Proud to announce our paper ‘Transcriptomic Analysis of the Human Habenula in Schizophrenia’ from @lieberinstitute.bsky.social is the cover article for the November issue of the American Journal of Psychiatry! 🧠 #HabenulaLIBD #snRNAseq #Habenula doi.org/10.1176/appi...
Transcriptomic Analysis of the Human Habenula in Schizophrenia | American Journal of Psychiatry
Objective: The objective of this study was to define the molecular neuroanatomy of the human habenula (Hb) and identify transcriptomic differences between brains of individuals with schizophrenia and ...
doi.org
November 4, 2025 at 9:31 PM
Proud to announce our paper ‘Transcriptomic Analysis of the Human Habenula in Schizophrenia’ from @lieberinstitute.bsky.social is the cover article for the November issue of the American Journal of Psychiatry! 🧠 #HabenulaLIBD #snRNAseq #Habenula doi.org/10.1176/appi...
Acá va en español 🇲🇽
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"¡Estamos orgullosos de anunciar que nuestro artículo ‘Análisis Transcriptómico de la Habénula Humana en Esquizofrenia’ es el artículo de portada de la edición de noviembre del American Journal of Psychiatry!" 🧠 #HabenulaLIBD #snRNAseq #Habénula doi.org/10.1176/appi...
--- o ---
"¡Estamos orgullosos de anunciar que nuestro artículo ‘Análisis Transcriptómico de la Habénula Humana en Esquizofrenia’ es el artículo de portada de la edición de noviembre del American Journal of Psychiatry!" 🧠 #HabenulaLIBD #snRNAseq #Habénula doi.org/10.1176/appi...
November 5, 2025 at 11:47 PM
Acá va en español 🇲🇽
--- o ---
"¡Estamos orgullosos de anunciar que nuestro artículo ‘Análisis Transcriptómico de la Habénula Humana en Esquizofrenia’ es el artículo de portada de la edición de noviembre del American Journal of Psychiatry!" 🧠 #HabenulaLIBD #snRNAseq #Habénula doi.org/10.1176/appi...
--- o ---
"¡Estamos orgullosos de anunciar que nuestro artículo ‘Análisis Transcriptómico de la Habénula Humana en Esquizofrenia’ es el artículo de portada de la edición de noviembre del American Journal of Psychiatry!" 🧠 #HabenulaLIBD #snRNAseq #Habénula doi.org/10.1176/appi...
(1/10) We’re excited to share our new preprint (doi.org/10.1101/2025...), which uncovers the spatiomolecular landscape of the human nucleus accumbens (NAc), by integrating snRNA-seq with Visium spatial transcriptomics across 10 control donors. 🧠 #NAcLIBD #snRNAseq #10xVisium
September 15, 2025 at 5:06 PM
(1/10) We’re excited to share our new preprint (doi.org/10.1101/2025...), which uncovers the spatiomolecular landscape of the human nucleus accumbens (NAc), by integrating snRNA-seq with Visium spatial transcriptomics across 10 control donors. 🧠 #NAcLIBD #snRNAseq #10xVisium
Our new snRNAseq paper on glia in Huntington’s disease is now out! eur02.safelinks.protection.outlook.com?url=https%3A...
Mapping the glial transcriptome in Huntington’s disease using snRNAseq: selective disruption of glial signatures across brain regions
eur02.safelinks.protection.outlook.com
October 21, 2024 at 6:39 AM
Our new snRNAseq paper on glia in Huntington’s disease is now out! eur02.safelinks.protection.outlook.com?url=https%3A...
