Fred Ramsdell was among those honoured with a 2025 Nobel Prize in Medicine but might not know because he is somewhere in Idaho and uncontactable

Mitophagy, the selective degradation of mitochondria, has been thought to occur via macroautophagy. Here, the authors present data indicating that microautophagy also mediates mitophagy in macrophages, and that it is essential for immune activation during M1 polarization.

Microautophagy involves direct engulfment of cytoplasmic components, including proteins and organelles, by lysosomes and late endosomes for degradation. Although it is one of three main types of autophagy — along with macroautophagy and chaperone-mediated autophagy — its mechanisms and physiological roles have only recently begun to emerge.

The complex architecture of neurons poses unique challenges in maintaining proteome balance. Lysosomes, cellular metabolic hubs and main degradative organelles, play a central role in this process, thus supporting synaptic activity. Recent findings suggest that a specialized subpopulation of lysosomes in dendrites fuse with plasma membrane and release aggregation-prone proteins to the extracellular space. At the same time, they lead to structural changes in synapses, an intriguing link between the control of protein concentration and structural synaptic plasticity.

Wir hatten schon einmal persönlich mit Versuchstieren zu tun und wollen offen und ehrlich darüber reden.

Li et al. uncover a lysosomal surveillance response whereby intestinal lumen deacidification induces a transcriptional programme that boosts lysosomal activity and improves protein aggregate clearance...

The portrayal of uncaring scientists without any thought for the animals being used in their research is far from the truth.

Nature Medicine - In Alzheimer’s disease, dimers do the damage

A first-in-class fluorescence lifetime-based FRET sensor for phosphatase and tensin homolog (PTEN) enables the dynamic monitoring of PTEN activity in cultured cells and in vivo with high spatiotempora...