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nickjonesimmuno.bsky.social
Nick Jones
@nickjonesimmuno.bsky.social
1K followers 310 following 16 posts
T-cell aficionado at Swansea University. Interested in metabolism of T-cell mediated disorders from autoimmunity to T-ALL.
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Reposted by Nick Jones
emmaschambers.bsky.social
Dr Emma S Chambers @emmaschambers.bsky.social · 6h
I am so proud to say that our paper is now available at Aging Cell. There is a paucity of data as to how the menopause impacts your immune system, and the aim of this study was to investigate the impact of the menopause on monocyte phenotype and function.
onlinelibrary.wiley.com/doi/10.1111/...
Age‐Associated Inflammatory Monocytes Are Increased in Menopausal Females and Reversed by Hormone Replacement Therapy
Post-menopausal females (> 64 years) have an increase in frequency of inflammatory monocyte populations with defective phagocytosis as compared to pre-menopausal (< 40 years) females. Hormone Replace....
onlinelibrary.wiley.com
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nickjonesimmuno.bsky.social
Nick Jones @nickjonesimmuno.bsky.social · Aug 14
Secondly, PhD student Emma Lucas and myself contributed towards how metabolism shapes relapsed/refractory T-cell acute lymphoblastic leukaemia, led by João Barata and colleagues from the T-ALL special interest group

www.nature.com/articles/s41...
Underlying biology, challenges and emergent concepts in the treatment of relapsed and refractory pediatric T-cell acute lymphoblastic leukemia - Leukemia
Leukemia - Underlying biology, challenges and emergent concepts in the treatment of relapsed and refractory pediatric T-cell acute lymphoblastic leukemia
www.nature.com
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nickjonesimmuno.bsky.social
Nick Jones @nickjonesimmuno.bsky.social · Aug 14
The first takes a look at repurposing metabolic drugs as anti-inflammatory agents with @andyhogan82.bsky.social @ben-j-jenkins.bsky.social @obesityimmunology.bsky.social
www.cell.com/trends/endoc...
Repurposing metabolic drugs as anti-inflammatory agents
Dysregulation of bodyweight systemic metabolism is intrinsically linked to an inflammatory phenotype, with each underpinning the other. Over the past decade, new classes of drug, such as glucagon-like...
www.cell.com
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nickjonesimmuno.bsky.social
Nick Jones @nickjonesimmuno.bsky.social · Aug 14
Really pleased to share two review articles the lab has been involved in lately 👇🏻
Thanks for the involvement!
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Reposted by Nick Jones
andyhogan82.bsky.social
Andy Hogan @andyhogan82.bsky.social · Aug 13
Delighted to share our new review in @cp-trendsendomet.bsky.social on Repurposing metabolic drugs (GLP-1s & SGLT2s) as anti-inflammatory agents! Thanks to @nickjonesimmuno.bsky.social for this joint effort
doi.org/10.1016/j.te...
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nickjonesimmuno.bsky.social
Nick Jones @nickjonesimmuno.bsky.social · Jul 3
Congratulations Megan!! Very well deserved indeed
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Reposted by Nick Jones
jeff-neuro.bsky.social
Jeff Davies @jeff-neuro.bsky.social · Jul 2
We have a PhD position open for a talented & enthusiastic grad student interested in Neuro-Immune communication in the context of dementia. Come and join myself and @nickjonesimmuno.bsky.social click 👇 or contact me for more info
www.swansea.ac.uk/postgraduate...
Medicine: Fully Funded BRACE PhD in Alzheimer’s Research (RS855) - Swansea University
We offer a wide range of funded and fully funded research scholarships in all subject areas. Explore your options and apply now.
www.swansea.ac.uk
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Reposted by Nick Jones
labwaggoner.bsky.social
Waggoner Lab @labwaggoner.bsky.social · Jun 20
Preprint: Characterization of the dual roles of senescent-like T cells that arise during healthy and unhealthy ageing
www.biorxiv.org/content/10.1...
@drsianh.bsky.social
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Reposted by Nick Jones
rhysmorganlab.bsky.social
Rhys Morgan @rhysmorganlab.bsky.social · Jun 6
Join me + Dr David Palmer, Haematology Clinician at UHS NHS @bsmsmedschool.bsky.social, for a 3.5yr School of Life Sci funded PhD (UK fees only) studying RUNX1 mutations in myeloid leukaemia here at @sussex.ac.uk @sussexbcr.bsky.social @sussexcancer.org