Beautiful story! Is it or would you expect the same dynamics in postmitotic cells? And does anyone know a good review/article on the impact on RNAseq data obtained from single cell versus nuclei? Knowing snRNAseq is regularly criticized for its low mRNA content representation
November 24, 2024 at 12:14 PM
Beautiful story! Is it or would you expect the same dynamics in postmitotic cells? And does anyone know a good review/article on the impact on RNAseq data obtained from single cell versus nuclei? Knowing snRNAseq is regularly criticized for its low mRNA content representation
We observed the same phenomenon in several other cancer types, such as CRC, prostate and breast. Specifically, it is a 10-year prospective cohort snRNAseq study of PDAC patients with initial metastatic recurrence in either liver or lung:
October 27, 2025 at 12:14 PM
We observed the same phenomenon in several other cancer types, such as CRC, prostate and breast. Specifically, it is a 10-year prospective cohort snRNAseq study of PDAC patients with initial metastatic recurrence in either liver or lung:
Congrats Kieran et al! Excited to play around with this as we start generating scRNAseq and snRNAseq data in studies getting underway now. https://t.co/mMNh3lc8te
November 13, 2024 at 6:26 PM
Congrats Kieran et al! Excited to play around with this as we start generating scRNAseq and snRNAseq data in studies getting underway now. https://t.co/mMNh3lc8te
Excited to share our findings on how APOE genotype impacts cell responses to AD using human brain snRNAseq. Huge thanks to the team for all the hard work! @drneurochic.bsky.social @mayoclinic.org @cp-neuron.bsky.social
March 20, 2025 at 1:38 AM
Excited to share our findings on how APOE genotype impacts cell responses to AD using human brain snRNAseq. Huge thanks to the team for all the hard work! @drneurochic.bsky.social @mayoclinic.org @cp-neuron.bsky.social
🚨 Latest contribution where we delve into the dementia-related snRNAseq data & spotlight the signature changes in #endothelialcells and #pericytes!
Proud of the effort led by Dr. Michael Sewell @pichaelmichael.bsky.social and Nela Fialova.
alz-journals.onlinelibrary.wiley.com/doi/full/10....
Proud of the effort led by Dr. Michael Sewell @pichaelmichael.bsky.social and Nela Fialova.
alz-journals.onlinelibrary.wiley.com/doi/full/10....
Unraveling the transcriptomic landscape of brain vascular cells in dementia: A systematic review
INTRODUCTION Cerebrovascular dysfunction plays a critical role in the pathogenesis of dementia and related neurodegenerative disorders. Recent omics-driven research has revealed associations between...
alz-journals.onlinelibrary.wiley.com
January 14, 2025 at 11:47 AM
🚨 Latest contribution where we delve into the dementia-related snRNAseq data & spotlight the signature changes in #endothelialcells and #pericytes!
Proud of the effort led by Dr. Michael Sewell @pichaelmichael.bsky.social and Nela Fialova.
alz-journals.onlinelibrary.wiley.com/doi/full/10....
Proud of the effort led by Dr. Michael Sewell @pichaelmichael.bsky.social and Nela Fialova.
alz-journals.onlinelibrary.wiley.com/doi/full/10....
Applying single-cell & single-nucleus genomics to studies of cellular heterogeneity & cell fate transitions in the nervous system
www.nature.com/articles/s41...
Discover the power of sc/snRNAseq in unraveling cellular diversity/transitions. Highlighting creation of cell atlases for neuroscience.
a man is sitting at a desk in front of a computer and smiling .
ALT: a man is sitting at a desk in front of a computer and smiling .
media.tenor.com
December 11, 2024 at 5:04 PM
Applying single-cell & single-nucleus genomics to studies of cellular heterogeneity & cell fate transitions in the nervous system
www.nature.com/articles/s41...
Discover the power of sc/snRNAseq in unraveling cellular diversity/transitions. Highlighting creation of cell atlases for neuroscience.
#SpatialTranscriptomics #ParkinsonsDisease
A role of #FGF9 in Glia #Ferroptosis in PD?😁
+snRNAseq
MPTP🐭 #SubstantiaNigra
FGF9 ⏬in PD Neuron ⏫in PD Ependymal cell
FGF9-to-FGFR1/2/3 (CellChat, likely Neuron-to-Oligodendrocyte/Astrocyte) ⏬in PD
#NPJParkinsonsDis 2025
www.nature.com/articles/s41...
A role of #FGF9 in Glia #Ferroptosis in PD?😁
+snRNAseq
MPTP🐭 #SubstantiaNigra
FGF9 ⏬in PD Neuron ⏫in PD Ependymal cell
FGF9-to-FGFR1/2/3 (CellChat, likely Neuron-to-Oligodendrocyte/Astrocyte) ⏬in PD
#NPJParkinsonsDis 2025
www.nature.com/articles/s41...
