Kristen Maynard
@kr-maynard.bsky.social
Investigator Lieber Institute for Brain Development
Reposted by Kristen Maynard
Finally on Bluesky and I’m really excited to share this latest preprint with @jorge-miranda.bsky.social in which we functionally examined the role of a medial prefrontal cortex (mPFC)- Locus Coeruleus (LC) circuit in regulating sustained attention.
1/7
www.biorxiv.org/content/10.6...
1/7
www.biorxiv.org/content/10.6...
Top-down control of sustained attention by the medial prefrontal cortex (mPFC)- locus coeruleus (LC) circuit during the rodent continuous performance task (rCPT)
The medial prefrontal cortex (mPFC) plays a pivotal role in attention by exerting top-down control to allocate cognitive resources toward behaviorally relevant stimuli based on learned context and exp...
www.biorxiv.org
December 15, 2025 at 9:53 PM
Finally on Bluesky and I’m really excited to share this latest preprint with @jorge-miranda.bsky.social in which we functionally examined the role of a medial prefrontal cortex (mPFC)- Locus Coeruleus (LC) circuit in regulating sustained attention.
1/7
www.biorxiv.org/content/10.6...
1/7
www.biorxiv.org/content/10.6...
Reposted by Kristen Maynard
This dataset is paired with a spatial transcriptomic analysis of the locus coeruleus from the same donors. This work led by @berniejmulvey.bsky.social is also now in pre-print!
bsky.app/profile/berniejmulvey.bsky.social/post/3m4isvuqabm2v
www.biorxiv.org/content/10.1...
bsky.app/profile/berniejmulvey.bsky.social/post/3m4isvuqabm2v
www.biorxiv.org/content/10.1...
December 11, 2025 at 12:13 PM
This dataset is paired with a spatial transcriptomic analysis of the locus coeruleus from the same donors. This work led by @berniejmulvey.bsky.social is also now in pre-print!
bsky.app/profile/berniejmulvey.bsky.social/post/3m4isvuqabm2v
www.biorxiv.org/content/10.1...
bsky.app/profile/berniejmulvey.bsky.social/post/3m4isvuqabm2v
www.biorxiv.org/content/10.1...
Reposted by Kristen Maynard
Excited to share our latest preprint from @lieberinstitute.bsky.social spatial + single-cell RNA-seq map the ERC & explore how AD risk shapes gene expression doi.org/10.1101/2025...
Our major finding: “APOE E4 Alzheimer’s Risk Converges on an Oligodendrocyte Subtype in the Human Entorhinal Cortex”
Our major finding: “APOE E4 Alzheimer’s Risk Converges on an Oligodendrocyte Subtype in the Human Entorhinal Cortex”
December 11, 2025 at 12:13 PM
Excited to share our latest preprint from @lieberinstitute.bsky.social spatial + single-cell RNA-seq map the ERC & explore how AD risk shapes gene expression doi.org/10.1101/2025...
Our major finding: “APOE E4 Alzheimer’s Risk Converges on an Oligodendrocyte Subtype in the Human Entorhinal Cortex”
Our major finding: “APOE E4 Alzheimer’s Risk Converges on an Oligodendrocyte Subtype in the Human Entorhinal Cortex”
Reposted by Kristen Maynard
Excited to share that our article on accurate sample deconvolution of pooled snRNA-seq data using sex-dependent gene expression patterns is live on NAR Genomics and Bioinformatics! 🎉
Check it out here: doi.org/10.1093/narg...
#NARGenomicsandBioinformatics #snRNAseq #Genomics #Bioinformatics
Check it out here: doi.org/10.1093/narg...
#NARGenomicsandBioinformatics #snRNAseq #Genomics #Bioinformatics
Validate User
doi.org
November 26, 2025 at 5:44 PM
Excited to share that our article on accurate sample deconvolution of pooled snRNA-seq data using sex-dependent gene expression patterns is live on NAR Genomics and Bioinformatics! 🎉
Check it out here: doi.org/10.1093/narg...
#NARGenomicsandBioinformatics #snRNAseq #Genomics #Bioinformatics
Check it out here: doi.org/10.1093/narg...
