Lightnews — Scholar-powered news

Jeffrey Huang @jkhuang.bsky.social · Apr 8

Very happy to share that Zeeba @zeebamehrin.bsky.social's work on cellular senescence in EAE is now published in J Neuroinflammation! Congratulations, Zeeba, on this informative study! 😀https://jneuroinflammation.biomedcentral.com/articles/10.1186/s12974-025-03425-3

Senescent cell reduction does not improve recovery in mice under experimental autoimmune encephalomyelitis (EAE) induced demyelination - Journal of Neuroinflammation

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS) characterized by immune cell-driven demyelination and progressive neurodegeneration. Senescent cells (SCs)...

jneuroinflammation.biomedcentral.com

5 15

Reposted by Jeffrey Huang

Phil Gross, PhD @philgrossphd.bsky.social · Mar 7

Excited to finally have this published! Out today in @naturecomms.bsky.social, we show that following demyelination in a mouse model of Multiple Sclerosis, treatment of senescent microglia with senolytics leads to improved remyelination. www.nature.com/articles/s41...

1/3

Senescent-like microglia limit remyelination through the senescence associated secretory phenotype - Nature Communications

The impact of senescent cells on remyelination is unknown. Here, the authors show that treatment with senolytics following demyelination enhances remyelination in young, but not aged mice, and these e...

www.nature.com

3 9 27

Jeffrey Huang @jkhuang.bsky.social · Mar 7

‪Congratulations Phil @philgrossphd.bsky.social and a huge thank you to all the lab members and collaborators for their contributions to our project on the role of senescence in remyelination, which has now been published in @naturecomms.bsky.social! 😀 www.nature.com/articles/s41...

Senescent-like microglia limit remyelination through the senescence associated secretory phenotype - Nature Communications

The impact of senescent cells on remyelination is unknown. Here, the authors show that treatment with senolytics following demyelination enhances remyelination in young, but not aged mice, and these e...

www.nature.com

1 7

Jeffrey Huang @jkhuang.bsky.social · Jan 18

Cool paper. Congrats Ethan and team!

1 2

Reposted by Jeffrey Huang

Ethan Hughes @ethanhugheslab.bsky.social · Jan 18

New paper out from the lab! Led by @gdfnunes.bsky.social and Lindsay Osso in collaboration with the lab of Dan Denman. Check it out! 🔬 🐭 🧠

www.nature.com/articles/s41...

Incomplete remyelination via therapeutically enhanced oligodendrogenesis is sufficient to recover visual cortical function - Nature Communications

Remyelination can restore neural function. Here, the authors characterize the drivers and limits of endogenous remyelination and explore a therapy that rescued remyelination deficits and accelerated n...

www.nature.com

2 26 60

Jeffrey Huang @jkhuang.bsky.social · Jan 12

Thx Ethan! 😀

2

Reposted by Jeffrey Huang

bioRxiv Neuroscience @biorxiv-neursci.bsky.social · Dec 26

Dissecting the evolving cellular landscape of a remyelinating microenvironment https://www.biorxiv.org/content/10.1101/2024.12.25.630253v1

4 11

Reposted by Jeffrey Huang

Michael D Kornberg @mdkornberg.bsky.social · Jan 8

Excited to share our new work identifying PKC as a druggable target for modulating microglia in order to enhance myelin repair. 🧵 #remyelination #multiplesclerosis www.science.org/doi/10.1126/...

The protein kinase C modulator bryostatin-1 therapeutically targets microglia to attenuate neuroinflammation and promote remyelination

Protein kinase C modulation with bryostatin-1 enables innate immune cells in the central nervous system to promote myelin repair and regeneration.

www.science.org

6 9 33

Jeffrey Huang @jkhuang.bsky.social · Jan 11

Congratulations to Phil, George, and Jingwen @PhilgrossPhD @thegliaguy @Jingwen_SMyelin on your doctoral hooding and graduation from @Georgetown! It’s been an incredible journey with you over the years. I’m so proud of your accomplishments.

1

Jeffrey Huang @jkhuang.bsky.social · Jan 11

Very proud that George Mechor @thegliaguy successfully defended his PhD thesis on the analysis of #remyelination via single nuc RNA-seq. We've learned that single cell studies are informative but an exhausting endeavor 😀. Congratulations Dr. Melchor on your remarkable

2

Jeffrey Huang @jkhuang.bsky.social · Jan 11

https://www.bbc.co.uk/sounds/play/w3ct5xh0

The Inquiry - Are we close to a breakthrough for Multiple...

