The Journal of Physiology
@jphysiol.bsky.social
The Journal of Physiology publishes original research in all areas of physiology and pathophysiology that illustrates new physiological principles or mechanisms.
@annabelcritchlow.bsky.social (@deakinuniversity.bsky.social) et al. share thier findings on profiling muscle mass, function and molecular signalling in females aged 18–80 years and their associations with sex hormones.
📜 physoc.onlinelibrary.wiley.com/doi/10.1113/...
📜 physoc.onlinelibrary.wiley.com/doi/10.1113/...
January 18, 2026 at 4:16 PM
@annabelcritchlow.bsky.social (@deakinuniversity.bsky.social) et al. share thier findings on profiling muscle mass, function and molecular signalling in females aged 18–80 years and their associations with sex hormones.
📜 physoc.onlinelibrary.wiley.com/doi/10.1113/...
📜 physoc.onlinelibrary.wiley.com/doi/10.1113/...
Geng-Lin Li and Henrique von Gersdorff of @volluminstitute.bsky.social present this #Perspective 'Electroreceptors with a different kind of buzz' based on the work of Raman and Hopkins (2025) ✍️ 💭
🔗 Access it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
🔗 Access it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
January 18, 2026 at 1:00 PM
Geng-Lin Li and Henrique von Gersdorff of @volluminstitute.bsky.social present this #Perspective 'Electroreceptors with a different kind of buzz' based on the work of Raman and Hopkins (2025) ✍️ 💭
🔗 Access it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
🔗 Access it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
In this recent study, Felix Preuss et al. observed that inhibitory circuit motifs of cortical #somatosensory layer 5 SST #interneurons are uniform within layers but specific across layers 💡 🔬
📜 Read the #Research here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
📜 Read the #Research here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
January 18, 2026 at 12:00 PM
In this recent study, Felix Preuss et al. observed that inhibitory circuit motifs of cortical #somatosensory layer 5 SST #interneurons are uniform within layers but specific across layers 💡 🔬
📜 Read the #Research here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
📜 Read the #Research here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
Crystal Lara-Santos, Maiwase Tembo, Jennifer M. Miller, Joel C. Rosenbaum and Anne E. Carlson (Department of Biological Sciences, University of Pittsburgh) examine the interplay of Ca2+ and PIP2 in TMEM16A channel function.
📜 physoc.onlinelibrary.wiley.com/doi/10.1113/...
📜 physoc.onlinelibrary.wiley.com/doi/10.1113/...
January 17, 2026 at 2:09 PM
Crystal Lara-Santos, Maiwase Tembo, Jennifer M. Miller, Joel C. Rosenbaum and Anne E. Carlson (Department of Biological Sciences, University of Pittsburgh) examine the interplay of Ca2+ and PIP2 in TMEM16A channel function.
📜 physoc.onlinelibrary.wiley.com/doi/10.1113/...
📜 physoc.onlinelibrary.wiley.com/doi/10.1113/...
Gerald M. Herrera from uvmlarnermed.bsky.social et al. observed that #adenosine and acute low oxygen conditions suppress #urinary bladder contractility through the activation of adenosine 2B receptors and large-conductance BKCa channels 🔎 ⤵️
📜 physoc.onlinelibrary.wiley.com/doi/10.1113/...
📜 physoc.onlinelibrary.wiley.com/doi/10.1113/...
January 17, 2026 at 12:01 PM
Gerald M. Herrera from uvmlarnermed.bsky.social et al. observed that #adenosine and acute low oxygen conditions suppress #urinary bladder contractility through the activation of adenosine 2B receptors and large-conductance BKCa channels 🔎 ⤵️
📜 physoc.onlinelibrary.wiley.com/doi/10.1113/...
📜 physoc.onlinelibrary.wiley.com/doi/10.1113/...
Read our latest special issue '#Neuromuscular mechanisms associated with deconditioning in #ageing and #pathological conditions'!
This was organised and edited by Dr Christoph Centner, Prof Ramona Ritzmann, Prof Uroš Marušic & Prof Luke Hughes.
📖 🔗 physoc.onlinelibrary.wiley.com/toc/14697793...
