Lightnews — Scholar-powered news

Reposted by Jim Januzzi

JACC Journals @jaccjournals.bsky.social · 9d

Selective in vitro enhancement of cardiac myosin motor function and myofilament force generation by danicamtiv prompted clinical evaluation. A short course of danicamtiv was generally well tolerated in participants with #DCM https://bit.ly/4mE3vcM

#HFSA2025 #JACC #cvGenetics @jimjanuzzi.bsky.social

2 3

Reposted by Jim Januzzi

Jonathan Davis, MD, MPHS @jonathandavishf.bsky.social · May 13

Short & sweet! Check out our review of #SGLT2i & #GLP1RA in #HeartFailure! Great work Jose Lopez & team! @ucsfcardiology.bsky.social @amitgoyalmd.bsky.social @robmentz.bsky.social @dranulala.bsky.social @jimjanuzzi.bsky.social @sjgreene-md.bsky.social

www.uscjournal.com/articles/sho...

The Short and Sweet on Sodium–Glucose Cotransporter Inhibitors and Glucagon-like Peptide-1 Receptor Agonists in Heart Failure

Heart failure (HF) affects 6 million people in the US, and type 2 diabetes (T2D) is a significant risk factor for HF. Since 2008, regulatory agencies have required cardiovascular safety trials

www.uscjournal.com

1 2 5

Reposted by Jim Januzzi

Shalen Fairbanks @shaykim.bsky.social · May 10

Great presentation by @jimjanuzzi.bsky.social at #ACCAsia in Singapore on optimizing decongestion using diuretics and GDMT in patients with HF. Access more HF resources in the @accintouch.bsky.social Guidelines Hub: acc.org/guidelines

1 2

Reposted by Jim Januzzi

Parham Eshtehardi MD @cardioobdoc.bsky.social · May 6

Get to Know Your Leaders | Leading With Purpose:
Meet Chris Kramer, MD, FACC
@chriskramermd.bsky.social
#CardiologyMagazine
#CardioSky
www.acc.org/Latest-in-Ca...
@accintouch.bsky.social @jaccjournals.bsky.social @jimjanuzzi.bsky.social @drmarthagulati.bsky.social @vietheartpa.bsky.social

7 9

Jim Januzzi @jimjanuzzi.bsky.social · Apr 17

The weekend cannot come fast enough.

3 10

Reposted by Jim Januzzi

B Grrl @bgrrl.bsky.social · Apr 16

Hope for tx of nHCM:

According to the company, this partial fatty acid oxidation (pFOX) inhibitor is an oral compound that promotes a shift in the heart’s preference from fatty acids to glucose, resulting in energy generation by the mitochondria.

#HCM #CardioSky #Cardiomyopathy #Cardiology

Imbria secures $57.5m to advance ninerafaxstat through Phase IIb trial

Imbria has secured $57.5m in a Series B funding round to support the progression of ninerafaxstat through a Phase IIb trial in nHCM.

www.pharmaceutical-business-review.com

1 7

Reposted by Jim Januzzi

Henry Han @hancardiomd.bsky.social · Apr 15

Clinical and plasma proteomic characterization of heart failure with supranormal left ventricular ejection fraction: An emerging entity of heart failure

#EJHF @escardio.bsky.social
#CardioSky @shelleyzieroth.bsky.social @jimjanuzzi.bsky.social @drmarthagulati.bsky.social @cardioobdoc.bsky.social

1 3 3

Jim Januzzi @jimjanuzzi.bsky.social · Apr 6

When I see something like this, I promise the patient that with the effort of initiating and titrating #GDMTworks, they can expect a bounce in their LVEF. In this case--since she's naive to therapy--likely a lot.

1

Jim Januzzi @jimjanuzzi.bsky.social · Apr 3

Back to the Garden with @julijanuzzi.bsky.social

@celticsnba.bsky.social

1 12

Jim Januzzi @jimjanuzzi.bsky.social · Apr 1

I am so incredibly grateful to the @accintouch.bsky.social for the honor of being named the 2025 Distinguished Clinical Researcher.

I am blessed to have stood on the shoulders of giants during my career and am thankful to @mgbresearch.bsky.social and #BaimInstitute for support.

3 6 30

Reposted by Jim Januzzi

Anju Bhardwaj MD @docbhardwaj.bsky.social · Apr 1

Congratulations @jimjanuzzi.bsky.social
Very well deserved 👏👏

Dr Ada Stefanescu @dradastefanescu.bsky.social · Apr 1

Congratulations @jimjanuzzi.bsky.social on your @accintouch.bsky.social Distinguished Scientist Award!! #ACC25

3 5

Jim Januzzi @jimjanuzzi.bsky.social · Apr 1

Thank you so much @dradastefanescu.bsky.social!

3

Reposted by Jim Januzzi

Dr Ada Stefanescu @dradastefanescu.bsky.social · Apr 1

Congratulations @jimjanuzzi.bsky.social on your @accintouch.bsky.social Distinguished Scientist Award!! #ACC25

3 5 15

Reposted by Jim Januzzi

American College of Cardiology @accintouch.bsky.social · Mar 31

Congratulations to new #ACCPresident Christopher M. Kramer, MD, FACC! Inspired by a movie classic, he shared: “Today I want to talk to you about two Fantastic Voyage-Related themes: innovation and mentorship.”

💬 bit.ly/41RJlF6 @ChrisKramerMD #ACC25 #ACCLeadership

1 8 19

Reposted by Jim Januzzi

Cristina Popa @nephroseeker.medsky.social · Mar 30

FRESH-UP Trial #ACC25 #medsky

RCT comparing liberal vs restricted fluid intake (≤1500 ml/d) in 504 pts with stable chronic HF

🌊No difference in status health quantified by Kansas City Cardiomyopathy Questionnaire at 3 mths
🌊 More thirst distress with restriction

www.nature.com/articles/s41...

15 24

Reposted by Jim Januzzi

Joe Cuthbert @jjcuthbert.bsky.social · Mar 31

Fluid restriction associated with trend to worse QoL and greater thirst in stable outpatients with HF. No difference in safety.
www.nature.com/articles/s41...

Liberal fluid intake versus fluid restriction in chronic heart failure: a randomized clinical trial - Nature Medicine

While fluid restriction is typically recommended for patients with chronic heart failure, this randomized clinical trial showed no difference in health status, as assessed by patient-reported outcomes...

www.nature.com

1 2 1

Reposted by Jim Januzzi

allisonghaysmd.bsky.social @allisonghaysmd.bsky.social · Mar 30

Terrific @accintouch.bsky.social @acc25 session on the intersection of heart failure and imaging. Great job @purviparwani.bsky.social @michaelsalerno.bsky.social moderating the interesting case-based discussions @jimjanuzzi.bsky.social

1 4 11

Jim Januzzi @jimjanuzzi.bsky.social · Mar 27

Opening day for the @redsox.com

Let’s go

#MLB2025 #DirtyWater

@heartbobh.bsky.social

5

Jim Januzzi @jimjanuzzi.bsky.social · Mar 24

Happy birthday to a person who makes the world more beautiful.

Walking the beach where just a few months ago our buddy was having the time of his life. Glad to share the moment together.

There are blue skies beyond this.

Happiest of birthdays, RSJ.

@robertasensen.bsky.social

1 4

Jim Januzzi @jimjanuzzi.bsky.social · Mar 22

I did not have habitually watching eaglets on my 2025 bingo card but we are completely here for #JackieandShadow and their babies.

#FOBBV #eagles @robertasensen.bsky.social