Kamyar Yazdani
@kamyaryzd.bsky.social
PhD candidate @UCSF chem bio, learning protein engineering from @realJimWells, B.S. Bio+CS @DukeU ’20, Postbac @NIH ‘22 - very Persian ... foodie in chief! follow my work here:
https://scholar.google.com/citations?user=xJotw5MAAAAJ&hl=en
https://scholar.google.com/citations?user=xJotw5MAAAAJ&hl=en
Pinned
Kamyar Yazdani
@kamyaryzd.bsky.social
· Dec 1
Targeting RNA-protein interactions with small molecules: promise and therapeutic potential - Medicinal Chemistry Research
The therapeutic potential of targeting protein-RNA interactions has not been fully explored. While several approaches to block the interactions between various RNA and protein partners have been devel...
link.springer.com
Honored to have contributed to this review with
@jschneek.bsky.social exploring the untapped potential of targeting protein-RNA interactions. Small molecules recognizing these pockets could open exciting therapeutic doors—think risdiplam and RocA, but beyond. #RNA
link.springer.com/article/10.1...
@jschneek.bsky.social exploring the untapped potential of targeting protein-RNA interactions. Small molecules recognizing these pockets could open exciting therapeutic doors—think risdiplam and RocA, but beyond. #RNA
link.springer.com/article/10.1...
Reposted by Kamyar Yazdani
Great news: NIH postbac program is recruiting again! If your grad school plans were affected by program cutbacks or admissions freezes this year I highly encourage you to apply, this could be a perfect opportunity. Please repost.
www.training.nih.gov/research-tra...
www.training.nih.gov/research-tra...
www.training.nih.gov
April 10, 2025 at 1:22 AM
Great news: NIH postbac program is recruiting again! If your grad school plans were affected by program cutbacks or admissions freezes this year I highly encourage you to apply, this could be a perfect opportunity. Please repost.
www.training.nih.gov/research-tra...
www.training.nih.gov/research-tra...
Reposted by Kamyar Yazdani
“The suppression of scientific inquiry into an area of study that has already saved millions of lives and has the potential to be one of our best defenses against future pandemics puts all of us in harm’s way”
By @lisamjarvis.bsky.social
www.bloomberg.com/opinion/arti...
By @lisamjarvis.bsky.social
www.bloomberg.com/opinion/arti...
The Anti-Vax Culture War on mRNA Just Got Worse
This time the government, by cutting NIH funding for research, is leading the charge.
www.bloomberg.com
March 20, 2025 at 4:33 PM
“The suppression of scientific inquiry into an area of study that has already saved millions of lives and has the potential to be one of our best defenses against future pandemics puts all of us in harm’s way”
By @lisamjarvis.bsky.social
www.bloomberg.com/opinion/arti...
By @lisamjarvis.bsky.social
www.bloomberg.com/opinion/arti...
!!!!!
NIH is abruptly terminating at least 33 research grants for projects studying why some people are hesitant to receive vaccines or evaluating strategies that could encourage vaccine uptake. scim.ag/4how23i
NIH to ax grants on vaccine hesitancy, mRNA vaccines
Move reflects vaccine skepticism of health secretary Robert F. Kennedy Jr.
scim.ag
March 10, 2025 at 11:47 PM
!!!!!
Reposted by Kamyar Yazdani
So important to mention this when talking to politicians or the public: $2.64 of economic activity for every $1 of NIH research funding!
“NIH produces an astounding return on investment to the American taxpayer. In Fiscal Year 2022, NIH research funding supported 568,585 jobs and generated $96.84 billion in economic activity — that’s $2.64 of economic activity for every $1 of research funding.”
www.researchamerica.org/2023-oped-us...
www.researchamerica.org/2023-oped-us...
Research supported by NIH has led more than 100 Nobel Prizes and has supported more than 99% of drugs approved by federal regulators from 2010 to 2019.
But come January, NIH may face a wrecking ball
nytimes.com/2024/12/01/h...
But come January, NIH may face a wrecking ball
nytimes.com/2024/12/01/h...
January 4, 2025 at 8:09 PM
So important to mention this when talking to politicians or the public: $2.64 of economic activity for every $1 of NIH research funding!
Reposted by Kamyar Yazdani
Deeply saddened by the news of Fraser Stoddart’s passing. Here is a piece I wrote on the occasion of his 2016 @nobelprize.bsky.social at ACSCentSci.