This was organised and edited by Dr Christoph Centner, Prof Ramona Ritzmann, Prof Uroš Marušic & Prof Luke Hughes.
📖 🔗 physoc.onlinelibrary.wiley.com/toc/14697793...
January 16, 2026 at 6:00 PM
Read our latest special issue '#Neuromuscular mechanisms associated with deconditioning in #ageing and #pathological conditions'!
This was organised and edited by Dr Christoph Centner, Prof Ramona Ritzmann, Prof Uroš Marušic & Prof Luke Hughes.
📖 🔗 physoc.onlinelibrary.wiley.com/toc/14697793...
This was organised and edited by Dr Christoph Centner, Prof Ramona Ritzmann, Prof Uroš Marušic & Prof Luke Hughes.
📖 🔗 physoc.onlinelibrary.wiley.com/toc/14697793...
This #Opinion piece from Sébastien Ratel (@ucauvergne.bsky.social), Joffrey Bardin (Universitéde la Réunion) and Anthony Blazevich (@edithcowanuni.bsky.social) provides a comparative perspective on mitochondrial efficiency in paediatric physiology.
💬 physoc.onlinelibrary.wiley.com/doi/10.1113/...
💬 physoc.onlinelibrary.wiley.com/doi/10.1113/...
January 16, 2026 at 4:15 PM
This #Opinion piece from Sébastien Ratel (@ucauvergne.bsky.social), Joffrey Bardin (Universitéde la Réunion) and Anthony Blazevich (@edithcowanuni.bsky.social) provides a comparative perspective on mitochondrial efficiency in paediatric physiology.
💬 physoc.onlinelibrary.wiley.com/doi/10.1113/...
💬 physoc.onlinelibrary.wiley.com/doi/10.1113/...
Geoanna M. Bautista et al. examine #Piezo1 in intestinal smooth muscle cells and propose a new conceptual framework which aims to provide a more nuanced understanding of #gastrointestinal #mechanobiology 🔬 📜
🔗 Read the #SymposiumReview: physoc.onlinelibrary.wiley.com/doi/10.1113/...
🔗 Read the #SymposiumReview: physoc.onlinelibrary.wiley.com/doi/10.1113/...
January 16, 2026 at 2:01 PM
Geoanna M. Bautista et al. examine #Piezo1 in intestinal smooth muscle cells and propose a new conceptual framework which aims to provide a more nuanced understanding of #gastrointestinal #mechanobiology 🔬 📜
🔗 Read the #SymposiumReview: physoc.onlinelibrary.wiley.com/doi/10.1113/...
🔗 Read the #SymposiumReview: physoc.onlinelibrary.wiley.com/doi/10.1113/...
Ken D. O'Halloran of ucc.ie, Rodrigo Iturriaga of cbmuchile.bsky.social & Asuncion Rocher examine chronic #hypoxia-induced carotid body #hypertonicity and the work of Nathanael et al. (2025) in this recent #Perspective piece✍️ 💭
🔗 physoc.onlinelibrary.wiley.com/doi/10.1113/...
🔗 physoc.onlinelibrary.wiley.com/doi/10.1113/...
January 16, 2026 at 12:01 PM
Ken D. O'Halloran of ucc.ie, Rodrigo Iturriaga of cbmuchile.bsky.social & Asuncion Rocher examine chronic #hypoxia-induced carotid body #hypertonicity and the work of Nathanael et al. (2025) in this recent #Perspective piece✍️ 💭
🔗 physoc.onlinelibrary.wiley.com/doi/10.1113/...
🔗 physoc.onlinelibrary.wiley.com/doi/10.1113/...
In this recent study, Raif Musa-Aziz and colleagues from uspoficial.bsky.social investigated the mechanism of CO2 and NH3 transport through human #aquaporin, providing evidence for #parallel CO2 #pathways 🔬 🔎
📜 Read the #Research: physoc.onlinelibrary.wiley.com/doi/10.1113/...
📜 Read the #Research: physoc.onlinelibrary.wiley.com/doi/10.1113/...
