Cytotoxic chemotherapy remains the standard-of-care treatment for patients with pancreatic ductal adenocarcinoma (PDAC). However, chemotherapy only has modest effects at improving patient survival due...

We will study systemic metabolic alterations which associate with cachexia in preclinical models of CRC and in CRC patients. A better understanding of these processes is critical for the development of effective therapies for this devastating disease.

Chronic inflammation in autoimmunity is driven by T cell hyperactivation. This unregulated response to self is fuelled by heightened metabolic programmes, which offers a promising new direction to unc...

The gut microbiome plays a crucial role in cancer development and progression, by influencing the host immune system and metabolism.

ALT: a bald man in a blue suit is making a funny face and pointing at something .