Are scientists close to a breakthrough for multiple scler...

www.bbc.co.uk

Jeffrey Huang @jkhuang.bsky.social · Jan 11

Are we close to a breakthrough for Multiple Sclerosis?Thanks @bbctanyabeckett @BBCTheInquiry for this informative program and the opportunity to discuss MS treatment and repair strategies with @tim_coetzee @TZiemssen @CShannonLowe. #MS #remyelination...

1

Jeffrey Huang @jkhuang.bsky.social · Jan 11

Very excited that Phil Gross @PSGrossScience @georgetown #IPN #GUBiology has successfully defended his PhD thesis on the role of cellular senescence in CNS remyelination. Next stop a postdoc at the NIH. Congratulations Dr. Gross! 🎉🎉🎉🍾🍾🍾

1 1 2

Jeffrey Huang @jkhuang.bsky.social · Jan 11

Ancient DNA helps trace multiple sclerosis origins in European descendants https://www.washingtonpost.com/science/2024/01/10/ancient-dna-multiple-sclerosis-european-ancestry/

Jeffrey Huang @jkhuang.bsky.social · Jan 11

https://www.nature.com/articles/s41536-023-00345-9

Myeloid cell-associated aromatic amino acid metabolism fa...

Regulation of myeloid cell activity is critical for succe...

www.nature.com

Jeffrey Huang @jkhuang.bsky.social · Jan 11

Congratulations to @Jingwen_SMyelin on the publication of her manuscript showing the effect of myeloid cell derived aromatic alpha-keto acids (AKAs) in remyelination. Big thanks to @thegliaguy, @Meng2Fu, @PavanBhargavaMD and everyone who contributed!...

1

Jeffrey Huang @jkhuang.bsky.social · Jan 11

Very proud that my brilliant grad student @Jingwen_SMyelin successfully defended her PhD thesis today on the effect of aromatic amino acid metabolism in #remyelination. Congratulations Dr. Hu! 😀 #MultipleSclerosis #GUBiology @Georgetown

Jeffrey Huang @jkhuang.bsky.social · Jan 11

Dr. Anthony Fauci To Join Georgetown Faculty as Distinguished University Professor - Georgetown University https://www.georgetown.edu/news/dr-anthony-fauci-to-join-georgetown-faculty-as-distinguished-university-professor/

Dr. Anthony Fauci To Join Georgetown Faculty as Distingui...

Dr. Fauci will serve as a Distinguished University Profes...

www.georgetown.edu

Jeffrey Huang @jkhuang.bsky.social · Jan 11

Proud of @lauren_rosko for receiving the @ASNeurochem Marian Kies Award for outstanding graduate research at #ASN2023. Congratulations Lauren!!! 😀

Jeffrey Huang @jkhuang.bsky.social · Jan 11

And thanks to all the awesome co-authors @Zeebamehrin, @JingwenHu10, @thegliaguy, and the wonderful undergraduate researchers in our lab @Georgetown for their contribution, and thanks to the reviewers and editors for their helpful comments on our study.

Jeffrey Huang @jkhuang.bsky.social · Jan 11

https://www.jneurosci.org/content/43/7/1143

1

Jeffrey Huang @jkhuang.bsky.social · Jan 11

Excited to see @lauren_rosko's PhD work published in @SfNJournals. Cerebral creatine deficiency syndrome is a rare disease that affects CNS development. Lauren found that oligodendrocytes are the major producers of creatine in adult CNS. Congratulations!...

1

Jeffrey Huang @jkhuang.bsky.social · Jan 11

@thegliaguy @PSGrossScience @Zeebamehrin @MiaCozart3 @Georgetown

Jeffrey Huang @jkhuang.bsky.social · Jan 11

If you are at #SfN2022 and interested in MS, remyelination, senescence, and immunometabolism, checkout my grad students posters
George Melchor 11/12 Diversity poster session 6:30-8:30pm
Phillip Gross 11/14 8-9am #G14
Mia Cozart 11/14 11-12am #B29
Zeeba Manavi 11/16 10-11am #N14

1