January 15, 2026 at 4:02 PM
In this recent study, Raif Musa-Aziz and colleagues from uspoficial.bsky.social investigated the mechanism of CO2 and NH3 transport through human #aquaporin, providing evidence for #parallel CO2 #pathways 🔬 🔎
📜 Read the #Research: physoc.onlinelibrary.wiley.com/doi/10.1113/...
📜 Read the #Research: physoc.onlinelibrary.wiley.com/doi/10.1113/...
#Research by D'Artagnan Greene and Yohannes Shiferaw observed that APD restitution controls #arrhythmia emergence in cardiac tissue with #RyR2 dysfunction 💻 🫀
🔗 Read their work here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
🔗 Read their work here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
January 15, 2026 at 2:02 PM
#Research by D'Artagnan Greene and Yohannes Shiferaw observed that APD restitution controls #arrhythmia emergence in cardiac tissue with #RyR2 dysfunction 💻 🫀
🔗 Read their work here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
🔗 Read their work here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
🎓 2026 Editorial Board Fellowship🎓
APPLICATIONS NOW OPEN 📣
Our #EditorialBoardFellowship is a great opportunity for ECRs to be directly involved in the editorial process under the guidance of a Senior Editor!
⏰ Apply by 15th March 👇 physoc.onlinelibrary.wiley.com/hub/journal/...
APPLICATIONS NOW OPEN 📣
Our #EditorialBoardFellowship is a great opportunity for ECRs to be directly involved in the editorial process under the guidance of a Senior Editor!
⏰ Apply by 15th March 👇 physoc.onlinelibrary.wiley.com/hub/journal/...
January 15, 2026 at 12:01 PM
🎓 2026 Editorial Board Fellowship🎓
APPLICATIONS NOW OPEN 📣
Our #EditorialBoardFellowship is a great opportunity for ECRs to be directly involved in the editorial process under the guidance of a Senior Editor!
⏰ Apply by 15th March 👇 physoc.onlinelibrary.wiley.com/hub/journal/...
APPLICATIONS NOW OPEN 📣
Our #EditorialBoardFellowship is a great opportunity for ECRs to be directly involved in the editorial process under the guidance of a Senior Editor!
⏰ Apply by 15th March 👇 physoc.onlinelibrary.wiley.com/hub/journal/...
This #SymposiumReview by Alfredo Ornelas, Jacob A. Countess, Ji Yeon Kim & Sean P. Colgan from colorado.edu discusses modifying #microbially derived short chain fatty acids to promote health 🔬 🔃
🔗 Read it here:
physoc.onlinelibrary.wiley.com/doi/10.1113/...
🔗 Read it here:
physoc.onlinelibrary.wiley.com/doi/10.1113/...
January 14, 2026 at 4:01 PM
This #SymposiumReview by Alfredo Ornelas, Jacob A. Countess, Ji Yeon Kim & Sean P. Colgan from colorado.edu discusses modifying #microbially derived short chain fatty acids to promote health 🔬 🔃
🔗 Read it here:
physoc.onlinelibrary.wiley.com/doi/10.1113/...
🔗 Read it here:
physoc.onlinelibrary.wiley.com/doi/10.1113/...
David Wolf et al. observed that deletion of NPAS4 in #olfactory bulb principal #neurons alters E/I balance and impairs decoding of chemically similar odour molecules 🧠 🔬
📜 Read the study here:
physoc.onlinelibrary.wiley.com/doi/10.1113/...
📜 Read the study here:
physoc.onlinelibrary.wiley.com/doi/10.1113/...
January 14, 2026 at 2:01 PM
David Wolf et al. observed that deletion of NPAS4 in #olfactory bulb principal #neurons alters E/I balance and impairs decoding of chemically similar odour molecules 🧠 🔬
📜 Read the study here:
physoc.onlinelibrary.wiley.com/doi/10.1113/...
📜 Read the study here:
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Marcos P. Rocha & Igor A. Fernandes discuss #platelets as the environmental messengers of the #neurotrophic pathway to brain plasticity and the work of Thomas et al. (2025) ✍️ 💭
🔗 Access the #Perspective: physoc.onlinelibrary.wiley.com/doi/10.1113/...
🔗 Access the #Perspective: physoc.onlinelibrary.wiley.com/doi/10.1113/...
