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Reposted by Junyue Cao

Junhong Choi @choijunhong.bsky.social · May 27

New preprint with the Shendure lab @jshendure.bsky.social ! We apply the DNA Typewriter lineage recorder to mouse 3D gastruloids, a powerful model of early mammalian development. Led by Sam Regalado and CX Qiu @cxqiu.bsky.social : www.biorxiv.org/content/10.1... (1/13)

Lineage recording in monoclonal gastruloids reveals heritable modes of early development

Mammalian stem cells possess a remarkable capacity for self-organization, a property that underlies increasingly sophisticated in vitro models of early development. However, even under carefully contr...

www.biorxiv.org

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Junyue Cao @junyuecao.bsky.social · May 12

Excited to share our first anti-aging intervention analysis, led by brilliant Zehao @tommyz626.bsky.social, Alex, and Chloe from our lab at @rockefelleruniv.bsky.social! We identified the aging-associated cell populations that can be rescued by caloric restriction in the mammalian brain!

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Reposted by Junyue Cao

Alex Merz 🇺🇸🇨🇦🇺🇦 @merz.bsky.social · Feb 10

Hero lawyers in state AG offices busted their asses over the weekend to get this done. Now do your part: call your Representative and Senators TODAY. Call your AG AND governor and voice your support for these lawsuits.

Josh Gerstein @joshgerstein.bsky.social · Feb 10

BREAKING: 22 states sue NIH over Trump administration's new 15% cap on overhead for federal research grants. Suit filed federal court in Boston contends lifesaving research 'will grind to a halt' under the policy. Doc: storage.courtlistener.com/recap/gov.us...

storage.courtlistener.com

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Reposted by Junyue Cao

Sudarshan Pinglay @sudpinglay.bsky.social · Jan 31

Now out in @science.org w/ @jshendure.bsky.social we present 'Genome-shuffle-seq': a method to shuffle mammalian genomes and characterize the impact of structural variants (SVs) with single-cell resolution in one experiment.

www.science.org/doi/10.1126/...

Multiplex generation and single-cell analysis of structural variants in mammalian genomes

Studying the functional consequences of structural variants (SVs) in mammalian genomes is challenging because (i) SVs arise much less commonly than single-nucleotide variants or small indels and (ii) ...

www.science.org

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Reposted by Junyue Cao

Zehao-Tommy Zhang @tommyz626.bsky.social · Dec 11

Joined @junyuecao.bsky.social's lab without knowing single-cell genomics - after 3 years of failing, crying, learning, and growing, I’m proud to share the PanSci! Huge thanks to amazing mentors Jun & Wei and support from @rockefelleruniv.bsky.social. The secrets of aging are starting to unfold!

Junyue Cao @junyuecao.bsky.social · Nov 29

Excited to share our work @science.org. led by our incredible @tommyz626.bsky.social at @rockefelleruniv.bsky.social! By profiling 21 million single cells across life stages, we reveal aging as distinct, development-like transitions, with dramatic cell population changes in specific time windows!

A panoramic view of cell population dynamics in mammalian aging

To elucidate aging-associated cellular population dynamics, we present PanSci, a single-cell transcriptome atlas profiling over 20 million cells from 623 mouse tissues across different life stages, se...

tinyurl.com

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Reposted by Junyue Cao

The Rockefeller University @rockefeller.edu · Dec 11

A newly created atlas of 21 million cells from @junyuecao.bsky.social's lab led by @tommyz626.bsky.social could upend long-held assumptions about how we age and provide fresh directions for anti-aging therapies. #RockefellerScience

Study reveals how unexpected shifts in cell populations are revising our understanding of the aging process - News

A newly created atlas of 21 million cells could provide fresh directions for anti-aging therapies.

www.rockefeller.edu

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