We also found striking defects in B cell function in vivo, by studying the response to SARS.CoV2 mRNA vaccination in a subset of patients. For many more interesting obsevations and experiments, please read the paper! 4/n

CBL deficient mice have defects in T cell development and function. Yet, surprisingly, the CBL deficient T cells of the patients were largely unaffected. Conversely, B cell development was strongly perturbed. 3/n

We studied patients with somatic CBL deficiency. These patients often have transient myeloproliferation in childhood, and as we published recently (www.jci.org/articles/vie...) chronic autoinflammation. We noticed that our cohort of CBL deficient patients had a high rate of severe infections. 2/n

I’m excited to announce our new paper that came out today! The second chapter of my Post-doc
@casanova_lab, published in @jclinical-invest.bsky.social
If you’re interested in the causes of autoinflammation, then this one is for you: t.co/uhVDdzqyx2