#NARGenomicsandBioinformatics #snRNAseq #Genomics #Bioinformatics
Reposted by Kristen Maynard
Congratulations to Michael Gandal, M.D., Ph.D. on being awarded the 2025 Eva King Killam Research Award! 👏 #ACNP2026
Please click here ➡️ tinyurl.com/52447muh to watch the acceptance video by Michael Gandal, M.D., Ph.D.
Please click here ➡️ tinyurl.com/52447muh to watch the acceptance video by Michael Gandal, M.D., Ph.D.
November 21, 2025 at 7:05 PM
Congratulations to Michael Gandal, M.D., Ph.D. on being awarded the 2025 Eva King Killam Research Award! 👏 #ACNP2026
Please click here ➡️ tinyurl.com/52447muh to watch the acceptance video by Michael Gandal, M.D., Ph.D.
Please click here ➡️ tinyurl.com/52447muh to watch the acceptance video by Michael Gandal, M.D., Ph.D.
Reposted by Kristen Maynard
Reposted by Kristen Maynard
Many people hours, calls and messages later: OSTA is now “in (pre)print”, though the real thing lives at bioconductor.org/books/OSTA.
Check it out, get in touch. We welcome any feedback, suggestions, wishes (& contributions).
It’s been a joy working with you @estellayixingdong.bsky.social!
Check it out, get in touch. We welcome any feedback, suggestions, wishes (& contributions).
It’s been a joy working with you @estellayixingdong.bsky.social!
November 21, 2025 at 5:31 PM
Many people hours, calls and messages later: OSTA is now “in (pre)print”, though the real thing lives at bioconductor.org/books/OSTA.
Check it out, get in touch. We welcome any feedback, suggestions, wishes (& contributions).
It’s been a joy working with you @estellayixingdong.bsky.social!
Check it out, get in touch. We welcome any feedback, suggestions, wishes (& contributions).
It’s been a joy working with you @estellayixingdong.bsky.social!
Reposted by Kristen Maynard
Our lateral septum (LS) team is representing for #SfN25! We have two posters on Wed afternoon from RA Madeline Abramson (PSTR463.16) and undergraduate Yufeng Du (PSTR463.17) showcasing newest molecular profiling results across mouse, non-human primate and human 🧠
I'm there too - get in touch!
I'm there too - get in touch!
November 14, 2025 at 4:11 PM
Our lateral septum (LS) team is representing for #SfN25! We have two posters on Wed afternoon from RA Madeline Abramson (PSTR463.16) and undergraduate Yufeng Du (PSTR463.17) showcasing newest molecular profiling results across mouse, non-human primate and human 🧠
I'm there too - get in touch!
I'm there too - get in touch!
Reposted by Kristen Maynard
Proud to announce our paper ‘Transcriptomic Analysis of the Human Habenula in Schizophrenia’ from @lieberinstitute.bsky.social is the cover article for the November issue of the American Journal of Psychiatry! 🧠 #HabenulaLIBD #snRNAseq #Habenula doi.org/10.1176/appi...
Transcriptomic Analysis of the Human Habenula in Schizophrenia | American Journal of Psychiatry
Objective: The objective of this study was to define the molecular neuroanatomy of the human habenula (Hb) and identify transcriptomic differences between brains of individuals with schizophrenia and ...
doi.org
November 4, 2025 at 9:31 PM
Proud to announce our paper ‘Transcriptomic Analysis of the Human Habenula in Schizophrenia’ from @lieberinstitute.bsky.social is the cover article for the November issue of the American Journal of Psychiatry! 🧠 #HabenulaLIBD #snRNAseq #Habenula doi.org/10.1176/appi...