July 2, 2025 at 12:08 PM
#SpatialTranscriptomics #ParkinsonsDisease
A role of #FGF9 in Glia #Ferroptosis in PD?😁
+snRNAseq
MPTP🐭 #SubstantiaNigra
FGF9 ⏬in PD Neuron ⏫in PD Ependymal cell
FGF9-to-FGFR1/2/3 (CellChat, likely Neuron-to-Oligodendrocyte/Astrocyte) ⏬in PD
#NPJParkinsonsDis 2025
www.nature.com/articles/s41...
A role of #FGF9 in Glia #Ferroptosis in PD?😁
+snRNAseq
MPTP🐭 #SubstantiaNigra
FGF9 ⏬in PD Neuron ⏫in PD Ependymal cell
FGF9-to-FGFR1/2/3 (CellChat, likely Neuron-to-Oligodendrocyte/Astrocyte) ⏬in PD
#NPJParkinsonsDis 2025
www.nature.com/articles/s41...
In this study, led by @Xuefei and @Leti, we generated snRNAseq & snATACseq data from the livers of 17 species, covering:
a. Different diets (herbivores, omnivores, carnivores, insectivores) 🌿¬🍖🐜
b. Main mammalian lineages (monotremes, marsupials, placentals)🐒🐈🐑🦘
c. A bird outgroup 🐔
a. Different diets (herbivores, omnivores, carnivores, insectivores) 🌿¬🍖🐜
b. Main mammalian lineages (monotremes, marsupials, placentals)🐒🐈🐑🦘
c. A bird outgroup 🐔
October 15, 2025 at 12:51 PM
In this study, led by @Xuefei and @Leti, we generated snRNAseq & snATACseq data from the livers of 17 species, covering:
a. Different diets (herbivores, omnivores, carnivores, insectivores) 🌿¬🍖🐜
b. Main mammalian lineages (monotremes, marsupials, placentals)🐒🐈🐑🦘
c. A bird outgroup 🐔
a. Different diets (herbivores, omnivores, carnivores, insectivores) 🌿¬🍖🐜
b. Main mammalian lineages (monotremes, marsupials, placentals)🐒🐈🐑🦘
c. A bird outgroup 🐔
snRNAseq post-stroke brain repair
Photothrombotic stroke
1 mo post injury
Stroke core vs border zone vs intact
Pleiotrophin signaling in Stroke
⏬EC-immune/-progenitor/-astrocyte
⏫Pericyte-progenitor/-astrocyte
@rrust.bsky.social #JNeuroInflam 2025
link.springer.com/article/10.1...
Photothrombotic stroke
1 mo post injury
Stroke core vs border zone vs intact
Pleiotrophin signaling in Stroke
⏬EC-immune/-progenitor/-astrocyte
⏫Pericyte-progenitor/-astrocyte
@rrust.bsky.social #JNeuroInflam 2025
link.springer.com/article/10.1...
May 18, 2025 at 12:24 PM
snRNAseq post-stroke brain repair
Photothrombotic stroke
1 mo post injury
Stroke core vs border zone vs intact
Pleiotrophin signaling in Stroke
⏬EC-immune/-progenitor/-astrocyte
⏫Pericyte-progenitor/-astrocyte
@rrust.bsky.social #JNeuroInflam 2025
link.springer.com/article/10.1...
Photothrombotic stroke
1 mo post injury
Stroke core vs border zone vs intact
Pleiotrophin signaling in Stroke
⏬EC-immune/-progenitor/-astrocyte
⏫Pericyte-progenitor/-astrocyte
@rrust.bsky.social #JNeuroInflam 2025
link.springer.com/article/10.1...
A single-cell transcriptomic atlas of sensory-dependent gene expression in developing mouse visual cortex
Read this this #LifelongDevSI #OA Techniques and Resources Article by Andre M. Xavier, Qianyu Lin, Chris J. Kang, Lucas Cheadle (@cheadlelab.bsky.social)
doi.org/10.1242/dev....