Details 👇

www.sussex.ac.uk/study/fees-f...
School of Life Sciences Studentship : University of Sussex
www.sussex.ac.uk
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nickjonesimmuno.bsky.social
Nick Jones @nickjonesimmuno.bsky.social · May 21
Very cool post doc position for someone with immunology and metabolism background. Looking at a ketogenic diet in a RCT setting with Dr Emma Vincent’s group at the University of Bristol. Please reshare! 👇🏻 www.linkedin.com/jobs/view/42...
University of Bristol hiring Senior Research Associate in Molecular Metabolism in City Of Bristol, England, United Kingdom | LinkedIn
Posted 7:56:20 AM. The roleWe are looking for an enthusiastic and skilled researcher to work as part of a team running…See this and similar jobs on LinkedIn.
www.linkedin.com
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nickjonesimmuno.bsky.social
Nick Jones @nickjonesimmuno.bsky.social · Apr 17
Congratulations Nicola looks a fantastic study 🎉
Reposted by Nick Jones
jury-lab.bsky.social
jury-lab.bsky.social @jury-lab.bsky.social · Apr 9
Great collaboration with @inespinedatorra.bsky.social @georgearobinson.bsky.social @anisurrahman.bsky.social @arrdept-ucldom.bsky.social
www.ahajournals.org/doi/10.1161/...
Subclinical Atherosclerosis Risk Can Be Predicted in Female Patients With Systemic Lupus Erythematosus Using Metabolomic Signatures: An Observational Study | Journal of the American Heart Association
www.ahajournals.org
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nickjonesimmuno.bsky.social
Nick Jones @nickjonesimmuno.bsky.social · Apr 8
Autoimmune mechanisms elucidated through muscle acetylcholine receptor structures www.cell.com/cell/abstrac...
www.cell.com
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Reposted by Nick Jones
herranzlab.bsky.social
Herranz Lab @herranzlab.bsky.social · Mar 26
Happy to share the copy-edited version of our story uncovering an ACLY-MYC feedforward loop in T-ALL! @bloodneoplasia.bsky.social @rutgerscancer.bsky.social @dasilva-diz.bsky.social

doi.org/10.1016/j.bn...
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Reposted by Nick Jones
bcellsrosser.bsky.social
Lizzy Rosser @bcellsrosser.bsky.social · Mar 25
So excited to see this out please read the paper, article and listen to us on the radio! Big thanks to @uclnews.bsky.social, our superstar postdoc @hlpeks.bsky.social, co-senior author Prof Coziana Ciurtin and collaborators @emmaschambers.bsky.social
uclnews.bsky.social
UCL News @uclnews.bsky.social · Mar 25
Until menopause women have more key immune cells, which may explain why they're less prone to some infections than men, finds a @jem.org study from @arrdept-ucldom.bsky.social including Dr Hannah Peckham @hlpeks.bsky.social & Dr Lizzy Rosser @bcellsrosser.bsky.social
www.ucl.ac.uk/news/2025/ma...
Abundance of key immune cells may be influenced by oestrogen and XX chromosomes
Women have a higher proportion of key immune cells between puberty and menopause, which may be linked to the sex hormone oestrogen and explain why they are less susceptible to certain infectious disea...
www.ucl.ac.uk
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Reposted by Nick Jones
herranzlab.bsky.social
Herranz Lab @herranzlab.bsky.social · Mar 21
Happy to share our In Focus comment on targeting metabolism in T-ALL in #BloodCancerDiscovery, single-handedly written by @dasilva-diz.bsky.social! Thanks for the invitation to write on such an exciting topic @tanyabondar.bsky.social! @rutgerscancer.bsky.social aacrjournals.org/bloodcancerd...
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Reposted by Nick Jones
biorxiv-immuno.bsky.social
bioRxiv Immunology @biorxiv-immuno.bsky.social · Mar 19
ABHD11 inhibition drives sterol metabolism to modulate T cell effector function and alleviate autoimmunity https://www.biorxiv.org/content/10.1101/2025.03.19.643996v1
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nickjonesimmuno.bsky.social
Nick Jones @nickjonesimmuno.bsky.social · Mar 20
First preprint from the lab! Massive effort from @ben-j-jenkins.bsky.social and Yasmin. Thanks always to great collaborators and co-leads James and Emma. Any feedback greatly appreciated:

www.biorxiv.org/content/10.1...
ABHD11 inhibition drives sterol metabolism to modulate T cell effector function and alleviate autoimmunity
Chronic inflammation in autoimmunity is driven by T cell hyperactivation. This unregulated response to self is fuelled by heightened metabolic programmes, which offers a promising new direction to unc...
www.biorxiv.org
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Reposted by Nick Jones
herranzlab.bsky.social
Herranz Lab @herranzlab.bsky.social · Mar 19
To all my #BlueSky friends...does anyone have Xbp1 conditional knockout mice alive in their labs? Thanks!
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Reposted by Nick Jones
cclguk.bsky.social
CCLG: The Children & Young People’s Cancer Association @cclguk.bsky.social · Mar 5
We have big news! 📣

Children’s Cancer and Leukaemia Group (CCLG) and Teenagers and Young Adults with Cancer (TYAC) have merged their memberships to form a new professional association.

Introducing CCLG: The Children & Young People’s Cancer Association!

www.cclg.org.uk

#CCLG #CYPCancer
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Reposted by Nick Jones
peronalab.bsky.social
Perona Lab, Edinburgh, UK @peronalab.bsky.social · Mar 3
I'm very pleased to have two lab positions open this week, to join our team looking at immune regulation in infection and co-infection. We're especially interested in tissue-based immunity, cytokine regulation and immune metabolism. Join us! Postdoc (3y) and research technician (12mo) posts open.
We're based in the Ashworth Laboratories, King's Buildings, University of Edinburgh. Photo shows the main staircase in the entrance to the Ashworth, stone steps from the 1920s, decorated with a series of bright, colurful banners depicting the science that's tackled in the building.
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Reposted by Nick Jones
lindavsinclair.bsky.social
Linda Sinclair @lindavsinclair.bsky.social · Mar 1
I am overjoyed to present our latest paper on Autophagy in CD8 Tcells!
www.nature.com/articles/s41...
It was, as all ‘sciencing’ is, a huge team effort.

I will try to do it some justice in the following thread 😊 1/n
@cantrell-lab.bsky.social @immpres.bsky.social @ajmhowden.bsky.social
Autophagy repression by antigen and cytokines shapes mitochondrial, migration and effector machinery in CD8 T cells - Nature Immunology
Sinclair et al. combine quantitative proteomics and an autophagy flux reporter to map autophagy substrates and triggers during CD8 T cell differentiation. Proteins degraded and fueled by autophagy in ...
www.nature.com
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Reposted by Nick Jones
ajbrenes.com
Alejandro Brenes @ajbrenes.com · Feb 27
Exciting paper from the Cantrell lab out in @natimmunol.bsky.social about the role of autophagy in CD8 T cells exploring the role of amino acid availability.

Lots of very cool proteomics data quantifying which proteins are degraded under what conditions.

@lindavsinclair.bsky.social
Autophagy repression by antigen and cytokines shapes mitochondrial, migration and effector machinery in CD8 T cells - Nature Immunology
Sinclair et al. combine quantitative proteomics and an autophagy flux reporter to map autophagy substrates and triggers during CD8 T cell differentiation. Proteins degraded and fueled by autophagy in ...
www.nature.com
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nickjonesimmuno.bsky.social
Nick Jones @nickjonesimmuno.bsky.social · Feb 2
Try Emma Vincent University of Bristol 👍🏻
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Reposted by Nick Jones
labwaggoner.bsky.social
Waggoner Lab @labwaggoner.bsky.social · Jan 25
Bi-specific CAR-iNKT cell immunotherapy for high-risk KMT2A-rearranged leukemia outperforms CAR-T in an NKG2D-dependent manner and eradicates leptomeningeal disease
doi.org/10.1101/2025...
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