Reposted by Kristen Maynard
Our paper using endoscopic in vivo calcium imaging to uncover how neuronal population dynamics in the prelimbic cortex track attention and task engagement during the rodent continuous performance test (rCPT) is now online
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Patterns of neural activity in prelimbic cortex neurons correlate with attentional behavior in the rodent continuous performance test - Translational Psychiatry
Translational Psychiatry - Patterns of neural activity in prelimbic cortex neurons correlate with attentional behavior in the rodent continuous performance test
www.nature.com
November 7, 2025 at 1:25 PM
Our paper using endoscopic in vivo calcium imaging to uncover how neuronal population dynamics in the prelimbic cortex track attention and task engagement during the rodent continuous performance test (rCPT) is now online
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Kristen Maynard
Happy to share that our paper characterizing PrL dynamics during sustained attention is finally out. This work was a collaboration between the @martinowk.bsky.social and Greg Carr groups at @lieberinstitute.bsky.social . www.nature.com/articles/s41...
#Calicumimaging #miniscopes #rCPT #PrL
#Calicumimaging #miniscopes #rCPT #PrL
Patterns of neural activity in prelimbic cortex neurons correlate with attentional behavior in the rodent continuous performance test - Translational Psychiatry
Translational Psychiatry - Patterns of neural activity in prelimbic cortex neurons correlate with attentional behavior in the rodent continuous performance test
www.nature.com
November 7, 2025 at 6:42 PM
Happy to share that our paper characterizing PrL dynamics during sustained attention is finally out. This work was a collaboration between the @martinowk.bsky.social and Greg Carr groups at @lieberinstitute.bsky.social . www.nature.com/articles/s41...
#Calicumimaging #miniscopes #rCPT #PrL
#Calicumimaging #miniscopes #rCPT #PrL
Congratulations to our habenula team! We've learned a lot about working in this tiny brain region. Here we characterize the molecular signatures of human habenula cell types and transcriptomic changes associated with schizophrenia. Stay tuned 👀 for more exciting habenula findings in the near future.
Proud to announce our paper ‘Transcriptomic Analysis of the Human Habenula in Schizophrenia’ from @lieberinstitute.bsky.social is the cover article for the November issue of the American Journal of Psychiatry! 🧠 #HabenulaLIBD #snRNAseq #Habenula doi.org/10.1176/appi...
Transcriptomic Analysis of the Human Habenula in Schizophrenia | American Journal of Psychiatry
Objective: The objective of this study was to define the molecular neuroanatomy of the human habenula (Hb) and identify transcriptomic differences between brains of individuals with schizophrenia and ...
doi.org
November 5, 2025 at 7:48 PM
Congratulations to our habenula team! We've learned a lot about working in this tiny brain region. Here we characterize the molecular signatures of human habenula cell types and transcriptomic changes associated with schizophrenia. Stay tuned 👀 for more exciting habenula findings in the near future.
Reposted by Kristen Maynard
We are hiring for a PhD-level Staff Scientist to join our teams in the Translational Neuroscience Division @lieberinstitute.bsky.social. This is an exciting opportunity to work at the intersection of human 🧠 neuroanatomy and molecular neuroscience
recruiting.paylocity.com/recruiting/j...
recruiting.paylocity.com/recruiting/j...
Lieber Institute For Brain Development - Staff Scientist I, Translational Neuroscience
A little about us:The Lieber Institute for Brain Development (LIBD) was established in 2010 to plot a new course in biomedical research that would change the lives of individuals affected with develop...
recruiting.paylocity.com
October 29, 2025 at 4:03 PM
We are hiring for a PhD-level Staff Scientist to join our teams in the Translational Neuroscience Division @lieberinstitute.bsky.social. This is an exciting opportunity to work at the intersection of human 🧠 neuroanatomy and molecular neuroscience
recruiting.paylocity.com/recruiting/j...
recruiting.paylocity.com/recruiting/j...
Reposted by Kristen Maynard
New Hot Topics piece from @rphillips3.bsky.social and Stephanie Page in @npp-journal.bsky.social describing emerging insights on roles of molecularly-defined cell types in the lateral septum, which serves as a hub for coordinating diverse social behaviors.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Role of molecularly defined lateral septum cell types and circuits in social behaviors - Neuropsychopharmacology
Neuropsychopharmacology - Role of molecularly defined lateral septum cell types and circuits in social behaviors
www.nature.com
September 30, 2025 at 9:30 PM
New Hot Topics piece from @rphillips3.bsky.social and Stephanie Page in @npp-journal.bsky.social describing emerging insights on roles of molecularly-defined cell types in the lateral septum, which serves as a hub for coordinating diverse social behaviors.