Read this this #LifelongDevSI #OA Techniques and Resources Article by Andre M. Xavier, Qianyu Lin, Chris J. Kang, Lucas Cheadle (@cheadlelab.bsky.social)
doi.org/10.1242/dev....
November 3, 2025 at 3:59 PM
A single-cell transcriptomic atlas of sensory-dependent gene expression in developing mouse visual cortex
Read this this #LifelongDevSI #OA Techniques and Resources Article by Andre M. Xavier, Qianyu Lin, Chris J. Kang, Lucas Cheadle (@cheadlelab.bsky.social)
doi.org/10.1242/dev....
Read this this #LifelongDevSI #OA Techniques and Resources Article by Andre M. Xavier, Qianyu Lin, Chris J. Kang, Lucas Cheadle (@cheadlelab.bsky.social)
doi.org/10.1242/dev....
snRNA-seq stratifies multiple sclerosis patients into distinct white matter glial responses -- very cool resource snRNAseq study of MS lesions highlighting patient variability in glial cell states
snRNA-seq stratifies multiple sclerosis patients into distinct white matter glial responses
Macnair and Calini et al. analyze 632,000 snRNA-seq profiles from multiple sclerosis and control brain samples, identifying distinct cellular responses in white and gray matter. They stratify MS patients into groups based on patterns of gene expression in white matter glia, suggesting different pathological processes and future personalized therapies.
www.cell.com
December 21, 2024 at 12:11 PM
snRNA-seq stratifies multiple sclerosis patients into distinct white matter glial responses -- very cool resource snRNAseq study of MS lesions highlighting patient variability in glial cell states
November 19, 2024 at 10:42 AM
Check out this cool preprint led by @ccstorytime.bsky.social with snRNAseq data on 60,000 nuclei from human muscle-tendon tissue 4 h after exercise
@myoblue.bsky.social
@myoblue.bsky.social
BSMB Autumn meeting Surrey talking about our latest work. Very proud of Team Tendon & collaborators for persevering with such a difficult tissue 👏
www.biorxiv.org/content/10.1...
@ismcopenhagen.bsky.social @steffendanielle.bsky.social @valerioizzi.bsky.social @abigailmackey1.bsky.social
www.biorxiv.org/content/10.1...
@ismcopenhagen.bsky.social @steffendanielle.bsky.social @valerioizzi.bsky.social @abigailmackey1.bsky.social
September 3, 2025 at 4:40 AM
Check out this cool preprint led by @ccstorytime.bsky.social with snRNAseq data on 60,000 nuclei from human muscle-tendon tissue 4 h after exercise
@myoblue.bsky.social
@myoblue.bsky.social
Over 425,000 dorsal forebrain organoid cells represented in these Single Nuclei RNA Sequencing transcriptomes.
Each dataset represents a publication in preparation right now. Hoping to have some preprints out soon (academic "soon") 🧪 #Organoid #snRNAseq #neuroscience
Each dataset represents a publication in preparation right now. Hoping to have some preprints out soon (academic "soon") 🧪 #Organoid #snRNAseq #neuroscience
November 20, 2024 at 9:01 PM
Over 425,000 dorsal forebrain organoid cells represented in these Single Nuclei RNA Sequencing transcriptomes.
Each dataset represents a publication in preparation right now. Hoping to have some preprints out soon (academic "soon") 🧪 #Organoid #snRNAseq #neuroscience
Each dataset represents a publication in preparation right now. Hoping to have some preprints out soon (academic "soon") 🧪 #Organoid #snRNAseq #neuroscience
I'm hoping to connect with the science community here!
I'm Ryan - my research in the Haussler-Salama Lab at UCSC is focused on everything cerebral organoids - culturing, patterning, microscopy, snRNAseq, ephys...
I've got a couple of papers in preparation
And plenty of science content to share
I'm Ryan - my research in the Haussler-Salama Lab at UCSC is focused on everything cerebral organoids - culturing, patterning, microscopy, snRNAseq, ephys...
I've got a couple of papers in preparation
And plenty of science content to share
November 17, 2024 at 8:08 PM
I'm hoping to connect with the science community here!