January 14, 2026 at 12:01 PM
Marcos P. Rocha & Igor A. Fernandes discuss #platelets as the environmental messengers of the #neurotrophic pathway to brain plasticity and the work of Thomas et al. (2025) ✍️ 💭
🔗 Access the #Perspective: physoc.onlinelibrary.wiley.com/doi/10.1113/...
🔗 Access the #Perspective: physoc.onlinelibrary.wiley.com/doi/10.1113/...
Edoardo Lecce and colleagues present this #TopicalReview examining resistance training-induced adaptations in the #neuromuscular system, focusing on physiological mechanisms and implications for human performance 🔎 🏃
📖 Read it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
📖 Read it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
January 13, 2026 at 5:03 PM
Edoardo Lecce and colleagues present this #TopicalReview examining resistance training-induced adaptations in the #neuromuscular system, focusing on physiological mechanisms and implications for human performance 🔎 🏃
📖 Read it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
📖 Read it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
Aguan D. Wei and colleagues from @seattlechildrens.org found that #fentanyl blockade of K+ channels contributes to wooden chest syndrome 🫁 💊
📜 Read the #Research: physoc.onlinelibrary.wiley.com/doi/10.1113/...
📜 Read the #Research: physoc.onlinelibrary.wiley.com/doi/10.1113/...
January 13, 2026 at 3:02 PM
Aguan D. Wei and colleagues from @seattlechildrens.org found that #fentanyl blockade of K+ channels contributes to wooden chest syndrome 🫁 💊
📜 Read the #Research: physoc.onlinelibrary.wiley.com/doi/10.1113/...
📜 Read the #Research: physoc.onlinelibrary.wiley.com/doi/10.1113/...
In this recent study, Stephen T. Barimah et al. observed that chronic #hypoxia impairs L-type Ca2+ channel-mediated myogenic #vasoconstriction and cerebral autoregulation in newborn lambs 🫀 🧠
🔗 Read the #Research here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
🔗 Read the #Research here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
January 13, 2026 at 12:01 PM
In this recent study, Stephen T. Barimah et al. observed that chronic #hypoxia impairs L-type Ca2+ channel-mediated myogenic #vasoconstriction and cerebral autoregulation in newborn lambs 🫀 🧠
🔗 Read the #Research here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
🔗 Read the #Research here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
Gaspard Montandon from unityhealthto.bsky.social offers this #Perspective into how ether-à-go-go potassium channels freeze your breath based on the work of Wei et al. (2025) 💭 ✍️
🔗 Access it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
🔗 Access it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
January 12, 2026 at 4:00 PM
Gaspard Montandon from unityhealthto.bsky.social offers this #Perspective into how ether-à-go-go potassium channels freeze your breath based on the work of Wei et al. (2025) 💭 ✍️
🔗 Access it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
🔗 Access it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...
🎓 EDITOR'S CHOICE 🎓
Alessio Daniele and colleagues uncovered #endothelial dysfunction in both fit and untrained males assigned to sit for only 2 hours, which was ablated by preadministration of cocoa containing the #flavanol, (-)-epicatechin🪑 ⏰
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Alessio Daniele and colleagues uncovered #endothelial dysfunction in both fit and untrained males assigned to sit for only 2 hours, which was ablated by preadministration of cocoa containing the #flavanol, (-)-epicatechin🪑 ⏰
physoc.onlinelibrary.wiley.com/doi/10.1113/...
January 12, 2026 at 12:01 PM
🎓 EDITOR'S CHOICE 🎓
Alessio Daniele and colleagues uncovered #endothelial dysfunction in both fit and untrained males assigned to sit for only 2 hours, which was ablated by preadministration of cocoa containing the #flavanol, (-)-epicatechin🪑 ⏰
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Alessio Daniele and colleagues uncovered #endothelial dysfunction in both fit and untrained males assigned to sit for only 2 hours, which was ablated by preadministration of cocoa containing the #flavanol, (-)-epicatechin🪑 ⏰
physoc.onlinelibrary.wiley.com/doi/10.1113/...
Stephen Schlecht, Benjamin Loflin, Adam Carter, Roufael Hanna, Simran Shergill (Indiana University) and Edward M. Wojtys (@umich.edu) examine the sex differences in the #physiological response to acute anterior cruciate #ligament overuse.