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Kristen Maynard
For #FluorescenceFriday✨ Exploring the beauty of the locus Coeruleus using IF staining: neurons🔵 surrounded by glowing astrocytes🟢 embracing delicate blood vessels🔴, alongside striking pTau signals💗. A vivid reminder of the cellular complexity shaping brain health and disease. #LC #Neuroscience
September 26, 2025 at 6:49 PM
For #FluorescenceFriday✨ Exploring the beauty of the locus Coeruleus using IF staining: neurons🔵 surrounded by glowing astrocytes🟢 embracing delicate blood vessels🔴, alongside striking pTau signals💗. A vivid reminder of the cellular complexity shaping brain health and disease. #LC #Neuroscience
Reposted by Kristen Maynard
Excited to share this new work from the lab, in collaboration with @jtuscher.bsky.social & Rob Sorge! Here, we used single cell transcriptional profiling to define molecular adaptations induced by chronic pain and opioid experience, which often occur in conjunction.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
September 23, 2025 at 6:27 PM
Excited to share this new work from the lab, in collaboration with @jtuscher.bsky.social & Rob Sorge! Here, we used single cell transcriptional profiling to define molecular adaptations induced by chronic pain and opioid experience, which often occur in conjunction.
www.biorxiv.org/content/10.1...
www.biorxiv.org/content/10.1...
Reposted by Kristen Maynard
A spatially resolved transcriptomic atlas of the primate amygdala (human, macaque, and baboon) now out in Science Advances (www.science.org/doi/10.1126/...). The amygdala contains 32 types of neurons with many neuron types specific to particular subdivisions.
Lots of updates from the preprint!
Lots of updates from the preprint!
Transcriptomic diversity of amygdalar subdivisions across humans and nonhuman primates
Specialized cell types and links to psychiatric disorders are revealed by genetic mapping of primate amygdala neurons.
www.science.org
September 17, 2025 at 7:31 PM
A spatially resolved transcriptomic atlas of the primate amygdala (human, macaque, and baboon) now out in Science Advances (www.science.org/doi/10.1126/...). The amygdala contains 32 types of neurons with many neuron types specific to particular subdivisions.
Lots of updates from the preprint!
Lots of updates from the preprint!
Reposted by Kristen Maynard
Excited to be co-chairing this @acnporg.bsky.social panel with chair @kr-maynard.bsky.social on opioid-responsive subpopulations in brain reward circuits. Special thanks to @rphillips3.bsky.social for helping to assemble the panel!
September 15, 2025 at 5:55 PM
Excited to be co-chairing this @acnporg.bsky.social panel with chair @kr-maynard.bsky.social on opioid-responsive subpopulations in brain reward circuits. Special thanks to @rphillips3.bsky.social for helping to assemble the panel!
Super excited to share this work & accompanying data resources in collab with @martinowk.bsky.social @stephaniehicks.bsky.social @alexisbattle.bsky.social! Congrats to all coauthors and big shout out to @svitlana-bach.bsky.social @prashanthi-ravi.bsky.social for leading this NIDA-funded project.
(1/10) We’re excited to share our new preprint (doi.org/10.1101/2025...), which uncovers the spatiomolecular landscape of the human nucleus accumbens (NAc), by integrating snRNA-seq with Visium spatial transcriptomics across 10 control donors. 🧠 #NAcLIBD #snRNAseq #10xVisium
September 15, 2025 at 5:41 PM
Super excited to share this work & accompanying data resources in collab with @martinowk.bsky.social @stephaniehicks.bsky.social @alexisbattle.bsky.social! Congrats to all coauthors and big shout out to @svitlana-bach.bsky.social @prashanthi-ravi.bsky.social for leading this NIDA-funded project.
