Johnny Thorstenson
@johnny-thorstenson.bsky.social
PhD candidate in the Horswill Lab at CU Anschutz 👨🏻🔬⛰️| Microbiology
Utilizing molecular genetics and protein biochemistry to investigate MRSA protease function and regulation during skin infection
Utilizing molecular genetics and protein biochemistry to investigate MRSA protease function and regulation during skin infection
Reposted by Johnny Thorstenson
Super excited to finally have this out! We characterized SSR42 as a novel RNA-based regulator of cytotoxicity in S. aureus. It is capable of responding to a host-like environment to activate the leukocidin LukAB and mediate neutriphil interactions. Check it out! journals.asm.org/doi/10.1128/...
SSR42 is a novel regulator of cytolytic activity in Staphylococcus aureus | mBio
Staphylococcus aureus is a master pathogen due to its formidable collection of virulence factors. These are tightly controlled by a diverse group of regulators that titrate their abundance to adapt to unique infectious niches. The role of regulatory RNAs ...
journals.asm.org
May 9, 2025 at 2:52 PM
Super excited to finally have this out! We characterized SSR42 as a novel RNA-based regulator of cytotoxicity in S. aureus. It is capable of responding to a host-like environment to activate the leukocidin LukAB and mediate neutriphil interactions. Check it out! journals.asm.org/doi/10.1128/...
Happy to share that our mini-review on the role of SspA (V8 protease) in Staphylococcus aureus skin pathogenesis is now live in PLOS Pathogens Pearls!
Read the full article here: journals.plos.org/plospathogen...
Read the full article here: journals.plos.org/plospathogen...
Staphylococcus aureus SspA (V8 protease): New skin pathogenesis insights into an old enzyme
journals.plos.org
April 27, 2025 at 4:58 PM
Happy to share that our mini-review on the role of SspA (V8 protease) in Staphylococcus aureus skin pathogenesis is now live in PLOS Pathogens Pearls!
Read the full article here: journals.plos.org/plospathogen...
Read the full article here: journals.plos.org/plospathogen...
Reposted by Johnny Thorstenson
A new protein sequencing method, which uses a biological motor to pull a protein through a tiny nanopore, could revolutionise protein analysis.
www.chemistryworld.c...
www.chemistryworld.c...
Nanopore sequencing set to transform our understanding of proteins
Rapid sequencing technique can not only deal with proteins hundreds of amino acids long but can detect modifications
www.chemistryworld.com
April 6, 2025 at 5:23 PM
A new protein sequencing method, which uses a biological motor to pull a protein through a tiny nanopore, could revolutionise protein analysis.
www.chemistryworld.c...
www.chemistryworld.c...
Reposted by Johnny Thorstenson
Yesterday, we got to watch as Jeff Kavanaugh, the long term research associate of the Horswill Lab received the PRA of the year award at @cuanschutz.bsky.social Jeff, your influence on the lab and all of us as trainees is immeasurable. To celebrate you was a light in these uncertain times.
February 20, 2025 at 4:49 PM
Yesterday, we got to watch as Jeff Kavanaugh, the long term research associate of the Horswill Lab received the PRA of the year award at @cuanschutz.bsky.social Jeff, your influence on the lab and all of us as trainees is immeasurable. To celebrate you was a light in these uncertain times.
Reposted by Johnny Thorstenson
OUT NOW: Upcycling of polyamides through chemical hydrolysis and engineered Pseudomonas putida
Nick Wierckx & co @fz-juelich.de @hhu.de
www.nature.com/articles/s41...
Nick Wierckx & co @fz-juelich.de @hhu.de
www.nature.com/articles/s41...
Upcycling of polyamides through chemical hydrolysis and engineered Pseudomonas putida - Nature Microbiology
Metabolic engineering guided by laboratory evolution enables upcycling of nylon by Pseudomonas putida.
www.nature.com
February 11, 2025 at 1:55 PM
OUT NOW: Upcycling of polyamides through chemical hydrolysis and engineered Pseudomonas putida
Nick Wierckx & co @fz-juelich.de @hhu.de
www.nature.com/articles/s41...
Nick Wierckx & co @fz-juelich.de @hhu.de
www.nature.com/articles/s41...
Reposted by Johnny Thorstenson
Why scratching makes a rash worse and a potential benefit to scratching--it reduced S. aureus on skin. Andrew Liu's paper from our lab is out now at #science #neuroimmune #immunology www.science.org/doi/10.1126/...
Scratching promotes allergic inflammation and host defense via neurogenic mast cell activation
Itch is a dominant symptom in dermatitis, and scratching promotes cutaneous inflammation, thereby worsening disease. However, the mechanisms through which scratching exacerbates inflammation and wheth...
www.science.org
January 30, 2025 at 8:31 PM
Why scratching makes a rash worse and a potential benefit to scratching--it reduced S. aureus on skin. Andrew Liu's paper from our lab is out now at #science #neuroimmune #immunology www.science.org/doi/10.1126/...