📜 physoc.onlinelibrary.wiley.com/doi/10.1113/...
📜 physoc.onlinelibrary.wiley.com/doi/10.1113/...
January 11, 2026 at 1:59 PM
Stephen Schlecht, Benjamin Loflin, Adam Carter, Roufael Hanna, Simran Shergill (Indiana University) and Edward M. Wojtys (@umich.edu) examine the sex differences in the #physiological response to acute anterior cruciate #ligament overuse.
📜 physoc.onlinelibrary.wiley.com/doi/10.1113/...
📜 physoc.onlinelibrary.wiley.com/doi/10.1113/...
This paper from Louise Bradshaw (@uniofbath.bsky.social) et al. assessed the independent effects of #carbohydrate and fatty acid availability on exercise-induced skeletal #muscle AMPK activation and downstream #signalling.
📜 physoc.onlinelibrary.wiley.com/doi/10.1113/...
📜 physoc.onlinelibrary.wiley.com/doi/10.1113/...
January 10, 2026 at 2:14 PM
This paper from Louise Bradshaw (@uniofbath.bsky.social) et al. assessed the independent effects of #carbohydrate and fatty acid availability on exercise-induced skeletal #muscle AMPK activation and downstream #signalling.
📜 physoc.onlinelibrary.wiley.com/doi/10.1113/...
📜 physoc.onlinelibrary.wiley.com/doi/10.1113/...
Check out this #JournalClub article from Jeff Jiefu Liu and Ryan Yunzhen Shen (@science.ubc.ca), as they provide further insights on exercise-induced arterial hypoxaemia and patients with heart failure, adding to the work of Leahy et al. (603.22).
📜 physoc.onlinelibrary.wiley.com/doi/10.1113/...
📜 physoc.onlinelibrary.wiley.com/doi/10.1113/...
January 10, 2026 at 12:00 PM
Check out this #JournalClub article from Jeff Jiefu Liu and Ryan Yunzhen Shen (@science.ubc.ca), as they provide further insights on exercise-induced arterial hypoxaemia and patients with heart failure, adding to the work of Leahy et al. (603.22).
📜 physoc.onlinelibrary.wiley.com/doi/10.1113/...
📜 physoc.onlinelibrary.wiley.com/doi/10.1113/...
Alireza Poshtkohi (@herts.ac.uk) and Brian D. Gulbransen (@michiganstateu.bsky.social) show off their generalised Hodgkin–Huxley model that provide quantitative insights into how P2XRs and AMPA receptors control ion channel function.
📜 physoc.onlinelibrary.wiley.com/doi/10.1113/...
📜 physoc.onlinelibrary.wiley.com/doi/10.1113/...
January 9, 2026 at 4:49 PM
Alireza Poshtkohi (@herts.ac.uk) and Brian D. Gulbransen (@michiganstateu.bsky.social) show off their generalised Hodgkin–Huxley model that provide quantitative insights into how P2XRs and AMPA receptors control ion channel function.
📜 physoc.onlinelibrary.wiley.com/doi/10.1113/...
📜 physoc.onlinelibrary.wiley.com/doi/10.1113/...
Our first issue of 2026 is now live!
Featuring cover art from David Wolf and colleagues' work into olfactory bulb principal neurons🧠🔎
🔗 📖 Access the full issue here:
physoc.onlinelibrary.wiley.com/toc/14697793...
Featuring cover art from David Wolf and colleagues' work into olfactory bulb principal neurons🧠🔎
🔗 📖 Access the full issue here:
physoc.onlinelibrary.wiley.com/toc/14697793...
January 9, 2026 at 11:02 AM
Our first issue of 2026 is now live!
Featuring cover art from David Wolf and colleagues' work into olfactory bulb principal neurons🧠🔎
🔗 📖 Access the full issue here:
physoc.onlinelibrary.wiley.com/toc/14697793...
Featuring cover art from David Wolf and colleagues' work into olfactory bulb principal neurons🧠🔎
🔗 📖 Access the full issue here:
physoc.onlinelibrary.wiley.com/toc/14697793...