Reposted by Kristen Maynard
For #FluorescenceFriday - image from Research Associate Kelsey Montgomery in @kr-maynard.bsky.social lab @lieberinstitute.bsky.social - RNAscope at 3 levels of the habenula in human 🧠. 🟢 is MBP, 🟣 is GPR151 (lateral habenula), 🔴 is POU4F1 (general habenula), and 🟡 is TAC3 (medial habenula) 🔬🧪👩🔬
August 22, 2025 at 7:15 PM
For #FluorescenceFriday - image from Research Associate Kelsey Montgomery in @kr-maynard.bsky.social lab @lieberinstitute.bsky.social - RNAscope at 3 levels of the habenula in human 🧠. 🟢 is MBP, 🟣 is GPR151 (lateral habenula), 🔴 is POU4F1 (general habenula), and 🟡 is TAC3 (medial habenula) 🔬🧪👩🔬
Reposted by Kristen Maynard
These understudied neuronal populations will be the topic of a panel at the upcoming @acnporg.bsky.social meeting, which I am co-chairing with @kr-maynard.bsky.social!
August 22, 2025 at 10:20 PM
These understudied neuronal populations will be the topic of a panel at the upcoming @acnporg.bsky.social meeting, which I am co-chairing with @kr-maynard.bsky.social!
Reposted by Kristen Maynard
We are thrilled to announce that OneNeuro Co-Director Patricia Janak, Ph.D., has been elected as the 2026-2027 President of the Society for Neuroscience (SfN). @janaklab.bsky.social
View the official announcement: www.sfn.org/publications...
View the official announcement: www.sfn.org/publications...
August 11, 2025 at 7:44 PM
We are thrilled to announce that OneNeuro Co-Director Patricia Janak, Ph.D., has been elected as the 2026-2027 President of the Society for Neuroscience (SfN). @janaklab.bsky.social
View the official announcement: www.sfn.org/publications...
View the official announcement: www.sfn.org/publications...
Reposted by Kristen Maynard
We are very excited to welcome @drjennkim.bsky.social as the newest addition to the Translational Neuroscience Division @lieberinstitute.bsky.social where she will be working as a postodoc with @kr-maynard.bsky.social group.
August 5, 2025 at 3:12 PM
We are very excited to welcome @drjennkim.bsky.social as the newest addition to the Translational Neuroscience Division @lieberinstitute.bsky.social where she will be working as a postodoc with @kr-maynard.bsky.social group.
Reposted by Kristen Maynard
Excited to share this huge team effort collaboration supervised by Stephanie Page in Translational Neuroscience @lieberinstitute.bsky.social and @stephaniehicks.bsky.social @jhubiostat.bsky.social to generate a spatio-molecular resource of the hippocampus in human 🧠
www.nature.com/articles/s41...
www.nature.com/articles/s41...
An integrated single-nucleus and spatial transcriptomics atlas reveals the molecular landscape of the human hippocampus - Nature Neuroscience
The topographical organization of cells in the hippocampus reflects its ability to regulate mood and cognition. Here the authors generate a spatially resolved gene expression map in the human hippocam...
www.nature.com
July 30, 2025 at 8:51 PM
Excited to share this huge team effort collaboration supervised by Stephanie Page in Translational Neuroscience @lieberinstitute.bsky.social and @stephaniehicks.bsky.social @jhubiostat.bsky.social to generate a spatio-molecular resource of the hippocampus in human 🧠
www.nature.com/articles/s41...
www.nature.com/articles/s41...
Reposted by Kristen Maynard
1/ I am beyond thrilled to share our new paper in @CellCellPress! We explored the regulatory principles underlying pleiotropy in psychiatric disorders.
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...
Massively parallel reporter assay investigates shared genetic variants of eight psychiatric disorders
High-throughput experimental validation of genetic variants linked to eight psychiatric
disorders reveals the regulatory mechanisms underlying variants with pleiotropic and
disorder-specific effects.
www.cell.com
January 27, 2025 at 7:02 PM
1/ I am beyond thrilled to share our new paper in @CellCellPress! We explored the regulatory principles underlying pleiotropy in psychiatric disorders.
www.cell.com/cell/abstrac...
www.cell.com/cell/abstrac...