I'm Ryan - my research in the Haussler-Salama Lab at UCSC is focused on everything cerebral organoids - culturing, patterning, microscopy, snRNAseq, ephys...
I've got a couple of papers in preparation
And plenty of science content to share
I'm Ryan - my research in the Haussler-Salama Lab at UCSC is focused on everything cerebral organoids - culturing, patterning, microscopy, snRNAseq, ephys...
I've got a couple of papers in preparation
And plenty of science content to share
I had to summarize a paper from a lab who are prolific in snRNAseq studies in my area of research for my department recently. That paper had 475 panels. Their UMAP was not what I was concerned about. :P
UMAP are fine, if anything UMAP that look weird are red flags and thus useful.
UMAP are fine, if anything UMAP that look weird are red flags and thus useful.
January 27, 2025 at 12:53 AM
I had to summarize a paper from a lab who are prolific in snRNAseq studies in my area of research for my department recently. That paper had 475 panels. Their UMAP was not what I was concerned about. :P
UMAP are fine, if anything UMAP that look weird are red flags and thus useful.
UMAP are fine, if anything UMAP that look weird are red flags and thus useful.
👉31 significant loci
👉Mendelian randomization showed
• effects of genetically proxied blood pressure & predisposition to diabetes on PSMD
• effects of genetically proxied PSMD on small vessel stroke & intracerebral hemorrhage
👉integration with transcriptomic and brain snRNAseq data
👉Mendelian randomization showed
• effects of genetically proxied blood pressure & predisposition to diabetes on PSMD
• effects of genetically proxied PSMD on small vessel stroke & intracerebral hemorrhage
👉integration with transcriptomic and brain snRNAseq data
February 17, 2025 at 6:33 PM
👉31 significant loci
👉Mendelian randomization showed
• effects of genetically proxied blood pressure & predisposition to diabetes on PSMD
• effects of genetically proxied PSMD on small vessel stroke & intracerebral hemorrhage
👉integration with transcriptomic and brain snRNAseq data
👉Mendelian randomization showed
• effects of genetically proxied blood pressure & predisposition to diabetes on PSMD
• effects of genetically proxied PSMD on small vessel stroke & intracerebral hemorrhage
👉integration with transcriptomic and brain snRNAseq data
In another study, @drlaramieduncan.bsky.social , Li, @deisseroth.bsky.social , @willgiardino.bsky.social , & team at @stanford.edu combined GWAS with snRNAseq to provide insight into the cellular basis of psych disorders. In @natureneuro.bsky.social : www.nature.com/articles/s41...
Mapping the cellular etiology of schizophrenia and complex brain phenotypes - Nature Neuroscience
Duncan and colleagues link specific human brain cell types to schizophrenia and other complex brain phenotypes, providing mechanistic insights and a cellular taxonomy for psychiatric disorders.
www.nature.com
February 11, 2025 at 1:36 PM
In another study, @drlaramieduncan.bsky.social , Li, @deisseroth.bsky.social , @willgiardino.bsky.social , & team at @stanford.edu combined GWAS with snRNAseq to provide insight into the cellular basis of psych disorders. In @natureneuro.bsky.social : www.nature.com/articles/s41...
Opposite directions of association of higher physical activity and higher insulin resistance with human skeletal muscle cell type abundance and fiber type-level gene expression #snRNAseq #SingleNucleus #RNAseq #genomics 🧪🧬🖥️ www.biorxiv.org/content/10.1...
www.biorxiv.org
October 31, 2025 at 11:06 AM
Opposite directions of association of higher physical activity and higher insulin resistance with human skeletal muscle cell type abundance and fiber type-level gene expression #snRNAseq #SingleNucleus #RNAseq #genomics 🧪🧬🖥️ www.biorxiv.org/content/10.1...
We first looked at the serotonin receptor transcripts. We see that the transcripts encoding the 5-HT1A, 5-HT2A, and 5-HT2C receptors are present, but with very distinct expression profiles across the cell types.
January 6, 2025 at 12:55 PM
We first looked at the serotonin receptor transcripts. We see that the transcripts encoding the 5-HT1A, 5-HT2A, and 5-HT2C receptors are present, but with very distinct expression profiles across the cell types.