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Design, Synthesis, Action! Molecular Machines Take the 2016 Nobel Prize in Chemistry
pubs.acs.org
December 31, 2024 at 11:05 PM
Deeply saddened by the news of Fraser Stoddart’s passing. Here is a piece I wrote on the occasion of his 2016 @nobelprize.bsky.social at ACSCentSci.
pubs.acs.org/doi/10.1021/...
pubs.acs.org/doi/10.1021/...
Another great work from the lab on proximity labeling this time on EGFR intra and extracellularly! Congrats @zhilindseylin.bsky.social and the team!
Excited to post a new paper from our group using photo-proximity labeling proteomics to identify signaling partners for EGFR on either side of the cell membrane. urldefense.com/v3/__https:/...
Spatiotemporal photocatalytic proximity labeling proteomics reveals ligand-activated extracellular and intracellular EGFR neighborhoods
Photo-proximity labeling proteomics (PLP) methods have recently shown that the cell surface receptors can dynamically form lateral interactome networks. Here, we present a paired set of PLP workflows ...
urldefense.com
December 23, 2024 at 2:01 AM
Another great work from the lab on proximity labeling this time on EGFR intra and extracellularly! Congrats @zhilindseylin.bsky.social and the team!
Reposted by Kamyar Yazdani
And here is my condensed guide on how to science: top 5 Rules
December 15, 2024 at 3:49 PM
And here is my condensed guide on how to science: top 5 Rules
Reposted by Kamyar Yazdani
Really excited to see this work out! In collaboration with Prof. Jen Prescher, we showed that their cyclopropenone labeling strategy can be applied to structured RNA! Thrilled to work with this fantastic team of scientists. pubs.acs.org/doi/10.1021/...
Bioorthogonal Cyclopropenones for Investigating RNA Structure
RNA sequences encode structures that impact protein production and other cellular processes. Misfolded RNAs can also potentiate disease, but a complete picture is lacking. To establish more comprehens...
pubs.acs.org
December 9, 2024 at 9:48 PM
Really excited to see this work out! In collaboration with Prof. Jen Prescher, we showed that their cyclopropenone labeling strategy can be applied to structured RNA! Thrilled to work with this fantastic team of scientists. pubs.acs.org/doi/10.1021/...
Reposted by Kamyar Yazdani
Neat study from Quanyin Hu engineering degrader platelets via HSP90 recruitment for targeted degradation of soluble intra- or extracellular proteins or membrane proteins based on POI ligand and HSP90 packaging. #ChemBio #OnWisconsin
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Engineered platelets as targeted protein degraders and application to breast cancer models - Nature Biotechnology
Protein degradation is targeted to disease sites using engineered platelets.
www.nature.com
December 3, 2024 at 5:59 PM
Neat study from Quanyin Hu engineering degrader platelets via HSP90 recruitment for targeted degradation of soluble intra- or extracellular proteins or membrane proteins based on POI ligand and HSP90 packaging. #ChemBio #OnWisconsin
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Honored to have contributed to this review with
@jschneek.bsky.social exploring the untapped potential of targeting protein-RNA interactions. Small molecules recognizing these pockets could open exciting therapeutic doors—think risdiplam and RocA, but beyond. #RNA
link.springer.com/article/10.1...
@jschneek.bsky.social exploring the untapped potential of targeting protein-RNA interactions. Small molecules recognizing these pockets could open exciting therapeutic doors—think risdiplam and RocA, but beyond. #RNA
link.springer.com/article/10.1...
Targeting RNA-protein interactions with small molecules: promise and therapeutic potential - Medicinal Chemistry Research
The therapeutic potential of targeting protein-RNA interactions has not been fully explored. While several approaches to block the interactions between various RNA and protein partners have been devel...
link.springer.com
December 1, 2024 at 5:39 AM
Honored to have contributed to this review with
@jschneek.bsky.social exploring the untapped potential of targeting protein-RNA interactions. Small molecules recognizing these pockets could open exciting therapeutic doors—think risdiplam and RocA, but beyond. #RNA
link.springer.com/article/10.1...
@jschneek.bsky.social exploring the untapped potential of targeting protein-RNA interactions. Small molecules recognizing these pockets could open exciting therapeutic doors—think risdiplam and RocA, but beyond. #RNA
link.springer.com/article/10.1...