @alexisrohou.bsky.social · 19d

Not sure. Below is a useful account to follow on immigration matters. bsky.app/profile/reic...

2 2

Reposted by Alexis Rohou

Popehat Agitates And Irritates @kenwhite.bsky.social · 20d

Can Jimmy Kimmel sue Brendan Carr, or other federal actors, for violating his First Amendment rights by coercing ABC to suspend his show, and maybe eventually to fire him?

To teal deer it, yes, but without an effective remedy.

/1

100 710 3.6K

Reposted by Alexis Rohou

Alister Burt @alisterburt.bsky.social · 21d

@grigoriefflab.bsky.social continues to push limits 👀

bioRxivpreprint @biorxivpreprint.bsky.social · 22d

Improved cryo-EM reconstruction of sub-50 kDa complexes using 2D template matching https://www.biorxiv.org/content/10.1101/2025.09.11.675606v1

2 11

Reposted by Alexis Rohou

Joe Stieb @joestieb.bsky.social · 25d

The right sets the terms of our political discourse in so many ways, one of which is the idea that there isn't enough "debate" and "free speech" on campus.

We need to push back on this. The truth is (speaking for myself as a history prof), I don't really emphasize debate much in my classes/

55 500 2.1K

Alexis Rohou @alexisrohou.bsky.social · 26d

This is super impressive. Thanks for sharing details of how you got these things to work.

2

Reposted by Alexis Rohou

Oli Clarke @olibclarke.bsky.social · 26d

This one is a bit of a departure from the usual and definitely a work in progress!

We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below.

Read on for details... 1/x

18 81 260

Alexis Rohou @alexisrohou.bsky.social · Sep 7

I wonder which manufacturer licensed it… either way I hope it makes it to market!

cryoEM papers @cryoempapers.bsky.social · Sep 7

Ultracold cryogenic TEM with liquid helium and high stability pubmed.ncbi.nlm.nih.gov/40911601/ #cryoem

1

Reposted by Alexis Rohou

cryoEM papers @cryoempapers.bsky.social · Sep 7

Unbend: Correction of local beam-induced sample motion in cryo-EM images using a 3D spline model www.biorxiv.org/content/10.1101/2025.09.05.674398v1 #cryoem

4 5

Alexis Rohou @alexisrohou.bsky.social · Sep 1

J’ai adoré ce livre. Belle recommendation!

1

Reposted by Alexis Rohou

Adam Kucharski @adamjkucharski.bsky.social · Sep 1

Results so stunningly clear they inspired this classic xkcd (xkcd.com/2400/):

16 1.4K 4K

Reposted by Alexis Rohou

Michael Stipe @michaelstipe.bsky.social · Aug 30

I can

360 4.1K 17K

Alexis Rohou @alexisrohou.bsky.social · Aug 30

Wow. Very impressive image analysis going on there, to unveil stunning biological architectures.

Oli Clarke @olibclarke.bsky.social · Aug 30

Happy to share a new preprint from the Clarke & Vallese (@fravallese.bsky.social) labs reporting #cryoem structures of two RBC stomatin complexes – with AQP1 & UT-B - continuing the SPFH theme from our recent vault preprint! This was a fun one and has been cooking for a while - read on for more! ⬇️

Upper - cryo-EM reconstruction of stomatin AQP1 complex. Lower - reconstruction of stomatin-UT-B complex.

4